The Giants Shoulder

🧠 JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing 👇 https://www.youtube.com/@thegiantsshoulder/joinSteven Barker is the chemist who has spent fifty years proving your brain makes its own psychedelic. He built the mass-spectrometry methods sensitive enough to find DMT in living tissue, and showed it sits in the brain at concentrations rivalling serotonin and dopamine. In 1981 the war on drugs cut his funding and the work stopped for fifteen years. He also synthesised his own supply — and took it.Expect to learn:- The locked cabinet: what his mentor kept behind two locks, and why Barker raided it- The missing neurotransmitter: why DMT meets every formal criterion and nobody noticed- Machine elves: why he calls the term marketing rather than science- DMT immunity: the lab technician who took a full dose and felt nothing- Receptors inside the neuron: the 2023 finding that explains the neuroplasticitySPONSORSDownload the most scientifically rigorous nutrition app MacroFactor! Use code GIANTS for a 2 week FREE trial - https://app.macrofactor.com/mfgiantsGS EPISODES MENTIONEDAndrew Gallimore - No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://youtu.be/USgWrxEFWDARick Strassman - Meet The Father Of Modern DMT Research: https://youtu.be/KeAZOj7tYscDennis McKenna - Dennis McKenna: "I've Spent 50 Years Investigating The Entities That Exist Within Ayahuasca": https://youtu.be/gTSBhfZhuD8David Nichols - Meet The Greatest Living Psychedelic Scientist You've Never Heard Of: https://youtu.be/6umTgXsW1lQGUEST LINKSResearchGate Profile: https://www.researchgate.net/scientific-contributions/Steven-A-Barker-2164230436N,N-Dimethyltryptamine, an Endogenous Hallucinogen (2018 review): https://doi.org/10.3389/fnins.2018.00536A Critical Review of Endogenous DMT in Humans 1955-2010 (with Strassman): https://doi.org/10.1002/dta.422LC/MS/MS Analysis of Rat Pineal Microdialysate (2013, the paper discussed on tape): https://doi.org/10.1002/bmc.2981Administration of DMT in Psychedelic Therapeutics (2022 review): https://doi.org/10.1007/s00213-022-06065-0LISTEN ONSpotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7MApple - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249SKOOLWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutFOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:02:15 50 Years Chasing One Molecule0:06:37 Huxley, Osmond and the Birth of "Psychedelic"0:08:01 The Schizotoxin Hypothesis That Started It All0:10:54 Finding DMT in Everyone, Not Just Patients0:11:56 How the War on Drugs Killed the Research0:16:39 The 40 Years of Research We Lost0:18:36 "Have You Ever Taken It Yourself?"0:19:20 Inside the Locked Psychedelic Cabinet0:20:22 The Overabundance He Didn't Want to Waste0:22:51 Why He Won't Describe What He Saw0:23:38 Set, Setting and the Expectancy Problem0:27:16 Dennis McKenna Has Never Seen a Machine Elf0:28:31 "Machine Elf" Was a Marketing Term0:30:40 The Tryptamine Family Tree Explained0:34:21 Bufotenine, 5-MeO-DMT and the Blood-Brain Barrier0:38:36 DMT as a Working Neurotransmitter0:41:34 "DMT Is the Missing Neurotransmitter"0:44:56 You Have Two Brains - and the Gut Makes More0:46:29 Pushing Back on Gallimore's Alien World0:54:04 96% Say the Entity Was Conscious0:57:52 Did the Caveman Experience an Alien?0:59:07 "These Are Not Real Elves"1:06:40 Are Some People Immune to DMT?1:10:51 You Can't Build Tolerance to Your Own Neurotransmitter1:15:46 The Receptors Hiding Inside Your Neurons1:24:24 What a Psychedelic Overdose Actually Is.....Email for sponsorship enquiries: [email protected]

🧠 JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing 👇https://www.youtube.com/@thegiantsshoulder/joinAlexander Batthyány is the philosopher and psychologist who turned a deathbed anecdote into a science. He ran the first modern study of paradoxical lucidity, co-authored the field's founding definition with Bruce Greyson, and has now collected around 450 cases of severely demented patients unexpectedly getting their memory, speech and personality back. Victorian doctors documented the phenomenon at length and called it "lightening up before death"; twentieth-century medicine stopped writing it down because there was no way to phrase it in a case study. He is now working with a group at the Mayo Clinic to put cameras in patients' rooms so the episodes stop being missed. In one case a woman came back for two hours, discussed her own diagnosis, died — and imaging taken immediately afterwards showed no change whatsoever.SPONSORSGet One Month Free of Consensus (The Best Ai Science Tool) - https://get.consensus.app/we00d2cmjpqeGS EPISODES MENTIONEDRick Strassman - Meet The Father Of Modern DMT Research: https://youtu.be/KeAZOj7tYscAndrew Gallimore - No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://youtu.be/USgWrxEFWDAGUEST LINKSX: https://x.com/Alxdr_BatthyanyGoogle Scholar: https://scholar.google.com/citations?user=VRL8CPYAAAAJPersonal Site: https://sites.google.com/view/alexanderbatthyany/startViktor Frankl Institute Vienna: https://www.viktorfrankl.org/Threshold (2023): https://us.macmillan.com/books/9781250782298/threshold/Psychology Today - Magic Mushrooms and Terminal Lucidity: https://www.psychologytoday.com/us/blog/consciousness-and-meaning-at-lifes-end/202607/magic-mushrooms-and-terminal-lucidityBatthyany & Greyson (2021), Spontaneous Remission of Dementia Before Death: https://med.virginia.edu/perceptual-studies/wp-content/uploads/sites/360/2021/04/terminal-lucidity-PC.pdfSKOOLWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutFOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:02:29 What Terminal Lucidity Actually Is0:05:33 Why He'd Rather Call It "Paradoxical Lucidity"0:06:01 "Call Your Grandma - She's Back Again"0:09:11 The Victorians Documented It, Then Medicine Stopped0:10:55 "We Saw It, But We Didn't Write It Down"0:12:58 Frankl's Rule: Treat Them As Fully Present0:17:35 What Brain Age Was She Speaking From?0:18:36 "It Was All As If In A Fog"0:21:11 The Wife Who Filmed It So People Would Believe Her0:25:40 The Art Historian Who Gave Back His Books0:30:27 Is It Comforting For Families, Or Crueller?0:32:02 The Three Shocks Every Family Goes Through0:38:05 450 Cases And Counting0:41:29 Does It Have Anything To Do With Death At All?0:45:12 Steven Pinker: "You're Seeing Figures In Clouds"0:47:10 "Everywhere And Nowhere"0:49:47 They Overdosed Her On Psilocybin. She Woke Up.0:51:37 She Got Her Sense Of Humour Back0:55:18 Dresden: The Brain Hadn't Changed At All0:56:37 "Some Of Our Personhood Is Platform Independent"1:02:40 Near-Death Experiences vs Paradoxical Lucidity1:05:52 Rick Strassman, DMT And Neuroprotection1:11:22 "How Can We Get Them Out?"1:20:20 When Vienna Gave Psychiatric Patients Malaria.....Email for sponsorship enquiries: [email protected]

🧠 JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing 👇 https://www.youtube.com/@thegiantsshoulder/joinCarl Hart is a human drug scientist — the Mamie Phipps Clark Professor of Psychology in Psychiatry at Columbia University and Chair of its Department of Psychology, who runs one of the very few laboratories on earth licensed to give people real doses of crack cocaine, methamphetamine and MDMA. His volunteers live inside a sealed four-room lab for weeks at a time, originally built for NASA to study astronauts, with no contact with the outside world while he measures their sleep, their food intake and how much they speak. He started that work believing drugs were what had gone wrong in neighbourhoods like the one he grew up in. Thirty years of data refused to agree with him.Expect to learn why there is no such thing as drug addiction in a rat, why "hard drugs" is a category the human body doesn't recognise, why he refuses to use the word "psychedelic", how one extra methyl group is the only difference between methamphetamine and the main ingredient in Adderall, why psychiatry still runs on a theory formalised in 1967 when only six neurotransmitters were known, what heroin actually feels like and why the real danger is constipation rather than overdose, why addiction tracks access rather than pharmacology, and much more…SPONSORSGet Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderGS EPISODES MENTIONEDDavid Luke - Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://youtu.be/qLKD1gt1X5oGUEST LINKSColumbia Psychiatry Profile: https://www.columbiapsychiatry.org/profile/carl-hart-phdPersonal Website: https://drcarlhart.com/X: https://x.com/drcarlhartDrug Use for Grown-Ups: Chasing Liberty in the Land of Fear: https://en.wikipedia.org/wiki/Drug_Use_for_Grown-UpsHigh Price: A Neuroscientist's Journey of Self-Discovery: https://en.wikipedia.org/wiki/High_Price_(book)FOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:02:16 Why Human Rights Became His Whole Mission0:03:45 "I Believed the Bullshit About Drugs"0:07:42 The Brain-Imaging Studies That Prove Nothing0:10:32 Why "Hard Drugs" Is a Made-Up Category0:12:42 There Is No Such Thing as Addiction in a Rat0:14:18 Put Cocaine on Your Gum and See What Happens0:15:50 Rat Models for Autism, ADHD and Depression0:18:03 How Many Hoops to Give a Human Crack Cocaine0:20:38 "Psychedelic" Is a Political Word, Not a Real Thing0:22:40 Why the One-Receptor Story Is Bullshit0:23:56 Psychiatry Is Still Running on a 1967 Theory0:31:17 One Methyl Group: Meth vs Adderall0:34:41 The Lab NASA Built for Astronauts0:37:45 The Phenomenology Gap Nobody Studies0:39:01 "I Was a Virgin to These Drugs, And Not Even Curious"0:44:14 What Heroin Actually Feels Like0:47:04 The Real Danger Is Constipation0:52:47 The Overdose Myth He's Trying to Destroy0:55:39 Education, Not Harm Reduction0:58:40 Addiction Isn't About Drugs, It's About Access1:01:38 Not Whether to Legalise, But How1:05:30 Dublin's Cocaine Problem, Evan Pushes Back1:06:46 "That's Quite Arrogant of You"1:09:05 The Same Argument That Delayed Emancipation1:12:50 "We Put People on the Moon. This Is Not Complicated.".....Email for sponsorship enquiries: [email protected]

JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing👇 https://www.youtube.com/@thegiantsshoulder/joinLuca Turin is a biophysicist who has spent thirty years arguing that the nose reads a molecule's vibrations rather than its shape, published in Nature at twenty-three, and co-wrote the definitive critical guide to perfume with his wife Tania Sanchez. The vibrational theory of olfaction was declared dead twice before he revived it, and he is still waiting for the one experiment that would settle it. His newest result has nothing to do with smell: fruit flies sealed in separate opaque wells, with no sight, sound or scent between them, coordinate their movement anyway — and the coordination vanishes the moment the plate is made of metal. This is a scientist who went looking for anaesthesia and found something that looks like insect telepathy.Expect to learn why creating a smell stimulus is nothing like creating a colour, how a startup elicited smell sensations with ultrasound for the first time in history, why the only two chemical groups in the universe that share one vibration are also the only two that smell of rotten eggs, how a receptor could read vibrations with no lenses or prisms anywhere in your nose, why the famous "trillion smells" figure was a mathematical error, why nobody in pharmacology can predict what a drug will do once it binds, how Google Quantum AI's xenon question led to fruit flies, what happened when the plates were swapped for aluminium, why radio frequency would be the perfect brain-wide reward signal, and much more…SPONSORSDownload the most scientifically rigorous nutrition app MacroFactor! Use code GIANTS for a 2 week FREE trial - https://app.macrofactor.com/mfgiantsGS EPISODES MENTIONEDEarl K Miller - Meet the MIT Neuroscientist Showing Brain Waves Are the Secret Engine Behind Consciousness: https://youtu.be/7OFb-NG3jIwMarjorie Woollacott - Neuroscientist: "Your Brain Doesn't Create Consciousness" — NDEs, Telepathy and Terminal Lucidity: https://youtu.be/mDWtmfmIUHAGUEST LINKSGoogle Scholar: https://scholar.google.com/citations?user=fgXXdQYAAAAJWi-Fly Project: https://wi-fly.eu/X: https://x.com/LucaTurinSubstack: https://lucaturin.substack.comYouTube: https://www.youtube.com/@lucaturinSKOOLWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutFOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:02:20 Biophysicists Are Dreamers, Biologists Are Doomed0:07:07 The Startup That Triggered Smells With Ultrasound0:12:22 The Rotten-Egg Coincidence That Convinced Him0:18:34 What The Receptor Is Actually Reading0:19:54 Electron Tunnelling, Explained Simply0:23:33 The Trillion-Smells Figure Was A Maths Error0:28:21 What Perfumers Perceive That You Don't0:32:14 Why Every Drug Receptor Might Be Electrical0:33:12 The Mystery Nobody Admits: Drug Efficacy0:39:28 "Cascade" Is A Word That Masks Ignorance0:44:04 The Receptor As A Transistor0:48:40 Google Quantum AI And The Xenon Puzzle0:52:24 Two Years Of Work, A Definite Maybe0:53:55 30 Flies Freeze Like The Guards At Buckingham Palace0:55:28 One Fly Per Well, No Way To Communicate0:56:17 To My Total Astonishment, They Coordinate0:58:45 Metal Plates Kill The Signal0:59:36 The Wi-Fly: A Radio Network For Flies1:11:26 Radical Pairs: How A Fly Could Listen1:16:34 What Is The Brain's Reward Signal?1:19:59 Standing Waves And The Binding Problem1:23:58 Could Humans Ever Do This?1:27:46 Ramanujan And Latent Abilities1:36:16 Giving Fruit Flies DMT.....Email for sponsorship enquiries: [email protected]

