PODCAST · health
Drugs (Sometimes) Work
by Craig Williams
An exploration of the science and the data behind many commonly used prescription drugs.
Episodes
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Vitamania, Part 2
In this second part of the 2-part episode "Vitamania," we dig in to the clinical trial data behind vitamins as dietary supplements. In Part 1 of this episode, we met a patient with Scurvy....and said that if you have Scurvy, Vitamin C definitely works. But what if you are generally nutritionally...
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Vitamania, Part 1
Vitamins are widely used in the U.S., to the tune of between $15-20 billion dollars per year. But what are vitamins and what do they do? How are they regulated by the FDA and does the clinical trial data on vitamin supplementation justify our consumer appetite for them? Over this two part episode...
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Drugs (Sometimes) Work: "Do ACE inhibitors treat Diabetes?"
Before we ask a patient to take any drug we should be confident that the benefits outweigh the risks. This involves considerations like duration of therapy and whether the drug is being used to treat a disease versus prevent it. But even more important is an understanding of how the pharmacology…
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Medicating the Failing Heart, Part 3 of 3: The finale
As we finish up we focus on the contemporary management of systolic heart failure or so called heart failure with reduced ejection fraction. Our focus in this episode is on RAAS blockade which includes the aldosterone antagonists along with a new kid on the block, Entresto. How does Entresto...
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Medicating the Failing Heart; Part 2: The difference between a drug and not a drug is dose
In this continuation of "Medicating the Failing Heart" we pick up the theme of systolic heart failure and how good beta blockers are or aren't compared to our newest agent for systolic heart failure - vericiguat. As we discuss, beta blockers hold their own quite well. But beware. Having a patient...
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Episode 9, Medicating the failing heart, Part 1
When it comes to treating symptomatic heart failure, many things have changed but many have not. Some things that haven't changed maybe should change - that depends on who you listen to. In this multi-part episode, we'll discuss the past and present of drug therapy for both common types of heart...
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"Ceph-a-Something" Part 2: pesky PK
The cephalosporin antibiotics are a confusing class of medications. We talk about them in "generations" like a pharmacologic family tree. And while there is a general rule regarding which bugs are covered by the different generations, the exceptions to that rule are numerous and just as important...
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"Ceph-a-Something" Part 1: Genealogy
The cephalosporin antibiotics are a confusing class of medications. We talk about them in "generations" like a pharmacologic family tree. And while there is a general rule regarding which bugs are covered by the different generations, the exceptions to that rule are numerous and just as important...
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40 mEq doesn't fix hypokalemia
Electrolytes are among the drugs we use in the hospital setting. And like any drug, we're better when we truly understand what we are using them to treat. In this episode, we tackle one of the most common electrolyte abnormalities in hospitalized patients....hypokalemia, and we discuss why it…
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Bugs and Drugs
Learning which antibiotics treat which bacteria and how to dose those antibiotics is like trying to learn a foreign language. Words sound weird and are difficult to pronounce. At first, nothing really makes any sense and what we all need is more practice. In this episode, we'll start talking…
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Correlation vs. Causation: Part 2, Will the COVID vaccine kill me and does insulin resistance make me fat?
In this second part of a 2-part episode on Correlation vs. Causation, we explore two relevant examples of where someone got it exactly wrong. Often times, the lay press and media coverage - especially social media coverage - make it difficult to figure out what's really going on. It's not our…
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Correlation vs. Causation: Part 1, a problematic clinical trial
Understanding correlation versus causation is important. It is important in clinical drug trials and it is important in making public policy. If we dont really understand what the underlying cause of a problem is, we cannot fix that problem. In this 2-part episode, we'll explore this concept a…
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Who should take a daily aspirin, Part 2
In this second part of our 2 part series on aspirin, we focus in on what aspirin does and what both the FDA and clinical guidelines say about who should take it for primary prevention. Then, to make sense of the conflicting advice, we briefly discuss the clinical trials themselves so we can make…
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Who should take a daily aspirin; Part 1
Aspirin is complicated. Advice on who should take it is conflicting and always changing. In this 2-part episode we'll explore why that is. We'll learn a bit about atherosclerosis - the disease that aspirin can treat. We'll explore what the FDA says about aspirin and what as well as what is...
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Drugs (Sometimes) Work; Introduction
Drugs - the legal kind that we get with a prescription, are fascinating. How do they work? Why to they work? Why do they sometimes not work very well? Why are some of them so expensive? In this podcast, we'll explore some of that. I've been teaching the science of drug therapy to medical and...
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Frequently Asked Questions
How many episodes does Drugs (Sometimes) Work have?
Drugs (Sometimes) Work currently has 15 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Drugs (Sometimes) Work about?
An exploration of the science and the data behind many commonly used prescription drugs.
How often does Drugs (Sometimes) Work release new episodes?
Drugs (Sometimes) Work has 15 episodes. Check the episode list to see recent publication dates and frequency.
Where can I listen to Drugs (Sometimes) Work?
You can listen to Drugs (Sometimes) Work on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Drugs (Sometimes) Work?
Drugs (Sometimes) Work is created and hosted by Craig Williams.
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