PODCAST · science
TGen Talks
by TGen
TGen Talks explores the human genome to tackle the latest science and discoveries in cancer, neurological disorders, rare diseases, metabolic disorders and infectious disease. Learn about causes and potential cures in our monthly podcast!
Episodes
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Episdoe 95: Using cell-free DNA to monitor glioblastoma
Glioblastoma—it's a diagnosis no one wants to receive. A deadly cancer with few treatment options, GBM is also incredibly difficult to monitor. Doctors simply cannot 'see' if a treatment is working well or not at all and must rely on MRI scans to try to look at a patient's tumor. Liquid biopsies...
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Episode 94: Dr. Ignazio Piras talks SuperAgers and Alzheimer's
SuperAgers and Alzheimer’s The quest for a fountain of youth goes back thousands of years. Stories throughout history have hinted at a secret that could stop time, but no one’s ever found it. While modern science keeps searching for ways to slow physical aging, many of us focus on something…
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Episode 93: Dr. John Fryer Discusses Mentorship in Biomedical Research
In this episode of TGen Talks, we explore the art and responsibility of mentorship in biomedical research. Behind every breakthrough is not just data and experiments, but the guidance of seasoned scientists who shape the next generation. And while the results may not appear in a lab notebook,...
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Episode 92: Helios Scholar Saahithi Mallapragada
For many Arizona students, the path into science begins with a single summer that reshapes their confidence and their future. Since 2007, the Helios Scholars Program at TGen has been that turning point. Each year, Helios Scholars spend eight weeks working directly with TGen researchers exploring...
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Episode 91: Drs. Simona Migliozzi and Luciano Garofano
May is Brain Tumor Awareness Month. In this episode, meet two new TGen researchers whose shared love of science—and math—first brought them together in the lab and later in life. Drs. Simona Migliozzi and Luciano Garofano are married to each other and to their work. They discuss their education…
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Episode 90: Study Links Obesity and Cancer
It’s well known that smoking is the number one factor that significantly increases your risk of developing cancer over a lifetime. But obesity also poses an increased risk. While the relationship is well known, the reasons behind the link between body weight and cancer were not … until now. In…
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Episode 89 Dr. Jonathan Keats
March is Multiple Myeloma Awareness Month. In this episode, we speak with TGen Associate Professor Jonathan Keats, Ph.D. Dr. Keats’ revisits the COMPASS study from the Multiple Myeloma Research Foundationm a 12-year research project that examined the different forms of this blood cancer and...
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Episdoe 88: Closing in on One Million
Why do some people stay mentally sharp well into their seventies and eighties, while others begin to struggle with memory much earlier in life? MindCrowd, an ambitious online brain study created at TGen, set out to explore that question more than a decade ago. Instead of bringing small groups of...
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Episode 87: From Deadly to Detectable?
Episode 87 of TGen Talks features Dr. Haiyong Han, who dives into his latest work on one of the deadliest of cancers: pancreatic cancer. He breaks down why this disease is so hard to catch early, how it can grow silently for years before symptoms appear, and why identifying true positives in the...
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Liquid Biopsy TGT September
In this episode of TGen Talks, we sit down with three researchers who are working to make cancer care safer and more precise for some of the most vulnerable patients—children with rare brain tumors. Dr. Floris Barthel, Dr. Shea Gallus, and graduate student Sharvari Mankame are part of a team at...
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Episode 85: Runway for Research
What connects a fashion show to biomedical research? More than you'd expect—especially in the fight against women’s cancers and the local support for TGen and City of Hope. TGen’s 5th annual Runway for Research takes place on Friday, October 17, in partnership with Neiman Marcus, Scottsdale…
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Episode 84 Precision Medicine
What if medicine worked to get you healthier overall—not just people like you or for one or another symptom? In the latest episode of TGen Talks, host Karie Dozer sits down with Nicholas Schork, Ph.D., and Laura Goetz, M.D., co-authors of a recent commentary published in Nature Communications…
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Episode 83: Discovering a Future in Science — The Helios Scholars at TGen Program
Summers at TGen offer a unique opportunity for students to dive into the world of biomedical research. The Helios Scholars Program at TGen actively engages student interns in real-world science and administrative functions, as they gain practical experience and contribute to ongoing projects.…
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Episode 82: The Ivy Neurological Sciences Internship Program at TGen
In this episode of TGen Talks, we spotlight the Ivy Neurological Sciences Internship Program at TGen. This year-long program bridges the gap between undergraduate studies and medical school, providing aspiring physicians with direct laboratory experience. Interns actively participate in ongoing...