🧠 JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing 👇 https://www.youtube.com/@thegiantsshoulder/joinKaren Konkoly is a dream scientist who led the first study to hold a real-time, two-way conversation with a person inside a dream, putting maths problems to sleepers in REM and getting answers back through their eye movements. She is a Marie Curie Postdoctoral Fellow in the Cambridge Consciousness and Cognition Laboratory, completed her PhD in the Paller Cognitive Neuroscience Laboratory at Northwestern University, and has spent her career building tools to engineer dreams — from targeted lucidity reactivation for narcolepsy nightmares to planting unsolved problems into REM sleep. She has also asked a dream character to swap bodies with her, and woken up inside it. This is the strangest conversation we have had on the channel.Expect to learn how scientists prove someone is awake inside a dream, why you still cannot fly in your own dream even when you know it is a dream, what happened when Karen swapped bodies with a dream character, whether time really slows down while you sleep, why practising darts in a lucid dream works about as well as practising awake, what galantamine and acetylcholine actually do to REM sleep, the exact protocol for having your first lucid dream, why Karen no longer believes lucidity is the key to consciousness, and much more…SPONSORSGet One Month Free of Consensus (The Best Ai Science Tool) - https://get.consensus.app/we00d2cmjpqeGS EPISODES MENTIONEDDavid Spiegel - World's Greatest Hypnosis Scientist Hijacks My Mind Live On Camera!: https://youtu.be/eCtRBZHIsgQGUEST LINKSPersonal Website: https://www.karenkonkoly.com/Google Scholar: https://scholar.google.com/citations?user=teYHEFIAAAAJ&hl=enCambridge Consciousness & Cognition Lab: https://www.ccc-lab.org/Dust Systems (Dream Engineering): https://www.dust.systems/people/karen-konkolyX: https://x.com/KarenKonkolyLISTEN ONSpotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7MApple - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249SKOOLWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutFOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:03:18 What Lucid Dreaming Actually Is0:05:37 Wake Back To Bed: The 4am Method0:06:40 Why You Still Can't Fly In Your Own Dream0:09:20 How You Prove Someone Is Lucid In A Dream0:11:53 Are The Sleep Stages Even Real?0:15:28 When A Dream Dissolves But You Don't Wake Up0:19:19 The Reality Check You Can Do Tonight0:21:00 Does Time Run Slower Inside A Dream?0:24:45 Trying And Failing To Become Her Dog0:26:10 Swapping Bodies With A Dream Character0:27:51 Is Lucidity A Glitch In Consciousness?0:33:37 Hyperphantasia And Maladaptive Daydreaming0:37:53 Practising Darts While You're Asleep0:41:52 When Lucid Dreaming Is A Bad Idea0:46:09 Why A Giraffe Can't Appear While You're Awake0:49:54 Galantamine, Acetylcholine And Dream Drugs0:52:17 The Squat Experiment0:58:38 The Full Protocol, Step By Step1:04:55 What This Teaches Us About Consciousness1:09:15 Who Are Your Dream Characters?1:12:55 "You're Not You"1:14:41 Hypnosis, David Spiegel And Lucid Dreaming1:18:20 What She's Working On Next.....Email for sponsorship enquiries: [email protected]

🧠 JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing 👇https://www.youtube.com/@thegiantsshoulder/joinDavid Spiegel is the world's leading hypnosis scientist — fifty years at Stanford spent proving that trance is a measurable brain state rather than a stage trick, across thirteen books, four hundred papers and roughly seven thousand patients hypnotised personally. I told him to his face that I thought his entire field was a scam, so he ran the hypnotisability test on me live on camera, my left arm floated off the desk and stopped obeying me for the next forty minutes, and he scored me seven out of ten.Expect to learn what hypnosis actually is and the three components it breaks down into, how stage hypnotists secretly screen their audiences before the show even starts, what changes in three separate brain networks the moment you go under, why "suggestibility" is the wrong word and cognitive flexibility is the right one, how hypnotised subjects cut their brain's electrical response to pain by 50%, why one in four smokers quit after a single session, the two very different childhoods that both produce highly hypnotisable adults, why eight-year-olds are the most hypnotisable people alive, how Rory McIlroy used self-hypnosis to break a seven-year Masters curse, what it feels like to have your own arm stop belonging to you, and much more…SPONSORSTry Reveri, Dr David Spiegel's Self-Hypnosis App (use code SPIEGEL20 for your discount) - https://reverihealth.app.link/e/spiegelGet One Month Free of Consensus (The Best Ai Science Tool) - https://get.consensus.app/we00d2cmjpqeGUEST LINKSStanford Profile: https://profiles.stanford.edu/david-spiegelReveri: https://www.reveri.com/Reveri on X: https://x.com/reveri_healthStanford Center on Stress and Health: https://med.stanford.edu/stresshealthcenter.htmlTrance and Treatment (his clinical textbook): https://www.appi.org/Products/Hypnosis/Trance-and-Treatment-Second-EditionSKOOLWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutFOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:02:27 Who Is David Spiegel?0:03:39 What Hypnosis Actually Is0:05:37 Why He Calls Stage Shows "Dumb Shows"0:06:29 How Hypnotists Secretly Screen The Audience0:09:08 The Student Who Relived Being A Newborn0:10:46 What Hypnosis Does To Three Brain Networks0:13:23 It's Not Suggestibility, It's Cognitive Flexibility0:16:12 Cutting The Brain's Pain Signal By 50%0:17:05 One In Four Quit Smoking In A Single Session0:18:33 The Meditator Whose Migraines Vanished0:22:36 Why Hypnotisability Is Partly Genetic0:23:54 The Two Childhoods That Make You Hypnotisable0:27:16 Hypnosis, Flow States And Peak Performance0:32:54 How Rory McIlroy Broke His Masters Curse0:38:05 Why You Can Forget Your Own Name0:44:29 Filtering The Hurt Out Of Pain0:55:00 The Hypnotisability Test, Live On Camera1:00:15 "It's Actually Going Up"1:08:52 Evan Scores 7 Out Of 101:18:42 Trying To Erase The Number Four1:31:04 "Please Don't Do This On My Other Arm".....Email for sponsorship enquiries: [email protected]

🧠 JOIN THE GIANT'S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing: https://www.youtube.com/@thegiantsshoulder/joinRick Strassman is the psychiatrist who ran the first new American psychedelic research in a generation — five years of DMT studies at the University of New Mexico, the first rating scale ever built specifically to measure a psychedelic experience, and the book that made DMT famous. DMT: The Spirit Molecule sold a quarter of a million copies and effectively created machine-elf culture. Thirty years on, he is the most sceptical man in the room about what those entities actually are.Expect to learn why your brain spends energy importing DMT across the blood-brain barrier, why the pineal gland story he made famous fell apart, how brain DMT sits at the same concentration as serotonin and dopamine, why DMT floods the visual cortex of a dying brain, why a molecule that shrinks strokes and protects kidneys should not be psychedelic at all, what the endomatrix is and why it raises the simulation question, why he now thinks psychedelics are super placebos, what a DMT entity actually is and why talking to one is like talking to an AI, how you would actually test whether the entities are real, why only one scientist on Earth is studying endogenous DMT, and much more…SPONSORSGet Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderJoin the Outskill AI Mastery Sprint (Free This Weekend) - https://links.outskill.com/GIASHOULAUG2GS EPISODES MENTIONEDSteven Barker - Meet The World's Greatest Endogenous DMT Psychedelic Scientist You've Never Heard Of: https://youtu.be/gTc5QjyZuvYDavid Luke - Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://youtu.be/qLKD1gt1X5oDeborah Mash - Meet The Ibogaine Psychedelic Scientist Who First Unravelled Its Big Mystery: https://youtu.be/z7eRtXV6ptARobin Carhart-Harris - No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://youtu.be/t-GkE4YtLRkAndrew Gallimore - No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://youtu.be/USgWrxEFWDAGUEST LINKSOfficial Site: https://www.rickstrassman.com/Books & Publications: https://www.rickstrassman.com/publications/Substack: https://rickstrassman.substack.com/YouTube: https://youtube.com/c/RickStrassmanBiosynthesis and Extracellular Concentrations of DMT in Mammalian Brain (Dean et al., Scientific Reports 2019): https://www.nature.com/articles/s41598-019-45812-wTIMESTAMPS0:00:00 Trailer0:04:31 The First Legal DMT Studies in a Generation0:07:41 The Bomb-Maker Who Became a Psychedelic Scientist0:14:13 The Iron Curtain Reason We Know DMT Works0:22:32 Why Your Brain Spends Energy Importing DMT0:28:26 Your Brain Makes DMT at Serotonin Levels0:29:26 DMT Floods the Dying Brain's Visual Cortex0:30:28 Stroke, Kidneys and Heart — DMT as a Survival Molecule0:32:39 The $64,000 Question Nobody Can Answer0:36:33 Does DMT Regulate How Real Reality Feels?0:39:32 Only One Person on Earth Studies This0:43:52 The Endomatrix and the Simulation Question0:49:48 "Psychedelics Are Super Placebos"0:55:12 The Man Who Wrote Down "Bananas Are Really Yellow"1:03:50 The Barking Patient — Entities as Dream Logic1:05:42 Talking to Entities Is Like Talking to an AI1:06:40 The Prime Number Test for Proving Entities Are Real1:13:36 Half His Volunteers Met Beings — And a Conscious Apartment1:18:08 "Your Brain On Drugs" vs Another Dimension1:26:58 The Entities That Curse You1:29:09 "Have You Started Yet?" — The Man Immune to DMT1:33:30 Why DMT Is the Only Psychedelic Without Tolerance1:36:12 Blocking 5-HT1A Tripled the Effect — Buried 30 Years1:39:06 Aphantasia and Seeing For the First Time.....Email for sponsorship enquiries: [email protected]

