Medical Digest & Congress Report

Professor Daisy Acosta delivers an essential expert overview on the shifting landscape of dementia prevalence across Latin America, building on crucial insights from the 10/66 studies. This concise brief highlights the unexpected increase in dementia prevalence over the past two decades across multiple catchment sites, contrasting sharply with the declining trends observed in high-income countries. Professor Acosta underscores the growing and uneven burden facing the region, outlining a critical roadmap that emphasizes the urgent need for strengthened surveillance, targeted risk reduction strategies, and substantial infrastructure investment to control modifiable risk factors and prevent dementia before it overwhelms healthcare systems.Video: https://medicaldigest.org/scientific-contents/interview:control-modifiable-risk-factors-prevent-dementia-insights-1066-studies

Professor Takaomi C. Saido, world renowned scientist, delivers a comprehensive expert overview on the current state of Alzheimer's disease research, moving past traditional models to explore groundbreaking therapeutic targets. This concise brief highlights the mechanisms behind approved disease-modifying therapies, the crucial role of neprilysin and somatostatin receptor in amyloid clearance, and the development of next-generation knock-in mouse models mapping the complex amyloid-tau pathology pathways. Professor Saido outlines a visionary roadmap toward preventing Alzheimer's before the clinical onset of cognitive impairment.Video: https://medicaldigest.org/scientific-contents/interview:new-landscape-alzheimers-therapy-targets-treatments-and-future-outlook

Dr. James Douketis delivers an essential overview of the key highlights from the newly updated ISTH guidelines and guidance documents at the ISTH 2026 Congress. This targeted brief focuses on practical, evidence-based clinical recommendations, highlighting two major clinical updates:Surgical and Procedural Bleed Risk Stratification for Anticoagulated Patients Undergoing Planned Surgery – A refined, three-tier classification framework to optimize periprocedural anticoagulation management.Monitoring and Management of Therapeutic-dose UFH in Practice – Key updates on standardizing and improving the safety of therapeutic unfractionated heparin (UFH) dosing and monitoring.Video: https://medicaldigest.org/scientific-contents/interview:highlights-isth-guidelines-and-guidance-documents

Dr. Zsuzsanna Bagoly presents the highly anticipated updated clinical recommendations for the diagnosis and classification of Factor XIII (FXIII) deficiencies at the ISTH 2026 Congress. This essential brief outlines the revised diagnostic algorithms, standardized laboratory assays, and clear classification pathways designed to improve the detection and management of this underdiagnosed, life-threatening bleeding disorder.Video: https://medicaldigest.org/scientific-contents/interview:updated-recommendations-diagnosis-and-classification-fxiii-deficiencies-isth-2026-diagnostic-highlights

Dr. Marco Donadini highlights the next generation of antithrombotic therapies at the ISTH 2026 Congress, featuring these breakthrough presentations:- A Synthetic, Allosteric, Highly Selective, Reversible Inhibitor of Human Factor XIa for Venous and Lung (Cancer-Associated) Thrombosis – Umesh Desai (Richmond, US)- EXocite ACTive site (EXACT) Inhibitors as Potent RNA Aptamer-Based Anticoagulants Targeting Various Coagulation Factors – Jeffrey Clancy (Durham, US)- Efficacy-Safety Paradox of Next-Gen Factor XI/XIa Inhibitors: Meta-Analysis of Phase 2 and 3 Trials – Rahul Falodia (Jodhpur, India)- BAY 3389934: A Dual Factor IIa/Xa Inhibitor – Nicole Juffermans (Rotterdam, The Netherlands)- REGN9533, a monoclonal antibody targeting Factor XII (FXII), Phase 1 study – Frédéric Vanhoutte (Antwerp, Belgium)Video: https://medicaldigest.org/scientific-contents/interview:future-anticoagulants

