Prime Movers

In this episode of Prime Movers, host Gavin Mathis welcomes Annette Kleiser, CEO and founder of Dalan Animal Health, to discuss her journey from scientist to entrepreneur and the critical issue of honeybee health. Annette shares her origin story and her passion for addressing the alarming decline in honeybee populations, which are essential for global food security. She emphasizes the importance of honeybees in pollinating a significant portion of the world's food crops and highlights the multifaceted challenges they face, including diseases, climate change, and pesticides.The conversation delves into Dalan's innovative approach to developing vaccines for honeybees, a groundbreaking solution that could revolutionize bee health management. Annette explains the science behind the bee's innate immune system and how her team has successfully developed a vaccine that protects colonies from disease. She shares early trial results, showcasing the positive impact of the vaccine on bee health and productivity, and discusses the potential for similar applications in other species, such as shrimp. The episode concludes with Annette's insights on the future of animal health and the importance of innovative solutions in addressing global challenges.Chapters00:00 Introduction to Annette Kleiser and Dalan Animal Health03:29 The Importance of Honeybees and the Problem of Colony Collapse08:33 Innovative Solutions: Developing Vaccines for Honeybees14:04 Field Trials and Early Results of the Bee Vaccine18:45 Expanding Horizons: Vaccination in Shrimp and Other Species24:21 Challenges and Insights from Founding Dalan Animal Health29:32 Future Predictions and the Vision for Animal Health

Dimension Bio CEO Caralynn Nowinski Collens, M.D., discusses the company's mission to create life-saving regenerative therapies, particularly for liver disease. She shares her journey in the startup world, the increasing demand for liver treatments, and the innovative approaches Dimension Bio is taking with cell-based therapies. The conversation also touches on recent advancements, regulatory challenges, and future predictions for the field of regenerative medicine.Chapters00:00 Introduction to Dimension Bio and Its Mission02:39 Caralynn's Journey and Leadership in Startups05:13 The Growing Need for Liver Disease Treatments08:23 Understanding Cell-Based Therapies11:15 Recent Milestones and Innovations in Therapy14:03 The Mechanism of Action and Placement of Therapies16:59 Regulatory Landscape and Future Predictions19:40 Final Thoughts and Future Aspirations

Wacomet and Polpis Founder and CEO Aaron Mandell discusses his journey as a founder of multiple companies focused on geothermal energy and desalination. He shares insights on the potential of geothermal energy in the U.S., the challenges of scaling it, and the importance of desalination as a critical resource for water management. Mandell advocates for a national water strategy to address the growing water crisis and emphasizes the need for innovative financing solutions to support desalination projects. He reflects on the lessons learned throughout his entrepreneurial journey and the importance of believing in the potential for technological advancements to transform industries.Chapters00:00 - The Journey of a Repeat Founder03:02 - Innovations in Geothermal Energy06:05 - Scaling Geothermal: Opportunities and Challenges09:06 - Site Selection for Geothermal Resources12:12 - Desalination: A Critical Resource14:55 - Advocating for a National Water Strategy20:07 - The Future of Water Management25:07 - Financing Desalination Projects27:49 - Lessons from the Founder Journey30:57 - Looking Ahead: Breakthroughs in Energy and Water33:01 - Inspiration and RecommendationsBooks mentioned: Cadillac Desert by Marc Reisner Hillbilly Elegy: A Memoir of a Family and Culture in Crisis by JD VanceTryptamine Palace: 5-MeO-DMT and the Sonoran Desert Toad by James Oroc

In this episode of the Prime Rovers podcast, Focused Energy CEO Scott Mercer discusses his journey in the energy sector and the advancements in fusion energy. He explains the unique approach of laser fusion technology, the commercialization process, and the regulatory environment surrounding fusion compared to fission. Scott emphasizes the importance of energy abundance for global progress and the bipartisan support for fusion initiatives. He also shares personal insights on the challenges of being a founder and his predictions for the future of energy.Chapters00:00 Introduction to Scott Mercer and Focus Energy02:51 The Evolution of Fusion Energy06:04 Understanding Laser Fusion Technology08:53 Commercialization of Fusion Energy12:13 Fusion's Role in Global Energy Demand14:54 Regulatory Environment for Fusion vs. Fission18:08 Bipartisan Support and Industrial Policy for Fusion20:57 Personal Insights and Future Predictions

LyGenesis CEO Michael Hufford joins Prime Movers Lab Partner Gavin Mathis to discuss Michael's extensive background in drug development and the innovative work being done at LyGenesis in regenerative medicine. The company has found a way to turn lymph nodes into bioreactors to grow functioning ectopic organs, particularly the liver. Michael shares insights into their clinical trials, the economic implications of their therapies, and the broader applications of their technology. He also addresses the regulatory landscape and personal reflections on the challenges and future of regenerative medicine.Chapters00:00 Introduction to LightGenesis and Michael Hufford03:53 Innovative Approaches in Regenerative Medicine10:00 Clinical Trials and Liver Regeneration15:11 Economic Impact of Liver Therapy19:50 Expanding Applications Beyond the Liver24:52 Regulatory Landscape and Challenges29:03 Personal Insights and Future Predictions

