PsylenciaMedia

In this episode of Inside the Revival on Healthcare NOW Radio, host Jim Tate sits down with Chris Pauli, Co-Founder and Molecular Biologist at Tryptomics, a Colorado-based biotech laboratory pioneering testing and research services for psychoactive plants and fungi. From his early work sequencing the cannabis genome to building one of the first dedicated psychedelic testing labs, Pauli brings a rigorous scientific lens to a field that urgently needs one. The conversation covers the extraordinary variability in psilocybin potency across mushroom strains and flush cycles; the case for full-spectrum "ensemble" medicine over single-compound isolates; the emerging science of pharmacogenomics and what it could mean for personalized psychedelic therapy; Colorado's landmark Natural Medicine Health Act (Proposition 122) and the regulatory challenges ahead for ibogaine and DMT; and the troubling proliferation of synthetic tryptamines in the unregulated market. Pauli also introduces a critical reframe: replacing the borrowed cannabis concept of the "entourage effect" with what Tryptomics colleague Ian Bollinger calls the ensemble effect, a metaphor that recognizes every alkaloid as an integral part of the orchestra, not merely support for a VIP molecule. Candid, technically grounded, and forward-looking, this episode is essential listening for clinicians, policymakers, researchers, and anyone navigating the rapidly evolving landscape of natural medicine.

S1E18: Ontological Shock and the Healing Threshold: A Psychedelic Clinician’s Field Guide with Peter Addy, PhD. Join host Jim Tate sits and his guest psychedelic researcher and psychotherapist Peter Addy, PhD for an honest, nuanced, and scientifically grounded survey of the current psychedelic landscape. From the mechanics of harm reduction and integration therapy to the politics of federal scheduling, the conversation moves fluidly between clinical science, cultural history, and personal experience. He addresses the promise and peril of the commercial psychedelic industry, reflects on Oregon’s pioneering psilocybin services framework, examines the FDA’s rejection of MDMA-assisted psychotherapy, and shares first-hand accounts from his clinical work with chronic pain patients. He also draws on deep field experience studying Salvia divinorum, including travel to Oaxaca, Mexico and years of postdoctoral research at Yale. Equal parts scholar, clinician, and thoughtful advocate, Dr. Addy offers a rare combination of scientific rigor and compassionate practice.

S1E17: Healing From the Inside Out: Bénédicte Mannix on Psilocybin, Mental Homeostasis, and the Art of the Private Retreat Join host Jim Tate and his guest Bénédicte (Ben) Mannix , holistic psilocybin therapist, sophrotherapist, and founder of Sophrodelic in Kingston, Jamaica for a candid and illuminating conversation about what truly personalized psychedelic-assisted therapy looks and feels like in practice.

S1E16: Clearing the Plaque: How DMT Saved One Man's Life and What Science Is Beginning to Confirm Join host Jim Tate and his guest DMT Field Guide author Adam Butler, psychedelic philosopher, prolific author, and passionate DMT advocate , for a candid, deeply personal conversation at the intersection of mental health, neuroplasticity, and the emerging science of psychedelic medicine. Butler, author of Butler's DMT Field Guide: A Brief History, Step-by-Step Recipes, and Personal Experiences From a DMT Saturated Consciousness, shares how N,N-dimethyltryptamine pulled him back from the edge of suicide and addiction, and why he believes, with growing scientific backing that this endogenous molecule may hold keys to treating everything from depression and PTSD to stroke and dementia. From harm reduction and ontological risk to extended-state DMT research, microdosing philosophy, and the urgent need for philanthropic investment in psychedelic science, this episode maps the terrain for anyone curious about the revival happening at the frontier of mind, medicine, and healing.

S1E15: The People's Mushroom: Psychedelics, Policy, and the Push to Reclaim Scotland's Indigenous Apothecary with Anna Ross, PhD Join host Jim Tate travels north of the border to speak with Dr. Anna Ross, lecturer at the University of Edinburgh, co-founder of the Scottish Psychedelic Research Group (SPRG), and self-described "lived and living experience researcher" who came up through Scotland's 1990s rave scene. Dr. Ross traces the founding of SPRG, Scotland's rich but under-documented relationship with indigenous psychoactive plants, the conspicuous absence of clinical psychedelic trials north of England, the thorny politics of Compass Pathways and IP enclosure in the psychedelic space, and the underground scene that has quietly thrived for decades. She also opens up about her own encounters with DMT and her ongoing research focus: ontological shock, the profound and sometimes destabilizing worldview ruptures that psychedelics can produce, and which mainstream psychiatry still struggles to name, let alone treat. A rich, candid, and highly informed conversation from the northern edge of the psychedelic renaissance.