Dr. Kerstin de Wit highlights critical updates on anticoagulant-associated bleeding risks, management, and reversal strategies presented at the ISTH 2026 Congress, featuring the following key studies:- Perioperative Anticoagulation Management and Outcomes in Thrombotic Antiphospholipid Syndrome: A Single-Center Cohort Study – Miguel Paquette (Ottawa, Canada)- The Incidence and Outcomes of LMWH-Related ISTH defined Major Bleeding: A National Observational Cohort Study – Gwendoline Fuller (London, UK)- Validation of a Treatment Decision Pathway for Andexanet Alfa (VALIDA) – Jan Beyer-Westendorf (Dresden, Germany)- Reversal efficacy of novel single domain antibodies against rivaroxaban, edoxaban or apixaban in vitro and ex vivo: studying platelet-dependent clot formation under flow – Xiang Gui (Maastricht, The Netherlands)Video: https://medicaldigest.org/scientific-contents/interview:anticoagulant-associated-bleeding-specific-populations-and-reversal

Dr. Oliver Schlager outlines the acute and long-term management of severe deep vein thrombosis (DVT) in alignment with the ESVM VTE Guidelines at the ISTH 2026 Congress. This brief highlights key recommendations for early intervention, tailored anticoagulation duration, and strategies to minimize the risk of post-thrombotic syndrome (PTS).Video: https://medicaldigest.org/scientific-contents/interview:acute-and-long-term-management-severe-dvt-esvm-vte-guideline

Dr. Fionnuala Ní Áinle presents an essential overview of the latest ISTH Guidelines and Guidance Documents at the ISTH 2026 Congress. This brief highlights key clinical recommendations, the methodological rigor behind the guidelines, and practical implementation strategies to standardize care in thrombosis and hemostasis globally.Video: https://medicaldigest.org/scientific-contents/interview:introductions-isth-guidelines-and-guidance-documents-report-isth-2026

Dr. Darko Antic presents key insights into the complex management of cancer-associated thrombosis (CAT) and hemostasis at the ISTH 2026 Congress. This brief highlights the latest clinical evidence on anticoagulation strategies, balancing bleeding versus recurrent thrombotic risks, and customizing treatment pathways for oncological patients.Video: https://medicaldigest.org/scientific-contents/interview:cancer-associated-thrombosis-hemostasis

Dr. Aurélien Delluc highlights key advancements in Venous Thromboembolism (VTE) diagnosis from the ISTH 2026 Congress. Video: https://medicaldigest.org/scientific-contents/interview:vte-diagnosis-whats-new

Dr. Rebecca Edelmayer presents an inspiring overview of the latest breakthroughs and novelties in the treatment of Alzheimer's disease at the AAIC 2026 Congress.Video: https://medicaldigest.org/scientific-contents/interview:novelties-treatment-alzheimers-disease

Dr. Courtney Kloske delivers a highly anticipated expert overview of the most impactful breakthroughs and scientific updates presented at the AAIC 2026 Congress. This concise brief highlights accelerated advances in early diagnostics, emerging multi-omics approaches, key clinical trial outcomes, and global initiatives shaping the future of Alzheimer's and dementia research.Video: https://medicaldigest.org/scientific-contents/interview:highlights-aaic-2026-congress

Dr. Emanuel Della Torre discusses the clinical evidence behind targeting CD19+ B-cells in IgG4-related disease in a post-congress interview following EULAR 2026. This recap focuses on the therapeutic impact of these strategies, underlying immunological mechanisms, and the long-term management implications for patients in clinical practice.Video: https://medicaldigest.org/scientific-contents/interview:targeting-cd19-b-cells-igg4-related-disease-clinical-evidence-and-implications-long-term-management

Professor Laura C. Coates highlights the rapidly evolving landscape of state-of-the-art treatments for psoriatic arthritis (PsA) in a post-congress interview following EULAR 2026. This recap focuses on personalized management pathways, novel targeted therapies, and strategic frameworks aimed at optimizing long-term patient outcomes.Video: https://medicaldigest.org/scientific-contents/interview:state-art-treatment-psoriatic-arthritis

Professor Elena Nikiphorou discusses the ongoing paradigm shift in rheumatoid arthritis (RA), presented at the EULAR 2026 Congress. This recap focuses on novel insights into RA pathogenesis and explores the promising therapeutic pipeline, highlighting how these scientific advancements are translating into more targeted, effective management strategies for clinical practice.Video: https://medicaldigest.org/scientific-contents/interview:ra-paradigm-shift-new-insights-pathogenesis-and-pipeline-promise

