Conference Coverage

Guest: Carel le Roux, MBChB, MSC, FRCP, FRCPath, PhD New findings from the SYNCHRONIZE-1 trial reveal that survodutide's impact extends beyond weight reduction, with a demonstrated decrease in liver fat and meaningful improvements across multiple markers of metabolic health in patients without type 2 diabetes. Dr. Carel le Roux joins us to share the efficacy and safety data and explore what these results could mean for the future of metabolic disease management. Dr. Le Roux is the Director of the Metabolic Medicine Group and a Professor of Chemical Pathology in the School of Medicine at University College Dublin, and he presented these findings at the 2026 American Diabetes Association Scientific Sessions.

Guest: Kimberly Narain, MD, MPH, PhD Cost-related medication nonadherence remains a significant but often hidden barrier to effective diabetes care, with out-of-pocket costs preventing patients from accessing essential therapies. Dr. Kimberly Narain joins us to explain why clinicians should look beyond insurance status alone and consider affordability challenges when developing strategies to improve diabetes outcomes. Dr. Narain is an Assistant Professor of Medicine at the David Geffen School of Medicine at UCLA, as well as the Director of Health Services and Health Optimization Research at the Iris Cantor UCLA Women's Health Center. She also spoke about this topic at the 2026 American Diabetes Association Scientific Sessions.

Guest: John W. Ostrominski, MD, MPH Despite advances in glycemic management, blood pressure control, lipid lowering, and disease-modifying therapies, patients with chronic kidney disease (CKD) and type 2 diabetes continue to face substantial residual cardiovascular risk. In this program, Dr. John Ostrominski reviews emerging evidence linking low-grade systemic inflammation to adverse cardiovascular outcomes in this high-risk population, highlighting findings from the FIDELITY pooled analysis of FIDELIO-DKD and FIGARO-DKD. Dr. Ostrominski is a fellow specializing in cardiovascular disease and obesity medicine at Brigham and Women's Hospital and Harvard Medical School. He spoke about this topic at the 2026 American Diabetes Association Scientific Sessions.

Guest: Jaime Imitola, MD As stem cell therapies continue to generate significant interest among patients with multiple sclerosis (MS), clinicians must be prepared to distinguish between approved treatments, investigational approaches, and unproven interventions marketed through stem cell tourism. Hear more as Dr. Jaime Imitola discusses the current landscape of stem cell therapies in MS, the risks associated with unregulated treatments, and the importance of patient education and evidence-based guidance. Dr. Imitola is the Vice Chair for Research of the Department of Neurology and the Director of the Division of Multiple Sclerosis and Translational Neuroimmunology at UConn Health. He also spoke about this topic at the 2026 Consortium of Multiple Sclerosis Centers Annual Meeting.

Host: Steve Jackson, PharmD Guest: Souptik Barua, PhD Guest: Emily Johnston, MPH, PhD Can older adults successfully engage with telehealth, wearable technology, and digital health tools to prevent type 2 diabetes? In this conversation with Dr. Steve Jackson, Dr. Emily Johnston and Dr. Souptik Barua discuss emerging insights on how these strategies could improve accessibility and engagement in a high-risk population. Dr. Johnston is a Research Assistant Professor in the Department of Medicine, and Dr. Barua is an Assistant Professor in the Division of Precision Medicine at the NYU Grossman School of Medicine. They presented these findings at the 2026 American Diabetes Association Scientific Sessions.

Guest: Javier Morales, MD, FACP, FACE For patients with obesity and type 2 diabetes (T2D), emerging incretin-based therapies that target multiple metabolic pathways are producing meaningful weight-loss outcomes. To learn more about these care strategies, tune in as Dr. Javier Morales shares key updates from the 2026 American Diabetes Association Scientific Sessions. Dr. Morales is an Associate Clinical Professor of Medicine at the Barbara and Donald Zucker School of Medicine at Hofstra University and Northwell Health.

