JACC Specialty Journals
by American College of Cardiology
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
Episodes
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XGBoost Model with CMR Features for Prognostic Assessment in Patients With ST‑Segment Elevation Myocardial Infarction | JACC: Asia
Commentary by Dr. Yoriyasu Suzuki.
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Design and Rationale of GPS-CAD: Global Pretest Probability Study of Coronary Artery Disease | JACC: Asia
Commentary by Dr. Junjie Yang.
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October 2026 Summary | JACC: CardioOncology
Editor-in-Chief Dr. Bonnie Ky introduces the October 2026 issue of JACC: CardioOncology, featuring Part 1 of a special focus on immunology and cardio-oncology. This issue brings together state-of-the-art reviews, primers, original research, and clinical cases examining the immune system's central...
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Fibrotic Rewiring of CD8+ T-cells by Doxorubicin Drives Pathological Remodeling of Cardiac Extracellular Matrix | JACC: CardioOncology
Dr. Caitlin O'Meara discusses a JACC: CardioOncology study showing that doxorubicin reprograms CD8+ T cells into matrix-remodeling T cells (mxT-cells) that produce lysyl oxidase (LOX) and stiffen the cardiac extracellular matrix through HIF1α-P53-TGFβ signaling. She explains how this new immune...
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High-Sensitivity Cardiac Troponin T and I Discordance in Patients Receiving Immune Checkpoint Inhibitors | JACC: CardioOncology
Dr. David Austin discusses a JACC: CardioOncology study showing that high-sensitivity cardiac troponin T was elevated in 37.9% of patients starting immune checkpoint inhibitor (ICI) therapy, compared with only 1.8% for high-sensitivity troponin I, a discordance linked to older age, male sex, and...
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Inflammatory Cell Profiles in Early- and Late-Manifestation Immune Checkpoint Inhibitor Myocarditis | JACC: CardioOncology
Dr. Cristina Gil-Cruz discusses a JACC: CardioOncology study comparing early- and late-manifestation immune checkpoint inhibitor (ICI) myocarditis, where endomyocardial biopsies showed greater T-cell and macrophage infiltration in early cases despite similar left ventricular ejection fraction and...
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Impact of Device Position and Aortic Valve Prolapse on Outcomes After Transcatheter VSD Closure | JACC: Asia
Commentary by Dr. Timothy Un.
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Prognostic Impact of Residual Thrombus After Aspiration Thrombectomy in ST-Elevation Myocardial Infarction | JACC: Asia
Commentary by Dr. Ziyad Ghazzal.
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Lifestyle and Metabolic Health, Low-Grade to Clinically Elevated Albuminuria, and Cardiovascular-Renal Diseases | JACC: Asia
Commentary by Dr. Hongmei Yan.
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Efficacy and Safety of Quarterly Dosing SHR-1918 in Patients With Suboptimally Controlled Hyperlipidemia | JACC: Asia
Commentary by Dr. Xiaojie Xie.
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Oncologic Benefits and Cardiovascular Risks of Pembrolizumab: Insights From a Nationwide Lung Adenocarcinoma Cohort | JACC: Asia
Commentary by Dr. Koohyar Ahmadzadeh.
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Author Interview: Cholesterol Management Gaps Among Patients with Established Coronary Artery Disease Hospitalized for Acute Coronary Events | JACC: Advances
Dinesh Kalra, Todd Villines, and Lisandro Colantonio discuss the importance of this article, what encouraged Dr. Colantonio to conduct this research, and how clinicians can address the concerns patients have.
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Association of Implantation Depth with Hemodynamics and Mechanical Consequences in Small Valve-in-Valve TAVR | JACC: Asia
Commentary by Dr. Shinichi Shirai
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Comparison of ASCVD Risk Prediction Models in STEMI: Insights from a South Asian Cohort | JACC: Asia
Commentary by Dr. Justin Paul Gnanaraj
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Author Interview: Defining Clinically Meaningful Within-Patient Changes in Heart Failure | JACC: Heart Failure
Akshay Desai and Amin Yehya discuss the newest JACC: Heart Failure Position Statement that proposes a pragmatic framework for defining clinically meaningful within-patient changes across heart failure outcomes to improve the patient-centeredness of care during shared decision-making. Learn more...
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Deep Dive Dialogue: Effect of Evolocumab on Grafts Post-Coronary Artery Bypass Surgery: Post-hoc Analysis of NEWTON-CABG CardioLink-5 | JACC: Advances
Dinesh Kalra, Andrew Choi, and G. B. John Mancini discuss the author group's post hoc analysis of the randomized NEWTON-CABG CardioLink-5 trial.
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Issue Summary: September 2026 | JACC: Advances
Audio Summary of three articles from the September 2026 issue of JACC: Advances.
