PODCAST · science
In Silico Trials, Real Impacts!
by UK CEiRSI | InSilicoUK
We’re uniting visionaries to craft a national strategy that fast-tracks virtual clinical trials, propelling the UK to the forefront of healthcare innovation. Join us as we explore how computational modelling is reshaping patient care, boosting the economy, and accelerating medical breakthroughs. Tune in for insights on creating the UK’s optimal ecosystem for in silico evidence in medicine. The future of healthcare is here – be part of the revolution.
Episodes
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Digital Twins & Virtual Patients: Revolutionising Paediatric Clinical Trials
Join us for an eye-opening exploration of how virtual patient data is revolutionising paediatric clinical trials. In our upcoming episode, we delve into groundbreaking research that addresses one of healthcare's most pressing challenges: the power crisis plaguing paediatric randomised controlled...
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Beyond the Scalpel: How Computer Models Are Rewriting Paediatric Heart Surgery
This episode explores groundbreaking research from Boston Children's Hospital and Harvard Medical School that demonstrates how multiphysiologic state computational fluid dynamics (CFD) modelling is transforming surgical planning for children with complex congenital heart conditions. We delve into...
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Future-Proofing the UK Life Sciences Sector
Are you prepared for the seismic shift transforming UK life sciences careers? This latest "In Silico Trials, Real Impacts!" episode reveals how AI and in silico technologies are creating unprecedented employment opportunities across health tech sectors. Discover the essential skills driving this...
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Exploring the Limitations and Potentials of RCTs: Beyond the Gold Standard
Are Randomised Controlled Trials (RCTs) always the definitive 'gold standard' in research? In the latest episode of In Silico Trials, Real Impacts!, we explore the nuanced landscape of RCTs, questioning their universal applicability and examining the complexities they often obscure. While RCTs…
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Simpler or Complex: Rethinking Occam's Razor in Modelling Science
Is simplicity always the smartest choice in science? Or could complexity be the key to groundbreaking discoveries? This episode explores the evolving role of simplicity and complexity in scientific modelling, questioning the age-old principle of Occam's razor in light of modern advancements:...
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Evaluating Continuous Glucose Monitoring Sensors with in Silico Trials: A Real-World Exemplar
Could computer simulations redefine diabetes care? In this episode, we focus on a real medical product and the role of in silico trials in the transition from the Medtronic Guardian Sensor 3 to the Guardian 4 sensor, central to the Medtronic 780G pump system, which aims to simplify diabetes...
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Unveiling Evidence-Based Medicine Plus and Mechanistic Reasoning
What is Evidence-Based Medicine Plus? This podcast episode explores the transformative power of computational modelling and simulated clinical trials in medical innovation. Discover the significance of evidence-based medicine (EBM) and evidential pluralism, emphasising the role of mechanistic...
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What Underpins Model Credibility? Three Philosophical Perspectives
How do philosophers of science think about model evaluation? Dive deep into the crucial process of model evaluation, a fundamental step in digital science that determines the effectiveness and precision of computational models. This episode explores three primary perspectives on model quality…
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Exploring Digital Twins: The Philosophy Behind Healthcare's Digital Revolution
Have you ever wondered what makes a digital twin truly "twin-like" and not just another computer model? This fascinating question lies at the heart of modern healthcare innovation, where virtual copies of real-world systems are revolutionising how we approach medical research and patient care.…
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Cracking the Code: Unveiling the Trustworthy World of In-Silico Trials
Are computational models ready to replace traditional clinical trials? This episode delves into the fascinating world of in silico trials and their growing role in regulatory evaluation of biomedical products. We explore a methodological framework based on the ASME VV-40-2018 standard that...
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Revolutionising Healthcare: The Power of Synthetic Data
Is the healthcare sector prepared to harness synthetic data's transformative potential whilst navigating its hidden pitfalls? This thought-provoking episode delves into the murky waters of synthetic data governance in medical research, examining how generative AI is reshaping our approach to...
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How Can We Trust Computational Models in Healthcare? A Framework for In Silico Clinical Trials
Are you curious about how computer simulations are changing the way we evaluate medical devices? In this episode, we delve into the fascinating world of in silico clinical trials (ISCTs), a cutting-edge approach that uses computational models to assess the safety and effectiveness of medical...
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Probability & Patients: The Stochastic Science Behind In Silico Trial Breakthroughs
𝗪𝗵𝗮𝘁 𝗶𝗳 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝘁𝗿𝗶𝗮𝗹 𝗯𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗰𝗼𝗺𝗽𝘂𝘁𝗲𝗿? This episode explores the fascinating world of virtual patient models and stochastic engineering, unveiling how digital simulations are revolutionising healthcare...
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How can we properly evaluate the true economic impact of AI in healthcare?
How are the CHEERS-AI guidelines transforming economic evaluations of healthcare AI? In our latest podcast episode, we delve into how the Consolidated Health Economic Evaluation Reporting Standards for AI (CHEERS-AI) are revolutionizing the economic assessment landscape for artificial…
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Revolutionising Healthcare: Inside the UK's MHRA Data Strategy
Will the MHRA's New Data Strategy Transform Healthcare Through Computational Innovation? In this episode, we explore the MHRA's groundbreaking data strategy for 2024-2027, a visionary plan heralding a fourth industrial revolution in healthcare. From supporting data-driven innovation to harnessing...