Guest: Javier Morales, MD, FACP, FACE From proactive screening to once-weekly insulin, the treatment landscape for type 1 diabetes is evolving rapidly. Join Dr. Javier Morales to hear about current and emerging care strategies in these patients, a topic he also discussed at the 2026 American Diabetes Association Scientific Sessions. Dr. Morales is an Associate Clinical Professor of Medicine at the Barbara and Donald Zucker School of Medicine at Hofstra University and Northwell Health.

Guest: Emily MacDuffie, MD A recent survey conducted by physicians at Penn Medicine found that one-third of female oncologists reported experiencing infertility. Join Dr. Emily Macduffie, Radiation Oncology Resident Physician at Penn Medicine, as she speaks about potential solutions related to infertility for women in medicine based on her 2023 ASCO presentation.

Guest: Alison Wakoff Loren, MD, MSCE Cancer occurs in approximately 1 in every 1,000 pregnant patients and requires complex solutions from a multidisciplinary team. Learn more about the expanding management options for these patients with Dr. Alison Loren, Chief of the Division of Hematology and Oncology at the University of Pennsylvania Perelman School of Medicine.

Guest: Elizabeth S. Gromisch, PhD Cognitive changes are a common but complex aspect of multiple sclerosis care, making practical and accessible screening strategies essential. In this program, Dr. Elizabeth Gromisch explores both traditional and digital cognitive screening tools for MS and shares real-world insights on selecting and implementing assessments across a range of clinical settings. Dr. Gromisch is a research neuropsychologist at the Joyce D. and Andrew J. Mandell Center for Comprehensive Multiple Sclerosis Care and Neuroscience Research at Mount Sinai Rehabilitation Hospital, Trinity Health of New England. She also discussed this topic at the 2026 Consortium of Multiple Sclerosis Centers Annual Meeting.

Presenter: Louis Bessette MD, FRCP(C), MSc What can nearly two decades of real-world data teach us about optimizing care in early inflammatory arthritis? Find out with Dr. Louis Bessette as he reviews key findings from the Canadian Early Arthritis Cohort (CATCH), a national, multicenter study of nearly 4,000 patients enrolled within weeks of symptom onset. Not only is Dr. Bessette a Professor of Medicine at Université Laval and the Director of the Centre for Osteoporosis and Rheumatology of Québec, but he also spoke about this topic at the 2026 Congress of Clinical Rheumatology East conference.

Guest: Avery H. LaChance, MD, MPH, FAAD Acute and subacute cutaneous lupus each have recognizable skin presentations that can help guide diagnosis, especially when distinguishing them from similar conditions. Join Dr. Avery H. LaChance as she breaks down their key diagnostic features, common mimics, and important considerations for clinical evaluation. Dr. LaChance is Director of the Connective Tissue Disease Clinic, Director of the Advanced Psoriasis Therapeutics Clinic, Director of Health Policy and Advocacy, and Program Director of the Dermatology-Rheumatology Fellowship at Brigham and Women’s Hospital. She’s also an Associate Professor of Dermatology at Harvard Medical School, and she spoke on this topic at the 2026 Congress of Clinical Rheumatology East.

Presenter: Louis Bessette MD, FRCP(C), MSc From early arthritis treatment pathways to emerging digital health tools, the 2026 Congress of Clinical Rheumatology East conference spotlights the clinical and scientific advances shaping the future of rheumatology care. Joining us to outline those key themes and sessions is Dr. Louis Bessette, Professor of Medicine at Université Laval and the Director of the Centre for Osteoporosis and Rheumatology of Québec.

Guest: Jeanette Andrade, PhD, RDN, LDN, FAND Food and nutrition insecurity in chronic kidney disease (CKD) can be difficult to detect, even when patients appear clinically stable. To help highlight this challenge, Dr. Jeanette Andrade presents a case from her research illustrating how social and financial stressors affected a dialysis patient’s dietary intake and food access. Dr. Andrade is an Associate Professor and the Director of the Master’s in Dietetic Internship Program at the University of Florida, and this patient case was part of her presentation at the 2026 National Kidney Foundation Spring Clinical Meeting.