S1E14: Extended-State DMT (DMTx) Method Join host Jim Tate and his guest Daniel McQueen, a professional psychedelic therapist and executive director of the Center for Medicinal Mindfulness, a psychedelic harm-reduction program and international psychedelic therapy training program focusing on Cannabis-Assisted Psychedelic Therapy and Cannabis-Assisted Psychotherapy. McQueen discusses his journey from underground guide to regulated access work in Colorado, his experiments extending DMT experiences via infusion, his views on psilocybin regulation, and the tensions inherent in commodifying sacred medicines.

S1E13: Sacred Healing or Clinical Care? Join host Jim Tate and his guest Justin Townsend, Founder and CEO of Myco Meditations, a leading psilocybin-assisted retreat organization based in Jamaica. Together, they explore the emerging role of psychedelics at the intersection of clinical treatment, sacred ceremony, and cultural transformation. From 6,000+ psilocybin journeys hosted in safe, structured retreats to debates over natural vs. synthetic psilocybin, Townsend sheds light on lessons learned, harm reduction practices, and the risks of unchecked commercialization in the US.

S1E12: Salvia, Somatics, and the Kappa Receptor: A Different Kind of Journey Join host Jim Tate and his guest Christopher Solomon, somatic Salvia guide, teacher, and inventor of a pipe that aids in the mindful exploration of Salvia divinorum, for a grounded conversation about one of the psychedelic ecosystem’s most misunderstood medicines. Solomon argues that salvia’s reputation is often shaped by “too much, too fast” use, while careful pacing, low-dose exploration, and somatic awareness can make the experience far more workable and instructive. They unpack what makes salvia pharmacologically distinct, including its relationship to the kappa opioid receptor, and why that difference matters for both potential benefits and limitations.

S1E11: Bridging Healing & Mystery, Psilocybin’s Role at the Intersection of Mental Health, Spirituality and Community Join host Jim Tate and his guest, prolific author, educator and psychedelic wellness expert Matt Zemon. Matt is a thought leader at the intersection of psychedelics, science, and spiritual experience. After his own profound mushroom experience transformed him from skeptic to seeker, he has been blending academic rigor with compassionate advocacy to promote safer, intentional, and transformative psychedelic use. He is a best-selling author of The Beginner’s Guide to Psychedelics, The Veteran’s Guide to Psychedelics, Psychedelics for Everyone, and Beyond the Trip: A Journal for Psychedelic Preparation and Integration.

S1E10: From Combat to Community: Jesse Gould and the Veteran-Led Psychedelic Movement Join host Jim Tate and his guest Jesse Gould, Founder and President of the Heroic Hearts Project, a 501(c)(3) nonprofit connecting military veterans and their families to structured psychedelic retreat programs with peer support and integration coaching. The conversation explores the veteran suicide crisis, the evolving legal landscape in Oregon and Colorado, emerging research on MDMA and psilocybin for PTSD and depression, and the policy tensions surrounding psychedelic-assisted therapy.

S1E9: Sacraments and Psychedelics with Pastor Dave Hodges Join host Jim Tate and his guest Dave Hodges, Founder and Pastor of the Church of Ambrosia. Pastor Dave has built a multi-pronged movement focusing on safety, education, community, and legal recognition of entheogenic sacraments. By fusing scientific rigor with spiritual guidance and activism, Dave’s created a model both pragmatic and profound, to awaken spiritual consciousness and promote healing through the sacramental use of entheogens, primarily psilocybin mushrooms and cannabis, within a safe, supportive, and legally protected religious community.