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Unleashing the Potential of Health Data: Insights from the Sudlow Review
What is the roadmap to transform how we use health data in the UK? This episode discusses the Sudlow Review and highlights the immense potential of linking health data, tackling accessibility challenges, and the importance of public trust. We discuss its five critical recommendations to make…
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Regulatory Frontiers: UK's Centres of Excellence in Regulatory Science and Innovation
How is the UK positioning itself at the forefront of regulatory science innovation through strategic investments in centres of excellence? This episode explores the UK Government-funded Centres of Excellence in Regulatory Science and Innovation (CERSI) Initiative and its pivotal role in shaping…
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Can NHS Secure Data Environments Unlock the Future of UK Life Sciences?
Could NHS Data Environments Revolutionise UK Life Sciences Innovation? This episode focuses on the incredible potential of NHS data in revolutionising medical product development and regulation. The Association of the British Pharmaceutical Industry (ABPI) report, published in February 2025,...
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Virtual You vs Cancer: How Digital Twins Are Revolutionizing Treatment
What if your doctor could test hundreds of cancer treatments on a virtual version of your tumour before giving you a single dose of medication? In this episode, we dive into the fascinating concept of digital twins, particularly their application in oncology. Discover how digital twins, virtual...
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Digital Footprints to Medical Breakthroughs: The Real-World Data Revolution
What if the future of healthcare innovation lies not in controlled trials, but in the digital footprints we leave every day? Real-world data from health records, wearables, and patient experiences revolutionises medical research. This episode explores the profound impact of real world data (RWD)…
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The Science Behind Making Virtual Trials Trustworthy: Ten Rules
Would you trust a computer to help decide your medical treatment? Imagine doctors using virtual experiments to test treatments before giving them to real patients - sounds like sci-fi, right? But it's happening now! Just like pilots train in flight simulators before flying real planes, scientists...
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STANDING Together: Equitable AI and In Silico Technologies in Healthcare
What if In Silico Technologies in healthcare could truly serve everyone? The STANDING Together recommendations are revolutionising how we think about health data diversity and inclusion. From bustling cities to remote villages, discover how this groundbreaking initiative is reshaping healthcare...
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Can Computer Simulations Make Medical Products Safer?
Ever wondered how we can make shoulder replacements safer without endless clinical trials? Step into the future of medical innovation where virtual patients help test new drugs and devices. Discover how computer simulations could make medicine safer, faster, and more ethical. Learn why experts...
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Cutting Costs, Boosting Results: The Tech Revolution in Clinical Trials
Why are clinical trials becoming so expensive? Dive into the financial maze of skyrocketing costs, from patient recruitment challenges to decentralization hurdles. Discover how patient-centric strategies and digital tools are reshaping the landscape, cutting costs, and boosting efficiency. Join…
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Breaking New Ground: The Virtual Trial Transforming Knee Surgery
Can 3D-printed, personalized knee surgery implants revolutionize arthritis treatment? Virtual clinical trials show promising results for a custom device that could make corrective knee surgery safer and more accessible. Discover how computer simulations are paving the way for the future of...
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Standards as Innovation Catalysts: The PAGIT Framework
How can we unlock innovation while ensuring responsible governance? Dive into the evolution of the PAGIT framework, where standards meet strategic oversight. From disruptive technologies to incremental advances, discover how this groundbreaking approach is reshaping the UK's innovation landscape....
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In Silico vs. Real Life: Can Computer Models Outperform Spine Surgery Tests?
Can computers predict if medical devices are safe? Discover how virtual testing revolutionises surgical implant design, potentially saving millions in development costs and speeding up innovation. Learn how digital twins are helping bring safer bone screws to the operating room, faster than ever...
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Heartware: Programming the Perfect Heartbeat
This week we ask: Can computers help us revolutionise heart failure treatment? Join us as we explore how computational modelling is transforming cardiac pacing therapy. Discover how virtual trials are accelerating research, optimising treatment strategies, and improving patient outcomes—all…
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Digital Twins Revolutionizing Shoulder Implant Design
Ever wondered how we can make shoulder replacements safer without endless clinical trials? In today's episode, we dive into groundbreaking research that's revolutionising orthopaedic device testing through virtual simulations. We'll explore how researchers have developed a sophisticated...
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Enhancing UK Medicine Regulation
Can the UK reclaim its crown as a clinical trials powerhouse? As Baroness Merron champions modernised regulations through Parliament, ABPI's candid assessment of MHRA reveals both progress and untapped potential. Join us in this bonus episode to explore how strategic reforms could transform the…
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How Regulatory-Ready is Model-Informed Drug Development?
Can we truly trust mathematical models to shape the future of medicine? In this episode, we explore the fascinating world of Model-Informed Drug Development (MIDD)—a game-changing approach that blends cutting-edge simulations with real-world data to revolutionise how drugs are developed and...