Guest: Abdallah Geara, MD IgA nephropathy is often asymptomatic and frequently identified through incidental lab findings, making timely recognition challenging. Hear Dr. Abdallah Geara discuss key diagnostic strategies that may help optimize long-term care for this disease. Dr. Geara is an Associate Professor of Clinical Medicine and the Clinical Director of the Glomerular Disease Program at the Perelman School of Medicine at the University of Pennsylvania, and he spoke at the 2026 National Kidney Foundation Spring Clinical Meeting.

Guest: Deborah Clegg, PhD For decades, potassium restriction has been a cornerstone of dietary management in patients with chronic kidney disease (CKD), but is it always necessary? Here to answer that exact question is Dr. Deborah Clegg. Since many patients may already be consuming potassium at restricted levels, she emphasizes the importance of individualized dietary assessment before imposing further limitations. Dr. Clegg is the Vice President for Research and a Professor in the Department of Internal Medicine at Texas Tech University Health Sciences Center in El Paso.

Guest: Deborah Clegg, PhD Not all potassium is created equal, especially in the context of chronic kidney disease (CKD). That’s why Dr. Deborah Clegg joins us to explore the key differences between potassium from whole foods and additives, emphasizing how bioavailability impacts serum potassium levels and hyperkalemia risk. She also examines how kidney function, comorbidities, medications, and metabolic factors all influence potassium tolerance. Not only is Dr. Clegg the Vice President for Research and a Professor in the Department of Internal Medicine at Texas Tech University Health Sciences Center in El Paso, but she also spoke about this topic at the 2026 National Kidney Foundation Spring Clinical Meeting.

Guest: Abdallah Geara, MD Early diagnosis is critical in IgA nephropathy, as most patients present with established kidney damage by the time they are identified. Tune in to hear Dr. Abdallah Geara highlight the importance of timely recognition and how emerging therapies are transforming treatment and improving patient outcomes when implemented early.

Guest: Jeanette Andrade, PhD, RDN, LDN, FAND Food and nutrition insecurity are increasingly recognized as critical factors affecting outcomes for patients with chronic kidney disease (CKD). That’s why Dr. Jeanette Andrade joins us to share practical screening strategies and emerging solutions, like dialysis center food pantries and digital health tools. Dr. Andrade is an Associate Professor and the Director of the Master’s in Dietetic Internship Program at the University of Florida, and she spoke about this topic at the 2026 National Kidney Foundation Spring Clinical Meeting.

Guest: Avery H. LaChance, MD, MPH, FAAD Cutaneous dermatomyositis has a distinct pattern of skin findings that, once recognized, can make diagnosis much more straightforward. Tune in to hear Dr. Avery H. LaChance walk through the key visual clues and exam tips that help bring this condition into focus. Dr. LaChance is Director of the Connective Tissue Disease Clinic, Director of the Advanced Psoriasis Therapeutics Clinic, Director of Health Policy and Advocacy, and Program Director of the Dermatology-Rheumatology Fellowship at Brigham and Women’s Hospital. She’s also an Associate Professor of Dermatology at Harvard Medical School, and she spoke on this topic at the 2026 Congress of Clinical Rheumatology East.

Host: Matt Birnholz, MD Guest: Susanna Gallani, PhD AI is enabling a more thoughtful, value-driven approach to healthcare—one that prioritizes patient outcomes over the volume of services delivered. At the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting, Dr. Matt Birnholz sat down with this year's keynote speaker, Dr. Susanna Gallani, to explore how rich data can be transformed into actionable insights that ultimately improve patients' lives. Tune in to hear how leaders are balancing innovation with ethical responsibility while empowering clinicians to reconnect with the human side of medicine. Dr. Gallani is the Tai Family Associate Professor of Business Administration at Harvard Business School.

