PODCAST · science
The Downstream Column Podcast
by Brandy Sargent
The Downstream Column (DsC) is an online publication targeting members of the biologics industry. Our intent is to provide a community to share expertise and best practices as well as discuss topics of interest. The Downstream Column covers areas important to the research, discovery, development, and manufacture of biologic therapeutics. Key industry coverage areas include: purification, formulation, fill/finish and QA/QC for cell and gene therapies, vaccines, biologics, and emerging therapeutic modalities.
Episodes
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Advancements in Buffer Management and Single Use Inline Buffer Formulation
In this podcast, we spoke with Nainesh Shah, Senior Application Engineer at Asahi Kasei Bioprocess about buffer management including the benefits of inline buffer formulation, and single use inline buffer formulation systems. Buffer Management We started the podcast by talking about how critical...
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New online Gene Therapy Academy offers great resources to support scaling up from lab to production scale
In this podcast, we spoke with Emanuel Krobath, Biopurification Specialist and Chiara Pacini, Bioprocess Specialist both with Pall Corporation about gene therapy process development including challenges and resources that are available for support. I began the discussion by asking Emanuel and...
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A Guide for Navigating the Single Use Technology Supply Chain
In this podcast we spoke with Derrick Alig, North American Western Regional Sales Manager for PSG Dover Biotech, Chris Couper, President and Founder of Liquidyne Process Technologies, and Phil Sanders Biotech Chief Innovation Officer at Agilitech about current supply chain challenges, possible...
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Manufacturing high concentration mAbs challenges and solutions
In this podcast, we spoke to Tom Watson, Group Leader, Product Management – Biotech Division, Gregor Kalinowski, Manager SLS Purification Consultants Europe, and Aude Iwaniec, R&D Bioprocessing Team Leader, all from Pall Corporation, about why high concentration mAbs are an increasingly important...
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Biomanufacturing Quality Management Systems – A holistic approach
In this podcast, we interviewed Katie Keller, Director of Quality and Safety at Asahi Kasei Bioprocess America, about the importance of quality management and how to achieve the best possible results. Topics included the most critical elements of quality management, how to ensure the purchase of...
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Flexible single-use mixers are key to achieving a next level mixing experience and reducing delivery lead times
In this podcast we spoke with Klaus Kienle, Global Product Manager for the Mixing portfolio at Pall Corporation about the latest mixing technologies including single-use solutions, the need for increased flexibility, and a more standard vendor agnostic approach. The Role of Mixing in...
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Optimizing Process Development Early – A critical factor in successful viral vector scale up and large scale manufacture
In this podcast, I spoke with John Ketz and Denis Kole about viral vector production, including current manufacturing challenges, navigating the road to commercialization, and successful scale up strategies. We began the interview by discussing the strides made in cell and gene therapy. Denis...
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Single-use Mixers – Ensuring the Customization, Scalability and Supply Required for Success
In this podcast, we talked with Dennis Hodgson and Phil Sanders from Agilitech about the benefits of single-use mixers, dealing with supply chain concerns, ensuring scalability, and tailoring a mixer to meet specific process needs. Benefits of Single-use Mixers We began the podcast by talking…
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Increasing Liquid Chromatography Efficiency with Fully-controlled Binary Blending
Cory Hinz talks about the different methods that are available for liquid chromatography mobile phase solutions and the benefits of inline blending. Cory also describes how to implement binary blending feeding of a liquid chromatography process using inline blending.
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Addressing the increasing demand for single-use technologies and supply chain shortages with future proof systems
Phil Sanders talks about the increase in demand for single-use equipment and consumables and how this has led to supply chain shortages.
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Evolving Beyond the Status Quo with Next Generation Buffer Prep Solutions
In this podcast, we spoke with Chris Rombach, Vice President of Sales and Marketing at Asahi Kasei Bioprocess America about buffer prep and delivery systems. We discussed current pain points and how next generation buffer prep solutions can greatly improve upon the status quo, including…
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Integrated Freezing Solutions to Minimize Risk and Preserve Product Quality
Claire Jarmey-Swan, Global Product Manager, Pall Corporation talks about the evolution freeze thaw technologies and how these new methods can streamline the process, minimize loss and maintain the highest product quality.
