PODCAST · science
Deep Dive On
by ONLABS
Deep Dive On is a podcast exploring research, science, and health through peer-reviewed academic papers. Each episode breaks down complex studies into engaging discussions, highlighting discoveries that shape science, medicine, and wellbeing. Whether you're a researcher, student, or curious mind, Deep Dive On offers clear insights and thoughtful analysis of the research that impacts our understanding of the world.
Episodes
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How Global Policies and Free Transit Rewrote City Movement During the Pandemic
This episode looks at a global analysis of how city mobility shifted during the COVID-19 pandemic. Drawing on Apple’s Mobility Trends Reports from 296 cities, researchers examined how public health policies influenced walking and public transport use. They found that initiatives promoting…
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Predicting Neonatal Sepsis
This episode explores a groundbreaking study published inb The Lancet that identified gene expression biomarkers capable of predicting neonatal sepsis before symptoms appear. Conducted in The Gambia, researchers analysed RNA sequencing data from healthy newborns to distinguish those who later...
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Can Early Geriatric Care Save Lives in C. diff Infections?
In this episode, we explore findings from the CLODIfrail trial, a Danish study published in The Lancet Healthy Longevity (2024). The trial tested whether early, comprehensive geriatric assessment (CGA) could improve outcomes for older adults hospitalised with Clostridioides difficile infection....
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The Shocking Truth About Helicopter Research and Resource-Limited Institutions
Here we address the issue of “domestic helicopter research,”which occurs when well-resourced institutions conduct studies on marginalised communities or through resource limited institutions (RLIs) with minimal involvement or equitable benefit for local researchers or community members. The...
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Iron-Dependent Telomerase Reactivation Drives Colorectal Cancer
This research article investigates the mechanistic link between high iron levels and the development of colorectal cancers (CRCs), focusing on the reactivation of telomerase, an enzyme associated with cellular immortalization. The authors identify Pirin, an iron-sensing protein, as a crucial...
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How Parenting Rewires the Brain for Lifelong Mental Health
This academic paper explores the impact of parenting styles, specifically harsh and warm approaches, on adolescent brain architecture and subsequent mental health outcomes in early adulthood. It investigates whether these associations are dependent on the child's developmental stage, early…
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Epigenetic Clocks Measuring Your Biological Age and Unlocking the Future of Healthspan
This article provides an overview of DNA methylation aging clocks, which are molecular tools used to measure an individual's age based on specific chemical modifications to their DNA. The authors discuss the current understanding and significant challenges in utilising these clocks, particularly…
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Early-life sugar rationing protects against diabetes and hypertension
This research article investigates the long-term effects of early-life sugar intake on the development of type 2 diabetes and hypertension. Utilising a natural experiment from the end of sugar rationing in the UK in 1953, the study compares adults with varying levels of sugar exposure during…
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Vaccine reactogenicity
This review article thoroughly examines vaccine reactogenicity, which encompasses the common, often mild, inflammatory responses individuals experience post vaccination, such as soreness or fever. The authors explore the underlying biological mechanisms that cause these reactions, detailing how…
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KIBRA anchors PKMζ for memory persistence
This research article investigates how long-term memories persist despite the turnover of brain molecules. The study reveals that a protein called KIBRA physically interacts with the enzyme PKMζ at synapses activated during learning. This KIBRA-PKMζ complex acts as a stable anchor, maintaining…
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Dietary inflammation and mortality risk in coronary heart disease
This research investigated the connection between the Dietary Inflammatory Index (DII) and the risk of all-cause mortality in adults with coronary heart disease (CHD) using data from a national health survey. The study found that higher DII scores, indicating a more pro-inflammatory diet, were...
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SARS-CoV-2 vaccine response
This research investigated the durability of SARS-CoV-2 specific plasma cells generated after mRNA vaccination by examining bone marrow samples. The study found that, unlike influenza and tetanus, SARS-CoV-2-specific antibody secreting cells were largely absent from the long-lived plasma cell...
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Multiplexed SERS detection of cardiac markers via metasurfaces
This research introduces a novel biosensing strategy using surface-enhanced Raman spectroscopy (SERS) for the multiplexed detection of serum cardiac markers, crucial for diagnosing acute myocardial infarction. The method employs a specially designed plasmonic metasurface with enhanced electric…
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Epigenetics in diabetic cardiovascular complications
This scientific review from Molecular Medicine explores the intricate link between diabetes mellitus and its cardiovascular complications, focusing on the emerging role of epigenetic modifications such as DNA methylation and histone alterations. The authors highlight how these heritable changes…
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Infections, brain atrophy, and long-term dementia risk
This study investigated the connection between prior infections and long-term brain health. The study found that a history of infections like influenza and herpes viruses is associated with accelerated brain volume loss in specific regions and an increased risk of developing dementia. By…
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Boosting aged neural stem cell activation via gene knockout
This research used CRISPR–Cas9 screening in mice to identify genes that regulate the activation of neural stem cells (NSCs) during ageing. They discovered several gene knockouts, particularly those involved in cilium organisation and glucose import, that could restore the function of old NSCs…
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Human sex ratio evolution
This research paper explores the genetic basis of the human sex ratio at birth, which is the proportion of males to females. It challenges a long-held scientific principle, known as Fisher’s principle, which suggests that the sex ratio should naturally converge to 50/50 through natural selection....