Host: Matt Birnholz, MD Guest: Justin O’Rourke, PhD, MBA Trust is foundational to effective scientific communication—but what factors actually drive it? Find out as Dr. Matt Birnholz speaks with Dr. Justin O’Rourke, a recent business psychology PhD graduate from The Chicago School, about his research on physician perceptions of medical science liaisons (MSLs) and their implications for delivering scientific information. Tune in for practical insights from this conversation at the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting.

Host: Matt Birnholz, MD Guest: Abigail Sporer, PhD, MBA At the intersection of expertise, strategy, and collaboration, medical affairs professionals are translating vaccine science into meaningful and actionable insights for healthcare providers. In this candid conversation from the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting, Dr. Matt Birnholz and Dr. Abigail Sporer, Director of US Medical Affairs at CSL Seqirus, discuss the evolving realities of vaccine education, from addressing misinformation to strengthening engagement. Learn more about how medical affairs plays a role in supporting clinicians and improving communication in a complex public health landscape.

Host: Matt Birnholz, MD Guest: Michael DeLuca, PharmD, MBA, MSRA From launch excellence to global operational support, medical affairs teams are evolving to enhance scientific exchange and drive meaningful outcomes for patients. Learn more with Dr. Matt Birnholz and Dr. Michael DeLuca, Executive Vice President of Global Medical Affairs and Medical Information at EVERSANA, who explored key trends shaping the field at the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting. Hear about how artificial intelligence and other innovations are transforming data generation, insight development, and engagement strategies.

Host: Matt Birnholz, MD Guest: Renu Juneja, PhD What do pharmaceutical leaders actually need from their agency partners? Find out as Dr. Matt Birnholz sits down with Dr. Renu Juneja to explore how insight-led collaboration can unlock stronger relationships, faster timelines, and more impactful medical education. In this conversation at the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting, they share perspectives on how challenging assumptions, leveraging artificial intelligence, and developing scalable strategies can help deliver meaningful value. Dr. Juneja is the President of ADPAL LLC, a boutique company advising consulting firms and agency partners.

Host: Matt Birnholz, MD Guest: Tony Page Early, integrated insights can dramatically improve pharmaceutical launch outcomes and reduce the risk of missed expectations. Discover best practices for aligning market needs with clinical strategy and leveraging AI for smarter insight planning with Dr. Matt Birnholz and Mr. Tony Page, who shared their perspectives at the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting. Mr. Page is the Senior Vice President of Insight at Within3, a platform dedicated to launch insights.

Host: Matt Birnholz, MD Guest: Brandon Young, PhD Today’s medical science liaisons (MSLs) are navigating a rapidly shifting healthcare landscape. Step inside the evolving world of medical affairs as Dr. Matt Birnholz sits down with Dr. Brandon Young, senior MSL at CSL Seqirus, to uncover how communication, collaboration, and emerging technologies are shaping the future of the field. Gain insights on these shifts in this discussion from the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting.

Host: Matt Birnholz, MD Guest: Karen Roy, MSc For medical affairs teams, demonstrating the value and impact of educational initiatives in a meaningful and measurable way is essential. At the 2026 Medical Affairs Professional Society (MAPS) Annual Meeting, Dr. Matt Birnholz spoke with Ms. Karen Roy, CEO and Co-Founder of Infograph-ed, about how CME-informed strategies can elevate planning, content design, and outcomes measurement. Learn more about new approaches that can help create more targeted, insight-driven education.

Guest: Mark Freedman, HBSc, MSc, MD, CSPQ, FAAN, FRCPC The role of cell-based therapies in multiple sclerosis (MS) is evolving, with immune system replacement via autologous stem cells, investigational mesenchymal repair strategies, and CAR T-cell approaches changing the treatment landscape. Hear from Dr. Mark Freedman as he dives into current and emerging mechanisms of action, which he also discussed at the 2026 Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting. Dr. Freedman is a Professor of Medicine in Neurology at the University of Ottawa and a Senior Scientist at the Ottawa Hospital Research Institute.

