PODCAST · health
QuadShot News Podcast
by Laura, Caleb, and Sam
With increasing information overload and packed work schedules, staying up-to-date on the newest oncologic advances is harder than ever. But take heart! The QuadShot is freshly brewed four mornings each week so you can quickly down and digest the day's most pertinent cancer news.
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271
6.15.2026 - Myxoid Signals
Check out this episode of the QuadCast where we highlight zero margin brain SRS, the benefit of chemoradiation in pancreatic cancer, the ability to reduce radiation dose in myxoid liposarcoma, and more! Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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270
6.1.2026 - T Time
Check out this week's QuadCast as we highlight testosterone replacement in favorable prostate cancer, SABR for breast cancer without surgery, smaller GBM margins, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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269
2.16.2026 - Hormone Therapy Reimagined
Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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268
1.20.2026 - The Voice
Check out this week's episode as we highlight immunotherapy in rectal cancer, single vocal cord radiation, and how to use a TrueBeam to deliver FLASH RT. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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267
12.22.2025 - A Positive Breakthrough
Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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266
11.24.2025 - Stiff Luck
Check out this week's QuadCast as we highlight the benefits of statins on aortic functioning in patients receiving anthracycline chemotherapy, the potential of nimotuzumab in cervical cancer, and the neurocognitive recovery seen after SRS compared to whole brain RT. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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265
11.3.2025 - Score to Settle
Check out this week's QuadCast as we highlight the role of elective nodal treatment in bladder cancer, the impact of cribriform morphology on prostate cancer metastasis risk, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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264
9.15.2025 - Ax the Dissection
Check out this week's QuadCast as we highlight the limited role of axillary dissection in breast cancer, the benefits of SBRT in oligometastatic renal cell carcinoma, more data on ultra central lung cancer radiation, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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263
9.8.2025 - Quick Mayo
Check out this week's QuadCast where we highlight the pros and cons of dose de-escalated RT for resected HPV+ oropharynx cancer, another trial showing that SBRT for oligometastatic prostate cancer improves outcomes, a model for predicting brain radiation necrosis with SRS, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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262
8.25.2025 - GGO To Go
Check out this week's QuadCast as we highlight the ability to skip a mediastinal nodal dissection with small GGOs, how Pluvicto improves outcomes in mCRPC with higher tumor volume, the lack of general knowledge about the link between HPV and oropharyngeal cancer, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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261
8.18.2025 - The Coccus Race
Check out this week's QuadCast as we highlight how intranasal mupirocin decreases radiation dermatitis associate with nasopharynx radiation, the lack of benefit of immunotherapy in MGMT-unmethylated GBM, the role of neoadjuvant chemoradiation in unresectable pancreatic cancer, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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260
8.11.2025 - The FLAME keeps burning
Check out this week's QuadCast as we highlight long term results from FLAME on DIL SIB in prostate cancer, how the benefits of Pluvicto are growing, the thought provoking question of surgical omission in breast cancer, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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259
8.4.2025 - De-Squamate
Check out this week's QuadCast as we highlight de-escalated therapy for cutaneous SCC based on pembro response, a comparison of fluciclovine vs. PSMA PET scan in biochemically recurrent prostate cancer, an important change to HPV+ oropharyngeal staging, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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258
7.28.2025 - Just Swell
Check out this week's QuadCast as we highlight the impact of perilesional edema on local failure risk for brain SRS, the benefits of RT in high risk prostate cancer, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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257
7.21.2025 - Depends
Check out this week's QuadCast that highlights the debate over T&O or T&R, the risk of incontinence after salvage, post-prostatectomy radiation, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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256
7.14.2025 - VIOLET
Check out this week's QuadCast as we highlight a PSMA Theranostic contender, new guidelines (and name) for GBM, current management limitations in NSCLC, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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255
6.30.2025 - Late TORS Outcomes
Check out this episode of the QuadCast where we highlight de-intensification for HPV mediated oropharyngeal squamous cell carcinoma, how the addition of radium 223 to enzalutamide improves outcomes, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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254
6.9.2025 - NIVONEWS
Check out this week's QuadCast with many highlights from ASCO, including adding nivo to postop CRT in HNSCC, the benefits of immunotherapy in resected MMRd colon cancer, how SRS beat HA-WBRT, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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253
