DASON Digest

Episode Notes In this episode of the DASON Digest, we discuss Chris Bland's study on IV push cefepime for Pseudomonas aeruginosa and the implications of these findings. The article can be found here: https://pubmed.ncbi.nlm.nih.gov/41166592/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join ID Pharmacy Resident Paul Puccio as he speaks with Dr. Arielle Cohen, an ID Fellow at Duke University, is about the antimicrobial updates in the 2026 Surviving Sepsis Campaign guidelines. They focus on timing of antibiotic initiation, antimicrobial coverage, and rapid diagnostic tests and what this means for the treatment of sepsis and septic shock. The guidelines can be viewed here: https://pubmed.ncbi.nlm.nih.gov/41870560/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest, we discuss Dr. Amy Kang’s study on antimicrobial transition errors from hospitals to skilled nursing facilities, highlighting that nearly one-third of patients experience errors and why stewardship efforts must extend beyond hospital discharge to improve continuity, safety, and infection outcomes. The article from the episode can be viewed here: https://pubmed.ncbi.nlm.nih.gov/41852555/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard and Dr. Rey Perez as they discuss the 2026 GOLD guideline updates regarding antibiotic use in COPD exacerbations. Together, they explore the clinical implications of antibiotic treatment indications—including prior positive sputum cultures—and discuss practical strategies for antimicrobial stewardship teams to reduce unnecessary empiric prescribing at the point of admission. The document for this episode can be viewed here: https://goldcopd.org/wp-content/uploads/2026/01/GOLD-REPORT-2026-v1.3-8Dec2025_WMV2.pdf For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard and UNC ID Pharmacy Resident Kelly Gaebel as they discuss a recent article from Open Forum Infectious Diseases examining physician antibiotic prescribing preferences for community-acquired pneumonia and complicated urinary tract infections. Together, they explore how clinicians weigh factors like guideline recommendations, patient risk, and treatment outcomes—and what these findings may mean for antimicrobial stewardship efforts in community hospitals. The article may be viewed here: https://pubmed.ncbi.nlm.nih.gov/41567263/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Angelina Davis talks with us about an article in Clinical Infectious Diseases called "State-of-the-Art Review: Diagnosis and Management of Acute and Chronic Bacterial Prostatitis." The article can be viewed here: https://pubmed.ncbi.nlm.nih.gov/41657226/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson talks with Drs. Ritika Prasad, Radhika Arya, and Natalie Medvedeva about their publication in Antimicrobial Stewardship & Healthcare Epidemiology entitled "Gut check: antimicrobial stewardship opportunities in intra-abdominal infections." The article can be viewed here: https://pmc.ncbi.nlm.nih.gov/articles/PMC12877908/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison, Dr. April Dyer, chats with us about an article in ASHE entitled "Implementation of an interruptive electronic health record alert improves optimal antibiotic prescribing in ambulatory patients with acute bacterial sinusitis: a quasi-experiment." The article can be viewed here: https://pubmed.ncbi.nlm.nih.gov/41607693/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard talks with Dr. Jarrod Kile from Jefferson University about an article in the New England Journal of Medicine entitled "Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026." Links for this and other materials reviewed in this episode can be found on the DASON website here: https://dason.medicine.duke.edu/blog/navigating-vaccine-changes-insights-and-updates-vaccine-integrity-project For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Liaison Jeannette Bouchard as she speaks about a hot off the press article from JAMA Internal Medicine titled 'Antibiotic De-Escalation in Adults Hospitalized for Community-Onset Sepsis”. The article can be viewed here: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2842980

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Angelina Davis talks with us about three stewardship interventions for hospitals to start using in 2026. The articles reviewed today can be found here: 1. https://pubmed.ncbi.nlm.nih.gov/41306709/ 2. https://pubmed.ncbi.nlm.nih.gov/41245846/ 3. https://pubmed.ncbi.nlm.nih.gov/41127160/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard speaks with Drs. Whitney Buckel and Jared Olson about a hot off the press article from ICHE titled “Interventions to optimize duration of antibiotic therapy and encourage oral transition for uncomplicated gram-negative blood stream infections across a health system”. Their findings highlight practical strategies for optimizing antibiotic therapy across large hospital networks, and the article can be viewed here: https://pubmed.ncbi.nlm.nih.gov/41263023/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Liaison Jeannette Bouchard as she speaks with Dr. Bruce Jones and aspiring pharmacist Jill Foster, authors on an IDWeek poster that caught the attention of a few DASON liaisons. The poster was titled  “Impact of Removing ‘Budding Yeast’’ From Urinalysis Reports on Fluconazole Use”. Take a listen to hear about a great local initiative that made a big impact on fluconazole use at their institution. Link to supporting article:

In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson talks with Dr. Tyler Mitzner and Dr. Lisa Dumkow from Trinity Health Grand Rapids Hospital about their new publication comparing cefdinir and cephalexin for uncomplicated UTI treatment. The article can be found here: https://pubmed.ncbi.nlm.nih.gov/41141459/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison, Dr. April Dyer, talk to us about a publication in Health Affairs Scholar, entitled "Sustainable solutions to the continuous threat of antimicrobial resistance." The article can be viewed here: https://pubmed.ncbi.nlm.nih.gov/39916975/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison and Operations Director, Dr. Libby Dodds Ashley, talks with Duke University Hospital Clinical Pharmacist, Dr. Jenna Januszka about the recent ICHE publication "2025 US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Post-exposure Prophylaxis in Healthcare Settings." For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison, Dr. Angelina Davis, talks about the pharmacokinetics of antibiotics in patients with obesity. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40383125/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Clinical Pharmacist Liaison Jeannette Bouchard as she speaks with Dr. Nick Turner, lead author of the DOTS randomized clinical trial, about the potential of dalbavancin as a simplified treatment for Staphylococcus aureus bacteremia. They discuss the trial’s findings, its implications for clinical practice, and whether two doses can truly replace weeks of IV antibiotics. The materials reviewed in this episode can be found here: https://dason.medicine.duke.edu/blog/new-rules-old-infections-what-dots-trial-tells-us For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes In this episode, Dr. Melissa Johnson, one of our DASON Clinical Pharmacist Liaisons, talks with Dr. Kim Claeys, from the University of Maryland, about her recent work on the implementation diagnostic stewardship to improve UTI antibiotic use. The two publications referenced in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40720743/ and here: https://pubmed.ncbi.nlm.nih.gov/37424224/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison, Dr. April Dyer, talks to us about an article in Antimicrobial Stewardship & Healthcare Epidemiology entitled "Implementation and performance of a nurse administered modified PEN-FAST clinical decision rule in the electronic health record." The article can be found here: https://pubmed.ncbi.nlm.nih.gov/40697885/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join host DASON Clinical Pharmacist Liaison Dr. Libby Dodds Ashley as she as talks with Dr. Emily Heil and Dr. Joe Kuti to review the recent article published in the Journal of Clinical Microbiology titled: “Point-Counterpoint: Cascade Reporting—Useful Tool to Support Antimicrobial Stewardship, or Dangerously Misleading?” Together, they explore the practical and controversial aspects of cascade reporting. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40526395/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest podcast, DASON clinical pharmacist liaison Dr. Angelina Davis talks with us about a national retrospective cohort study comparing the effects of cefepime versus piperacillin-tazobactam on the development of severe acute kidney injury in patients with septic shock. The article for this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39657005/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Liaison Jeannette Bouchard as she hosts Dr. Dan Ilges and Dr. Ryan Stevens to discuss the recent article published in Infection Control & Hospital Epidemiology titled: “Real-world Utility of Procalcitonin in Patients Hospitalized with Community-Acquired Pneumonia: A Matched Cohort Study.” Together, they unpack how this study challenges the utility of procalcitonin in guiding antibiotic use for CAP, explores implications for diagnostic stewardship, and reflects on strategies to optimize antimicrobial decision-making in inpatient care. The articles reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40017121/ and here: https://www.fda.gov/media/100879/download For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson talks with Dr. Jason Trubiano, Director of Infectious Diseases at Austin Health in Australia. Drs. Johnson and Trubiano discuss an article in Journal of Infection entitled "Development and validation of a cephalosporin allergy clinical decision rule." The article can be found here: https://pubmed.ncbi.nlm.nih.gov/40288499/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Join DASON Clinical Pharmacist Liaison Dr. Jeannette Bouchard as she reviews the recent article published in Antimicrobial Stewardship & Healthcare Epidemiology titled: “(Re)Moving the Needle: A Retrospective, Quasi-Experimental Assessment of the Impact of a Treatment Guideline on Oral Antibiotic Prescribing for Orthopedic Infections." She discusses how this study highlights the real-world impact of guideline implementation on shifting antibiotic prescribing practices for bone and joint infections. