PODCAST · science
Sensible Medicine
by Sensible Medicine Authors and Editors
Common sense and original thinking in bio-medicineA platform for diverse views and debate www.sensible-med.com
Episodes
-
Lecture 9 - multiplicity
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
This Fortnight in Medicine XXXV
Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy * The Hubris of Screening for Disease — Again Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment * Why Blood Tests Are a Poor Screening Tool for Alzheimer’s…
more -
This Fortnight in Medicine XXXIV
Cancer-Related Mortality Among US Pilots and Flight Attendants Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
Lecture 8 - endpoints
Our free series is almost over This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
Lecture 7
New lectures coming soon (after part 9) This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
Friday Reflection 63: Foxes, Hedgehogs, Generalists, and Specialists
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
Fortnight in medicine
A royal mistake This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
Lecture 6 KM Curves
we are making all the old episodes available for free, and then on to the new ones -v This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
Lecture 5
New episodes coming soon. First 9 parts free now. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
This Fortnight in Medicine XXXIII
Coronary-Artery Revascularization before Elective Major Vascular Surgery Discontinuation of statins for primary prevention of atherosclerotic cardiovascular disease in adults aged 75 years or older (SAGA/SITE): a multicentre, open-label, pragmatic, non-inferiority randomised trial This is a…
more -
Lecture 4 - How not to be fooled
I notice that someone was angry that we are re-posting old episodes BEFORE we post the new ones. Just a reminder, we said we would do this! We will make the old ones available for free, and then post the new ones. Bear with us. In the meantime, enjoy. This is a public episode. If you'd like to...
-
Lecture 3: How Not to Be Fooled - VP's Intro
And here is lecture 3 of How Not to Be Fooled series 19 parts coming! 9 for free, and 10 for subscribers. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
This Fortnight in Medicine XXXII
Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study This is a public episode. If you'd like to discuss this with other subscribers or get access…
more -
This Fortnight in Medicine XXXI
Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men A Randomized Clinical Trial * Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment Cost-Effectiveness of Fecal Immunochemical Testing Alone vs Co-Testing With Helicobacter pylori Stool Antigen This is…
more -
This Fortnight in Medicine XXX
Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial John Mandrola: I am torn on the PolyPill concept This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
This Fortnight in Medicine XXIX
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia * Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis The Impact of Midodrine on Guideline-Directed Medical Therapy in Patients Admitted With…
more -
Friday Reflection 62: The Ethics of Telling Patients We Have Nothing Left to Offer
TR is an 88-year-old man who is disabled and in chronic pain from spinal stenosis and knee osteoarthritis. He has multiple other medical issues, including coronary artery disease and COPD. He has been through years of treatment for his knees and back, including physical therapy, multiple joint...
-
This Fortnight in Medicine XXVIII
Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults * Prespecified Falsification End Points: Can They Validate True Observational Associations? * Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis GLP-1 receptor agonist use and cancer risk in obese…
more -
This Fortnight in Medicine XXVII
Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up GLP-1 Receptor Agonists or SGLT2 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy * Previously discussed on Fornight XXII: Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US...
-
This Fortnight in Medicine XXVI
Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
This Fortnight in Medicine XXV
Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients * Real-World Effectiveness of Nirmatrelvir–Ritonavir Against Severe Outcomes of COVID-19 in Taiwan: A Nationwide Population-Based Cohort Study Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage…
more -
This Fortnight in Medicine XXIV
RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism * Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon...
-
This Fortnight in Medicine XXIII
Dengue Suppression by Male Wolbachia-Infected Mosquitoes * World Mosquito Program Antibiotic Therapy for Uncomplicated Acute Appendicitis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
This Fortnight in Medicine XXII
* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study * Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction * Andrew’s previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of...
-
This Fortnight in Medicine XXI
Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia: A Retrospective Cohort Study * A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients Effect of Neuromuscular Warm-up on Injuries in Female Soccer and Basketball Athletes in Urban...
-
Going Beyond "AI in Medicine"
Most conversations about “AI in Medicine” bore me. I think this is because either we lack the imagination to consider how AI will change medicine in the next decade, or we are not being specific enough about how small parts of medicine could be productively affected. Dr. Shantanu Nundy, MD, MBA…
more -
This Fortnight in Medicine XX
High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults * High-Dose Influenza Vaccine to Reduce Hospitalizations * Efficacy of high-dose versus standard-dose influenza vaccine in older adults Beta-blockers after myocardial infarction: effects according to sex in the…
more -
Alternative Modalities for Breast Cancer Screening
Today on the podcast, I am joined by Dr. Jennifer Rusiecki. Dr. Rusiecki is an Associate Professor of Medicine at the University of Chicago. She is the Director of Women’s Health and Gender-Based Care in the internal medicine residency program and the assistant clinic director overseeing...
-
This Fortnight in Medicine XIX
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction * Should Evidence Come with an Expiration…
more -
This Fortnight in Medicine XVIII
No video this week — we had a bit of a computer meltdown — but two interesting articles. As always, thanks for listening. If you have articles you would like us to cover, please send us a suggestion at [email protected]. This Substack is reader-supported. If you appreciate our work,...
-
Friday Reflection 56: Comments that Stuck
In a lifetime of possible memories, only some are accessible. There are a few comments — made by mentors, co-residents, and patients — that have lingered and shaped my medical practice. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes,...