Professor Oliver Distler dives into the complex landscape of systemic sclerosis (SSc), presented at the EULAR 2026 Congress. This recap focuses on recent breakthroughs in deciphering SSc pathogenesis, identifying and managing critical comorbidities, and evaluating emerging therapeutic strategies that pave the way for highly targeted clinical treatments.Video: https://medicaldigest.org/scientific-contents/interview:systemic-sclerosis-deciphering-pathogenesis-unveiling-comorbidities-and-paving-way-targeted-treatment

Professor Lorenzo Cavagna discusses the developed EULAR / ACR classification criteria for anti-synthetase syndrome, presented at the EULAR 2026 Congress. This recap highlights the critical diagnostic parameters, clinical features, and serological markers involved in these standardized criteria, aiming to improve early recognition and harmonize research and patient care globally.Video: https://medicaldigest.org/scientific-contents/interview:eular-acr-classification-criteria-anti-synthetase-syndrome

Professor Annelies Boonen explores systemic workflows and their critical role in advancing global healthcare within rheumatology, presented at the EULAR 2026 Congress. This recap highlights optimized clinical pathways, health economics, and strategic workflow improvements designed to enhance patient care and sustainability on a global scale.Video: https://medicaldigest.org/scientific-contents/interview:workflow-focus-advancing-global-health-rheumatology

Professor Radmila Matijevic addresses the complexities of diagnosing osteoporosis within the context of inflammatory rheumatic conditions, presented at the EULAR 2026 Congress. This recap focuses on best practices for early identification, the impact of chronic inflammation on bone density, and diagnostic strategies to effectively assess fracture risk in this specific patient population.Video: https://medicaldigest.org/scientific-contents/interview:diagnosing-osteoporosis-inflammatory-rheumatic-conditions

Professor Tore K. Kvien explores the evolving landscape of biosimilars and their vital role in advancing global healthcare within rheumatology, presented at the EULAR 2026 Congress. This recap highlights clinical application, access strategies, and the overall impact of biosimilar therapies in improving patient outcomes and healthcare sustainability on a global scale.Video: https://medicaldigest.org/scientific-contents/interview:biosimilars-focus-advancing-global-health-rheumatology

Dr. Paul Whelton shares critical insights from the ESH Congress on the management of hypertension in the elderly. While high blood pressure is highly prevalent in older age and carries an elevated cardiovascular risk, clinical practice often overestimates the risks of treatment. This expert overview challenges common misconceptions, highlighting how the elderly are frequently undertreated and emphasizing the clinical benefit of proactive hypertension management in older populations.Video: https://medicaldigest.org/scientific-contents/interview:treating-hypertension-elderly-insights-esh-congress

Dr. Francesco Del Galdo discusses the screening, monitoring, and management of connective tissue disease-associated interstitial lung disease (CTD-ILD), presented at the EULAR 2026 Congress. This recap focuses on the practical application of the joint ERS/EULAR guidelines, highlighting key diagnostic steps, monitoring tools, and therapeutic strategies to handle lung involvement in clinical practice.Video: https://medicaldigest.org/scientific-contents/interview:screen-monitor-and-manage-ctd-ild-practical-application-erseular-guidelines-and-expert-insights

Dr. Philippe Dieudé discusses current strategies for treating interstitial lung disease associated with rheumatoid arthritis (RA-ILD), presented at the EULAR 2026 Congress. This recap focuses on the management of pulmonary complications, the selection of appropriate immunosuppressive or antifibrotic therapies, and the clinical approach needed to stabilize lung function in these patients.Video: https://medicaldigest.org/scientific-contents/interview:treatment-rheumatoid-arthritis-associated-interstitial-lung-disease

Dr. José Antonio P. Da Silva discusses the importance of promoting happiness and well-being in older adults living with rheumatic and musculoskeletal diseases (RMDs), presented at the EULAR 2026 Congress. This recap focuses on rethinking traditional care models by incorporating psychological health and positive outcomes alongside standard medical management to improve the overall quality of life for aging patients.Video: https://medicaldigest.org/scientific-contents/interview:promote-happiness-rethinking-care-brighter-outcomes-older-adults-rmds

Dr. Filip Van den Bosch discusses strategies for improving care in spondyloarthritis, presented at the EULAR 2026 Congress. This recap focuses on the practical use of a multidisciplinary approach to manage both joint symptoms and extra-musculoskeletal manifestations, such as uveitis, psoriasis, and inflammatory bowel disease, to achieve better overall patient outcomes.Video: https://medicaldigest.org/scientific-contents/interview:improving-care-spondyloarthritis-multidisciplinary-approach-disease-and-its-extra-musculoskeletal-manifestations