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40160226/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this episode, DASON Clinical Pharmacist Liaison Dr. April Dyer talks with us about how a microbiology-driven electronic health record-algorithm and order set can decrease antipseudomonal use in diabetic foot infections. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40160223/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Angelina Davis chats with us about several articles about antibiotic prophylaxis for spontaneous bacterial peritonitis (SBP) in patients with cirrhosis. The materials reviewed in this episode can be found on the DASON Digest page on our website: https://dason.medicine.duke.edu/blog/sbp-prophylaxis-what-were-doing-why-were-doing-it-and-should-we-keep-doing-it For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join the Duke ID PGY2 resident Natalie Harris as she talks with Dr. Julie Gray about her new article published in ASHE this year titled “Short versus long treatment duration for streptococcal bloodstream infection." The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/40026772/ for more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON liaison Jeannette Bouchard as she talks with Dr. Kati Shihadeh about her new article published in ASHE this year titled “Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-experimental study. The article reviewed in this episode can be found here: https://pmc.ncbi.nlm.nih.gov/articles/PMC11822621/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join Drs. Emily Stevenson and Jessie Seidelman as they discuss Dr. Seidelman’s experience with blood culture stewardship and her recent publications as well as a new publication out of Virginia and their experience of their efforts during the shortage. Materials discussed today: Main article: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology/article/blood-culture-bottle-shortage-mitigation-efforts-analysis-of-impact-on-ordering-and-patient-impact/6E6B3256942821F7C7C4758739F79BC3 Other articles mentioned: https://www.sciencedirect.com/science/article/pii/S0196655324004723?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC11007355/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11758502/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson chats with Dr. Sunish Shah from University of Pittsburgh Medical Center about metronidazole dosing for bloodstream infections. The article reviewed in the episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39667533/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode DASON Clinical Pharmacist Liaison Dr. April Dyer talks with Dr. Rebekah Moehring talk to us about outcomes of antibiotic de-escalation in patients with suspected sepsis. The article discussed in the episode can be viewed here: https://pubmed.ncbi.nlm.nih.gov/39657050/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join Drs. Libby Dodds Ashley and Dev Anderson as they discuss one of the latest articles from the Duke ID team regarding C. difficile testing and the confusion that surrounds certain testing results. The articles reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39828613/ and https://pubmed.ncbi.nlm.nih.gov/39180325/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this episode of the DASON Digest Podcast, Dr. Angelina Davis, one of our DASON Clinical Pharmacist Liaisons, talks to us about the BALANCE Trial and the work the investigators did with duration of antibiotic treatment for bloodstream infections in hospitalized patients. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39565030/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join Dr. Jeannette Bouchard and DiRTE Lab Director Bobby Warren to discuss a fun BMJ article from their end of the year edition titled Bug in a Mug: Are Hospital Coffee Machines Transmitting Pathogens. We hope everyone has a happy New Year! The article reviewed in today's episode can be found here: https://www.bmj.com/content/383/bmj.p2564 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson talks with Dr. Dan Morgan from University of Maryland School of Medicine. The articles and documents reviewed can be found here: https://www.cdc.gov/patient-safety/hcp/hospital-dx-excellence/index.html https://www.cdc.gov/patient-safety/media/pdfs/DxEx-Tool-Priority-Examples-508.pdf https://www.cdc.gov/patient-safety/media/pdfs/DxEx-Tool-Additional-Examples-508.pdf https://www.cdc.gov/patient-safety/media/pdfs/DxEx-Tool-Medical-Test-Checklist-508.pdf https://pubmed.ncbi.nlm.nih.gov/36786646/ https://pubmed.ncbi.nlm.nih.gov/39602334/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this very special episode we have guest appearances from old and new stewardship friends. References for this episode can be found at this link: https://dason.medicine.duke.edu/blog/episode-100-celebration-stewardship For more information about DASON, please visit: https://dason.medicine.duke.edu

