PODCAST · health
PubReading
by Mando Mourad
Researchers would love if they can expand time to fit in that publication, article, or review of their topic of interest; if that were true, however, there is no end to bottomless scrolling and missing the important details. PubReading would read out the abstract, results, and discussions to allow hassle-free information and a chance to create connections with like-minded individuals.
Episodes
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PubReading [346] - Transparency Is the Key to Quality - A. Fosang & R. Colbran
A workshop held last June by the National Institutes of Health (NIH) Director’s Office, Nature Publishing Group, and Science focused on the role that journals play in supporting scientific research that is reproducible, robust, and transparent. The “Principles and Guidelines for Reporting...
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PubReading [343] - The changing career trajectories of new parents in STEM - E. Cech & M. Blair-Loy
The gender imbalance in science, technology, engineering, and math (STEM) fields has remained constant for decades and increases the farther up the STEM career pipeline one looks. Why does the underrepresentation of women endure? This study investigated the role of parenthood as a mechanism of...
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PubReading [341] - Carbon Nanomaterials (CNMs) in Cancer Therapy- A Database of CNM-Based Nanocarrier Systems - H. Mohan, A. Fagan & S. Giordani
Carbon nanomaterials (CNMs) are an incredibly versatile class of materials that can be used as scaffolds to construct anticancer nanocarrier systems. The ease of chemical functionalisation, biocompatibility, and intrinsic therapeutic capabilities of many of these nanoparticles can be leveraged to...
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PubReading [340] - The application of human tissue for drug discovery and development - M. Clotworthy
Human tissues are invaluable resources for pharmaceutical research. They provide information about disease pathophysiology - and equally importantly, healthy function; confirmation (or refutation) of potential drug targets; validation (or otherwise) of other models employed; and functional models...
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PubReading [339] - Pleiotropic Effects of Icariside II on the Cardiovascular System- Novel Applications of Ethnopharmacology in Targeting Vascular Remodeling - C. Shan, R. Murphy et al.
Albert Einstein once eloquently stated “We still do not know one thousandth of one percent of what nature has revealed to us.” Mother Nature has proven time and again to be the best engineer, architect, scientist, and doctor. This fact has not been lost on mankind, and since time immemorial, we...
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PubReading [338] - A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to Cisplatin - N. Mukherjee, A. Eustace et al.
Triple negative breast cancer (TNBC) remains a therapeutic challenge due to the lack of targetable genetic alterations and the frequent development of resistance to the standard cisplatin-based chemotherapies. Here, we have taken a systems biology approach to investigate kinase signal…
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PubReading [337] - Training early career researchers to use meta- research to improve science- A participant- guided “learn by doing” approach - T. Weissgerber
Meta-research, or the science of science, is a powerful technique that scientists can use to improve science, however most scientists are unaware that meta-research exists and courses are rare. This initiative demonstrates the feasibility of a participant-guided “learn by doing” approach, in…
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PubReading [336] - Foldaxanes- Rotaxane-like Architectures from Foldamers - V. Koegler, Y. Ferrand et al.
Mechanically interlocked molecules such as rotaxanes and catenanes contain free-moving components that cannot dissociate and have enabled the investigation and control of various translational and rotational molecular motions. The architecture of pseudo-rotaxanes and of some kinetically labile...
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PubReading [335] - Delta chirality ruthenium ‘light-switch’ complexes can bind in the minor groove of DNA with five different binding modes - J. Hall, C. Cardin et al.
[Ru(phen)2 (dppz)]2+ has been studied since the 1990s due to its ‘light-switch’ properties. It can be used as a luminescent DNA probe, with emission switched on through DNA binding. The luminescence observed is dependent on the solvent accessibility of the pyrazine nitrogen atoms, and therefore…
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PubReading [334] - Open science challenges, benefits and tips in early career and beyond - C. Allen & D. Mehler
The movement towards open science is a consequence of seemingly pervasive failures to replicate previous research. This transition comes with great benefits but also significant challenges that are likely to affect those who carry out the research, usually early career researchers (ECRs). Here…
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PubReading [333] - Enzymatic assembly of DNA molecules up to several hundred kilobases - D. Gibson, H. Smith et al.
We describe an isothermal, single-reaction method for assembling multiple overlapping DNA molecules by the concerted action of a 5' exonuclease, a DNA polymerase and a DNA ligase. First we recessed DNA fragments, yielding single-stranded DNA overhangs that specifically annealed, and then…
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PubReading [332] - Do natural DNA triple-helical structures occur and function in vivo? -
Formation of natural intramolecular triple-helical structures of DNA is still an intriguing research topic in view of the possible involvement of these structures in biological processes. The biochemical and biophysical properties of DNA triplex structures have been extensively studied, and...