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Episode 81: Accelerating Discovery to Market
This month on TGen Talks, we get an insider’s perspective on how today’s biomedical research translates into tomorrow's treatments. We sit down with Stephanie Pond, Ph.D., Vice President of Emerging Opportunities at TGen. We’ll Learn about the crucial role of TGen’s START and EDP programs – the...
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Episode 58: Tracing Ancient History with Modern Science
Understanding how infectious diseases spread in the past is important to understanding how they affect populations today. The difficulty lie in piecing together information given that so little is known about how microbes spread historically. Applying academic rigor with scientific assessment…
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Episode 39: A TGen Overview
Science has come a remarkably long way, especially since sequencing the human genome, but has it come far enough for everyone? A focus of TGen research has always been finding a path to the clinic and ensuring the work is relevant to patients in need. But that’s not always easy. Jeffrey Trent...
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Episode 80: A Spatial Map of Pulmonary Fibrosis
Pulmonary Fibrosis. A debilitating disease that restricts a person’s lung capacity, controllable with drug therapies, but it’s only “cure” is a double lung transplant. Researchers at TGen have released the results of a study that investigated the disease on a cellular level. Using advanced…
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Episode 79: Breaking Barriers — How Women in Science Help Shape the Future
In this episode of TGen Talks, which celebrates Women’s History Month (March), we’ll explore how women in science have shaped the world around us, and how their stories continue to inspire future generations of young women to become researchers, leaders, and trailblazers who continue to break...
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The Power of Nanotherapeutics
What if the cure for diseases like Alzheimer’s or cancer lay hidden inside the immune systems of llamas, cows, or even sharks? On this episode of TGen Talks, TGen’s newest faculty member, Dr. John Fryer, introduces us to the world of nanotherapeutics—a new class of biologics derived from the…
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Glyphosate’s Long-Lasting Effects on Brain Health
Scientists have long known that farm chemicals can be harmful to human health. Many lawn and garden products used by consumers carry warnings, so that users can protect themselves when applying herbicides in their own yards. But which chemicals are the most dangerous? And how much exposure is too...
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Episode 76: Leigh Nicholson, Ph.D., Researcher and Ambassador
On this month’s TGen Talks, our host sits down with Leigh Nicholson, Ph.D., who was recently named a research assistant professor in TGen’s Early Detection and Prevention Division. Nicholson studies neurological diseases of all kinds — from the rarest to the very common — including a childhood...
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A Postdoc’s Perspective: Dr. Aya Kamzina’s Path to Research
Every September, the scientific community recognizes postdoctoral researchers during Postdoc Appreciation Week. Postdocs bring new ideas and deep expertise as they tackle complex questions and expand knowledge through experiments. In this month’s episode of TGen Talks, Aya Kamzina, Ph.D., one of...
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Episode 74: Breaking Down Multiple Myeloma’s New Subtypes and Their Impact
Scientists at TGen have released the results of a more than decade-long study into multiple myeloma. Looking at more than 1100 patients from four different countries, scientists identified new genetic subtypes of the disease, providing insights that could transform how we approach treatment (see...
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Episode 73: The Science of Longevity
Aging. It’s something we’d all like to do better. Americans spend an estimated $5 Billion on anti-aging products every year. But at TGen and City of Hope, scientists like TGen distinguished professor Nicholas Schork, Ph.D., are working to unlock the secrets to not just better ‘aging,’ but disease...