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Multimodality Imaging and Pace-Mapping Patterns in Patients With Cardiac Sarcoidosis and Ongoing Inflammation Undergoing Ventricular Tachycardia Ablation | JACC: Clinical Electrophysiology
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study of ventricular tachycardia ablation in patients with active cardiac sarcoidosis. Using integrated FDG-PET and cardiac MRI imaging, the investigators found that VT exit sites were often...
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Author Interview: Aortic Stenosis Mortality Across the TAVR Expansion Era, 1999-2024: Rising Mortality in Middle-Aged Adults and a Widening Rural-Urban Gap | JACC: Advances
Nicole Bhave, Ashwini Kerkar, and Ahmed Kamal Siddiqi discuss what inspired this study, differences in mortality trends among age groups, and the most important takeaways from the paper.
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Computed Tomography–Defined Ridges and Functional Mapping in Ablation of Postinfarction Ventricular Tachycardia | JACC: Clinical Electrophysiology
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating how CT-defined myocardial ridges and functional mapping can be combined to identify critical ablation targets in post-infarction ventricular tachycardia. The investigators found...
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Effect of Colchicine on Left Atrial Mechanics in Rheumatic Heart Disease: COL-RHD A Pilot Trial | JACC Asia
Commentary by Dr. Jian'an Wang.
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The Impact of PCSK9 Inhibitors on Circulatory Inflammation: Mechanisms, Evidence, and Application Prospects | JACC Asia
Commentary by Dr. Jian'an Wang.
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The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and Its Clinical Implications | JACC Asia
Commentary by Dr. Jian'an Wang.
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Vutrisiran in East Asian Patients With Transthyretin Amyloidosis With Cardiomyopathy: Post-Hoc Analysis of HELIOS-B | JACC Asia
Commentary by Dr. Jian'an Wang.
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Cost-Effectiveness of TAVI VS Minimally Invasive SAVR for Low-Risk Aortic Stenosis in Japan | JACC Asia
Commentary by Dr. Jian'an Wang.
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Patient Characteristics and Diagnosis of Transthyretin Amyloid Cardiomyopathy in Japan: Baseline Analysis of J-COSSA | JACC Asia
Commentary by Dr. Jian'an Wang.
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Wearable Electrocardiogram Technologies for the Early Detection of Acute Coronary Syndromes
Commentary by Dr. Jian'an Wang.
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August 2026 Issue Summary | JACC: Asia
Audio Summary of the August 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
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July 2026 Issue Summary | JACC: Asia
Audio Summary of the July 2026 Issue of JACC: Asia, by Dr. Jian'an Wang.
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Author Interview: Clinical Characteristics and Emergency Response to Sudden Cardiac Arrest/Death Secondary to Cardiomyopathies in Young Athletes | JACC: Advances
Matt Martinez and Bradley Petek discuss how the study came about, what results were discovered, and what call to action this study brings.
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Prognostic Value of Right Ventricular Circumferential Strain in Patients Undergoing Isolated Tricuspid Valve Surgery | JACC: Asia
Commentary by Dr. Kevin Ka-Ho Kam
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Radial Wall Strain for Predicting Severe Dissection After Drug-Coated Balloon | JACC: Asia
Commentary by Dr. Lei Song
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Issue Summary: August 2026 | JACC: Advances
Audio Summary of three articles from the August 2026 issue of JACC: Advances.
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Author Interview: Opportunistic Genetic Testing for Familial Hypercholesterolemia in Premature Acute Coronary Syndrome: Results of ACCURATE Study | JACC: Advances
Michael Wilkinson, Dinesh Kalra, Liam Brunham, and Robert Rosensen discuss the motivation behind the ACCURATE Study, unmet needs in identifying and treating HeFH, and how future studies can be designed to address the unmet need of identifying patients with HeFH and starting intensive LLT earlier…
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Author Interview: Social Drivers of Health Advisory: Cardiovascular Disease Projections Through 2050 | JACC: Advances
Dinesh Kalra and Khadijah Breathett discuss the estimated future projections of risk factors for CVD, individual CVD conditions (i.e. heart failure), and total CVD from 2020 to 2050 according to SDOH of the U.S. using the National Health and Nutrition Examination Survey, Medical Expenditure Panel...
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Computed Tomography–Derived Abrupt Wall-Thickness Transitions as Complementary Markers of Ventricular Tachycardia Substrate in Ischemic Cardiomyopathy
In this episode, Frank Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a study evaluating whether abrupt wall-thickness transitions on cardiac CT scans can help identify critical ventricular tachycardia (VT) substrate in patients with ischemic cardiomyopathy. The...
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Author Interview: INSIGHT Model: Explainable Artificial Intelligence for Real-World EHR-Based Screening of Transthyretin Amyloidosis Cardiomyopathy | JACC: Advances
Dinesh Kalra and Javed Butler discuss the development of an artificial intelligence screening tool to identify high-risk patients who should be considered for diagnostic testing for ATTR-cardiomyopathy (ATTR-CM) from an unselected heart failure (HF) population.
About this show
In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.
Hosted by
American College of Cardiology