5.19.2025 - PLATO-ACT4
Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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252
5.5.2025 - Listen To This
Check out this week's QuadCast as we highlight SRS vs. fSRS for hearing preservation in vestibular schwannomas, preoperative immunotherapy in HNSCC, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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251
4.28.2025 - Making Smarter Choices
Check out this week's QuadCast as we highlight the predictive abilities of AI for ADT duration in prostate cancer, how consolidative chemoRT benefits patients with unresectable gallbladder cancer, the benefits of immunotherapy in clear cell GYN cancer, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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250
4.21.2025 - Personal Toxicity Profile
Check out this week's QuadCast as we highlight PROSTOX's ability to predict late GU toxicity, why long course chemoradiation may be better than short course RT in rectal cancer, how to identify aggressive chromosomal alterations in meningiomas, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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249
4.7.2025 - A Chance Not To Cut
Check out the this week's QuadCast as we highlight omission of surgery in breast cancer patients, best management of small cell lung cancer, adaptive radiation for cervical cancer, the best approach for prostate brachytherapy boost, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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248
3.31.2025 - Calculus problem
Check out this week's QuadCast where we highlight the link between dental hygiene and oral mucositis risk, the optimal timing of post-treatment PSMA PET scans, the impressive impact of immunotherapy in MSI-high colorectal cancer, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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247
3.18.2025 - DEPEND
Check out this week's QuadCast as we highlight the role of induction chemoimmunotherapy, the scenarios where partial breast irradiation and cosmetic breast surgeries can be considered, and how the Sedlis criteria treatment paradigm remains standard for intermediate risk cervical cancer patients after surgery. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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246
2.10.2025 - Head in the Game
Check out this week's QuadCast as we highlight the role of staging brain MRI in metastatic breast cancer, the link between acute and late toxicity in prostate cancer treatment, the benefits of liver SBRT over TACE, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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245
2.3.2025 - Bone to Pick
Check out this week's QuadCast as we highlight bone SBRT guidelines, best practice in the treatment of WHO grade II meningioma, frequency of partial breast IMRT treatment, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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244
1.27.2025 - RTOG 0920
Check out this week's QuadCast as we highlight the results of RTOG 0920 for adjuvant therapy in H&N cancer, the benefit of bone protective agents in patients receiving radium 223 + enzalutamide, the benefit of incorporating counseling into smoking cessation strategies, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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243
1.13.2025 - Cord Constraints
Check out this week's QuadCast as we highlight spinal cord constraints for spine SBRT, published results of RTOG 1112 where liver SBRT shines, the role of prophylactic nodal RT in prostate SBRT, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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242
1.6.2025 - NRG 258
Check out this week's QuadCast as we highlight ideal adjuvant management of endometrial cancer from GOG 258, the best approach to locally recurrent rectal cancer, and also highlight recurrent GBM management guidelines. Welcome to 2025! Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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241
12.23.2024 - EUROPA
Check out this week's QuadCast where we highlight the benefits of considering short course RT instead of years of endocrine therapy for low risk breast cancer patients, the superiority of SBRT over ablation for recurrent HCC, and much more! Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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240
11.25.2024 - Real Time
Check out this week's QuadCast where we highlight the reduced toxicity of reduced-margin MRI-guided prostate SBRT, the response rate of double hit lymphoma to radiation, the inappropriate radiation services denial rate of Medicare Advantage plans, and more! Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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239
11.18.2024 - Extended Benefit
Check out this week's QuadCast as we highlight the oncologic benefit of extended nodal dissection for prostate cancer, the comparison of Durvalumab and Cetuximab in cisplatin-ineligible H&N cancer patients, the high incidence of psoriasis development on immunotherapy, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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238
11.4.2024 - Timing Isn't Everything
Check out this week's Quadcast as we highlight the impact of post-prostatectomy radiation on quality of life outcomes, APBI for invasive lobular carcinoma, the disproportionate rate of depression amongst head and neck cancer patients, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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237
10.28.2024 - POLA
Check out this week's QuadCast as we discuss if PCV is better than TMZ for oligodendroglioma, discuss results of the hypo-FLAME trial for prostate cancer, highlight adjuvant RT for high risk bladder cancer in the BART trial, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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236
10.21.2024 - Slow & Steady