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Episode 72: Fowl Play: Viewing the New Strain of Bird Flu Through a Genomic Lens
On this month’s TGen Talks, David Engelthaler, Ph.D., professor and director of TGen’s Pathogen and Microbiome Division, discusses the recent surge of bird flu, also known as H5N1. H5N1 has been in the news a lot lately, but what does it all mean? Engelthaler breaks down the science and talks…
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Episode 71: Understanding Your Risk with a PRS
This month, TGen Talks explores polygenic risk scores with Dr. David Duggan, an associate professor in the Quantitative Medicine and Systems Biology Division at TGen. A polygenic risk score is a number that indicates the combined effect of many genetic variants on a person's risk of developing a...
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Episode 70: United Against Brain Cancer
Glioblastoma. It’s the most aggressive and least treatable type of brain cancer. Research into treatment has been slow, mostly because of the difficulty in accessing and treating a tumor that exists behind the blood-brain barrier. A new two year fellowship into Glioblastoma Multiforme, or GBM…
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Episode 69 – Beyond the Surface: Inside the Science of Skin Cancer
In this episode of TGen Talks, we explore the overlooked yet vital world of skin cancer prevention and treatment. Our skin, the body's largest organ, often takes a back seat in discussions about cancer. Join us as we delve into this crucial topic with our guest, Dr. Aleksandar Sekulic. Dr.…
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TGen Talks Live
Cancer continues to be the second most common cause of death in the United States, with a total of nearly 2 million diagnoses every year. In this episode of TGen Talks, recorded in front of a live studio audience, we take a look at how genomic information is leading to better and earlier…
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Episode 67: Tiny particles offer big clues toward predicting Alzheimer’s decades in advance
Alzheimer’s disease affects an estimated six million Americans. Diagnosing and treating the disease is challenging, and for families taking care of a loved one with Alzheimer’s, it’s even more difficult. Detecting and addressing the disease early on is crucial due to its progressive nature....
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Episode 66: The Transformational Power of Education
Paul J. Luna, president and CEO of Helios Education Foundation, sits down with TGen Talks to discuss the transformational power of education, in particular, how internships help prepare students for future success. Helios Education Foundation supports postsecondary attainment for all students,...
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Episode 65 Of TGen Talks
More than three years after the beginning of the pandemic, humans still spread COVID to one another every day, though with less severe symptoms in most cases. Scientists also know that we can spread COVID to our pets as well, because of the close relationships many of us have with our four-legged...
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Episode 64: An Insider’s View of TGen
Today, the world of biomedical science is changing how we think about disease and, certainly, how we treat it ... but did you ever wonder how discovery happens? What does a lab look like? What type of equipment do they use? Who exactly is working inside? How many scientists and staff? And on what...
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Episode 63: Unlocking the Secrets of T Cell Therapy Resistance
For a patient diagnosed with multiple myeloma, a type of blood cancer, there are more treatment options than ever and traditional chemotherapies that cause debilitating side effects have been all but completely replaced by immunotherapies, treatments that help a patient's own immune system better...
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Episode 62: QIIME in if You’ve Heard This One Before
The phrase "gut health" has become quite a buzzword in recent years, and researchers like this month's guest will tell you quite candidly that we have a lot to learn about the community of microorganisms that live INSIDE the human body. But one thing seems to be clear. The human being with a...
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Episode 61: Beyond a Summer of Science
Most of us had a summer job when we were in high school or college, and if we were lucky, we had one that helped us make meaningful decisions about college or a career. At TGen, summer interns in the Helios Scholars at TGen program work alongside researchers on projects that are much more than...
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Episode 60: Tracking Infection and Immunity Over Time
What if you could take a simple test to find out just how susceptible you are to Covid19, the Flu, or any other virus? What if you could test your exposure and immunity to EVERY virus known to mankind using a single drop of blood? The technology is here, now. And at TGen, researchers are using it...
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Episode 59: The Resilience of Maria Fundora and Purple Pansies
This month, our host Karie Dozer sits down for a personal conversation with Maria Fundora, who is neither a scientist nor a clinician. She's a businesswoman from Alpharetta, Georgia, a restauranteur and founder of Purple Pansies, a nonprofit organization dedicated to raising awareness and funds…
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Episode 57: Yun Rose Li, M.D., Ph.D.