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PubReading [331] - Addressing Isolation in the Scientific Community - D. Tomasello
In STEM, and particularly in science, many early career researchers find themselves isolated and lacking guidance. There is an enormous need to connect early career scientists with experienced professionals outside their immediate work environment. A new initiative aims to create a supportive...
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PubReading [330] - Diversity and Complexity of the Large Surface Protein Family in the Compacted Genomes of Multiple Pneumocystis Species - L. Ma, J. Kovacs et al.
Pneumocystis, a major opportunistic pathogen in patients with a broad range of immunodeficiencies, contains abundant surface proteins encoded by a multicopy gene family, termed the major surface glycoprotein (Msg) gene superfamily. This superfamily has been identified in all Pneumocystis species...
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PubReading [329] - The immune suppressive tumor microenvironment in multiple myeloma- The contribution of myeloid-derived suppressor cells - C. Giannotta, F. Autino and M. Massaia
Myeloid derived suppressors cells (MDSC) play major roles in regulating immune homeostasis and immune responses in many conditions, including cancer. MDSC interact with cancer cells within the tumor microenvironment (TME) with direct and indirect mechanisms: production of soluble factors and...
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PubReading [328] - Reflections on scientific collaboration between basic researchers and clinicians - J. Muia & C. Casari
Early career researchers face uncertainties with respect to their job prospects due to dwindling job markets, decreased availability of funding and undefined career paths. As basic researchers and clinicians tend to have different approaches to scientific problems, there are many advantages from...
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PubReading [327] - DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access - B. Bögels, T. de Greef et al.
DNA has emerged as an attractive medium for archival data storage due to its durability and high information density. Scalable parallel random access to information is a desirable property of any storage system. For DNA-based storage systems, however, this still needs to be robustly established....
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PubReading [326] - Drug screening for human genetic diseases using iPSC models - M. Elitt, L. Barbar & P. Tesar
Induced pluripotent stem cells (iPSCs) enable the generation of previously unattainable, scalable quantities of disease- relevant tissues from patients suffering from essentially any genetic disorder. This cellular material has proven instrumental for drug screening efforts on these disorders…
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PubReading [325] - The Costs of Reproducibility - R. Poldrack
Improving the reproducibility of neuroscience research is of great concern, especially to early-career researchers (ECRs). Here I outline the potential costs for ECRs in adopting practices to improve reproducibility. I highlight the ways in which ECRs can achieve their career goals while doing...
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PubReading [325] - pH-dependent sedimentation of DNA in the presence of divalent, but not monovalent, metal ions - C. England, L. K. Lewis et al.
Precipitation of DNA is performed frequently in molecular biology laboratories for the purpose of purification and concentration of samples and also for transfer of DNA into cells. Metal ions are used to facilitate these processes, though their precise functions are not well characterized. In the...
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PubReading [324] - DNA sequencing with chain-terminating inhibitors - F. Sanger, S.Nickel & A. Coulson
A new method for determining nucleotide sequences in DNA is described. It is similar to the "plus and minus" method but makes use of the 2',3 '- dideoxy and arabinonucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA…
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PubReading [323] - Factors that influence PhD candidates’ success: the importance of PhD project characteristics - E. van Rooij, M. Fokkens-Bruinsma & E. Jansen
High dropout rates, delay, and dissatisfaction among PhD students are common problems in doctoral education. Research shows that many different factors are associated with doctoral success, but these factors have not often been studied simultaneously. Moreover, characteristics of the PhD project...
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PubReading [322] - Millisecond-timescale, genetically targeted optical control of neural activity - E. Boyden, K. Deisseroth et al.
Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene...
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PubReading [321] - Controlling the double helix - G. Felsenfeld & M. Groudine
Chromatin is the complex of DNA and proteins in which the genetic material is packaged inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts profound control over gene expression and other fundamental cellular processes. Changes in its structure can be inherited by...
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PubReading [320] - Deep Neural Networks as Scientific Models - R. Cichy and D. Kaiser
Artificial deep neural networks (DNNs) initially inspired by the brain enable computers to solve cognitive tasks at which humans excel. In the absence of explanations for such cognitive phenomena, in turn cognitive scientists have started using DNNs as models to investigate biological cognition…
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PubReading [319] - The Science Behind NMN—A Stable, Reliable NAD+ Activator and Anti-Aging Molecule - Christopher Shade
In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging. The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related...