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Frailty and cardiovascular disease
This study investigates the association between frailty and cardiovascular disease (CVD) in three large, prospective cohorts from China, the UK, and the USA. The researchers assessed participants' frailty status using the Rockwood frailty index, taking into account changes in frailty over time.…
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Mendelian randomization for cardiovascular diseases
This review from the European Heart Journal focuses on the use of Mendelian randomization (MR) in cardiovascular epidemiology. MR leverages genetic variants to uncover causal relationships between modifiable risk factors and various cardiovascular diseases (CVDs). By drawing parallels to…
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Climate change and healthcare
This systematic review examines the ways healthcare systems are contributing to climate change and explores strategies and tactics to reduce their carbon footprint. The authors analyzed 205 studies, reports, and frameworks from 18 years of research to identify themes and overarching strategies…
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Move to survive
This study, conducted by the Prospective Physical Activity, Sitting, and Sleep (PROPASS) consortium, looked at the relationship between various movement behaviours and cardiometabolic health outcomes. They analysed data from over 15,000 participants from six studies across five countries using...
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Recording research harms
This article discusses the shortcomings of current methods for recording harms in behavioural change intervention trials, which primarily rely on definitions designed for drug trials. The authors argue that these definitions can miss important harms specific to behavioural interventions, leading…
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Origin of complex cells
This research paper examines the current state of knowledge surrounding the evolution of eukaryotic cells, which are more complex than their prokaryotic counterparts. The paper focuses on the two key events involved in eukaryogenesis: the evolution of the host cell, which is now believed to be...
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Digital wellbeing
This article examines the complex relationship between mobile connectivity and well-being. The author argues that achieving digital well-being requires a delicate balance between the benefits and drawbacks of ubiquitous connectivity. The article then proposes a dynamic systems model of digital...
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How to conduct a meta-analysis
This is a comprehensive guide on conducting a meta analysis, a research technique that combines results from multiple studies to reach a more robust conclusion. The paper outlines eight key steps, starting with defining the research question and searching for relevant literature, and then...
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Digital health in clinical care
This article from the New England Journal of Medicine examines the integration of wearable digital health technologies (DHTs) into clinical care, focusing on the challenges and opportunities presented by their increasing use. The authors highlight six key issues: data ownership, patient trust,...
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How to conduct a systematic review
This is a guide on how to conduct a systematic review, which is a type of research that aims to synthesise the best available evidence on a particular topic. We talk about the key stages involved in conducting a systematic review: identifying the research question, defining inclusion and…
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Improving outcomes for cervical cancer
This research, published in The Lancet, explores the benefits of adding a short course of chemotherapy before standard chemoradiotherapy for women with locally advanced cervical cancer. The INTERLACE trial, an international, multicentre, randomised phase 3 trial, compared the standard treatment...
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What is GRADE?
The GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) system is a widely used framework for systematically assessing and presenting the quality of evidence for clinical practice recommendations. It outlines a structured approach for evaluating the certainty of evidence...
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Diet, genes, and longevity
This podcast episode discusses a groundbreaking study published in Nature that examined the effects of calorie restriction and intermittent fasting on the lifespan and health of genetically diverse mice. The study, unlike previous research using single mouse strains, used 960 mice with different...
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Body shape and health
This research investigates the Body Roundness Index (BRI), a new anthropometric measure, and its association with all-cause mortality. The study, conducted on a nationally representative cohort of US adults, reveals a rising trend in BRI over almost 20 years, particularly among women, older...
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Mpox (monkeypox)
This article from the Journal of the American Medical Association (JAMA) provides a comprehensive review of mpox, formerly known as monkeypox. The authors discuss the virus’s origins, transmission, clinical presentation, diagnostic approaches, management, and prevention strategies, highlighting…
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Time restricted eating: Good or not?
This research article from the New England Journal of Medicine investigates the effectiveness of time-restricted eating, where individuals only consume food within a specific eight-hour window, compared to daily calorie restriction alone. The study, involving 139 obese participants in China,...
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Arm position and BP readings
This study, published in JAMA Internal Medicine, examines the effect of different arm positions on blood pressure readings. The study, which involved 133 participants, found that common arm positions such as resting the arm on the lap or leaving it unsupported at the side resulted in…
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Face and personality
This research paper investigates whether facial images can be used to predict personality traits. Using a large dataset of real-life photographs and self-reported personality scores, the researchers trained a cascade of artificial neural networks to predict personality based on facial cues. The...
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ABOUT THIS SHOW
Deep Dive On is a podcast exploring research, science, and health through peer-reviewed academic papers. Each episode breaks down complex studies into engaging discussions, highlighting discoveries that shape science, medicine, and wellbeing. Whether you're a researcher, student, or curious mind, Deep Dive On offers clear insights and thoughtful analysis of the research that impacts our understanding of the world.
HOSTED BY
ONLABS
CATEGORIES
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Frequently Asked Questions
How many episodes does Deep Dive On have?
Deep Dive On currently has 35 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Deep Dive On about?
Deep Dive On is a podcast exploring research, science, and health through peer-reviewed academic papers. Each episode breaks down complex studies into engaging discussions, highlighting discoveries that shape science, medicine, and wellbeing. Whether you're a researcher, student, or curious mind,...
How often does Deep Dive On release new episodes?
Deep Dive On has 35 episodes. Check the episode list to see recent publication dates and frequency.
Where can I listen to Deep Dive On?
You can listen to Deep Dive On on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Deep Dive On?
Deep Dive On is created and hosted by ONLABS.
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