Dr. Mwidimi Ndosi provides an overview of the key Health Professionals in Rheumatology (HPR) sessions at the EULAR 2026 Congress. This recap highlights the main topics discussed, including collaborative care models, the expanding role of non-physician specialists, and practical strategies implemented to enhance multidisciplinary teamwork in daily clinical practice.Video: https://medicaldigest.org/scientific-contents/interview:hpr-sessions-eular-2026

Dr. Mwidimi Ndosi explains the role of patient-centered care in rheumatology, presented at the EULAR 2026 Congress. This recap covers the practical use of shared decision-making and how involving the patient in the care team helps improve treatment adherence and clinical outcomes.Video: https://medicaldigest.org/scientific-contents/interview:patient-middle

Dr. Christian Dejaco presents highly anticipated data from the Phase 3 REPLENISH trial, evaluating the efficacy and safety of secukinumab in patients with Polymyalgia Rheumatica (PMR), highlighted at the EULAR 2026 Congress. This breakthrough recap examines how targeting the IL-17A pathway provides a powerful steroid-sparing therapeutic alternative, significantly improving clinical remission rates while reducing the burden of glucocorticoid-related side effects.Video: https://medicaldigest.org/scientific-contents/interview:secukinumab-polymyalgia-rheumatica-results-phase-3-replenish-trial

Dr. Lars Arendt-Nielsen delivers a compelling expert perspective on revolutionizing treatment priorities in rheumatic and musculoskeletal diseases, featured at the EULAR 2026 Congress. This brief explores the complex mechanisms of chronic pain, moving beyond traditional inflammatory markers to emphasize that achieving true, long-term pain remission is the ultimate measure of therapeutic success and patient quality of life.Video: https://medicaldigest.org/scientific-contents/interview:no-pain-gain-rheumatoid-diseases

Dr. Diane van der Woude provides a fascinating expert overview of the discovery of novel autoantibodies and their clinical translation in rheumatic and musculoskeletal diseases (RMDs), presented at the EULAR 2026 Congress. This recap highlights the latest breakthroughs in biomarker identification, how these emerging antibody profiles refine early diagnosis and risk stratification, and their practical implications for guiding highly targeted, personalized treatment pathways.Video: https://medicaldigest.org/scientific-contents/interview:unveiling-novel-antibodies-and-their-practical-implication-rmds

Rikke Helene Moe, EULAR Vice-President HPR, delivers an inspiring expert overview of the vital role Health Professionals in Rheumatology (HPR) play in transforming patient care, highlighted at the EULAR 2026 Congress. This brief focuses on the latest advancements in structured patient education, comprehensive support frameworks, and innovative multi-disciplinary strategies aimed at breaking down barriers and significantly improving access to high-quality rheumatology care.Video: https://medicaldigest.org/scientific-contents/interview:hpr-patient-education-support-and-improving-access-rheumatology-care

Dr. Jasminka Milas-Ahic provides a comprehensive expert overview of the contemporary challenges and advancements in pain management across rheumatological diseases, presented at the EULAR 2026 Congress. This recap explores the critical shift toward multimodal treatment strategies, the integration of pharmacological and non-pharmacological interventions, and how addressing centralized pain mechanisms is vital to improving long-term patient outcomes and quality of life.Video: https://medicaldigest.org/scientific-contents/interview:pain-management-rheumatological-diseases

Dr. Claudia Iannone delivers a vital expert perspective on the strategic management of comorbidities in patients with Systemic Sclerosis, featured at the EULAR 2026 Congress. This brief emphasizes the profound impact of overlapping systemic, cardiovascular, and metabolic complications on disease progression, highlighting the integrated care approaches and proactive screening protocols essential for optimizing long-term therapeutic outcomes and patient quality of life.Video: https://medicaldigest.org/scientific-contents/interview:managing-comorbidities-systemic-sclerosis-achieve-better-outcome

Dr. Claudia Iannone delivers a vital expert perspective on the strategic management of comorbidities in patients with Rheumatoid Arthritis, featured at the EULAR 2026 Congress. This brief emphasizes the profound impact of cardiovascular, metabolic, and mental health conditions on RA progression, highlighting integrated care approaches and early screening protocols essential for optimizing long-term therapeutic outcomes and patient quality of life.Video: https://medicaldigest.org/scientific-contents/interview:managing-comorbidities-rheumatoid-arthritis-better-outcome

