PODCAST · education
eCritCare Podcast
by Swapnil Pawar
The landscape of Intensive care is changing. In the era of evidence based medicine, we try to make best possible decision for our patients based on best available evidence. Every fortnight, Dr Swapnil Pawar & Dr Jose Chacko will bring you one hot topic in Critical care. If you want to stay up to date with recent evidence or learn how to critically evaluate the literature in critical care, this podcast is for you.
Episodes
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#Epi 135 - SODa-BIC Trial: Sodium Bicarbonate for Metabolic Acidosis and Shock, with Prof. Ary Serpa Neto.
A patient in shock, on noradrenaline, with a pH of 7.22 and a base excess of minus 8. Do you give bicarbonate? Depending on which ICU you work in, the answer ranges from almost never to almost always. In this episode of the eCritCare Podcast, Dr Swapnil Pawar is joined by Professor Ary Serpa Neto...
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#Epi 134 - GASTRIC-PICU Trial: Stopping Routine Gastric Residual Volume Checks in Ventilated Children with Prof Lyvonne Tume
Draw back the stomach contents, measure, and hold the feed if the number looks big. It has been routine in paediatric intensive care for decades. But does gastric residual volume tell us anything useful? In this episode of the eCritCare Podcast, Dr Swapnil Pawar is joined by Professor Lyvonne…
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#Epi 133 - The Green ICU: Cutting the Environmental Footprint of Intensive Care with Dr Nicole Hunfeld
More than one box of gloves per patient, per day. Glass bottles of IV paracetamol filling the waste room. Intensive care saves lives, but at what cost to the planet? In this episode of the eCritCare Podcast, Dr Swapnil Pawar is joined by Dr Nicole Hunfeld, ICU pharmacist and Chief Sustainability...
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#Epi 132 - TRICYCLE Trial: Early Triple Vasopressor Therapy in Septic Shock with Prof Giovanni Landoni & Dr Žiga Kalamar
Norepinephrine first, titrate up, add vasopressin when the dose gets high, reach for a third agent when things get desperate. That stepwise approach is how most of us treat septic shock. What if all three went in together, early? In this episode of the eCritCare Podcast, Dr Swapnil Pawar is…
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#Epi 131 - T4P Trial: Platelet Transfusion Thresholds Before ICU Procedures with Prof Peter Watkinson & Prof Simon Stanworth
A platelet count of 40 and a central line to put in. Transfuse first, or go ahead? Right now the answer depends on which ICU you work in, and nobody actually knows which is right. In this episode of the eCritCare Podcast, Dr Swapnil Pawar is joined by Professor Peter Watkinson (Professor of...
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Beyond the P Value Series #Ep 1 - Why RCTs Matter and Why They Mislead Us with Prof Paul Young
Randomised controlled trials shape almost everything we do in the ICU. So why do so many of them seem to show nothing? And when a trial says "no benefit," what does that actually mean for the patient in front of you? This is the first episode of Beyond the P Value, a new eCritCare sub-series on...
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#Epi 129 - CLIP-II Trial: Cryopreserved vs Liquid-Stored Platelets with Prof Michael Reade
Conventional platelets last five to seven days. Cryopreserved platelets last two years. So why aren't we using them everywhere? In this episode of the eCritCare Podcast, Dr Swapnil Pawar sits down with Professor Michael Reade, intensivist, researcher and chief investigator of the CLIP-II trial,...
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#Epi 128 - SuDDICU & The SDD Story with Prof Ian Seppelt
In this episode, Dr Swapnil Pawar sits down with Professor Ian Seppelt, intensivist at Nepean Hospital, Sydney, and one of the lead investigators of the SuDDICU trial, to unpack the decades-long story of Selective Digestive Decontamination (SDD) in intensive care. Ian traces SDD from its...
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#Epi 126 - The GUARDS Trial with Dr Ary Serpa Neto
In this episode, Dr Swapnil Pawar is joined by Dr Ary Serpa Neto to discuss the GUARDS trial, which is testing whether dexamethasone reduces 60-day mortality in patients with moderate to severe ARDS. We cover the rationale for steroids in ARDS, the choice of drug and dose, the expanded…
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#Epi 127 - The LOGICAL Trial: Conservative Oxygen Therapy After Cardiac Arrest
Dr Swapnil Pawar is joined by Dr Jose Chacko to discuss the LOGICAL trial, published in the New England Journal of Medicine in June 2026. Does limiting oxygen after cardiac arrest protect the brain from reperfusion injury? LOGICAL (the largest randomised trial of oxygen therapy after cardiac…
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#Epi 125 - The SOHO Trial: High-Flow Nasal Oxygen in Acute Hypoxaemic Respiratory Failure
In this episode, we discuss the SOHO trial, a large multicentre randomised controlled trial comparing high-flow nasal oxygen with conventional oxygen therapy in patients with acute hypoxaemic respiratory failure. We cover the trial methodology, the key findings on 28-day mortality and intubation...
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#Epi 124 - 2026 AHA/ACC Pulmonary Embolism Guidelines
In this episode, Dr Swapnil Pawar is joined by Dr Jose Chacko to discuss the 2026 American Heart Association and American College of Cardiology guidelines on the management of pulmonary embolism. We cover the new A to E classification, evaluation and diagnostic algorithms, acute management...