Guest: Jeffrey Hsu, MD, PhD The field of sports cardiology has experienced remarkable growth, with new guidelines, expanding programs, and increasing recognition of cardiovascular risk in athletes. Hear from Dr. Jeffrey Hsu as he shares current and emerging approaches to risk assessment, prevention, and management of cardiac conditions in this population. Dr. Hsu is a Clinical Assistant Professor of Medicine at the David Geffen School of Medicine at UCLA, and he spoke about this topic at the 2026 American College of Cardiology (ACC) Scientific Sessions.

Guest: Riley Bove, MD, MMSc Multiple sclerosis (MS) is often diagnosed during peak reproductive years, making proactive, informed care essential across the lifespan. Hear from Dr. Riley Bove as she discusses the importance of early, ongoing conversations about fertility, pregnancy, and menopause in this population. Dr. Bove is an Associate Professor at UCSF Weill Institute for Neurosciences, and she discussed this topic at the 2026 American Academy of Neurology (AAN) Annual Meeting.

Guest: Aaron Miller, MD Early real-world experience with the 2024 McDonald criteria suggests a meaningful increase in multiple sclerosis (MS) diagnoses, driven largely by recognition of optic nerve involvement and reclassification of radiologically isolated syndrome. Hear from Dr. Aaron Miller as he reviews emerging evidence, explains how these updates are reshaping diagnostic pathways, and addresses practical challenges in implementation. Dr. Miller is the Medical Director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis and a Professor of Neurology at the Icahn School of Medicine at Mount Sinai in New York. He also spoke about this topic at the 2026 American Academy of Neurology (AAN) Annual Meeting.

Guest: Aaron Miller, MD Hear from Dr. Aaron Miller as he shares important updates in multiple sclerosis (MS) at the 2026 American Academy of Neurology (AAN) Annual Meeting. Dr. Miller is the Medical Director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis and a Professor of Neurology at the Icahn School of Medicine at Mount Sinai in New York.

Guest: Elizabeth Wilson, MD At the 2026 American Academy of Neurology (AAN) Annual Meeting, experts are sharing the latest developments in pediatric multiple sclerosis (MS). Dr. Elizabeth Wilson is here to share insights on how new adult MS research, neuro-ophthalmology collaboration, and emerging clinical data are shaping the future of care. Dr. Wilson is the Director of the Multiple Sclerosis and Neuroimmunology Center at Cincinnati Children's Hospital.

Guest: Raphael Schneider, MD, PhD, FRCPC, CIP Multiplex proteomic biomarker panels are redefining how we understand and monitor multiple sclerosis (MS) by capturing interconnected pathways in a single sample. Hear from Dr. Raphael Schneider as he explores how these tools could inform prognosis, risk stratification, and clinical trial design, which he spoke about at the 2026 ACTRIMS Forum. Dr. Schneider is a neurologist and researcher at the BARLO MS Centre at St. Michael’s Hospital as well as an Assistant Professor and the Elizabeth S. Barford Early Career Professor in Multiple Sclerosis in the Department of Medicine at the University of Toronto.

Guest: Jennifer Yang, MD Emerging evidence shows that children with multiple sclerosis exhibit accelerated biological aging. Learn more about the potential implications with Dr. Jennifer Yang, who spoke about this topic at the 2026 ACTRIMS Forum. She's an Assistant Professor of Neurosciences at the UC San Diego School of Medicine and the Division of Pediatric Neurology at Rady Children's Hospital.

Guest: Adil Harroud, MD Guest: Dylan Hamitouche Host: Ryan Quigley Multimodal aging signatures are reshaping our understanding of progression and prognosis in multiple sclerosis (MS). Host Ryan Quigley sits down with Dr. Adil Harroud and Mr. Dylan Hamitouche to learn more about implications for the future of risk stratification and personalized treatment in MS, a topic they presented on at the 2026 ACTRIMS Forum. Dr. Harroud is a neurologist and the co-leader of the Neuroimmunology Diseases Research Group at the Montreal Neurological Institute at McGill University. Mr. Hamitouche is a medical student at McGill University.