When treating cancer patients, physicians are often faced with tough choices. Treatment options like radiation can often come with unpleasant, for some, unbearable side-effects. Doctors walk a fine line between stopping the growth of cancer cells and giving cancer cells the very thing they need…
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Episode 56: TGen Talks Live, Part II
In part two of TGen Talks Live, we continue our conversation on precision aging with Drs. Matthew Huentelman and Nicholas Schork. Aging encompasses a variety aspects—both physical and mental—a fact made evident by the topics covered and the research presented. Where Huentelman’s work covers the...
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TGen Talks Live (part 1)
TGen offers listeners a deeper dive into a particular biomedical-related topic or program through its monthly podcast TGen Talks. Each free-flowing episode allows a TGen scientist to connect with a broader audience by explaining the finer details involved in their research at a listener-friendly...
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Episode 54: Precision Aging
Humans have been searching for the fountain of youth (a mythical endless supply of waters that purport to keep us young forever) for thousands of years—but there’s no such thing in the world of science. At TGen, scientists are working toward a virtual fountain of youth, and they call it precision...
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Episode 53: Vidium: A Dog’s Best Friend
Cancer is the number one worry of pet parents, and it's no wonder. More than half of all dogs older than 10 will be diagnosed with cancer. Cancer is hard to treat in many dogs, and is often diagnosed when it's too late to treat. Americans spent more than $120 billion on their pets just last year....
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Episode 52: Number One Worldwide
With COVID infections and deaths on the decline worldwide, many researchers are turning their attention back to a familiar foe. Tuberculosis (TB) was the number one infectious disease killer before the emergence of COVID-19, and it is number one again today. Although most Americans are not at…
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Episode 51: In Search of Outbreaks
For Crystal Hepp, PhD, the newest member of the TGen North team, understanding how different pathogens move over time and space and through different populations is all in a day’s work. Recently, that work has centered heavily on RNA viruses, and given that the translational aspects of her work...
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Episode 50: The World of Pathogens
This episode of TGen Talks takes the listener along I-17 from Phoenix to Flagstaff, where our host, Karie Dozer, sits down with David Engelthaler, Ph.D., professor and director of TGen’s Pathogen and Microbiome Division, more commonly known as TGen North. Whereas TGen uses genomics to solve…
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Episode 49: Nonalcoholic Liver Disease
Dr. Johanna DiStefano joins TGen Talks to discuss nonalcoholic fatty liver disease, or NAFLD, a condition that causes excess amount of fat in one’s liver cells. As evidenced by its name (which could use an update, according to our guest) NAFLD covers a wide-range of liver conditions with the...
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Episode 48: Celebrating 20 Years of Precision Medicine
This year marks the 20th anniversary of TGen's founding on what at the time was a relatively unknown idea outside the circles of academia and scientific research, precision medicine. The concept of using a person's own genome to diagnose and treat disease at an individual level, to move beyond…
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Episode 47: Math Meets Cancer
Applied mathematics dramatically advanced the field of finance in the 1970’s, where its application allowed for the modeling of financial markets by mathematicians highly skilled in quantitative analytics. Today, these highly sought-after mathematicians are making a name for themselves in the…
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ABOUT THIS SHOW
TGen Talks explores the human genome to tackle the latest science and discoveries in cancer, neurological disorders, rare diseases, metabolic disorders and infectious disease. Learn about causes and potential cures in our monthly podcast!
HOSTED BY
TGen
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How many episodes does TGen Talks have?
TGen Talks currently has 100 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is TGen Talks about?
TGen Talks explores the human genome to tackle the latest science and discoveries in cancer, neurological disorders, rare diseases, metabolic disorders and infectious disease. Learn about causes and potential cures in our monthly podcast!
How often does TGen Talks release new episodes?
TGen Talks has 100 episodes. Check the episode list to see recent publication dates and frequency.
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You can listen to TGen Talks on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts TGen Talks?
TGen Talks is created and hosted by TGen.
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