🧠 JOIN THE GIANT’S SHOULDER FAMILYBecome a YouTube Member for exclusive episodes, early access + ad-free viewing: https://www.youtube.com/@thegiantsshoulder/joinDeborah Mash is a neuropharmacologist who holds the first FDA licence ever granted to give ibogaine to a human being, built one of America's largest brain banks, and discovered noribogaine — the metabolite now entering its first US clinical trial. She has spent over thirty years on a drug that appears to interrupt addiction after a single dose. This April a US president named it specifically. This is the scientist who was right three decades early.Expect to learn what Trump's executive order actually changes for ibogaine, why Sasha Shulgin put ibogaine in a box of its own, how noribogaine blocks nicotine, alcohol, cocaine and opioid use in animal models, why ibogaine holds the brain's neuroplasticity window open for four weeks when ketamine manages days, why some patients get the full therapeutic benefit with no psychedelic experience at all, why the reported ibogaine deaths are almost impossible to interpret, why more than 80% of her patients said they never wanted to repeat it, and much more...SPONSORSGet Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderJoin the Outskill AI Mastery Sprint (Free This Weekend) - https://links.outskill.com/GIASHOULAUG2GS EPISODES MENTIONEDDavid Nutt - Meet the Neuroscientist Fired For Exposing the Truth! Dr David Nutt: https://youtu.be/BLk6a5Vb2O0David Nutt - Neuroscientist Ranks Every Drug By How Hard They Are to Quit! Tier List: https://youtu.be/G-OZ_UBGvvoGUEST LINKSUniversity of Miami Faculty Profile: http://neurology.med.miami.edu/about-us/faculty-list/deborah-c-mash-ph-dX: https://x.com/drdeborahmashGoogle Scholar: https://scholar.google.com/citations?user=4383E7wAAAAJ&hl=enDemeRx: https://www.demerx.com/team/deborah-c-mash-phd/2018 Frontiers in Pharmacology paper (St. Kitts cohort): https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00529/fullWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutFOLLOW EVANhttps://x.com/evan_mcglTIMESTAMPS0:00:00 Trailer0:02:00 Why Ibogaine Is Suddenly Everywhere0:02:22 Trump's Executive Order and What It Actually Does0:05:55 The Drug That Breaks the Cycle of Addiction0:08:07 Why One Drug Treats Addiction, Depression and Trauma0:11:30 Noribogaine: The Metabolite Nobody Talks About0:14:20 The Real Risks Nobody Reports Properly0:16:36 How Ibogaine Became a Vast Underground Experiment0:17:44 Veterans, Brain Trauma and the Testimonials0:22:55 The Master Molecule: Why Ibogaine Stands Alone0:23:30 Sasha Shulgin Draws Four Boxes0:26:48 Is a Psychedelic Just a Hard Reboot?0:28:11 Four Weeks of Neuroplasticity, Longer Than Anything Else0:28:44 Fast, Slow and Ultra-Rapid Metabolisers0:31:39 The First Patient in St. Kitts, Decades Later0:34:35 Do You Need the Trip to Reach the Destination?0:35:05 One Molecule, Every Addiction0:37:39 Miami Vice and the Bodies at the Morgue0:41:18 The Man Who Slept Through His Own Trip0:44:11 Why America Will Lead on Ibogaine0:47:51 Dual Dosing: The Second Stage of the Rocket0:54:52 Why More Than 80% Never Want to Repeat It0:57:33 What Would Ibogaine Do to a Healthy Brain?0:58:18 Why She's Never Taken Ibogaine0:59:39 Psychedelics, Longevity and Ageing Brains......Email for sponsorship enquiries: [email protected]

Get Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderJoin the Outskill AI Mastery Sprint (Free This Weekend): https://links.outskill.com/GIASHOULAUG2Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutMartin Picard is a mitochondrial psychobiologist at Columbia University who just won the inaugural $1.5 million Baszucki Prize for a new theory of life. His radical claim: consciousness doesn't just run on energy, it might actually be made of it, generated inside your mitochondria rather than your brain.Expect to learn why calling mitochondria "the powerhouse of the cell" does them a disservice, how mitochondria might generate consciousness rather than just power the brain that has it, why some of history's most rigorous physicists ended up believing consciousness is more fundamental than matter, how psychedelics might work by reshaping the way energy is patterned through your body, why grey hair can reverse itself within weeks of a stressful period lifting, how a simple blood test might one day predict whether you're about to have a good or bad trip, why "no drug actually heals you" and what does instead, and much more.Timestamps:0:00:00 Trailer0:02:00 What Actually Keeps You Alive (Not What You Think)0:04:40 Why There's No Experience Without Energy Flow0:07:11 Are You Conscious Because of Matter, or Despite It?0:10:13 Why History's Greatest Physicists Became Idealists0:17:17 The Doctor Who Watched Patients Come Back From Death0:22:09 Don Hoffman and the Day the Beach Disappeared0:24:12 What Actually Triggers a Near-Death Experience0:24:51 You Are an Eddy in a River of Consciousness0:31:59 Bernardo Kastrup's Idealism, Tested Live0:33:34 Could We Scan Your Energy and Predict Your Mind?0:39:37 Stop Calling Mitochondria "The Powerhouse"0:40:03 Your Cells Are Basically Tiny GPUs0:41:04 How Psychedelics Might Rewrite Your Energy Pattern0:49:10 The Study Testing Whether Psilocybin Changes Your Mitochondria0:52:06 "It's Not the Drug That Heals You"0:52:38 A Blood Test That Predicts Your Best (and Worst) Trip0:57:27 The Psychedelic Paradox: Less Brain, More Experience0:58:57 Aldous Huxley's "Reducing Valve" Theory of the Brain1:02:03 "The Brain Is Overrated"... Email for sponsorship enquiries: [email protected] Episodes Mentioned:Robin Carhart-Harris - No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://youtu.be/t-GkE4YtLRkGuest Links:Columbia Faculty Profile: https://www.columbiapsychiatry.org/profile/martin-picard-phdPersonal Website: https://www.martinpicard.energy/X (Twitter): https://x.com/MitoPsychoBioGoogle Scholar: https://scholar.google.com/citations?user=IG2t_uMAAAAJ&hl=enMitochondrial Psychobiology Lab: https://www.picardlab.org

Try Mind Lab Pro, The Universal Nootropic For A Sharper Brain: https://www.mindlabpro.com/?a_aid=67fd1cb8d9ad3&a_bid=6d45f5c3Join The Outskill Claude Mastery Sprint (2 Days, Free): https://links.outskill.com/GIASHOULAUG2Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutMin Zhao is the UC Davis professor whose lab discovered the first genes ever found in electrical signalling — proof that every cell in your body runs on a current, not just your brain. He can reverse the polarity of a field and watch a living cell physically turn around and walk the other way.Expect to learn why every wound in your body generates its own measurable electric current, how a single postdoc's "failed" experiment revealed a force that overrides genetics, how reversing an electric field can make a cell physically turn around mid-migration, how a damaged potato generates the same electrical signal that guides wound healing in humans, why Min stops short of fully agreeing with Michael Levin on whether cells count as agents, and where the fight between bioelectricity and genetics currently stands.Timestamps0:00:00 Trailer0:02:20 What Everyone Gets Wrong About Wound Healing0:07:20 Your Skin Is Secretly Electric (And So Is Everything Alive)0:11:09 The 200-Year-Old Discovery Hiding in Every Wound0:15:19 The Postdoc Result That Changed the Whole Lab0:19:19 How Do Cells Know Where to Grow? (Five Fingers, Not Six)0:21:19 The Potato Experiment That Reveals How Infections Start0:25:24 Reverse the Field, Watch a Cell Turn Around0:38:10 The Bioelectricity Nobody Taught in Biology Class0:44:17 Is Bioelectricity More Fundamental Than Genes?0:45:33 "No Electricity, No Life"0:49:14 When Electric Fields Override Genetics Entirely1:03:40 Michael Levin's Xenobots, Debated1:12:22 Do Cells Have Agency? The Fuzziest Question in Biology1:15:16 To Be Continued... (Members Get the Rest)... Email for sponsorship enquiries: [email protected] Episodes MentionedMichael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://www.youtube.com/watch?v=LTBZRVKUwyMPhilip Ball — Philip Ball: "Biology Is Infinitely Weirder Than We Thought": https://www.youtube.com/watch?v=9SseGx0R0fYDenis Noble — Denis Noble: Evolution Has Purpose, Cell Consciousness & Why The Last 70 Years of Genetics Is Wrong: https://www.youtube.com/watch?v=xqw-DaWVK24Michael Levin & Earl Miller — Michael Levin & Earl Miller: Platonic Space of Minds, Bioelectricity, Cell Intelligence & Neurobots: https://www.youtube.com/watch?v=6mU5nN5nlLAGuest LinksUC Davis Faculty Profile: https://health.ucdavis.edu/dermatology/faculty/zhao.htmlZhao Lab (UC Davis Dermatology): https://health.ucdavis.edu/dermatology/research/lab/zhao.htmlGoogle Scholar: https://scholar.google.com/citations?user=G7-zWBcAAAAJ&hl=enNeuroengineering at UC Davis: https://neuroengineering.ucdavis.edu/people/min-zhao-md-phdUC Davis Profiles (Publications): https://profiles.ucdavis.edu/min.zhao

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeUpgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutKirsten Cherian is the Stanford neuropsychologist who gave Special Forces veterans with traumatic brain injuries a single dose of ibogaine — a psychedelic root used in African shamanic ritual for millennia — and watched their injury scores collapse from severe to normal in a month. It's a weak agonist for nearly every receptor in the body, yet it somehow delivers a tailor-made result to each person — a form of pharmacology science has never seen before.Expect to learn why veteran suicide outpaces combat deaths, how one dose collapsed PTSD, depression, and anxiety at once, why users describe their brains being "defragged," a researcher's 12-hour "conversation" with the ibogaine molecule itself, the bizarre phenomenon of "DMT blocking" by hostile entities, why ibogaine has no single receptor target — "matrix pharmacology," how brain age dropped by over a year in a single month, and why the results contradict science's leading theory of consciousness.Timestamps0:00:00 Trailer0:02:11 How This Ibogaine Study For Veterans Began0:04:06 Veteran Suicide Now Outpaces Combat Deaths0:07:31 The 30-Veteran Study With Staggering Effect Sizes0:12:22 Ibogaine Isn't A Trip, It's A Waking Dream0:13:14 Vivid Trip Imagery: Slideshows And "Defragged" Brains0:15:02 Reconciling Trauma By Talking To The Dead0:20:01 What A Bad Ibogaine Trip Actually Looks Like0:24:50 Purging "Black Demons" In A Room Full Of Strangers0:27:23 The Scientist Who Talked To The Ibogaine Molecule0:33:36 Why Elite Special Forces Veterans Still Broke0:34:30 DMT Blocking: When Entities Refuse To Let You In0:41:22 The Psilocybin Researcher Who Believes In Telepathy0:43:00 Why Ibogaine Has No Single Target In The Brain0:46:25 The 1920s Thought Experiment That Proves We're Too Skeptical0:49:38 Ibogaine As A Full-System Diagnostic, Not A Drug1:03:36 Measurable Brain Change From An African Tree Fruit1:05:19 Brain Age Dropped Over A Year After One Dose1:17:21 The Finding That Contradicts The Leading Theory Of Consciousness1:20:28 If Ibogaine Research Got A Blank Billion-Dollar Check1:23:21 Could Ibogaine Help Parkinson's And ALS Patients?... Email for sponsorship enquiries: [email protected] Episodes MentionedDalibor Sames — Meet The Greatest Ibogaine Psychedelic Scientist You've Never Heard Of: https://www.youtube.com/watch?v=K9whp_wtCocAndrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDADavid Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oMatthew Johnson — Consciousness Expert Explains The 5 Levels Of The Psilocybin Experience: https://www.youtube.com/watch?v=FHyy3aW09skRobin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://youtu.be/t-GkE4YtLRkGuest LinksStanford Profile: https://profiles.stanford.edu/kirsten-cherianStanford Brain Stimulation Lab: https://bsl.stanford.edu/MISTIC Study (Nature Medicine, 2024): https://pubmed.ncbi.nlm.nih.gov/38182784/ResearchGate: https://www.researchgate.net/profile/Kirsten-CherianVETS — Veterans Exploring Treatment Solutions: https://vetsolutions.org/

Download the most scientifically rigorous nutrition app MacroFactor! Use code GIANTS for a 2 week FREE trial: https://app.macrofactor.com/mfgiantsTry Mind Lab Pro, The Universal Nootropic For A Sharper Brain: https://www.mindlabpro.com/?a_aid=67fd1cb8d9ad3&a_bid=6d45f5c3Andrés Gómez Emilsson is a consciousness mathematician at the Qualia Research Institute, and he's back for round two of ranking altered states of consciousness by sheer intensity. He and Evan spend two hours ranking every substance and practice they can think of — arguing that ibogaine may be the most ethically urgent drug on Earth, that a hardcore meditation retreat can rival 5-MeO-DMT, and that an obscure nootropic produces psychedelic visuals through a mechanism nobody understands.Expect to learn why ibogaine seems to "scan" your whole nervous system instead of hitting one receptor, how advanced jhana meditation can go toe-to-toe with 5-MeO-DMT in depth, why ordinary DMT produces far more alien entity encounters than its "stronger" cousin, the topology behind why feeling like God and feeling like there's no self are almost the same state, why cannabis's real danger isn't addiction but a specific schizophrenia risk in young men, how combining LSD and ketamine produces "freewheeling hallucinations" you can consciously direct, why mescaline might be the best nootropic for doing actual math yet never caught on, and where MDMA, salvia, and a little-known nootropic called coluracetam land on the scale, and much more…Timestamps0:02:53 Ibogaine0:17:28 5-MeO-DMT0:36:05 Meditation0:46:33 DMT0:58:41 Cannabis1:05:15 Psilocybin1:11:41 Ayahuasca1:18:42 Coluracetam1:21:09 MDMA1:29:26 Salvia1:44:21 Ketamine1:54:37 Mescaline1:58:48 LSD...... Email for sponsorship enquiries: [email protected] a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutGS Episodes MentionedDavid Nutt — Neuroscientist Ranks Every Drug By How Hard They Are to Quit! Tier List Part 2: https://www.youtube.com/watch?v=CEgbv6IHYaYMichael Levin & Earl Miller — Platonic Space of Minds, Bioelectricity, Cell Intelligence & Neurobots: https://www.youtube.com/watch?v=6mU5nN5nlLAGuest LinksQualia Research Institute: https://qri.orgQualia Computing (blog): https://qualiacomputing.comSubstack: https://andrsgmezemilsson.substack.comX (Twitter): https://x.com/algekalipso