Presenter: Ryan Quigley Can real-time transepidermal water loss (TEWL) monitoring reduce the risk of anaphylaxis during oral food challenges in young children with peanut allergy? A pilot trial suggests it may. TEWL-guided stopping significantly lowered anaphylaxis rates and reaction severity without delaying treatment. This benefit was linked to earlier discontinuation of allergen exposure based on physiologic changes, rather than faster intervention. While larger studies are needed, these findings support TEWL monitoring as a promising tool to enhance safety and decision-making during food challenges. Learn more in this episode of AudioAbstracts.

Host: Brian P. McDonough, MD, FAAFP Guest: Christopher T. Chen, MD What if a simple blood draw could reveal whether a patient is responding to treatment before surgery? That question is at the heart of a study presented at the 2025 ESMO Congress, which investigated neoadjuvant immune checkpoint blockade in mismatch-repair-proficient (MMR-p) colon cancer. In addition to confirming that combination immunotherapy prior to surgery is a safe and feasible approach, the study also found that circulating tumor DNA (ctDNA) levels correlated with both tumor burden and early treatment response. Joining Dr. Brian McDonough to unpack these insights is Dr. Christopher Chen, Assistant Professor in the Division of Oncology in the Department of Medicine at Stanford University School of Medicine.

Guest: Marc Avram, MD Lengthy hair transplant procedures place significant physical demands on patients, physicians, and staff, making ergonomics a critical part of success. Dr. Marc Avram outlines practical, real-world strategies to improve positioning, workflow, and the procedural environment to enhance comfort, efficiency, and long-term musculoskeletal health. Dr. Avram is a dermatologist, hair loss and transplant specialist, and Clinical Professor of Dermatology at New York-Presbyterian Hospital/Weill Cornell Medical Center.

Guest: Marc Avram, MD Understanding the differences between follicular unit extraction (FUE) and follicular unit transplantation (FUT) is essential for selecting the most appropriate approach for each patient. Dr. Marc Avram shares how harvesting methods, scarring patterns, and other patient-specific considerations can help inform technique choice. Dr. Avram is a dermatologist, hair loss and transplant specialist, and Clinical Professor of Dermatology at New York-Presbyterian Hospital/Weill Cornell Medical Center.

Host: Hallie Blevins, PhD For patients with multiple sclerosis (MS), cognitive impairment can quietly erode independence and quality of life. In this AudioAbstract, Dr. Hallie Blevins discusses a head-to-head comparison of cognitive training, aerobic exercise, and a combined approach and explores how we can better support cognition in these patients.

Guest: John H. Strickler, MD The treatment landscape for HER2-positive gastroesophageal cancer is rapidly evolving, with zanidatamab emerging as a new option following years of limited progress beyond trastuzumab. Dr. John Strickler joins us to share insights on how recent FDA approvals and novel agents are transforming outcomes in this complex disease setting. Dr. Strickler is a Professor of Medicine in the Division of Medical Oncology at Duke University School of Medicine and Co-Leader for the Precision Cancer Medicine and Investigational Therapeutics Program at the Duke Cancer Institute.

Guest: William Hall, MD From tumor detection to biomarker development, artificial intelligence (AI) is rapidly reshaping the landscape of gastrointestinal oncology. In this expert-led program, Dr. William Hall explains how AI is being applied to data to identify tumor features and treatment susceptibilities faster and more precisely than traditional methods. Dr. Hall is a Professor and Chair of Radiation Oncology at the Medical College of Wisconsin, and he spoke about this topic at the 2026 ASCO Gastrointestinal Cancers Symposium.

Guest: Daniela Molena, MD For patients with locally advanced gastroesophageal cancer, surgery remains a critical component of curative treatment—even in the era of chemoradiation and advanced imaging. Dr. Daniela Molena explores the challenges of assessing complete clinical response and the risks of non-operative management. Dr. Molena is an Associate Professor of Surgery at Weill Cornell Medicine and a Thoracic Surgeon at Memorial Sloan Kettering Cancer Center, and she discussed this topic at the 2026 ASCO Gastrointestinal Cancers Symposium.