Dr. Anca Dinu Askanase provides an essential expert overview of the latest breakthrough advancements and novel therapeutic developments in the treatment of Systemic Lupus Erythematosus (SLE), presented at the EULAR 2026 Congress. This recap highlights the evolving paradigm of targeted biologics, innovative small molecules, and combination strategies designed to achieve deeper clinical remission, minimize steroid dependency, and prevent long-term organ damage.Video: https://medicaldigest.org/scientific-contents/interview:novel-development-treatment-lupus

Professor Xenofon Baraliakos, President of EULAR, presents pivotal data from a Phase 2 study evaluating the impact of sonelokimab, an IL-17A/F-inhibiting Nanobody, on clinical outcomes in axial spondyloarthritis. Highlighted at the EULAR 2026 Congress, this breakthrough recap explores how the integration of advanced 18F-NaF PET imaging and MRI provides unprecedented visualization of reduced bone inflammation and metabolic activity, opening new pathways for targeted biologic therapies.Video: https://medicaldigest.org/scientific-contents/interview:impact-sonelokimab-clinical-and-imaging-outcomes-axial-spondyloarthritis-results-phase-2-study

Dr. Laura Andreoli and Dr. Karen Schreiber share essential insights from EULAR 2026 on managing fertility and family planning in patients with rheumatic and musculoskeletal diseases (RMDs). This recap explores clinical strategies from early diagnosis to pregnancy, focusing on safe medication management, patient counseling, and the multidisciplinary support needed to ensure positive maternal and fetal outcomes.Video: https://medicaldigest.org/scientific-contents/interview:diagnosis-family-building-navigating-fertility-rmds

Dr. Victoria Werth provides a concise update on the rapidly evolving therapeutic landscape for lupus, highlighting breakthrough data from EULAR 2026. This recap focuses on novel, targeted therapies designed to address unmet needs in both systemic (SLE) and cutaneous lupus (CLE), exploring how these precision strategies are successfully reshaping disease modification.Video: https://medicaldigest.org/scientific-contents/interview:novel-treatment-horizons-lupus-key-updates-eular-2026

Professor Xenofon Baraliakos, President of EULAR, delivers an authoritative executive summary of the definitive highlights from the EULAR 2026 Congress in London. Reflecting on a record-breaking year of scientific submissions, this overview captures the most impactful advancements spanning basic translational research, groundbreaking clinical trials in rheumatology, and newly updated management guidelines, emphasizing a 360-degree approach to bridging the gap between bench research and routine clinical practice.Video: https://medicaldigest.org/scientific-contents/interview:highlights-eular-2026

Dr. Muriel Elhai provides an essential expert overview of the critical role of chest high-resolution computed tomography (HRCT) in systemic autoimmune rheumatic disease-associated interstitial lung disease (SARD-ILD), presented at the EULAR 2026 Congress. This recap highlights the latest advancements in early HRCT screening protocols, radiographic staging techniques, and optimal monitoring strategies designed to accurately track disease progression and guide therapeutic decisions.Video: https://medicaldigest.org/scientific-contents/interview:chest-hrct-detecting-staging-and-follow-sard-ild

Dr. Cristiana Sieiro Santos delivers a vital expert analysis on the heterogeneous clinical manifestations and unpredictable disease course of Systemic Sclerosis, featured at the EULAR 2026 Congress. This brief highlights the crucial updates in early risk stratification, the progression of organ-specific complications like interstitial lung disease (ILD), and how deep clinical phenotyping is driving the shift toward precision medicine and targeted therapeutic intervention.Video: https://medicaldigest.org/scientific-contents/interview:clinical-manifestations-and-disease-course-systemic-sclerosis

Dr. Victoria Werth provides an expert analysis of the EULAR 2026 session exploring the role of Toll-like receptor 7 and 8 (TLR7/8) inhibition in systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). This recap looks beneath the surface at the underlying pathogenic mechanisms of the disease, highlighting the latest clinical data and new therapeutic perspectives on how targeting the TLR7/8 pathway could transform future treatment strategies and patient outcomes.Video: https://medicaldigest.org/scientific-contents/interview:under-surface-new-perspectives-lupus-tlr78-inhibition