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutDr. Reshanne Reeder is a cognitive neuroscientist at the University of Liverpool and creator of the Ganzflicker — a flickering screen that makes most people hallucinate complex scenes within a minute, no drugs required. Her research suggests hallucinations themselves are just disordered mental imagery, and that the most vividly imaginative among us may be the closest normal-range group to a psychotic break.Expect to learn why a simple red-and-black flicker makes most people hallucinate faces and landscapes within a minute, the accidental lab discovery that led to the Ganzflicker experiment, why she believes hallucinations are simply "disordered mental imagery," why psychedelic and clinical hallucinations come from entirely different brain mechanisms, the 1960s art device built to replace the television, why almost nobody hallucinates their own phone, how aphantasia may carry a hidden cost to face recognition, how she's trying to predict psychosis risk years before it ever develops, and much more…Timestamps0:00:00 Trailer0:02:29 How She Discovered Imagery Isn't One Thing0:08:43 Can You Decode Images in an Aphantasic's Brain?0:10:37 The Truth About "Unconscious" Mental Imagery0:16:01 Imagery vs Imagination: Why They Aren't the Same Word0:18:55 Imagery, Perception, Hallucination, Dreaming: Where's the Line?0:20:36 The Hyperphantasics Who Project Images Into the Real World0:22:23 Her Bold Claim: Hallucinations Are Disordered Imagery0:23:37 Can Aphantasics Hallucinate on Psychedelics?0:27:55 The DMT Study Where 90% Said It Felt More Real Than Reality0:29:39 Why Mental Imagery Breaks the Predictive Brain Theory0:32:21 The Irish Castle Test: Are Mental Images Just Priors?0:38:58 She Made People See Faces in Pure Random Noise0:42:04 The Illusion That Turns Faces Into Monsters0:45:48 Why Aphantasia Might Come With a Face-Recognition Cost0:47:35 His Sister Went 31 Years Without Knowing She Had Aphantasia0:49:59 The Accidental Origin Story of Ganzflicker0:51:26 The 1700s Origin of the "Whole Field" Hallucination Effect0:57:41 "I See a Lighthouse": The Moment Ganzflicker Was Born1:00:28 Why Aphantasics Barely Hallucinate on Ganzflicker1:05:31 The Sharp Cliff Between Zero and Weak Mental Imagery1:12:30 Why Nobody Hallucinates Their Phone1:19:45 The Hypnosis Session That Left His Arm Frozen in the Air1:22:13 The 1960s "Dream Machine" That Was Supposed to Replace TV1:35:59 Can This Predict Psychosis Before It Happens?...... Email for sponsorship enquiries: [email protected] Episodes MentionedAdam Zeman — The Blind Mind's Eye: How Aphantasia Is Rewriting Consciousness ! Dr Adam Zeman: https://www.youtube.com/watch?v=SgA2up6-BokAlfredo Spagna — Meet The Neuroscientist Proving We Got Imagination & Aphantasia WRONG!: https://www.youtube.com/watch?v=k8SBHefDnEkDavid Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oKarl Friston — Meet The Neuroscientist Who Created The Best Universal Theory Of Brain Function: https://www.youtube.com/watch?v=R-IZOFs4qmYAnil Seth — No. 1 Consciousness Expert: Optical Illusions that Prove Reality is a Lie, Emotions, Books and AI!: https://www.youtube.com/watch?v=lOSA06K0l1oGuest LinksUniversity of Liverpool Faculty Page: https://www.liverpool.ac.uk/people/reshanne-reederPersonal Website (Ganzflicker Demo): https://www.reshannereeder.com/Bluesky: https://bsky.app/profile/kerblooee.bsky.socialGoogle Scholar: https://scholar.google.com/citations?hl=en&user=DfdUB3UAAAAJLinkedIn: https://uk.linkedin.com/in/reshanne-reeder-53182123b

Check out Scispace: (JNGIANT35: Get 35% off on the Max plan) https://scispace.com/?via=jun1giantshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutDavid Resnik is the NIH's Senior Advisor for Research Integrity and a philosopher of science who has spent his career defending careful, sober naturalism. He just co-authored a paper with biologist Michael Levin arguing that the shape of your body — and maybe your mind — is pulled from a nonphysical space of mathematical forms.Expect to learn why cicadas evolved to emerge only in prime-numbered years to dodge predators, why a mule's infertility comes down to simple odd-and-even chromosome math, why mathematics might be a "free lunch" baked into the universe rather than something we invented, why there may be no real difference between an electron and the equation that describes it, why Michael Levin's leap to calling certain mathematical forms "minds" might be the biggest jump in modern biology, why a Xenobot growing eyes and ears it doesn't need raises the question of where biological information actually comes from, why even a few lines of sorting-algorithm code can behave in ways nobody predicted, and why David thinks it might not matter whether Platonism is literally true, as long as it keeps producing good science.Timestamps0:00:00 Trailer0:02:52 Is Math Discovered or Invented?0:15:48 Why Cicadas Emerge in Prime-Numbered Years0:19:45 Why Mules Can't Reproduce (It's Just Math)0:21:19 Michael Levin's "Free Lunch": Math That Isn't Physical0:24:16 Is Materialism Actually Incomplete?0:29:43 Xenobots: Where Did the Information Come From?0:35:08 Why Do Xenobots Grow Ears and Eyes They Don't Need?0:43:40 The Magnet and Iron Filings Experiment0:45:26 Is There Really a Difference Between an Electron and Math?0:46:40 Michael Levin's "Grand Canyon Jump" to Platonic Minds0:48:03 What Is a Cognitive Light Cone?0:54:26 Cutting a Triangle: What "Ingression" Actually Means0:59:40 Michael Levin's Biological Compiler Idea1:01:27 The Two-Headed Worm and the Eye That Shouldn't Exist1:02:02 A Sorting Algorithm That Does the Unexpected1:05:17 Laplace's Demon and the Limits of Prediction1:09:43 Does It Matter If Platonic Space Is Real?1:16:00 Could AI Access Minds Human Brains Can't?1:17:36 The Limits of Any Mind in the Universe... Email for sponsorship enquiries: [email protected] Episodes MentionedMichael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://youtu.be/LTBZRVKUwyMMichael Levin & Earl Miller — Meet the Scientist Showing Every Cell In Your Body is Conscious!: https://youtu.be/eNi-_2cOVtcJulian Barbour — Meet The Greatest Mathematician You've Never Heard Of: https://youtu.be/LcYdhjcFnzAGuest LinksDavid Resnik — NIH Office of Intramural Research: https://oir.nih.gov/about/leadership-staff/david-resnikLevin & Resnik — "Mind Everywhere" Part One (Biological Theory): https://doi.org/10.1007/s13752-025-00523-6Levin & Resnik — "Mind Everywhere" Part Two (Biological Theory): https://doi.org/10.1007/s13752-025-00524-5David Resnik — ResearchGate: https://www.researchgate.net/profile/David-Resnik-2David Resnik — NIEHS Bioethics: https://www.niehs.nih.gov/research/resources/bioethics/bioethicist

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutElliot Murphy is a neurolinguist at UTHealth Houston who records language directly from inside the human brain, placing electrodes deep in the cortex of epilepsy patients and watching meaning get built in real time. His claim is unsettling: every time you speak, your brain performs an operation no other cognitive system — and no AI — can do, and the structure of grammar may be something the brain discovers rather than invents.Expect to learn why the phrase "old men and women" proves language breaks the laws of algebra, how "red boat" and "barco rojo" hide the same secret structure, what it means to record single words forming inside a living brain, why the deepest things you feel are impossible to put into words, how one word like "lunch" can be food, an event, and a time all at once, where Elliot stands on Michael Levin's idea that meaning lives in a Platonic space, why he thinks large language models don't understand a word they produce, what really separates human intelligence from pattern-matching, and much more…Timestamps0:00:00 Trailer0:01:56 From Liverpool Bookworm to Brain Scientist0:10:25 The Phrase That Breaks the Laws of Logic0:12:36 Why "Red Boat" and "Barco Rojo" Are Secretly Identical0:15:14 Where Language Actually Lives in Your Brain0:20:02 Recording Single Words Inside a Living Brain0:23:38 The Surgery That Changed How We Study Language0:36:12 Does Anything Else Work Like Language? Even Music?0:40:28 The Feelings No Words Can Ever Reach0:42:19 The Nietzsche Line Elliot Can't Shake0:44:52 How "Lunch" Is Three Contradictory Things at Once0:57:47 Does Meaning Have a Mathematical Shape?1:03:34 Is Grammar Invented — or Discovered in a Platonic Space?1:13:54 What Even Is Agency?1:25:00 What Actually Separates You From an AI1:30:12 Where to Start With Nietzsche and Dostoevsky... Email for sponsorship enquiries: [email protected] Episodes MentionedMichael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://www.youtube.com/watch?v=LTBZRVKUwyMMichael Levin & Earl Miller — Meet the Scientist Showing Every Cell In Your Body is Conscious!: https://www.youtube.com/watch?v=eNi-_2cOVtcGuest LinksElliot Murphy — Website: https://elliot-murphy.comElliot Murphy — Google Scholar: https://scholar.google.co.uk/citations?user=4AYNRj0AAAAJElliot Murphy — UTHealth Profile: https://www.uth.edu/people/profile?id=a676259c-6b83-45de-bba3-f9ce464344a6

Try Mind Lab Pro, The Universal Nootropic For A Sharper Brain: https://www.mindlabpro.com/?a_aid=67fd1cb8d9ad3&a_bid=6d45f5c3Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutAdam Butler is a DMT researcher and author who has taken the molecule over 100 times and completed the same Monroe Institute consciousness program the CIA funded during the Cold War. He went from suicidal alcoholic to sober and mission-driven through a molecule his own brain already produces -- and then, one day, found himself completely locked out of the DMT space with zero pharmacological explanation for why.Expect to learn why DMT stops working for some people with no pharmacological explanation for it, how the body produces its own DMT internally, what the Monroe Institute's Hemi-Sync binaural beats protocol has in common with a DMT trip without any substance at all, why a declassified CIA-linked report took remote viewing seriously enough to fund it for decades, what DMT entities actually look like across 100+ trips, the controversial DMT laser experiment that claims to reveal a rigid code-like grid in the visual field, why effect sizes in psychedelic-assisted therapy trials are becoming impossible to ignore, and much more…Timestamps0:00:00 Trailer0:02:17 Who Is Adam Butler? From Rock Bottom to a Mission0:07:18 The Story That Changed Everything0:13:21 Inside His First DMT Session0:24:22 Why DMT Doesn't Build Tolerance0:31:56 Blocked: The Night DMT Just Stopped Working0:38:22 The Telepathy Tapes and the DMT Laser Experiment0:40:38 Huxley's Reducing Valve and the DMT "Cheat Code"0:44:29 What Is a DMT Entity, Really?0:48:21 Jesters, Mantis Beings, and the Entity Portfolio0:54:48 Carhart-Harris's Theory vs Alien World-Building1:02:52 Do DMT Entities Have Their Own Agency?1:09:20 The Mantis "Technicians" and the Body Upgrade1:11:23 Meeting His Future Self on DMT1:17:28 Inside the Monroe Institute1:32:17 The Declassified CIA Gateway Project1:41:10 Temporal Lobe Epilepsy and DMT-Like States1:44:27 The DMT Laser Experiment Explained1:53:21 Debating the "Code of the Simulation" Claim1:58:37 Near-Death Experience and Why It All Matters... Email for sponsorship enquiries: [email protected] Episodes Mentioned:Robin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://youtu.be/t-GkE4YtLRkAndrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDAAndrés Gómez Emilsson — Consciousness Expert Explains The 6 Levels Of The DMT Experience: https://youtu.be/xMdl7zF2MWEGuest Links:Instagram: https://www.instagram.com/booksbyadambutlerYouTube: https://www.youtube.com/@ButlersDMTFieldGuidePatreon: https://www.patreon.com/BooksByAdamButlerBook — Butler's DMT Field Guide: https://www.amazon.com/dp/196050505XBook — Butler's Psychedelic Integration Field Guide: https://www.amazon.com/dp/B0H4GL8H6V...Email for sponsorship enquiries: [email protected]