Check out this week's QuadCast where we highlight the important results of the PACE-B trial for prostate SBRT, the utility of frozen section analysis of SLN bx in oral cavity cancer, dose de-escalation for gastric MALT lymphoma, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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235
10.14.2024 - Jason Efstathiou - PARTIQoL - ASTRO 2024
Check out the latest QuadCast where we interview Jason Efstathiou at the 2024 ASTRO Annual Meeting about his Plenary Session on the PARTIQoL trial, which is a first of its kind randomized trial of IMRT vs. Proton Therapy for localized prostate cancer. Don't miss it. @QuadShotNews@drjefstathiou@HarvardRadOnc@SamuelMarcromMD Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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234
10.3.2024 - Matthew Poppe - RT CHARM - ASTRO 2024
Check out the latest QuadCast where we interview Dr. Matthew Poppe on RT CHARM about the new standard of care for post-mastectomy radiation. @huntsmancancer@UofUradonc@QuadShotNews Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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233
9.30.2024 - Sue Yom - HN005 - ASTRO 2024
Check out this episode of the QuadCast where we speak with Sue Yom (editor of the Red Journal and PI for HN005) about the history of HPV+ oropharyngeal cancer, the current status of the data, and future directions for the field. Don't miss out as this episode is packed with great information! @SueYom@UCSF@QuadShotNews@ASTRO_org@SamuelMarcromMD@UABradonc Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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232
9.23.2024 - There's No Padding These Results
Check out this week's Quadcast as we highlight the first randomized trial of SBRT vs. Surgery for prostate cancer, the impact of pembrolizumab on survival in triple negative breast cancer, and the improved survival in limited stage small cell lung cancer with the addition of Durvalumab. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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231
9.9.2024 - Long Story Short
Check out this week's episode of the QuadCast where we highlight short course vs. long course RT as part of TNT for rectal cancer, the cost-effectiveness of bevacizumab for radiation necrosis, an evaluation of induction chemo for elderly patients with nasopharynx cancer, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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230
8.26.2024 - In The Middle
Check out this week's QuadCast where we highlight PET-adaptive therapy for primary mediastinal B-cell lymphoma, the benefits of cannabis extract on refractory chemotherapy-induced nausea, bladder preservation treatment strategies, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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229
8.12.2024 - EXTEND
Check out this week's QuadCast as we highlight SBRT for oligometastatic pancreatic cancer, preoperative APBI, the role of post-lumpectomy mammograms prior to RT, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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228
8.5.2024 - Contralateral Risk
Check out this week's QuadCast as we highlight the benefits or lack thereof for prophylactic contralateral mastectomy, the benefits of bone marrow sparing IMRT in cervical cancer, the best concurrent cisplatin dosing regimen for H&N cancer, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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227
7.8.2024 - Debate Watch
Check out this week's QuadCast as we highlight the need for Radiation Oncology payment reform, the challenges of metaplastic breast cancer, appropriate resection margins for melanoma in situ, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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226
7.1.2024 - CONTINUUM
Check out this week's QuadCast as we highlight the benefit of immunotherapy for nasopharynx cancer, new ASTRO guidelines for HPV+ oropharynx cancer treatment, the benefits of surgery for low grade serous ovarian cancer, the potential of PSMA PET to help with recurrent GBM, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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225
6.24.2024 - You Gotta See This
Check out this week's QuadCast as we highlight the role of radiation for macular degeneration, IMRT in soft tissue sarcoma, SABR for GYN malignancies, the ongoing underutilization of lung cancer screening, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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224
6.10.2024 - Put Me In Coach
Check out this week's QuadCast as we highlight major findings from ASCO 2024! Learn about immunotherapy neoadjuvantly for Stage III melanoma, the role of osimertinib in localized NSCLC, the role of short vs. long course ADT in salvage prostate treatment, and much more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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223
6.3.2024 - FMISO
Check out this week's Quadcast where we highlight the role of FMISO PET to identify tumor hypoxia for attempts at dose de-escalation in HPV mediated HNSCC, ASTRO's new guidelines on bone metastasis treatment, SBRT for mediastinal LNs, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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222
5.20.2024 - Local Time
Check out this week's QuadCast as we highlight optimal treatment for locally recurrent endometrial cancer, the use of GARD in nasopharyngeal cancer, improved survival outcomes with patient portal utilization, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom
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ABOUT THIS SHOW
With increasing information overload and packed work schedules, staying up-to-date on the newest oncologic advances is harder than ever. But take heart! The QuadShot is freshly brewed four mornings each week so you can quickly down and digest the day's most pertinent cancer news.
HOSTED BY
Laura, Caleb, and Sam
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