JACC Specialty Journals

Nicole Bhave, Michael Reardon, and Joe Aoun discuss what inspired their paper, the unique microbiology of TAVR endocarditis, and a challenging endocarditis case example.

Akl Fahed and Carlo Gaspardone discuss the impact of APT duration on long-term outcomes after PFO closure.

Commentary by Dr. Kenichi Sakakura.

Commentary by Dr. Cheng Liu.

Commentary by Dr. Alena Shantsila.

Commentary by Dr. Chi Chiu Wang.

Commentary by Dr. Sung-Han Yoon.

Commentary by Dr. Yuxin He.

Commentary by Dr. Raffi Bekeredjian.

Commentary by Dr. Jae-Sik Jang.

Commentary by Dr. Xinqi Zhong.

Commentary by Dr. Zhenjie Liu.

Commentary by Dr. Ching-wei Lee.

Commentary by Dr. Panteleimon Papakonstantinou.

Commentary by Dr. Timothy Ka-chun UN.

In this episode of the JACC: Clinical Electrophysiology podcast, Executive Editor Emile Daoud discusses the primary analysis of the HEAL‑LAA study. The paper by Oluseun Alli, et al, evaluates real‑world outcomes with a next‑generation, fluoropolymer‑coated left atrial appendage occlusion device. In 500 patients across 32 U.S. centers, the study demonstrated excellent early device sealing, no significant peri‑device leaks, and favorable safety outcomes through 12 months, offering timely insights into contemporary LAAC practice and post‑implant antithrombotic management.

In this episode, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel study evaluating high‑voltage pulsed field ablation (hv‑PFA) for redo ventricular tachycardia ablation in patients with nonischemic cardiomyopathy. He highlights why VT ablation remains particularly challenging in this population, the rationale for using high‑voltage PFA to achieve deeper and more durable lesion formation, and the key findings from this early clinical experience. Dr. Marchlinski also comments on the encouraging efficacy signals, important safety considerations—including device and mapping system interactions—and what these results may mean for the future evolution of VT ablation strategies.

In this episode, Dr. Kenneth Ellenbogen discusses an important analysis from the PRAETORIAN-DFT trial examining whether shock impedance can reliably predict defibrillation success after subcutaneous ICD implantation. While low impedance values are increasingly used in practice as a surrogate for defibrillation testing, this multicenter study shows that although an impedance

In this episode, Jeremy Moore, MD, MS, Associate Editor of JACC: Clinical Electrophysiology, reviews a study showing that adults with Ebstein anomaly face a high lifetime risk of atrial arrhythmias, with more than half developing one by age 60. The most common arrhythmias were intra-atrial re-entrant and focal atrial tachycardias, which were more frequent than atrial fibrillation. Older age, prior cardiac surgery, significant tricuspid valve leakage, and severe right ventricular dysfunction were key risk factors, underscoring the need for lifelong specialized follow-up.

In this JACC Advances Author One-on-One podcast, Editor-in-Chief Dr. Dinesh Kalra and Associate Editor Dr. Purvi Parwani speak with Dr. Priscilla Wesley and Dr. Renuka Jain about their prospective study on occupational radiation exposure among interventional echocardiographers during structural heart procedures. The authors discuss findings from 230 TEE-guided interventions, including left atrial appendage occlusion, transcatheter mitral interventions, and transcatheter tricuspid procedures. The conversation highlights reassuring data on pelvic radiation exposure while addressing ongoing concerns about chest-level exposure, shielding strategies, and opportunities to improve safety in the structural heart cath lab. Tune in for an engaging discussion on radiation safety and the future of structural heart imaging.

The JACC Advances Podcast brings you expert perspectives on the most important developments in cardiovascular medicine. Through author one-on-one interviews, deep-dive discussions with editorial experts, and concise monthly research summaries, each episode highlights impactful science, clinical innovation, and emerging evidence from JACC Advances. Join us every month to stay informed on the latest breakthroughs shaping cardiovascular care.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on SGLT2 Inhibitors in Cardio-Oncology: A Systematic Review and Meta-Analysis.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Sex Differences in Heart Transplantation Outcomes: A 5-Year Review of the 2018 U.S. Allocation Policy.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Audiovisual Distraction During Mitral Transcatheter Edge-to-Edge Repair: A Sedation-Sparing Randomized Trial.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Artificial Intelligence-Enhanced Electrocardiography and Health Records to Predict Cardiac Arrest.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Trends in the Co-Occurrence of Alcohol Use and Cardiovascular Disease Among U.S. Adults, 1999 to 2023.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression: Meta-Analysis of 68,629 Participants.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jinho Lee.

Commentary by Dr. Kevin Kam.

Commentary by Dr. Mark Tuttle.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Chrishan Ramachandra.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.

Audio summary of JACC: CardioOncology's June issue.

This podcast by Dr. Larissa Araújo de Lucena discusses the development of the ONCO‑DOAC BLEED score for predicting major bleeding in patients with cancer‑associated venous thromboembolism (VTE) receiving direct oral anticoagulants. The findings support a more personalized, risk‑based approach to anticoagulation in cardio‑oncology, integrating cancer type, comorbidities, and clinical factors while highlighting the need for broader validation.

This podcast by Dr. Ron Witteles reviews new data on transthyretin amyloid cardiomyopathy (ATTR‑CM), highlighting differences in transthyretin stabilization between acoramidis and tafamidis across wild-type and variant disease. The discussion underscores the clinical importance of TTR stabilization, emerging biomarkers such as serum transthyretin, and the expanding therapeutic landscape in cardiac amyloidosis.

This podcast by Dr. Dan Zlotoff reviews new research on immune checkpoint inhibitor–associated myocarditis, a rare but serious complication of cancer immunotherapy, focusing on emerging inflammatory biomarkers such as interleukin‑6 and immune cell signatures. The study highlights potential pathways for risk stratification and targeted therapies, while underscoring the need for larger trials to develop reliable diagnostic and treatment strategies in cardio‑oncology.

This podcast by Dr. António Araújo highlights new insights from a large international registry study showing that cancer‑associated upper extremity deep vein thrombosis (UEDVT) carries increased risks of recurrent venous thromboembolism and bleeding. The findings emphasize tumor‑specific risk patterns and support more personalized anticoagulation strategies in cardio‑oncology.

This podcast by Dr. Marie Pigeyre explores emerging evidence on clonal hematopoiesis, highlighting its role as a systemic driver of inflammation and its association with increased risk of cardiovascular disease, stroke, and type 2 diabetes. The discussion emphasizes the growing importance of clonal hematopoiesis in cardiometabolic risk, precision prevention, and aging biology, while noting that routine clinical screening is not yet recommended.

Commentary by Dr. Jian'an Wang.

Commentary by Dr. Jian'an Wang.