S1E8: Inside Oregon’s Psilocybin Experiment: Practice, Policy, and Lived Experience with Heidi Venture Join host Jim Tate and his guest Heidi Venture, co-founder of Vital Reset, one of Oregon’s first licensed psilocybin service centers. Heidi shares her insights on how Oregon’s landmark psilocybin law translates into day-to-day realities for clients, facilitators, and service center owners. Jim and Heidi examine the broader ecosystem: financial pressures on licensed centers, the resilience of underground markets, retreat-based models abroad, and how regulatory decisions by the Oregon Health Authority shape both safety and sustainability.

S1E7:: Sky Mountain 5-MeO-DMT Retreats Join host Jim Tate and his guest Roger Kaufman, co‑host and co‑facilitator at Sky Mountain, a private retreat where psychotherapists Roger Kaufman and Dustin Kerrone will serve as your emissaries to the infinite. Roger shares insights on the mission and therapeutic philosophy of Sky Mountain.

S1E6: The Spirit Pharmacist: Psychedelic Safety, SSRIs, and the Myth of Serotonin Syndrome Join host Jim Tate and his guest Ben Malcolm, PharmD, MPH. known globally as The Spirit Pharmacist, for a deep, science-grounded exploration of psychedelic pharmacology, psychiatric medications, and safety. From SSRI tapering and serotonin syndrome myths to psilocybin dosing, ibogaine’s role in opioid addiction, and the neurobiology of addiction interruption, Malcolm bridges academic rigor with compassionate harm-reduction. This conversation challenges outdated assumptions, clarifies real versus imagined risks, and underscores the urgent need for accessible, evidence-based psychedelic education.

S1E5: From Battlefield to Beckley: Neil Markey on Psychedelics, PTSD, and Purpose Join host Jim Tate and his guest Neil Markey, Co‑Founder and CEO of Beckley Retreats, to uncover how their immersive, legally sanctioned five‑night psilocybin retreats in Jamaica (and truffle retreats in the Netherlands) combine artisanal ritual, high‑caliber safety standards, and group dynamics for transformational experiences.

S1E4: Ibogaine Isn’t a Pill: Building a Hospital-Grade Psychedelic ‘Reset’ at Beond. Host Jim Tate speaks with Tom Feegel, CEO & Co-Founder of Beond Ibogaine, about what it means to deliver ibogaine in a medically monitored setting.

S1E3: Melissa Stangl on Soltara’s Shipibo-Guided Ayahuasca Model, Safety Screening, and Integration That Actually Sticks. In this timely conversation, host Jim Tate engages Melissa Stangl, Founding Partner & Chief Operating Officer (COO), Soltara Healing Center, about her unlikely pivot from biomedical engineering and cancer research into the operational “backbone” of plant medicine work. Melissa walks through Soltara’s decision to focus on ayahuasca in the Shipibo tradition, why Costa Rica became the home base, and how the retreat arc is designed - from intake, medical/therapy screening, and preparation to post-retreat integration support. Along the way, we unpack practical realities: medication contraindications (especially SSRIs + MAOI risk), why some guests report 'nothing happened,' (a failure to hit escape vel;ocity - of you will) individualized dosing, and why Soltara treats integration as a year-long continuum - not an afterthought.

S1E2: Mushrooms, Methods, and Meaning: Inside Jamaica’s Legal Psilocybin Supply with Rose Hill’s Charles Lazarus Host Jim Tate and Charles Lazarus, from Rose Hill discuss legal context, cultivation science, clinical collaboration, whole mushroom vs. synthetics, veteran healing programs, microdosing and mindset, along with ethical entrepreneurship.

S1E1: Modern Psychedelics and the Neuroplastic Revolution with Joe Dolce On this episode, host Jim Tate and executive producer Gregg Anthony Masters, MPH engage Joe Dolce, author of 'Modern Psychedelics: The Handbook for Mindful Exploration'. Jim sits down with Joe to unpack the new science and ancient wisdom reshaping humanity’s relationship with consciousness. From the citizen-science wave of microdosing to Dr. Gül Dölen’s “critical period” breakthroughs in brain plasticity, the conversation spans neuroscience, spirituality, ethics, and policy. Dolce’s message is clear: psychedelics are not shortcuts, they’re sacred tools demanding reverence, responsibility, and reciprocity.