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PubReading [318] - The essential metals for humans- a brief overview - M. Zoroddua, V. Nurchi et al.
The human body needs about 20 essential elements in order to function properly and among them, for certain, 10 are metal elements, though for every metal we do need, there is another one in our body we could do without it. Until about 1950 poor attention was given to the so-called “inorganic...
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PubReading [317] - Nucleic acid sensing via electrochemical oligonucleotide-templated reactions - P. Gillespie, D. O’Har et al.
Short single-stranded nucleic acids as found in a variety of bodily fluids have recently emerged as minimally invasive biomarkers for a broad range of pathologies, most notably cancer. Because of their small size, low natural abundance and high sequence homology between family members they are...
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PubReading [316] - A brief history of human disease genetics - M. Claussnitzer, M. McCarthy et al.
A primary goal of human genetics is to identify DNA sequence variants that influence biomedical traits, particularly those related to the onset and progression of human disease. Over the past 25 years, progress in realizing this objective has been transformed by advances in technology…
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PubReading [315] - Technology transfer programme for influenza vaccines – Lessons from the past to inform the future - C. Chadwick, E. Sparrow et al.
In 2006, to address the global inequitable access to influenza vaccines in the event of an influenza pandemic, WHO, with support of donors and partners, embarked on an ambitious project, the Technology Transfer Initiative (TTI), to facilitate influenza vaccine production capacity-building in low-...
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PubReading [314]- MicroRNAs, damage levels, and DNA damage response control - H. Visser and A. Thomas
DNA damage–inducible miRNAs are likely to be functional in the DNA damage response. This response can elicit damage resolution and cell survival or apoptosis. The current, albeit incomplete, picture suggests that miRNAs can affect cell fate via modulation of key response proteins, but the…
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PubReading [313] - Physical activity, exercise, and chronic diseases- A brief review - E. Anderson, J. L. Durstine
Chronic diseases are the leading cause of death worldwide with increasing prevalence in all age groups, genders, and ethnicities. Most chronic disease deaths occur in middle-to low-income countries but are also a significant health problem in developed nations. Multiple chronic diseases now…
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PubReading [312] - Identification of endocrine disrupting chemicals acting on human aromatase - R. Baravalle, G. Gilardi et al.
Human aromatase is the cytochrome P450 catalysing the conversion of androgens into estrogens playing a key role in the endocrine system. Due to this role, it is likely to be a target of the so-called endocrine disrupting chemicals, a series of compounds able to interfere with the hormone system...
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PubReading [311] - Chemical biology of non-canonical structures of nucleic acids for therapeutic applications - H. Tateishi-Karimata and N. Sugimoto
DNA forms not only the canonical duplex structure but also non-canonical structures. Most potential sequences that induce the formation of non-canonical structures are present in disease-related genes. Interestingly, biological reactions are inhibited or dysregulated by non-canonical structure...
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PubReading [310] - How to Write the Methods Section of a Research Paper - R. Kallet
The methods section of a research paper provides the information by which a study’s validity is judged. Therefore, it requires a clear and precise description of how an experiment was done, and the rationale for why specific experimental procedures were chosen. The methods section should describe...
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PubReading [309] - What We Talk About When We Talk About “Junk DNA” - N. Fagundes, A. Zani et al.
“Junk DNA” is a popular yet controversial concept that states that organisms carry in their genomes DNA that has no positive impact on their fitness. Nonetheless, biochemical functions have been identified for an increasing fraction of DNA elements traditionally seen as “Junk DNA”. These findings...
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PubReading [308] - Deep learning in cancer pathology- a new generation of clinical biomarkers - A. Echle, J. Kather et al.
Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers. However, the growing number of these complex biomarkers tends to increase the cost and time for decision-making in routine daily oncology practice; furthermore, biomarkers often require tumour tissue on top of...
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PubReading [307] - Comparison of X-ray and NMR Structures- Is There a Systematic Difference in Residue Contacts between X-ray- and NMR-Resolved Protein Structures? - S. Garbuzynskiy, O. Galzitskaya et al.
We have compared structures of 78 proteins determined by both NMR and X-ray methods. It is shown that X-ray and NMR structures of the same protein have more differences than various X-ray structures obtained for the protein, and even more than various NMR structures of the protein. X-ray and NMR...