Download the most scientifically rigorous nutrition app MacroFactor! Use code GIANTS for a 2 week FREE trial: https://onelink.to/giantsGet Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutDalibor Sames is the chemist who reverse-engineered ibogaine into a version that appears to erase heroin addiction in a single dose, without the cardiac risk that can kill people on the original drug. He also took his own medicine — and says he watched the molecule's exact 3D structure rotate in front of him for 36 hours straight.Expect to learn why ibogaine breaks every rule of classical pharmacology, what "matrix pharmacology" means and why it's heresy to a one-drug-one-target industry, how editing a single atom deletes ibogaine's fatal heart risk, why a common antidepressant turned out to be a secret opioid for thirty years, what it's like to watch a molecule's structure appear during a 36-hour flood dose, why ibogaine seems to erase interest in alcohol overnight, whether the "DMT block" phenomenon researchers describe is real, and much more…Timestamps0:00:00 Trailer0:02:39 Meet the Chemist Who Fell for a Molecule's Shape0:04:13 The Dogma That the Adult Brain Can't Heal0:09:00 Why Synapses Might Explain Every Brain Disorder0:10:28 Reverse-Engineering Nature's Own Drugs0:16:44 The Paper That Changed Everything About Addiction0:20:01 Why Ibogaine Breaks Every Rule of Pharmacology0:33:08 The Weakest Drug That Works the Strongest0:38:21 The Traffic Jam That Explains Matrix Pharmacology0:44:18 A Human Genome Project — For One Molecule0:47:48 Deciding to Take Ibogaine Himself0:50:02 Inside a 36-Hour Flood Dose0:54:38 The Chapter Called "Treatment"0:56:26 Ibogaine Shows Him the Future of Design1:00:01 Seeing Ibogaine's 3D Molecular Structure1:03:14 High-Fiving a Molecule1:06:47 "This Is a Computational Technology"1:16:36 The Simulation So Real It Panicked Him1:24:26 Did He Earn This Experience?1:30:56 Six Months Later — What Actually Changed1:36:01 Did This Change His View of Consciousness?...... Email for sponsorship enquiries: [email protected] Episodes MentionedAndrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDADavid Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oGuest LinksColumbia Chemistry faculty page: https://www.chem.columbia.edu/content/dalibor-samesSames Lab: https://www.samesgroup.org/professor-dalibor-samesGilgamesh Pharmaceuticals: https://www.gilgameshpharmaceutical.com/Oxa-Iboga paper (Nature Communications, 2024): https://doi.org/10.1038/s41467-024-51856-yBeond Ibogaine Clinic (where he took ibogaine): https://beondibogaine.com

Download the most scientifically rigorous nutrition app MacroFactor! Use code GIANTS for a 2 week FREE trial: https://onelink.to/giantsWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutDráulio Barros de Araújo is a physicist who spent twenty years pointing MRI scanners at the ayahuasca experience, and ran the world's first controlled trial proving a single dose of a psychedelic could lift treatment-resistant depression in a week. He thinks DMT entity encounters are not hallucinations, and he wants to know if they could be real.Expect to learn why calling ayahuasca visions "hallucinations" is scientifically wrong, why you can't overdose or build tolerance to ayahuasca the way you can with alcohol or cocaine, why vomiting is considered part of the medicine rather than a side effect, how a physicist measured the entropy of a mystical experience and watched it rise, why your eyes physically won't stay open during a vision, the hippocampal memory glitch that may explain why DMT entities feel real, and why psychedelic science may be measuring altered states with the wrong tools entirely.Timestamps0:00:00 Trailer0:02:50 Who Is the Physicist Studying Ayahuasca Visions0:05:05 The 1930s Origin of Brazil's Ayahuasca Churches0:10:13 Why You Can't Buy Ayahuasca Like a Coca-Cola0:11:22 What a Typical Ayahuasca Trip Actually Feels Like0:16:53 Why LSD Visions Happen With Eyes Open, Ayahuasca Doesn't0:17:22 Your Brain on Ayahuasca Looks Like a Dream, Not a Hallucination0:21:08 Why Ayahuasca Visions Never Feel Like "Just a Dream"0:22:23 There's No Such Thing as an Ayahuasca Overdose0:24:18 Why Vomiting and Diarrhea Are Part of the Medicine0:28:34 The Hippocampus Theory of Why DMT Entities Feel Real0:33:22 Would Irish People See Snakes on Ayahuasca Too?0:35:40 We're Measuring Trips With the Wrong Scientific Tools0:40:44 Speech Analysis: A New Way to Study the Trip0:44:31 The Flawed Questionnaire Behind Every Psychedelic Study0:50:23 Why Dráulio Refuses to Ask a Single Direct Question0:55:19 The Entropic Brain Hypothesis, Explained by a Physicist1:02:01 Why Psychedelics Dissolve Your Career Ambitions1:04:02 The Most Important Psychedelic Question Science Avoids: Death1:06:09 What the West Should Learn From Indigenous Ayahuasca Traditions... Email for sponsorship enquiries: [email protected] Episodes MentionedDavid Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oRobin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://www.youtube.com/watch?v=t-GkE4YtLRkDavid Nutt — Neuroscientist Ranks Every Drug By How Hard They Are to Quit! Tier List Part 2: https://www.youtube.com/watch?v=CEgbv6IHYaYGuest LinksUFRN Brain Institute — Faculty Profile: https://neuro.ufrn.br/institute/members/investigators/draulioGoogle Scholar: https://scholar.google.com/citations?user=NoO4Rt0AAAAJCentro Avançado de Medicina Psicodélica (CAMP): https://www.camp-sci.com/ptLinkedIn: https://www.linkedin.com/in/draulio-araujo-06ab47125

Get Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutDennis McKenna is an ethnopharmacologist who spent fifty years decoding the chemistry of psychedelic plants, producing the first hard pharmacological proof of why ayahuasca actually works. He's also the younger brother of Terence McKenna, and in 1971 the two of them ran an experiment on their own minds in the Colombian Amazon that ended in a two-week psychotic break neither has ever fully explained.Expect to learn why the McKenna brothers thought DMT was a portal to another dimension rather than a drug trip, what happened during Dennis's two-week dissociation from reality in the Amazon, how ayahuasca's DMT and MAO-inhibitor plants actually work together in the body, why Dennis still calls the entire 1971 expedition "an act of science fiction, not science," how his PhD research became the first pharmacological proof of why ayahuasca works, why he thinks his own brother unintentionally seeded the "machine elf" into everyone else's DMT trips, why a career pharmacologist has never personally seen one himself, and why DMT entity encounters may be linked to real mental health outcomes, and much more…Timestamps0:00:00 Trailer0:03:07 How Dennis Got Into Psychedelics0:06:07 Terence The Philosopher vs Dennis The Scientist0:11:11 The 1971 Expedition To The Colombian Amazon0:16:05 Why DMT Was "The Holy Grail"0:17:50 The Ayahuasca Chemistry Nobody Understood Yet0:18:45 Hunting For The Legendary Oo-Koo-Hé0:22:00 Stumbling Into A Mushroom Paradise0:27:05 When The Mushrooms Started "Talking"0:28:38 The DNA Resonance Experiment0:36:01 The Two-Week Psychotic Break0:40:46 Psychotic Break, Shamanic Initiation, Or Alien Encounter?0:47:08 From Psychotic Break Back To The Lab0:53:16 Proving How Ayahuasca Actually Works0:58:47 The Book That Seeded Mushrooms Into Society1:05:39 Sasha Shulgin And The Chemistry Of Psychedelics1:11:02 "I've Never Seen A Machine Elf Myself"1:17:56 Pushing The DMT Experience To Five Hours1:20:02 What Makes DMT Different From Psilocybin1:26:18 DMT Entities And Mental Health Outcomes...... Email for sponsorship enquiries: [email protected] MentionedAndrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDADavid Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oGuest LinksHeffter Research Institute Bio: https://www.heffter.org/dennis-j-mckenna-phd/McKenna Academy of Natural Philosophy: https://mckenna.academy/mka-team/dennis-mckenna/X: https://x.com/DennisMcKenna4Book — The Brotherhood of the Screaming Abyss: http://brotherhoodofthescreamingabyss.com/ResearchGate: https://www.researchgate.net/profile/Dennis-Mckenna

Get Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderGet Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10Denis Noble is the physiologist who built the first computer model of the heart in 1960 — and has spent the sixty years since using it to dismantle the gene-centric view of life that dominates modern biology. He took Richard Dawkins's Selfish Gene and rewrote its most famous passage word for word in reverse — and every single experiment still fits.Expect to learn why the central dogma of molecular biology is provably wrong, how your immune system rewrites its own DNA to fight off new viruses, why the peppered moth story in every biology textbook turns out to be false, what happened when Denis told Richard Dawkins "Lamarck is back" to his face, why a cell corrects roughly 800,000 DNA replication errors before it's allowed to divide, how epigenetic inheritance can persist indefinitely if the environment stays changed, whether plants might have a form of experience, and where exactly agency ends and pure chemistry begins.Timestamps0:00:00 Trailer0:02:27 Meet The Man Who Modeled The Heart By Hand0:04:43 Why The Central Dogma Of Biology Is Wrong0:06:39 The 1866 Split Between Darwin And Wallace0:09:02 The Infinite Monkey Theorem, Tested For Real0:17:30 The Peppered Moth Myth Textbooks Still Teach0:20:19 The Nobel Laureate Textbooks Forgot To Cite0:22:53 Telling Richard Dawkins "Lamarck Is Back"0:27:43 Was Lamarck's Giraffe Neck Story Actually Right?0:29:40 How Your Body Talks To Your DNA0:38:17 A New Species Evolved In Two Generations0:44:18 So What's Actually Controversial Here?0:48:09 Cellular Agency: When Cells Act Like Organisms0:53:04 Steelmanning The Case Against Cellular Agency0:55:05 The 17th-Century Prediction That Proved Purpose Works1:04:20 Your Cells Correct 800,000 DNA Errors Per Division1:13:14 Life Lives On The Edge Of Order And Chaos1:15:27 Do Plants Have Experience?1:27:31 How Does Consciousness Fit Into Systems Biology?...... Email for sponsorship enquiries: [email protected] Episodes MentionedMichael Levin — Meet the Scientist Creating New Forms of Synthetic Life! Dr Michael Levin: https://www.youtube.com/watch?v=LTBZRVKUwyMPhilip Ball — Philip Ball: "Biology Is Infinitely Weirder Than We Thought": https://www.youtube.com/watch?v=9SseGx0R0fYGuest LinksOxford Faculty Page: https://www.dpag.ox.ac.uk/team/denis-noblePersonal Website: https://www.denisnoble.comGoogle Scholar: https://scholar.google.com/citations?user=J6kLmsIAAAAJ&hl=enUnderstanding Living Systems (Book): https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367The Third Way of Evolution: https://www.thethirdwayofevolution.com/people/view/denis-noble

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeGet Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10Matthew Johnson is a psychedelic addiction scientist who spent over two decades at Johns Hopkins before becoming the senior researcher at Sheppard Pratt's Center of Excellence for Psilocybin Research. He's personally guided over 100 people through high-dose psilocybin sessions and says the "mystical experience" that shows up in the data predicts recovery even after you strip out how strong the drug felt.Expect to learn how the psilocybin experience changes as the dose climbs from one gram to a full "heroic dose," why a mystical-type experience predicts addiction recovery even after controlling for how intense the drug felt, what separates a mystical experience from personal insight and emotional catharsis as predictors of healing, why DMT users around the world keep reporting the same handful of entity archetypes, the peer-reviewed Rupert Sheldrake experiment testing whether people can sense who's about to call them before the phone rings, why he thinks rigorous telepathy research keeps getting ignored rather than debunked, why a hard-nosed behavioral pharmacologist ends up leaning toward an idealist view of reality, and much more…Timestamps:0:00:00 Trailer0:02:28 Who Matt Johnson Actually Is0:04:34 How He First Got Into Psychedelics0:09:07 Did He Sense Addiction Benefits Early On0:15:03 The First Mystical Experience Trial At Hopkins0:16:42 What Counts As A High Dose Session0:22:17 How The Trip Changes From 1 To 5 Grams0:30:41 Why Mystical Experiences Predict Better Outcomes0:33:34 Insight And Catharsis As Separate Predictors0:39:49 DMT Entities And Machine Elves Explained0:44:02 Why 20% Of DMT Users See The Same Beings0:52:58 The Peer-Reviewed Telepathy Experiment That Shocked Him0:59:32 Why No One Has Funded A Real Telepathy Study1:11:04 Attention Schema Theory And The Illusion Of Self1:16:00 Could A Single Cell Have Experience1:17:54 Why He Leans Toward Idealism Over Materialism...Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about... Email for sponsorship enquiries: [email protected] Episodes MentionedMichael Graziano — Challenging a Famous Neuroscientist On When Consciousness First Emerged: https://www.youtube.com/watch?v=ZnasmLpY5_8Guest LinksSheppard Pratt Profile: https://www.sheppardpratt.org/news-views/story/sheppard-pratt-announces-dr-matthew-w-johnson-as-senior-researcher-for-the-center-of-excellence-for-psilocybin-research-and-treatment/X: https://x.com/drug_researcherGoogle Scholar: https://scholar.google.com/citations?user=fWhYUvwAAAAJ&hl=enResearchGate: https://www.researchgate.net/profile/Matthew-Johnson-57JHU Faculty Bio: https://hub.jhu.edu/experts/profiles/matthew-johnson/