Host: Pavani Chalasani, MD, MPH Guest: Timothy Yap, MBBS, PhD, FRCP Early findings from the PETRA study suggest that combining saruparib with camizestrant may offer added clinical benefit in ER+/HER2– advanced breast cancer, particularly in patients with BRCA or PALB2 mutations. Tune in to hear from Dr. Pavani Chalasani and Dr. Timothy Yap as they discuss this encouraging new data on tolerability and antitumor activity. Dr. Yap is the Ransom Horne, Jr. Endowed Professor for Cancer Research, Vice President and Head of Clinical Development in the Therapeutic Discovery Division, and a professor in the Department of Investigational Cancer Therapeutics at the University of Texas MD Anderson Cancer Center. He recently presented this research at the 2025 San Antonio Breast Cancer Symposium.

Guest: Seth Wander, MD, PhD Over the past decade, CDK4/6 inhibitors have transformed the treatment landscape for HR+ breast cancer, but resistance remains a key clinical challenge. Hear from Dr. Seth Wander as he explores the latest translational insights into resistance mechanisms, including genomic alterations affecting cell cycle and signal transduction pathways, and discusses evolving therapeutic strategies. Dr. Wander is an Assistant Professor of Medicine at Harvard Medical School and the Director of Precision Medicine at the Termeer Center for Targeted Therapies at Mass General Brigham Cancer Institute. He also spoke about this topic at the 2025 San Antonio Breast Cancer Symposium.

Host: Ryan Quigley Guest: Kathrin M. Bernt, MD Guest: Rushabh Mehta, BS Guest: Fatemeh Alikarami New data presented at the American Society of Hematology (ASH) Annual Meeting and Exposition reveals how chemotherapy and immunotherapy may drive the emergence of CD-19–negative, myeloid-like subclones in pediatric B-cell acute lymphoblastic leukemia (B-ALL). Mr. Ryan Quigley sits down with Dr. Kathrin Bernt, Dr. Fatemah Alikarami, and Mr. Rushabh Mehta to discuss how their findings could impact minimal residual disease detection, therapy resistance, and future risk stratification strategies. Dr. Bernt is a pediatric oncologist and an Associate Professor of Pediatrics at the Children’s Hospital of Philadelphia. Dr. Alikarami is a Research Associate Scientist at the Children’s Hospital of Philadelphia. Mr. Mehta is a PhD candidate in cell and molecular biology at the University of Pennsylvania.

Guest: Victoria Coleman-Cowger, PhD Gene therapy offers transformative potential for individuals with sickle cell disease, but the psychosocial challenges that accompany such a major decision are often underestimated. Hear from Dr. Victoria Coleman-Cowger as she highlights recommendations for supporting emotional wellbeing during and after gene therapy and explains the importance of recognizing both the psychological and social impacts of curative treatment. Dr. Coleman-Cowger is a licensed clinical psychologist and the Associate Vice President of Neurology and Cell and Gene Therapy at Emmes, a full-service clinical research foundation.

Guest: Ashvini Keshavan, MRCP, PhD Very few patients in UK memory services receive an Alzheimer’s diagnosis supported by molecular testing, limiting timely access to emerging therapies. The ADAPT trial—which was funded by the Blood Biomarker Challenge, a multi-million-pound program supported by the Alzheimer's Society, Alzheimer's Research UK, and players of People's Postcode Lottery—aims to close this gap by evaluating the real-world integration of blood-based biomarkers into standard NHS memory care pathways. Join Dr. Ashvini Keshavan as she discusses how this approach may impact diagnostic accuracy, treatment access, and healthcare resource use across the UK. Dr. Keshavan is a Senior Clinical Research Fellow and Honorary Consultant Neurologist specializing in Alzheimer’s disease biomarkers at the University College London, and this topic was presented as a poster at the 2025 CTAD conference.