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PubReading [306] - A Brief History of IL-9 - R. Goswami and M. Kaplan
IL-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A resurgence of interest in IL-9 has been spurred by...
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PubReading [305] - The sciences of science communication - B. Fischhoff
The May 2012 Sackler Colloquium on “The Science of Science Communication” brought together scientists with research to communicate and scientists whose research could facilitate that communication. The latter include decision scientists who can identify the scientific results that an audience…
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PubReading [304] - What are Biomarkers? - K. Strimbu and J. Tavel
This article provides working definitions and a conceptual framework to understand the roles of biomarkers in clinical research. The definitions of the terms discussed in this article—medical signs, symptoms, biomarkers, surrogate endpoints, clinical endpoints, validation—are still under...
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PubReading [303] - The Epigenomics of Cancer - P. Jones and S. Baylin
Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations...
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PubReading [302] - The evolution, evolvability and engineering of gene regulatory DNA - E. Vaishnav, A. Regev et al.
Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal phenotype and fitness1–3. Constructing complete fitness landscapes, in which DNA sequences are mapped to fitness, is a long-standing goal in biology, but has remained elusive because it is challenging to...
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PubReading [301] - Cancer Progress and Priorities- Lung Cancer - M. Schabath and M. Cote
In the United States, lung cancer is the second most common diagnosed cancer and the leading cause of cancer-related death. Although tobacco smoking is the major risk factor accounting for 80% to 90% of all lung cancer diagnoses, there are numerous other risk factors that have been identified as...
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PubReading [300] - Randomisation in clinical trials - E. Beller, V. Gebski & A. Keech
Randomisation is the process of assigning clinical trial participants to treatment groups. Randomisation gives each participant a known (usually equal) chance of being assigned to any of the groups. Successful randomisation requires that group assignment cannot be predicted in advance. DOI:...
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PubReading [299] - The Formation and Displacement of Ordered DNA Triplexes in Self- Assembled Three-Dimensional DNA Crystals - Y. Zhao, R. Sha et al.
Reconfigurable structures engineered through DNA hybridization and self-assembly offer both structural and dynamic applications in nanotechnology. Here, we have demonstrated that strand displacement of triplex-forming oligonucleotides (TFOs) can be translated to a robust macroscopic DNA crystal…
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PubReading [298] - Simultaneous sequencing of genetic and epigenetic bases in DNA - J. Füllgrabe, S. Balasubramanian et al.
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. Most DNA sequencing approaches address either genetics or epigenetics and thus capture incomplete information. Methods widely used to detect epigenetic DNA bases…
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PubReading [297] - Modulation of the helical properties of DNA- next-to-nearest neighbour effects and beyond - A. Balaceanu, M. Orozco
We used extensive molecular dynamics simulations to study the structural and dynamic properties of the central d(TpA) step in the highly polymorphic d(CpTpApG) tetranucleotide. Contrary to the assumption of the dinucleotide model and its nearest neighbours (tetranucleotide-model), the properties…
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PubReading [296] - Telomerase structural biology comes of age - Y. He & J. Feigon
Telomerase is an RNA–protein complex comprising telomerase reverse transcriptase, a non-coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or recruitment. Telomerase synthesizes the telomeric DNA at the 30-ends of linear chromosomes. During the past decade,...
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PubReading [295] - Decentralized Clinical Trials The Future of Medical Product Development? - G. Van Norman,
The Covid-19 pandemic disrupted many clinical trials that were potentially bringing new therapeutics to market—an additional untallied cost of the pandemic in lives and quality of life owing to delays in releasing potentially beneficial therapeutics to patients in need. A separate side effect of...
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ABOUT THIS SHOW
Researchers would love if they can expand time to fit in that publication, article, or review of their topic of interest; if that were true, however, there is no end to bottomless scrolling and missing the important details. PubReading would read out the abstract, results, and discussions to allow hassle-free information and a chance to create connections with like-minded individuals.
HOSTED BY
Mando Mourad
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Frequently Asked Questions
How many episodes does PubReading have?
PubReading currently has 343 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is PubReading about?
Researchers would love if they can expand time to fit in that publication, article, or review of their topic of interest; if that were true, however, there is no end to bottomless scrolling and missing the important details. PubReading would read out the abstract, results, and discussions to allow...
How often does PubReading release new episodes?
PubReading publishes regularly with 343 episodes available. Check the episode list for the typical release schedule.
Where can I listen to PubReading?
You can listen to PubReading on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts PubReading?
PubReading is created and hosted by Mando Mourad.
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