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutMarjorie Woollacott is a neuroscientist who spent three decades as a hard materialist and co-wrote the textbook used to train physiotherapists worldwide. After a meditation experience her own field said was impossible, she hid it from her colleagues for over 25 years before concluding the brain does not produce consciousness — it filters it.Expect to learn why a career materialist neuroscientist hid her own paranormal experience for 25 years, the prospective hospital studies that corroborate what patients report while clinically dead, how a comatose man with zero brain activity accurately described a nurse hiding his dentures, what terminal lucidity is and why dying Alzheimer's patients regain full clarity minutes before death, the ongoing lab research into non-speaking autistic children who appear to communicate telepathically, why Christof Koch said the data would turn his world upside down, how Bernardo Kastrup's analytic idealism compares to Woollacott's own theory of consciousness, and much more…Timestamps0:00:00 Trailer0:02:46 Where Her Story Really Begins0:05:05 The Materialist Neuroscientist She Used To Be0:06:15 The Meditation Retreat That Broke Her Skepticism0:14:24 What Actually Caused Her Awakening0:22:59 How Rigorous Is Near-Death Experience Research, Really0:24:19 The Prospective Studies Skeptics Ignore0:25:06 The Coma Patient Who Knew Where His Dentures Were0:35:48 Bernardo Kastrup's Analytic Idealism Explained0:43:19 Is Terminal Lucidity Just Wishful Interpretation?0:46:09 The Three-Year-Old's Last Request Before Dying0:53:07 Can Consciousness Move Physical Objects?0:58:20 Why Jung And A Nobel Physicist Believed In Idealism1:02:59 The Telepathy Tapes, Explained1:19:40 The Autism Vulnerability Problem With This Research1:21:21 The 5% Above Chance Telepathy Effect1:35:13 Designing an Experiment Skeptics Can't Dismiss...... Email for sponsorship enquiries: [email protected] Episodes MentionedChristof Koch — The Psychedelic Trip that Convinced Christof Koch Consciousness is Fundamental: https://www.youtube.com/watch?v=kJlV-b2bvaEGuest LinksWebsite: https://marjoriewoollacott.com/University of Oregon Faculty Page: https://ion.uoregon.edu/about/person-page/459Book – Infinite Awareness: https://www.amazon.com/Infinite-Awareness-Awakening-Scientific-Mind/dp/144225033XAcademy for the Advancement of Postmaterialist Sciences Bio: https://www.aapsglobal.com/marjorie-woollacott/ResearchGate: https://www.researchgate.net/profile/Marjorie-Woollacott

Check out Scispace (JNGIANT20: 20% off the monthly plan or JNGIANT40: 40% off the annual plan): https://scispace.com/?via=jun1giantshoulderGet Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutRick Doblin is the founder of MAPS and the man who spent 50 years dragging the world's most demonized drug into the doctor's office. He taxed legal ecstasy dealers to fund the first MDMA toxicity studies, sued the DEA with the profits, and got a Harvard PhD in public policy to beat the system from inside — then ran the only completed Phase 3 trials in history showing that two-thirds of severe PTSD patients no longer had the diagnosis after MDMA-assisted therapy.Expect to learn how he taxed ecstasy dealers to sue the DEA, why MDMA was a couples-therapy drug before it was a party drug, the real reason Nixon criminalized psychedelics in 1970, why 88% of severe PTSD patients responded to MDMA therapy while half dropped out of standard VA treatment, why you can't get addicted to MDMA the way you can to cocaine, why you'll do more jail time for MDMA than for the same weight of cocaine, his plan for "net zero trauma by 2070," and much more…Timestamps0:00:00 Trailer0:03:03 Winning the Generational Lottery After the Holocaust0:05:27 Dropping Out of College to Study LSD0:08:15 The Forgotten Golden Era of Psychedelic Research0:09:33 When the CIA Weaponized LSD for Mind Control0:13:10 Half a Pound of Mescaline and Ten Years to Recover0:15:09 The Day a Stranger Said "There's This Drug Called Adam"0:15:56 MDMA Was a Therapy Drug Before It Was Ecstasy0:18:39 Sasha Shulgin, the Man Who Invented 200 Psychedelics0:24:12 How Dealers Tweaked Molecules to Stay Legal0:27:21 Why Nixon Really Criminalized the Hippies0:30:04 Going to War With the DEA — and Winning0:33:56 Founding MAPS and $200 Million Later0:39:09 Taxing the Ecstasy Dealers to Fund the Lawsuit0:41:33 The First MDMA Safety Study, Run on a Beach0:42:43 The 1992 Moment That Reopened Psychedelic Science0:44:31 The First PTSD Study, Shut Down for Politics0:48:08 Cannabis Is Palliative, Psychedelics Are Curative0:50:08 The Veteran Suicide Epidemic Nobody Will Fund0:53:33 Why MAPS Bet Everything on MDMA0:58:35 The Effect Sizes That Should Have Changed Everything1:01:01 Why Half of Veterans Quit Standard PTSD Therapy1:02:13 Why the Data Alone Was Never Going to Win1:04:54 The Absurd Reason the FDA Cited: "Euphoria"1:06:34 Why You Can't Get Hooked on MDMA1:07:26 More Jail for MDMA Than for Cocaine1:08:36 Net Zero Trauma by 20701:10:47 MDMA for Couples, and Bringing It to the World...... Email for sponsorship enquiries:[email protected] LinksRick Doblin — MAPS: https://maps.org/people/rick-doblin/Rick Doblin on X: https://x.com/RickDoblinMAPS: https://maps.org

Check out Scispace (Use Code JNGIANT20: 20% OFF MONTHLY): https://scispace.com/?via=jun1giantshoulderGet Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutManoj Doss is a cognitive neuroscientist and one of the only people studying what psychedelics actually do to memory — trained inside the field's most prestigious lab at Johns Hopkins, he's now its most rigorous internal sceptic. His claim is heretical: the profound sense of revelation you get on a trip may be a memory glitch — a familiarity signal firing without the detail that would normally justify it, so the trip feels like downloading the truth while your brain quietly degrades what it's actually recording.Expect to learn why the profound insights you get on psychedelics might be a memory glitch, why the entire default mode network story "needs to go to hell", what a 250-subject mega-analysis revealed that small studies missed, why salvia melts you into the couch while DMT builds whole worlds, whether DMT entities and mantises are real contact or just a brain built to see faces, why blocking a single receptor proves psychedelics aren't "keys to reality", the flaw Doss says sinks the entropic brain and REBUS, how you'd ever tell a true revelation from a beautiful lie, and much more…Timestamps0:00:00 Trailer0:02:24 The One Thing Psychedelic Science Ignores: Memory0:05:38 Why Your Worst Beliefs Feel Like Hard Facts0:07:38 The "Sense of Knowing" That Fools Everyone0:09:00 How Psychedelics Rewire What You Remember0:16:11 Why Yoga Feels Better on Psilocybin0:20:27 "The Default Mode Network Story Needs to Go to Hell"0:27:26 How Neuroscience Invents Stories From Noise0:35:42 Why Psychedelic Studies Are Too Small to Trust0:40:31 Salvia: Becoming a Sentient Piece of Corn0:44:13 The Kappa-Opioid Door Into Another Reality0:48:00 Why Salvia Is Heaven and Ibogaine Is Hell0:53:03 Does the Brain Have Two Reality Generators?0:59:24 Has 20 Years of Psychedelics Taught Us Anything?1:05:18 Are DMT Entities Real? The Mantis Problem1:13:28 Why You See Machine Elves (But His Mum Wouldn't)1:24:29 Tearing REBUS and the Entropic Brain Apart1:36:21 "Do Stuff in the Scanner, Stuff Happens in the Brain"1:44:25 The Debate Robin Was Warned Not to Do...... Email for sponsorship enquiries: [email protected] Episodes MentionedKarl Friston — Meet The Neuroscientist Who Created The Best Universal Theory Of Brain Function: https://www.youtube.com/watch?v=R-IZOFs4qmYRobin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://www.youtube.com/watch?v=t-GkE4YtLRkMichael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://www.youtube.com/watch?v=LTBZRVKUwyMChristof Koch — The Psychedelic Trip that Convinced Christof Koch Consciousness is Fundamental: https://www.youtube.com/watch?v=kJlV-b2bvaEDavid Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5oGuest LinksManoj Doss — Dell Medical School: https://dellmed.utexas.edu/directory/manoj-dossX (Twitter): https://x.com/manojdossGoogle Scholar: https://scholar.google.com/citations?user=KFo44R0AAAAJORCID: https://orcid.org/0000-0003-2939-2522

Check out Scispace (JNGIANT20: 20% off the monthly plan or JNGIANT40: 40% off the annual plan): https://scispace.com/?via=jun1giantshoulderProfessor David Nutt is a neuro­psychopharmacologist, former UK chief drug adviser, and author of Drugs Without the Hot Air, Drink?, Cannabis, and Psychedelics. After two rounds that sparked an overwhelming response, round three goes fringe — ibogaine, salvia, mescaline, peyote, GHB, xylazine, the nitazines, and the Amanita muscaria "Santa Claus" mushroom — ranking each on Nutt's evidence-based harm scale.Timestamps:2:56 Ibogaine7:21 Salvia18:02 Mescaline & Peyote23:59 San Pedro Cactus28:55 GHB40:59 Kratom & 7-Hydroxy46:05 Xylazine ("Tranq")51:34 Nitazines54:53 Amanita Muscaria...Email for sponsorship enquiries: [email protected] Nutt's BooksDrink?: The New Science of Alcohol and Your Health: https://amzn.to/4dZTP9ZPsychedelics: The Revolutionary Drugs That Could Change Your Life―A Guide from the Expert: https://amzn.to/3SJXAX6Drugs without the hot air: Making sense of legal and illegal drugs: https://amzn.to/4kyu7eSCannabis (Seeing Through the Smoke): The New Science of Cannabis and Your Health: https://amzn.to/3FOiLo2Check out the amazing work of Drug Science (Dr David Nutt's Charity)Website - https://www.drugscience.org.uk/Prof Nutt Twitter (X) - @ProfDavidNuttDrug Science SocialsFacebook - @DrugScienceISCDTwitter (x) - @drug_scienceInstagram - @drugscienceinfoLinkedIn - @drugscience-ltdBlueSky - @drugscience.bsky.socialYouTube - @DrugScienceMore Resources on Drug SafetyMedical Cannabis: https://www.drugscience.org.uk/medical-cannabis-working-groupMedical Psychedelics: https://www.drugscience.org.uk/medical-psychedelics-working-groupHarm Reduction: https://www.drugscience.org.uk/enhanced-harm-reduction-working-groupAcademic Research: https://www.drugscience.org.uk/research