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#Epi 123 - SWITCH Trial - Decompressive Craniectomy with Medical treatment Vs Best medical treatment for Deep intra-cerebral haemorrhage
In this episode, we discuss the recently published SWITCH trial which compared the efficacy of decompressive craniectomy with best medical treatment vs best medical treatment alone for deep intra-cerebral hemorrhage.
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#Epi 122 - Diaphragmatic Dysfunction in Critically Ill patients
In this episode, we discuss the etiology of diaphragmatic dysfunction, its management and strategies for prevention.
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# Epi 121 - AMIKINHAL Trial - Inhaled Amikacin to prevent Ventilator associated pneumonia
In this episode, we discuss the recently published RCT AMIKINHAL, which tested the efficacy of inhaled amikacin in preventing VAP in ICU patients who were ventilated for> 72 hours. Although, this trail demonstrated reduced incidence of VAP in intervention arm, it's premature to adopt these...
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#Epi 120 - NICO Trial - Intubation in Acute Drug Overdose - Does GCS matter?
In this episode, we discuss recently published RCT in JAMA "NICO trial", which evaluated the role of GCS based intubation vs non-invasive airway management. It is important to understand the nuances before generalising the conclusion of this trial.
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#Epi 119 - The role of IV Thyroxine in Brain Dead Organ Donor
In this episode, we discuss the recently published RCT in NEJM, which challenged the current dogma regarding the role of IV thyroxine in potential organ donor patient population.
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#Epi 118 - ECLS Shock Trial - Extra-corporeal support in Cardiogenic shock post-MI
In this episode, we discuss the recently published RCT "ECLS-Shock" trial in NEJM. This trial tested the benefit of instituting early extra-corporeal support in cardiogenic shock and suggested more harm in intervention arm compared to control arm.
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#Epi 117 - ELAN Trial - Early Vs Late Anticoagulation in Ischaemic stroke post -AF
In this episode, we discuss recently published landmark RCT which compared the timing for initiation of oral anticoagulation in patients who presented with ischaemic stroke with rapid AF.
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#Epi 116 - Steroids in Community Acquired Pneumonia
In this episode, we discuss the controversy surrounding the usage of steroids in Community-acquired pneumonia. This controversy arose after the CAPE-COD trial was published recently in NEJM. We discuss the pros and cons of administering steroids as a blanket treatment. We recommend caution and...
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#Epi 115 - ICU Journal Club - MERCY Trial
In this episode, we discuss recently published RCT "MERCY Trial" which evaluated the efficacy of continuous infusion vs intermittent dosing strategy of Meropenem.
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#Episode 114- ICU Journal Club - PATCH Trial
In this episode, we discuss the recently published RCT "PATCH Trial", which evaluated the efficacy of pre-hospital tranexamic acid in patients with severe trauma. This trial confirmed the results of CRASH-2 trial, which demonstrated 28-day mortality benefit with the use of tranexaic acid in…
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#Episode 113- ICU Journal Club - RESCUE-ASDH Trial
In this episode, we discuss recenetly published RCT, which compared the role of craniotomy vs decompressive craniectomy in managing acute SDH.
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#Episode 112- ICU Journal Club - PACER Trial
In this episode, we discuss the recently published non-inferiority RCT "PACER Trial", which evaluated the efficacy of prophylactic platelet transfusion in thrombocytopenic patients requiring CVC insertion.
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#Episode 111- Selective Digestive Decontamination - To be or Not to be
In this episode, Prof Ian Seppelt, one of the lead investigators of SuDDICU, shares his insights and talks about the rationale for SDD in ICU. He also explains the reasons behind the failure to change practices despite the evidence of mortality benefit from the recent meta-analysis. He discusses...
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#Episode 110- High Flow Nasal Cannula Vs NIV in High risk patients
In this episode, we dive deeper into the controversy surrounding using high-flow nasal cannula vs NIV in high-risk patients to prevent reintubation. The recently published trial raised some crucial questions and forced us to reconsider our overall approach to extubation in this subset of patients.
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#Episode 109- CAPE-COD Trial - Hydrocortisone in Community Acquired Pneumonia
In this episode, we discuss recently published RCT, which demonstrated the mortality benefit in Community-acquired pneumonia.
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#Episode 108- INCEPTION Trial - ECMO CPR in OHCA due to Shockable Rhythm
In this episode, we discuss the recently published RCT in NEJM, which evaluated the efficacy of ECMO CPR ( eCPR) in patients with OHCA secondary to a shockable rhythm.
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#Episode 107- CLOVERS Trial - Restrictive fluid with early vasopressors vs liberal fluid in Septic shock
In this episode, we discuss the recently published CLOVERs trial, which compared fluid dominant vs vasopressor-dominant resuscitation strategies for patients in septic shock.