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Start With The End In Mind. How to facilitate transfer from non-GMP to GMP Manufacturing
In this podcast, we interviewed Avril Vermunt, bioprocess hardware specialist at GE healthcare about transferring a process from a non-GMP to a GMP environment, particularly how resource-intensive it is for process development and manufacturing groups. Avril has several years of experience…
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Modeling Downstream Disruptive Technologies to Improve Downstream Bioprocessing.
In this podcast, we interviewed Dr. Yuyi Shen about the benefits of modeling disruptive technologies to improve downstream bioprocessing and evaluating the financial impact of implementing these technologies. View show notes at...
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Cell Harvesting – Selecting a technology compatible with cell density and feed turbidity
In this podcast and accompanying article, we interviewed Silke Bergheim-Pietza, Global Product Manager Depth Filtration, Pall. We discussed challenges faced in the cell harvesting step, in particular, selecting the best cell harvesting method based on the cell density and feed turbidity of the...
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Continuous Biomanufacturing Implementation Now and in The Future
In this podcast, we interviewed Dr. Peter Levison, Senior Marketing Director – Downstream Processing, Pall Life Sciences about the evolution and benefits of continuous biomanufacturing, what implementation looks like today and what still needs to be realized for full industry adoption. View show...
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Addressing Challenges in Downstream Biomanufacturing with a Platform Purification Approach
In this podcast, we interviewed Jonathan Royce, Business Leader, Chromatography Resins, GE Healthcare Life Sciences, about the biggest challenges in Downstream biomanufacturing including overcoming bottlenecks, changing antibody structures and bioburden control. Jonathan shared how a purification...
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Protein A Chromatography – A look at where we have been and where we are going
In this podcast, we interviewed Jonathan Royce, Business Leader, Chromatography Resins, GE Healthcare Life Sciences, about the evolution of Protein A including the latest developments in Protein A chromatography resins. We also discussed what the future holds for this purification mainstay and…
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Resolving Large Scale Buffer Management Challenges
In this podcast, we interviewed Joakim Lundvist, Modality Manager, BioProcess™ Hardware, GE Healthcare about large-scale buffer management challenges. Buffer preparation is known to be one of the most resource-intensive activities in biomanufacturing as large volumes of buffers and process…
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Job Outlook for the Biomanufacturing Industry a Recruiter’s Perspective
In this podcast, we interviewed Hillary Kaplan, Director, Bioprocess CMC Development & Operations, Klein Hersh about the job outlook for the biomanufacturing industry from a recruiter's perspective. Hillary partners with organizations ranging from VC backed start-ups and mid-size biotechs to…
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Cell Culture Media Optimization – It’s about more than just high protein titer
Dr. Adam Elhofy, Ph.D., CSO, Essential Pharmaceuticals, talks about cell culture media optimization. We discussed the evolution of cell culture media optimization, current goals, and the latest strategies and tools being used.
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Automated Stem Cell Based High Throughput Drug Screening for ALS and Parkinson’s
Dr. Jan Bruder talks about his work at the Max Planck Institute for Molecular Biology in Münster Germany and his group’s use of automated high throughput drug screening program for ALS and Parkinson’s Disease.
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ABOUT THIS SHOW
The Downstream Column (DsC) is an online publication targeting members of the biologics industry. Our intent is to provide a community to share expertise and best practices as well as discuss topics of interest. The Downstream Column covers areas important to the research, discovery, development, and manufacture of biologic therapeutics. Key industry coverage areas include: purification, formulation, fill/finish and QA/QC for cell and gene therapies, vaccines, biologics, and emerging therapeutic modalities.
HOSTED BY
Brandy Sargent
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Frequently Asked Questions
How many episodes does The Downstream Column Podcast have?
The Downstream Column Podcast currently has 22 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is The Downstream Column Podcast about?
The Downstream Column (DsC) is an online publication targeting members of the biologics industry. Our intent is to provide a community to share expertise and best practices as well as discuss topics of interest. The Downstream Column covers areas important to the research, discovery, development,...
How often does The Downstream Column Podcast release new episodes?
The Downstream Column Podcast has 22 episodes. Check the episode list to see recent publication dates and frequency.
Where can I listen to The Downstream Column Podcast?
You can listen to The Downstream Column Podcast on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts The Downstream Column Podcast?
The Downstream Column Podcast is created and hosted by Brandy Sargent.
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