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeGet Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutDavid Nichols is the chemist who made the molecules behind the entire psychedelic renaissance; Bryan Roth is the pharmacologist who cracked how those drugs actually work inside the brain. Together they reveal how little we still understand about the compounds now entering mainstream medicine — and how the same technology could, in Roth's own words, build a literal zombie apocalypse.Expect to learn why the word "psychedelic" could once kill a research grant, how Nichols hand-made the MDMA, DMT and psilocybin behind the field's most famous trials, what profiling 41 psychedelics against 318 receptors actually revealed, why we still don't know what half of those receptors even do, whether the trip itself is the medicine or a side effect that can be engineered away, why a twitching mouse is the most reliable predictor of a human trip, how Roth's "remote control for neurons" could rewrite memory, pain and aggression, and much more…Timestamps0:00:00 Trailer3:22 Two Godfathers of Psychedelics, Together4:03 The Man Who Made the Molecules by Hand7:34 How Roth Fell Into Serotonin by Accident16:46 When "Psychedelic" Was a Forbidden Word20:18 318 Receptors, 41 Psychedelics: The Big Paper31:18 Nobody Knows What Half These Receptors Do35:46 How Nixon's Drug War Killed the Science46:06 The LSD in the Famous Structure Was Dave's55:52 1.4 Kilos of MDMA for $4,00057:29 The Psilocybin That Stunned Johns Hopkins1:00:19 The Real-Life Walter White1:01:20 Where Psychedelic Medicine Goes Next1:07:13 "It's Just GQ": How Psychedelics Actually Work1:11:35 The Hidden Proteins Behind Mental Illness1:20:03 Is the Trip Itself the Medicine?1:34:33 Why a Twitching Mouse Predicts a Trip1:38:14 Your Personalised Psychedelic, Designed by AI1:45:51 The Tech to Build a Zombie Apocalypse...Email for sponsorship enquiries: [email protected] Episodes MentionedDavid Nichols — Meet The Greatest Living Psychedelic Scientist You've Never Heard Of: https://www.youtube.com/watch?v=6umTgXsW1lQBryan Roth — Meet The World's Greatest Psychedelic Receptor Scientist: https://www.youtube.com/watch?v=sEmmmMma8QsGuest LinksBryan Roth — UNC Pharmacology: https://www.med.unc.edu/pharm/directory/bryan-roth-md-phd/Roth Lab & NIMH Psychoactive Drug Screening Program: https://pdspdb.unc.edu/rothlab/David Nichols — Heffter Research Institute: https://www.heffter.orgThe 318-receptor psychedelics paper (Neuron, 2025): https://www.cell.com/neuron/abstract/S0896-6273(25)00470-2

Want a full breakdown of your own conscious inner experience? Join the Giant’s Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutJoseph LeDoux is, by almost any measure, the greatest emotion neuroscientist who has ever lived. His work has been cited more than 185,000 times, he wrote The Emotional Brain — the book that defined the field — and he put the amygdala on the map as the brain’s fear centre. Then he spent a decade arguing that everyone, including himself, got the lesson wrong.Expect to learn how a marketing student accidentally became the most-cited emotion researcher alive, what split-brain experiments reveal about why your brain invents fake explanations for your behaviour, why the amygdala is not a fear centre and what it actually does, how every act of remembering chemically rewrites the memory, why anxiety drugs have been targeting the wrong brain circuit for 50 years, what the Four Realms of Existence means for the concept of self, why emotions are culturally acquired schema rather than universal hardwired states, and much more…Timestamps0:00:00 Trailer0:02:43 From Marketing Student to Neuroscientist0:06:18 Moving to New York and Meeting Gazzaniga0:07:37 How Split-Brain Surgery Works0:09:58 The Chicken and Shovel Experiment0:12:13 We Are Confabulating 24/70:17:13 Why He Chose to Study Emotion in Rats0:19:26 His Grant Was Rejected for Studying Emotions0:22:30 Masquerading as a Learning Researcher0:25:22 Growing Discomfort With the Amygdala Fear Centre0:28:23 Rethinking the Emotional Brain0:30:47 Why Fear Isn’t Universal — Danger Is0:33:19 Emotions as Acquired Schema0:35:22 The Four Realms of Existence0:40:36 Cognition vs Consciousness in Animals0:41:29 Tulving’s Three Kinds of Consciousness0:47:57 The Brain Region Only Humans Have0:53:40 Your Model Is Still on the Slide — And You Disagree0:55:05 The George Martin Analogy0:56:37 Why Anxiety Drugs Don’t Actually Work0:58:21 The Three-Step Fix for Fear1:01:27 Higher-Order Theories of Consciousness1:05:36 Using AI to Decode Conscious vs Unconscious Speech...... Email for sponsorship enquiries: [email protected] LinksNYU Faculty Page: https://as.nyu.edu/faculty/joseph-e-ledoux.htmlPersonal Website: https://www.joseph-ledoux.com/Google Scholar: https://scholar.google.com/citations?user=iAqJssMAAAAJ&hl=enPsychology Today: https://www.psychologytoday.com/us/contributors/joseph-e-ledoux-phdThe Four Realms of Existence (Harvard University Press): https://www.hup.harvard.edu/books/9780674291003

Get Jenni, Your Intelligent Research Assistant (GIANT20 for 20% off): http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderGet the Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulderPaul Cisek is a control neuroscientist at the University of Montreal who records from single neurons in the brains of monkeys as they think, and who has spent decades reconstructing how the brain evolved across hundreds of millions of years. His verdict cuts against everything Silicon Valley believes: the brain was never a computer — it's a control system built to keep a body alive, and the most advanced AI on Earth understands nothing it says.Expect to learn why Richard Dawkins is wrong that Claude could be conscious, why every era wrongly compares the brain to its fanciest technology, how a baseball outfielder reveals what the brain is really doing, why large language models are "Eliza on steroids" and 100% illusion, where meaning actually comes from and why LLMs can never have it, why the real danger isn't ChatGPT but the agentic systems that come next, whether a paramecium could be conscious, what Michael Levin's neuron-growing biobots tell us about minds, and much more…Timestamps0:00:00 Trailer0:02:33 Why Paul Rescheduled to Watch a Monkey Learn0:06:13 Probing Electrodes Into a Living Brain0:13:42 What a Single Neuron Actually Sounds Like0:20:41 The Brain Is Not a Camera Plugged Into a Computer0:24:55 How an Outfielder Catches a Ball Without Doing Physics0:33:24 Why Federer "Lets the Cerebellum Run the Show"0:38:09 Richard Dawkins Says Claude Might Be Conscious0:39:11 Every Era Thinks the Brain Is Its Latest Gadget0:42:36 Why AI Is "Eliza on Steroids" and 100% Illusion0:45:38 The Mechanical Turk and the Stage Magician0:48:09 The Mimicry Irony at the Heart of Dawkins' Mistake0:52:32 The One Thing AlphaFold and ChatGPT Both Lack0:53:30 Where Meaning Actually Comes From0:57:55 Language Is Persuasion: The Crying Baby Problem1:03:14 The Paper With Friston and Clark on What AI Misses1:04:48 Could You Build a Machine That Wants Things?1:10:23 Build a Mind, Build a Rival: Do We Even Want To?1:13:32 Is a Paramecium Conscious?1:18:11 Why There's No Line Between a Lump of Cells and You1:23:18 Population Thinking: It's All Continuums1:30:36 The Mad Scientist Won't Be Sam Altman — It'll Be Michael Levin1:36:29 Does Synthetic Biology Deserve Its Own Doomsday?1:39:37 Why Real Intelligence Would Be a Competitor We Should Fear1:43:20 Why the Real World Humbles Every Robot...Want a full breakdown of your own conscious inner experience?Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutEmail for sponsorship enquiries: [email protected] Episodes MentionedPaul Cisek Round 1: https://youtu.be/C6frE6nj1tYMichael Levin — Meet the Scientist Creating New Forms of Synthetic Life! Dr Michael Levin: https://www.youtube.com/watch?v=LTBZRVKUwyMAnil Seth — No. 1 Consciousness Expert: Optical Illusions that Prove Reality is a Lie, Emotions, Books and AI: https://www.youtube.com/watch?v=lOSA06K0l1oKarl Friston — Meet The Neuroscientist Who Created The Best Universal Theory Of Brain Function: https://www.youtube.com/watch?v=R-IZOFs4qmYMark Solms — Meet the Scientist Proving Dreams Hold the Key to Consciousness! Dr Mark Solms: https://www.youtube.com/watch?v=nMWaQ1U6dcc...Guest LinksPaul Cisek — Faculty page, Université de Montréal: https://neurosciences.umontreal.ca/en/our-team/staff-directory/staff/cisek-paul/Cisek Lab: https://www.ciseklab.umontreal.ca/Google Scholar: https://scholar.google.com/citations?user=Bbk0DEcAAAAJX / Twitter: https://x.com/PaulCisek...

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeUpgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutHaleh Fotowat is a neuroscientist who builds nervous systems from scratch — the scientist who gave neurons to Michael Levin's xenobots, the living robots made from frog cells. When those neurons self-organised into a working nervous system, they switched on genes for eyes, in a creature that has never had eyes and never existed in nature.Expect to learn how a clump of frog skin cells becomes a moving biological robot, why these cells secretly default to becoming neurons unless their neighbours stop them, what happened when the neurons grew axons and reached out for the body, why every neurobot develops its own movement personality, how a brainless blob forces you to redefine agency and goals, why the neurons switched on genes for eyes despite having none, what a seizure drug revealed about which biobots truly have nervous systems, what might happen if you gave the neurobots DMT, and much more…Timestamps0:00:00 Trailer0:02:05 What Is a Neurobot?0:02:39 Building a Living Robot From Frog Cells0:08:46 Why These Cells Secretly Want to Be Neurons0:10:48 What's the Point of This Research?0:16:26 Brain Cells in a Dish Playing Doom0:18:16 A Warehouse Full of Human Neurons0:19:16 What Happened When the Neurons Grew0:21:36 The Neurons Reached Out for the Body0:25:51 Why Each Neurobot Has Its Own Personality0:28:51 Can a Blob of Neurons Have Goals?0:39:42 Braitenberg's Vehicles: Complexity From Simplicity0:42:25 Biology Is Cognition All the Way Down0:49:12 The Eyes That Shouldn't Exist0:54:18 Xenobots Grew Genes for Hearing1:01:16 The Role of Bioelectricity1:04:02 One Question for Michael Levin1:06:53 What If You Gave the Neurobots DMT?1:07:27 The Seizure Drug That Surprised Everyone...... Email for sponsorship enquiries: [email protected] Episodes MentionedMichael Levin — Meet the Scientist Creating New Forms of Synthetic Life! Dr Michael Levin: https://www.youtube.com/watch?v=LTBZRVKUwyMBrett Kagan — Meet The Neuroscientist Creating New Forms of Sentient Biological Intelligence: https://www.youtube.com/watch?v=TXlJc4tu1F8Philip Ball — Biology Is Infinitely Weirder Than We Thought: https://www.youtube.com/watch?v=9SseGx0R0fYJosh Bongard — Meet The Scientist Who Created The First Living Robot: https://www.youtube.com/watch?v=3h908uoH6n4Guest LinksAllen Discovery Center (Tufts) Profile: https://allencenter.tufts.edu/our-team/haleh-fotowat-ph-d/Art Website: http://www.halehfotowat.comGoogle Scholar: https://scholar.google.com/citations?user=W5KTeEMAAAAJLinkedIn: https://www.linkedin.com/in/haleh-fotowat/ResearchGate: https://www.researchgate.net/scientific-contributions/Haleh-Fotowat-2245482149

Get Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderUpgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutMichael Levin is a developmental biologist who builds living creatures that have never existed before, and Earl Miller is a neuroscientist who has spent thirty years arguing that your thoughts live in the brain's electric fields, not its wiring. In the same room together for the first time, they agree on something that sounds insane — that bioelectricity is the engine of mind at every scale of life, from a single cell deciding to grow an eye to a human deciding what to eat for lunch.Expect to learn how cells use a bioelectric code you can read and rewrite to grow an eye on a tadpole's tail, why no single cell knows what an eye is but the collective does, how a flatworm regrows a whole new brain and keeps its old memories, why the brain is an orchestra of electric waves and not a telegraph of wires, how three different anaesthetics switch off consciousness through one mechanism reductionism can't explain, why consciousness may just be the story your brain tells about what it already did, whether memories can be transplanted between bodies, what the Platonic space of minds is and why Levin thinks physicalism died with Pythagoras, and much more…Timestamps: 0:00:00 Trailer0:02:46 The Vacuum Tubes That Started It All0:08:36 How to Read and Rewrite the Bioelectric Code0:12:36 Why No Single Cell Knows What an Eye Is0:15:22 Your Brain Is Not a Telegraph System0:19:30 Why They Called It Magic and Bullshit0:24:56 Flatworm or Human Brain — Same Code?0:30:00 Where Is Memory Actually Stored?0:32:24 The Flatworm That Regrows Its Memories0:34:34 People Living Without Most of Their Brain0:40:32 Can Memories Live Outside the Brain?0:43:26 Will a Rat Pop Down to the 7-Eleven for Smokes?0:49:14 Consciousness Is Overrated (Says a Neuroscientist)0:53:17 Hey Liver, Why Do I Feel Like Crap?0:54:20 Nobody Knows Why Anaesthesia Works0:57:21 Three Drugs, One Mystery, One Mechanism0:58:50 Why Anaesthesia Is Dangerous When You're Old1:02:12 What Is a Neurobot?1:08:18 The Eyes That Shouldn't Exist1:13:28 What Is the Platonic Space of Minds?1:20:44 Devil's Advocate: Have We Just Not Figured It Out?1:24:03 The Free Lunch: More Out Than You Put In1:29:36 Why Physicalism Died With Pythagoras1:32:52 How Bioelectricity Touches the Platonic Space...GS Episodes MentionedAnil Seth — No. 1 Consciousness Expert: Optical Illusions that Prove Reality is a Lie, Emotions, Books and AI!: https://www.youtube.com/watch?v=lOSA06K0l1oGuest LinksMichael Levin — Allen Discovery Center (Tufts): https://allencenter.tufts.edu/our-team/michael-levin/Michael Levin — Website: https://www.drmichaellevin.orgEarl Miller — The Miller Lab (MIT): https://ekmillerlab.mit.edu/Earl Miller — X: https://x.com/MillerLabMIT