-
When to treat (or not treat) a high cholesterol
I was shocked at the comments on this post. Many people, some of them I know to be smart, thought I was nuts for suggesting two middle-aged women who had isolated high LDL-C needn’t take meds because their calculated 10-year risk was less than 3% What shocked me is that our guidelines suggest...
-
This Fortnight in Medicine XVII
Medical Management and Revascularization for Asymptomatic Carotid Stenosis Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial We spent quite a bit of time talking about blinding. This is the table on the adequacy of blinding from the...
-
This Fortnight in Medicine XVI
We try to answer the remainder of your AUA questions. We will be back in the new year with more article discussions! Here are a few of the things we referenced. GDMT Bugs Me: A bit of a rant against the standard of care A Plan to Refocus Primary Care Sacrificing patient care for prevention:...
-
This Fortnight in Medicine XV
We cover questions from Amy J, Benjamin Hourani, Diana Stiles Friou, Chris Costas, Errol Laurie, Jim Healthy, Elizabeth Fama, Never Dull, Rod Rodriguez, Ellison Burns, David Araujo, and George. We have more to come! One nice reference I found while looking into some of the topics: DMSO Is Not a...
-
This Fortnight in Medicine XIV
Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health records Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic...
-
This Fortnight in Medicine XIII
European Study of Prostate Cancer Screening — 23-Year Follow-up Association Between Baseline Diastolic Blood Pressure and the Efficacy of Intensive vs Standard Blood Pressure–Lowering Therapy Further Reading * Effects of intensive blood-pressure control in type 2 diabetes mellitus * A Randomized...
-
This Fortnight in Medicine XII
Effects of Intensive Blood Pressure Control in Patients With Frailty: A Post Hoc Analysis From ESPRIT * Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label,...
-
This Fortnight in Medicine XI
Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults * The Ideal Cholesterol Level ... Depends...And Cannot Be Determined From Observational Studies Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive…
more -
This Fortnight in Medicine X
Two papers this week, with a bunch of articles that we referenced in the conversation. Also, the last Fortnight podcast was accidentally posted behind a paywall. It is now up and free to listen to. My apologies. Sensible Medicine is reader-supported. If you appreciate our work, consider becoming…
more -
This Fortnight in Medicine IX
We go all observational this week. A look at data suggesting the safety of GLP-1s and a re-examination of data on patient/doctor race concordance/discordance (a topic Adam said we should not study, and then John forces him to). GLP-1 Receptor Agonists and Cancer Risk in Adults With Obesity...
-
Friday Reflection 53: Eradicating the Very Important Patient from the Medical Ecosystem
NT is a 55-year-old man admitted to the general medicine service with cellulitis of his left leg. When the attending sees him the morning after admission, he notices the patient’s “Medical Center Trustee” hospital ID on his bedside table. After gathering a history and examining the leg, the...
-
Friday Reflection 52: The Three Worst Phone Calls of My Career
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
-
This Fortnight in Medicine VIII
Last week, John was at the European Society of Cardiology conference in Madrid, and Adam was at the Preventing Overdiagnosis 2025 International Conference in Oxford. A conversation about what we learned. Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction Beta-Blockers Post-MI…
more -
This Fortnight in Medicine VII
Metformin for Treatment of Knee Osteoarthritis in Patients With Overweight or Obesity Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes This is a public episode. If you'd like to…
more -
Friday Reflection 50: The Look
TR is a 72-year-old woman, a retired executive, who had been in excellent health until she began experiencing exertional dyspnea and palpitations. After waiting out the symptoms for about a month, she called and made an appointment to see her primary care doctor. The day before her appointment…
more -
This Fortnight in Medicine VI
A “manel” reviewing trials and studies that explore the benefits and harms of hormone replacement therapy. The Women’s Health Initiative * Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled…
more -
This Fortnight in Medicine V
Primary Articles * As-Needed Albuterol–Budesonide in Mild Asthma * Early versus Later Anticoagulation for Stroke with Atrial Fibrillation Referenced Articles * Albuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma * Stopping Randomized Trials Early for Benefit and Estimation of...
-
This Fortnight in Medicine IV
Primary articles discussed: * First myocardial infarction: risk factors, symptoms, and medical therapy * Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use DisorderA Randomized Clinical Trial Articles referenced: * Pharmacotherapy for Alcohol Use Disorder: A...
-
Friday Reflection 49: The Patients of 12 Reisman
A visit brings back the memories of patients and the lessons they taught. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
We're indexing this podcast's transcripts for the first time — this can take a minute or two. We'll show results as soon as they're ready.
No matches for "" in this podcast's transcripts.
No topics indexed yet for this podcast.
Loading reviews...
Loading similar podcasts...
Frequently Asked Questions
How many episodes does Sensible Medicine have?
Sensible Medicine currently has 146 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Sensible Medicine about?
Common sense and original thinking in bio-medicineA platform for diverse views and debate www.sensible-med.com
How often does Sensible Medicine release new episodes?
Sensible Medicine publishes regularly with 146 episodes available. Check the episode list for the typical release schedule.
Where can I listen to Sensible Medicine?
You can listen to Sensible Medicine on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Sensible Medicine?
Sensible Medicine is created and hosted by Sensible Medicine Authors and Editors.
URL copied to clipboard!