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#Episode 106- BOX Trial - Oxygenation targets in OHCA Comatose Survivors
In this podcast, we discuss another RCT which evaluated the efficacy of restrictive Vs liberal oxygenation targets in comatose OHCA survivors. The trial showed no difference between the two groups w.r.t 90-day mortality or discharge from hospital
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#Episode 105- DOSE VF Trial - Double Sequential Early Defibrillation in OHCA
In this episode, we discuss the recently published DOSE VF trial, which evaluated the efficacy of early double sequential defibrillation strategy over vector change and standard defibrillation strategies. This trial has demonstrated that this innovative strategy has the potential to improve...
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#Episode 104- TEAM Trial - Early Mobilisation in Intensive care patietns
In this episode, we discuss the recently published RCT "TEAM trial", which evaluated the role of early mobilisation in mechanically ventilated intensive care patients.
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#Episode 103- SETPOINT 2 Trial - Early vs Late Tracheostomy in ICU patients with Stroke
In this episode, we discuss the SETPOINT 2 trial, which evaluated the controversy around the timing of tracheostomy.
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#Episode 102- WATERFALL Trial - Fluid resuscitation in Acute Pancreatitis
In this episode, we discuss a recently published randomised controlled trial evaluating the role of aggressive fluid resuscitation strategy in mild acute pancreatitis.
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Episode 101- Tranexamic Acid (TXA) in Intensive Care
Join us in this episode to discuss the evidence behind the use of tranexamic acid for various indications in intensive care.
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Episode 100- Oxygen Therapy in Intensive Care
In our landmark 100th episode, we discuss the controversy around one of the most commonly used drugs in intensive care, i.e. Oxygen. In this episode, we dive deeper into the available evidence and recommend our approach for using oxygen in critically ill patients.
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Episode 99- Targeted Temperature Management in TBI
In this episode, we discuss the role of therapeutic hypothermia and targeted temperature management in severe TBI. We dive deeper into the available literature on this topic and share our recommendations on this controversy.
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Episode 98- Ventilator Associated Pneumonia
In this episode, we discuss the controversies around the definitions, diagnostic criteria, investigations and management of ventilator-associated pneumonia.
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Episode 97- CLASSIC Trial - Liberal vs Restrictive fluid in Septic Shock
In this episode, we discuss the recently published trial evaluating the efficacy of liberal vs restrictive fluid resuscitation strategy in patients with septic shock.
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Episode 96: LOVIT Trial - final nail in the coffin for Vit C in Septic Shock?
In this episode, we discuss the recently published RCT evaluating the role of IV Vitamin C in patients with septic shock. This trial has given us a clear answer on the future of vitamin C in these patients. We discuss the available evidence on this topic so far and suggest our approach to this...
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Episode 95: Resuscitation targets in Septic Shock
In this episode, we discuss the evidence behind each target used in resuscitating a patient with septic shock.
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Episode 94: ICU Journal Club - eCPR in OOHCA
In this episode, we discuss the landmark trial published in JAMA, which evaluated the efficacy of eCPR over standard strategy. We believe although a well-conducted trial, it's still not enough evidence to decide one way or the other w.r.t performing eCPR in patients with out of hospital cardiac...
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Episode 93: ICU Journal Club - Noradrenaline vs Adrenaline in OHCA patients
In this episode, we discuss the evidence behind the choice of adrenaline vs noradrenaline in patients who achieved ROSC (return of spontaneous circulation) after OHCA(out of hospital cardiac arrest).
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Episode 92: NIV in COVID-19
In this episode, we discuss the controversy surrounding the use of NIV in hypoxemic respiratory failure in severe COVID-19. The results of the RECOVERY-RS trial has provided us with significant evidence on this topic.
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Episode 91: ICU journal Club - Long term outcomes in COVID- MONITOR-IC Study
In this episode, we discuss the recently published trial on long term outcomes in COVID patients.
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Episode 90: ICU journal Club - PLUS Study
In this episode, we discuss a recently published PLUS study comparing saline solution with Plasmalyte-148. This study demonstrated no significant mortality difference between the saline group and the plasmalyte-148 group.
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Episode 89: ICU journal Club - MICHELLE Trial
In this episode, we discuss the recently published RCT evaluating the role of extended thromboprophylaxis in COVID-19.
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Episode 88: Omicron Variant - Facts and Challenges
In this episode, we discuss the challenges faced by healthcare systems and the patterns emerging from the current COVID-19 pandemic wave caused by the Omicron variant.
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Episode 87: ICU journal Club - COVID HighFlow Trial
In this episode, we discuss a recently published trial comparing conventional oxygen therapy and high flow nasal oxygen therapy.
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Episode 86: Glycemic Control in ICU
In this podcast, we discuss the controversy surrounding glycemic control in intensive care. We discuss the target range, the ideal amount of time spent in the target range and the utility of continuous glycemic monitoring in critically ill patients.
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ABOUT THIS SHOW
The landscape of Intensive care is changing. In the era of evidence based medicine, we try to make best possible decision for our patients based on best available evidence. Every fortnight, Dr Swapnil Pawar & Dr Jose Chacko will bring you one hot topic in Critical care. If you want to stay up to date with recent evidence or learn how to critically evaluate the literature in critical care, this podcast is for you.
HOSTED BY
Swapnil Pawar
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