Dr. Marco Gattorno provides an essential overview of the EULAR 2026 session focused on the transition of young patients with autoinflammatory diseases from pediatric to adult rheumatology care. This recap highlights the practical and clinical implications for daily medical management, emphasizing the need for structured multidisciplinary protocols. The discussion explores how to maintain treatment continuity, empower young patients, and address the unique disease trajectories that cross the age divide.Video: https://medicaldigest.org/scientific-contents/interview:transitioning-young-patients-autoinflammatory-diseases-adult-care-implications-daily-clinical-management

Professor Ruxandra Ionescu delivers an expert overview of the EULAR 2026 session dedicated to the advanced management of Rheumatoid Arthritis. This comprehensive recap explores the latest clinical evidence, emerging therapeutic pathways, and refined treat-to-target protocols designed to address complex, difficult-to-treat cases. The discussion highlights practical strategies for optimizing long-term outcomes, balancing drug safety, and improving overall quality of life for RA patients.Video: https://medicaldigest.org/scientific-contents/interview:advanced-management-rheumatoid-arthritis-critical-updates-eular-2026

Dr. Elena Elefante provides an expert look into the EULAR 2026 joint session "Tired is not just a state of mind," focusing on the clinical realities of pathological fatigue in patients with rheumatic and musculoskeletal diseases (RMDs). This overview dives into how chronic fatigue is increasingly recognized as a complex biological symptom rather than a purely psychological state. The recap explores current challenges and advancements in defining, objectively measuring, and managing this debilitating condition to improve patient quality of life.Video: https://medicaldigest.org/scientific-contents/interview:tired-not-just-state-mind-addressing-pathological-fatigue-eular-2026

Dr. Michael Zauner provides a comprehensive expert overview of the latest advancements in assessing disease activity in Psoriatic Arthritis, presented at the EULAR 2026 Congress. This recap explores the evolving role of multi-domain assessment tools, the integration of patient-reported outcomes, and how more precise tracking measures are shaping modern treat-to-target strategies to improve long-term joint and skin outcomes.Video: https://medicaldigest.org/scientific-contents/interview:assessment-disease-activity-psoriatic-arthritis

Dr. Carel le Roux delivers an expert overview of the highly anticipated findings from the SYNCHRONIZE™ Phase 3 clinical studies, presented at the ADA Scientific Sessions. The discussion focuses on the clinical benefits of glucagon/GLP-1 receptor dual agonism, showcasing new data on survodutide. This recap highlights how targeting both pathways offers a powerful approach to weight management and metabolic health, marking a significant step forward in obesity care.Video: https://medicaldigest.org/scientific-contents/interview:benefits-glucagonglp-1-receptor-dual-agonism-insights-synchronize-phase-3-studies-survodutide

Dr. Joshua Brody provides an expert overview of the most impactful clinical updates and essential takeaways from the 2026 ASCO Annual Meeting, focusing on groundbreaking advancements in lymphoma care. The recap explores the latest data on bispecific antibodies, including remarkable complete remission rates in Mantle Cell Lymphoma, crucial safety updates for outpatient administration, and the rapidly evolving role of frontline combination therapies in DLBCL.Video: https://medicaldigest.org/scientific-contents/interview:lymphoma-highlights-and-key-takeaways-2026-asco-annual-meeting

Professor Giampaolo Bianchini discusses the evolving landscape of immunotherapy in early-stage breast cancer, focusing on predictive biomarkers, patient selection, and the integration of checkpoint inhibitors into neoadjuvant and adjuvant treatment settings to improve long-term outcomes.Video: https://medicaldigest.org/scientific-contents/interview:immunotherapy-early-stage-breast-cancer-report-esmo-bc-2026

Professor Hope S. Rugo discusses the final overall survival results from the Phase 3 CAPItello-291 trial, evaluating the efficacy, long-term disease control, and safety of combining the AKT inhibitor capivasertib with fulvestrant for patients with AI-resistant, HR+/HER2− advanced breast cancer.Video: https://medicaldigest.org/scientific-contents/interview:capitello-291-trial-final-overall-survival-results-capivasertib-and-fulvestrant-hrher2-advanced-breast-cancer