SummaryAnthony Jules, co-founder of Robust AI, discusses how his company is building robots that are designed for real-world tasks. He also addresses the misconception that robots will replace human jobs, highlighting the potential for increased productivity and job satisfaction through human-robot collaboration.Chapters00:00 Introduction and Background03:35 The Importance of Form Factor in Robotics06:22 Challenges of Humanoid Robots10:53 Partnership with DHL and Applications of Collaborative Robots13:56 Addressing Dystopian Views of Robots and AI20:15 Preparing for a Career in Robotics and AI22:40 Prime Mover Questionnaire

How do advances in computer vision help us understand the environment? What does generative AI have to do with climate tech? How do we turn satellite imagery into actionable knowledge? Listen as we answer these questions and more with our panel of founders applying computer vision to solve challenging problems in the natural world.Panelists:Igino Cafiero, CEO and Founder of Bear Flag RoboticsMatt King, CEO and Founder of FruitScoutScott Larson, CEO of SpaceAlpha

Former Prime Movers Lab Futurist Ramez Naam moderates a panel with The Roots of Progress Founder Jason Crawford, Idea Machines Host Ben Reinhardt, and Prime Movers Lab Venture Partner Amy Kruse to discuss the fundamental research that the US needs to invest in and how it will impact the economy.The conversation is an excerpt from the Prime Movers Lab Breakthrough Science Summit hosted in Scottsdale, Arizona on October 27th, 2022.

Learn about the top trends and technologies in ocean energy. Hosted by Prime Movers Lab Partner Josh Agenbroad and Fellow Nicholas May-Varas. Panelists include: - Anthony DiMare, CEO & Co-Founder - Bedrock - Anders Jansson, Head of Business Development - CorPower Ocean - Beth Hartman, Strategic Innovation and Outreach Program Manager - Department of Energy - Marcus Lehmann, CEO - CalWave

Learn about the top trends and technologies in mineral extraction. Hosted by former Prime Movers Lab Partner Gaetano Crupi and Research fellow Mitch Juneau. This conversation was originally recorded on Sep 28, 2022.Panelists include:Aaron Wilson, Chemical Separations Group Lead and Research Chemist at the Idaho National LaboratoryNicholas Myers, CEO & Co-Founder of Phoenix TailingsJeff Urban, Lead of LBL Thermoelectric Program, MSD Lead on Water-Energy Initiative at Berkeley Lab

Learn about President Joe Biden’s FY2024 budget request for science and technology programs and which ones are the most likely to pass the Republican-controlled House. Hosted by Prime Movers Lab Partners Gavin Mathis and Pritha Ghosh. Panelists include: Marissa Serafino, Associate - Holland & Knight Matt Hourihan, Associate Director of R&D and Advanced Industry - Federation of American Scientists Mike O'Neill, Associate - K&L Gates

What industries are being automated first? Why now? What developments make this the right moment to build robots? Just how automated is the world today? And what about humanoids? Panelists:Rodney Brooks, CTO and Founder at Robust.AI, Founder at Rethink Robotics, iRobot, Lucid Inc, Panasonic Professor of Robotics at MIT, and former director of the MIT Computer Science and Artificial Intelligence LaboratoryJoyce Sidopoulos, Cofounder and COO at MassRobotics, Co-founder at Robots.JobsDavid Bell, Cofounder and CEO at Remedy Robotics

Advances in scientific breakthroughs, such as single-cell technologies, have led to the increased ability to detect diseases. Accurate and early detection of disease can lead to the enhanced effectiveness of treatments and reduce burdens on the healthcare system. Join Partner Justin Briggs and Research Fellow Ted Ling Hu as they do a deep dive into the emerging trends in the field of diagnostics with our panel of experts.PanelistsSwamy Vijayan, CEO & Co-founder of Zafrens — Vijayan is a serial entrepreneur who founded Omniome and Plexium. Swamy’s current venture, Zafrens, unlocks cellular analysis through ultra-high throughput single-cell screening. The technique provides deep insights that unlock unprecedented diagnostic and therapeutic value.Daniel Georgiev, CEO and Co-founder of Sampling Human — Daniel is the co-founder and CEO of Sampling Human, which creates new technologies that harness the processing power of biology to measure single cells at scale. He is also a tenured professor at the Faculty of Applied Sciences at the University of West Bohemia.John McDevitt, Chief Scientist & Founder of OraLiva — McDevitt is the Scientific Founder of Oraliva, Inc. and is a pioneer in the development of programmable bio-nano-chip technologies. He is a Full Professor in the Department of Biomaterials at NYU Dentistry and a member of NYU’s Bioengineering Institute. He also holds a joint appointment at the Tandon School of Engineering (Department of Chemical and Biomolecular Engineering).