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Shaping In Silico Medicine: The Power of Patient and Public Involvement
Public and patient involvement (PPI) have a central role in advancing the adoption of in silico technologies. We explore insights from two pivotal documents: a position paper from the Avicenna Alliance advocating for a coordinated international approach to PPI in digital health and feedback from…
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Model-Informed Medicine Revolutionising Pregnancy Prescriptions
In an era where precision matters most, computational modelling is reshaping how we approach medication during pregnancy. Join us as we explore groundbreaking research revealing how healthcare providers and expectant mothers are embracing mathematical simulations to tackle one of medicine's most...
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Can Synthetic Data Solve Healthcare's Bias Problems?
Ever wondered how scientists test new treatments without real patients? Discover how cutting-edge technology creates 'virtual twins' for medical research, ensuring everyone's fairly represented. Learn how this groundbreaking approach revolutionises healthcare testing while keeping it safer and…
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Revolutionising Drug Discovery with Digital Twins
This week, we explore the ground-breaking potential of digital twins (DTs) to transform drug discovery and clinical trials. Generative AI, capable of creating realistic virtual representations of biological systems, is at the heart of this revolution. From simulating drug responses in individual...
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Unlocking the Future of Medicines with PBPK Modelling
In this episode, we dive into the fascinating field of Physiologically Based Pharmacokinetic (PBPK) modelling, a revolutionary approach to transforming drug development. Discover how digital replicas of the human body are created to predict drug behaviour, offering a safer, more efficient, and…
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Can Computer Simulations Provide Trustworthy Regulatory Evidence?
This episode asks: Can computer simulations provide credible regulatory evidence? Learn about the hierarchical framework that ensures the trustworthiness of virtual trials, using a Lego analogy to break down complex processes into manageable pieces. Understand how virtual devices, patients, and...
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The Digital Revolution in Medical Imaging Trials: The VICTRE Trial
In this episode, we explore the fascinating world of in silico trials—a cutting-edge approach that could revolutionize how new medical technologies are tested and approved. Imagine conducting clinical trials entirely within a computer simulation, bypassing the need for expensive and…
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Virtual Trials and the Future of Medical Imaging
In this episode, we embark on a journey into the world of virtual trials, particularly in the realm of medical imaging. Discover how digital twins—virtual replicas of human anatomy—are revolutionizing healthcare by offering safer, faster, and more efficient methods for testing new imaging...
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The Brain's Hidden Power: Self-Healing Aneurysms
Ever wondered if your brain has the ability to heal itself? In this episode, we delve into a medical mystery that feels like science fiction: the phenomenon of spontaneous thrombosis, where brain aneurysms may naturally seal themselves off. Discover how researchers are using advanced computer...
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In Silico Trials for Off-Label Use and Equitable Evidence
Can virtual patients revolutionise medical device testing? Our latest episode dives into groundbreaking in silico trials of the Pipeline Embolization Device for brain aneurysms. We'll explore how anatomical variations impact treatment success, and why this matters for equitable care. Join us to...
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Virtual Patients, Real Breakthroughs: FD-PASS and the Future of Medical Device Trials
Our latest episode explores FD-PASS, a virtual study that's revolutionising medical device testing. We'll unpack how this innovative approach simulated virtual patients to evaluate flow-diverting stents for intracranial aneurysms. Discover how FD-PASS not only mirrored real-world clinical trial...
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Revolutionising Medical Device Development with In Silico Clinical Trials
Welcome to Insilico Trials Real Impact, the podcast that's transforming our understanding of medical innovation. Discover how in silico clinical trials are revolutionising medical device development! Join us as we explore how computer simulations are making healthcare safer, faster, and more...
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ABOUT THIS SHOW
We’re uniting visionaries to craft a national strategy that fast-tracks virtual clinical trials, propelling the UK to the forefront of healthcare innovation. Join us as we explore how computational modelling is reshaping patient care, boosting the economy, and accelerating medical breakthroughs. Tune in for insights on creating the UK’s optimal ecosystem for in silico evidence in medicine. The future of healthcare is here – be part of the revolution.
HOSTED BY
UK CEiRSI | InSilicoUK
CATEGORIES
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Frequently Asked Questions
How many episodes does In Silico Trials, Real Impacts! have?
In Silico Trials, Real Impacts! currently has 43 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is In Silico Trials, Real Impacts! about?
We’re uniting visionaries to craft a national strategy that fast-tracks virtual clinical trials, propelling the UK to the forefront of healthcare innovation. Join us as we explore how computational modelling is reshaping patient care, boosting the economy, and accelerating medical breakthroughs....
How often does In Silico Trials, Real Impacts! release new episodes?
In Silico Trials, Real Impacts! has 43 episodes. Check the episode list to see recent publication dates and frequency.
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You can listen to In Silico Trials, Real Impacts! on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts In Silico Trials, Real Impacts!?
In Silico Trials, Real Impacts! is created and hosted by UK CEiRSI | InSilicoUK.
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