Episode Notes For this episode, Dr. Libby Dodds Ashley is joined by Dr. Chris Hostler to discuss Dr. Hostler’s recent article evaluating postoperative outcomes in patients receiving ertapenem for colon surgery. This article that includes some data from our DASON sites so this is a MUST listen! The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39363596/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Join Dr. Angelina Davis as she discusses a recent article in Clinical Infectious Diseases on differences in outpatient community-acquired pneumonia treatment regimens. the article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39442057/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. Melissa Johnson reviews an article that compares the efficacy and safety of intravenous (IV) versus oral (PO) stepdown therapy for uncomplicated streptococcal bacteremia. The article can be found here: https://academic.oup.com/ofid/article/11/7/ofae361/7701251 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Dr. Jeannette Bouchard and guest Dr. Emily Heil walk listeners through key updates to the IDSA Resistant Gram-negative Guidance and what may be most pertinent for our community partners. The materials reviewed today can be found here: https://www.idsociety.org/practice-guideline/amr-guidance/#UpdateHistory For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, Dr. April Dyer discusses a recent article in Antimicrobial Stewardship and Hospital Epidemiology on how pharmacists can help with post-hospital discharge micro result review. The article reviewed in today's episode can be found here: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology/article/impact-of-pharmacistled-microbiology-result-followup-postdischarge-for-patients-undergoing-inpatient-infectious-diseases-consultation/ED155B2C10D145480228E715ABCFB000 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes Join DASON Clinical Pharmacist Dr. Libby Dodds Ashley as she discusses a recent article in Pharmacotherapy on daptomycin dosing with one of the primary authors, Dr. Katie Olney. The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/39078247/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this exciting episode, DASON Clinical Pharmacist Dr. April Dyer discusses a hot off the press article that follows up the results from the big PALACE trial that was published in 2023. The article reviewed in this episode can be found here: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822413 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this exciting episode, Dr. Jeannette Bouchard is joined by Drs. Katie Lambert and Catessa Howard to discuss their newly published brief report in OFID that helps shine a light on a common clinical issue, is cefazolin or ceftriaxone a better surrogate for third generation oral cephalosporins. The article reviewed in this episode can be found here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11245689/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, DASON Clinical Pharmacist Liaison Dr. April Dyer walks us through an article from Clinical Infectious Diseases entitled "Beyond Infection: Mortality and End-of-Life Care Associated with Infectious Disease Consultation in an Academic Health System." The article reviewed in this episode can be found here: https://pubmed.ncbi.nlm.nih.gov/38867715/ For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this exciting episode, Drs. Libby Dodds Ashley and Jeannette Bouchard are joined by Dr. Jason Roberts to discuss his two newly published articles in JAMA that help to answer the question: is there a difference between continuous and intermittent infusions of beta-lactam antibiotics, especially in the critically ill populations? The reviewed materials can be found here: https://dason.medicine.duke.edu/blog/it-goes-and-and-reviewing-new-rct-continuous-infusion-vs-intermittent-infusion-beta-lactams For more information about DASON, please visit: https://dason.medicine.duke.edu/

In this episode of the DASON Digest podcast, DASON Clinical Pharmacist Liaison Dr. Angelina Davis talks to us about the use of AI in the management of bloodstream infections. The article reviewed can be found here: https://academic.oup.com/cid/article-abstract/78/4/825/7308526

Episode Notes In this episode, Dr. Jeannette Bouchard discusses a newly published article in JAMA about the use of piperacillin-tazobactam and cefepime in sepsis. This episode also ties into a previous episode (#74) and we would recommend listening to both episodes! The article reviewed in this episode can be found here: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2818278 For more information about DASON, please visit: https://dason.medicine.duke.edu/

Episode Notes In this episode, University of Kentucky Infectious Diseases Pharmacy Residents, Will Harris and Tyler Pitcock, review a recently published article evaluating the impact of the implementation of rapid blood culture identification technology and stewardship intervention on treatment of blood cultures contaminated with coagulase-negative staphylococci. The article reviewed in this episode can be found here: https://academic.oup.com/ofid/article/10/8/ofad416/7233915 For more information about DASON, please visit: https://dason.medicine.duke.edu/