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeUpgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/aboutSteven Barker is the world's longest-running DMT researcher and the analytical chemist who helped prove the molecule exists in the mammalian brain. He argues your brain manufactures its own psychedelic at the same concentration as serotonin — and floods your cortex with it under stress and as you die.Expect to learn why Steven believes your brain produces DMT at serotonin-level concentrations, how 29 years of drug-testing racehorses gave him the tools to find it, why he says David Nichols is wrong about endogenous DMT, why stress can make brain DMT spike tenfold, how a hidden receptor inside your neurons may explain how psychedelics rewire the brain, why the DMT trip might be neuroplasticity you can actually feel, what DMT entities really are, and much more…Timestamps0:00:00 Trailer0:02:40 The Recurring Dream That Started a 50-Year Obsession0:06:53 Hunting For The Brain's Own Psychedelic In 19720:12:54 The Discovery That We ALL Make DMT0:19:07 Were Psychedelics Ever Meant To Be Medicine?0:22:17 How The War On Drugs Killed The Research0:24:02 Funding Psychedelic Science With Racehorse Drug Tests0:34:56 Why You Can't Patent A Psychedelic0:36:31 The Psychedelic Trip Is Just An "Overdose"0:41:58 Why David Nichols Is Wrong About DMT0:50:16 The "Pineal Is Too Small" Argument Is Ludicrous0:54:20 DMT Is In Your Brain At Serotonin Levels1:01:00 Stress Floods Your Brain With DMT1:02:32 Why Everyone Else Failed To Detect DMT1:12:05 The Hidden Receptor Inside Your Neurons1:19:54 Is The DMT Trip Just Neuroplasticity You Can Feel?1:26:09 What DMT Entities Actually Are1:32:15 Are We Building A New Psychedelic Religion?1:42:11 50 Years of DMT and The Nature of Consciousness1:44:26 Why He's Still A "Proud Reductionist"...Email for sponsorship enquiries: [email protected] Episodes MentionedDavid Nichols — Meet The Greatest Living Psychedelic Scientist You've Never Heard Of: https://www.youtube.com/watch?v=6umTgXsW1lQBryan Roth — Meet The World's Greatest Psychedelic Receptor Scientist: https://www.youtube.com/watch?v=sEmmmMma8QsAndrew Gallimore — No.1 DMT Neurobiologist: Alien Worlds, DMT Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDAGuest LinksResearchGate: https://www.researchgate.net/profile/Steven-Barker-8Cottonwood Research Foundation: https://www.cottonwoodresearch.org

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeGet Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulderWant a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community (100% free): https://www.skool.com/the-giants-shoulder-6526/aboutDavid Luke is the world's first and only Professor of Exceptional Experience — a parapsychologist and psychedelic researcher at the University of Greenwich who has spent two decades running experiments on the phenomena mainstream science refuses to touch. His naturalistic DMT field study found that 90% of participants encountered autonomous entities, 85% believed they were real — and some were blocked from returning by the entities themselves.Expect to learn why 90% of DMT users encounter entities and 85% say they're real, what happens when the entities refuse you entry, how your body responds to images before you've seen them, why someone with zero visual imagery can still meet elves on DMT, how entity encounters shift people's sense of purpose and meaning more than any other psychedelic effect, what the telepathy tapes are and why they show 100% success rates, why physics gets to be weird but consciousness doesn't, what a neo-pagan shamanically-informed lazy mystic actually believes about reality, and much more…0:00:00 Trailer0:04:03 Double Career Suicide0:07:32 The DMT Field Study0:13:45 Your Body Predicts the Future0:16:01 Huxley's Reducing Valve Theory0:20:23 Chris Timmermann's DMT Research0:23:20 90% Encounter Entities0:24:48 Punched in the Head by God0:27:17 The DMT Entity Taxonomy0:29:03 Experiencing Entities Without Vision0:48:28 The Aphantasia DMT Trip0:53:47 Entities Leaking Into Other People's Trips0:54:23 DMT Blocking0:56:30 The Entities Said Bugger Off0:59:57 Endogenous DMT and the Pineal Gland1:02:55 David Nichols Dismantles the Pineal Theory1:05:52 Giant Mantis Entities1:11:12 Purpose & Meaning: The #1 Wellbeing Shift1:12:06 The Telepathy Tapes1:19:54 The Ganzfeld Experiment1:24:16 Physics Gets To Be Weird But We Can't1:26:33 Why DMT Entities Are So Reliable1:29:33 Pablo Amaringo's Ayahuasca Art1:36:34 Do You Have a Stable Ontology?1:38:12 The Lazy Mystic1:39:34 In the Province of the Mind There Are No Limits...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Want to go deeper on consciousness? Join our community where we run live discussions, inner experience challenges and early ad free access to every episode: https://www.skool.com/the-giants-shoulder-6526/aboutPhilip Goff is a professor of philosophy at Durham University and author of Galileo's Error and Why? The Purpose of the Universe. Stephen Fry called him the most persuasive panpsychist alive.Physics tells us everything about what matter does — but nothing about what it actually is. Goff argues this isn't a gap we'll close — it's a permanent hole. And the best candidate to fill it is consciousness itself.Expect to learn why physics can only describe what stuff does and not what it is, how Evan's sister discovered at 31 she has zero mental imagery, why Bertrand Russell may have already solved consciousness a hundred years ago, what 5-MeO-DMT revealed to a philosopher about the nature of reality, the difference between weak and strong emergence and why it matters for AI, and much more…Timestamps:00:00 Trailer02:21 What Makes Consciousness Radically Different05:24 Evan's Descriptive Experience Sampling Experiment06:42 Discovering Aphantasia at 3108:27 Change Blindness and the Invisible Gorilla10:40 Mary's Room: What Red Looks Like13:21 Why Consciousness Theories Ignore Subjective Experience16:48 The Resurgence of Panpsychism18:14 Bertrand Russell: The Darwin of Consciousness20:13 Evan's Psychedelic Journey Toward Biopsychism22:12 Taking 5-MeO-DMT as a Philosopher24:38 Michael Pollan, Plants and Psychedelic Openness28:45 Is Consciousness Computational or Biological?30:43 The Combination Problem: How Tiny Minds Become One37:17 Russell's Inversion: Start With Consciousness40:21 The Hole in Physics: What Stuff Does vs What It IS41:50 Why Bernardo Kastrup Gets Cross44:41 Galileo's Error: The Decision That Broke Science47:20 Aphantasia, Visual Decoding and the Consciousness Gap49:50 Front Brain vs Back Brain: Where Is Consciousness?52:40 Eric Schwitzgebel's Snail Problem55:40 Philosopher-Scientist Teams: A New Model1:03:01 Strong Emergence and New Causal Dynamics1:04:47 Will We Fall in Love With Robots?1:07:22 The Genome Didn't Solve Life1:10:54 The $10 Billion Consciousness Experiment...GS Episodes MentionedAnil Seth — Consciousness, Controlled Hallucination, Perception: https://www.youtube.com/watch?v=lOSA06K0l1oPhilip Ball — Quantum Mechanics, Brain Organoids, How Life Works: https://www.youtube.com/watch?v=nNbG5lnp51EKevin Mitchell — Free Will, Neuroplasticity, Strong Emergence: https://www.youtube.com/watch?v=0VGWzGqA32EMatthias Michel — Consciousness Philosophy, Aphantasia, Fish Consciousness: https://www.youtube.com/watch?v=gtVWgpVPr1sRussell Hurlburt — Inner Experience, Descriptive Experience Sampling: https://youtu.be/j0gKl-g3DNgRobert Prentner — Conscious Agent Theory, Mathematics of Experience: https://www.youtube.com/watch?v=kTKE8eLo8CUCharles Fernyhough — Inner Speech, Hearing Voices, Memory: https://www.youtube.com/watch?v=mJFY6dypPc4 Email for sponsorship enquiries: [email protected]❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249

Want to truly understand your own conscious inner experience? I built a tool and its free - https://www.skool.com/the-giants-shoulder-6526/aboutDr Simon Ruffell is a clinical psychiatrist and the CEO of Onaya Science, the research organisation that studies Amazonian ayahuasca healing alongside Shipibo curanderos in the Peruvian rainforest. His team ran the first-ever study on a psychedelic and human epigenetics — finding that ayahuasca methylates the trauma-memory gene SIGMAR1, mapping precisely onto what the Shipibo have called "cleaning ancestral lines" for thousands of years.Expect to learn why a Maudsley-trained psychiatrist walked away from the NHS to apprentice as a Shipibo shaman, what happens when a curandero performs an exorcism on you mid-ceremony, how 80% of veterans no longer met PTSD criteria six months after a two-week retreat, why the curandero traditionally drinks the ayahuasca and the patient doesn't, what happened when Simon gave a Shipibo curandero a hit of pure crystal DMT, why DMT entities might be real and where Robin Carhart-Harris and Andrew Gallimore disagree about it, and much more…Timestamps:00:00 Trailer03:20 What is Shipibo Curanderismo?04:52 From disillusioned NHS psychiatrist to the Peruvian Amazon10:14 First ayahuasca: shown two versions of myself15:41 The demon attack and the three suckers26:13 Bridging Western psychiatry and Amazonian shamanism36:04 Are DMT entities real? Carhart-Harris vs Gallimore49:50 Inside the multimodal veteran PTSD study52:41 DMT vs ayahuasca — what's actually different57:11 Should you try this? Preparation and "gringo wasca"1:04:52 The first-ever psychedelic epigenetics study (SIGMAR1)1:12:17 "Cleaning ancestral lines" — when Indigenous science met Western1:16:51 80% no longer meet PTSD criteria — the real numbers1:20:37 The shaman drinks, not the patient — traditional protocol1:30:41 The spiritual mechanism of action1:34:54 The dream experiment — plant personalitiesEmail for sponsorship enquiries: [email protected] FOLLOW SIMON:Website: https://www.drsimonruffell.comInstagram: @sgdruffellOnaya Science: https://www.onaya.ioHeroic Hearts UK: https://www.heroicheartsuk.orgPAST EPISODES MENTIONED:Robin Carhart-Harris — Entropic Brain, How Psychedelics Really Work and Consciousness: https://youtu.be/t-GkE4YtLRkAndrew Gallimore — DMT Neurobiologist: Alien Worlds, Entity Encounters, Attractor States and Consciousness: https://www.youtube.com/watch?v=USgWrxEFWDAGrace Blest-Hopley — Psychedelics Expert: Who is Blocking Psychedelic Research?: https://www.youtube.com/watch?v=FBcLxMfUzxw

Join the #1 Community Dedicated to Rigorous & Radical Biology: https://www.skool.com/the-giants-shoulder-6526/aboutBrett Kagan is the Chief Scientific Officer at Cortical Labs, the Australian startup that fuses living human neurons with silicon chips to create a fundamentally new kind of intelligence. His team's DishBrain paper showed that neurons in a dish learned to play Pong in under five minutes — without any reward signal — providing some of the strongest experimental evidence for Karl Friston's Free Energy Principle.Expect to learn how neurons on a chip actually play Pong and Doom, why unpredictable stimulation drives learning better than reward, what the Free Energy Principle really says and where Brett disagrees with Friston, why 200,000 neurons outperform 800,000 on certain tasks, how Brett's baby daughter staring at fractals led to a new theory of intelligence, why no AI system can walk into your kitchen and make a cup of tea, what biological data centres look like and why they already exist, and much more…Timestamps: 00:00 Trailer02:30 Brett Kagan — Neurons Playing Doom03:04 The stepping stones from Pong to Doom04:00 What is the CL1 and Cortical Cloud?05:20 The moonshot goal of Cortical Labs06:46 Giant buildings of neurons as computation hubs07:13 The biocomputing data centre already running in Melbourne07:38 Not building a brain in a dish09:00 What does a biological computer actually look like?09:29 Electricity as the shared language between biology and silicon10:49 How neurons on a chip play Pong11:10 Topographic mapping inspired by the whisker barrel system13:10 Why the neurons hit the ball — and what happens when they miss14:33 The Free Energy Principle explained simply16:03 The trap door analogy for unpredictable stimulation18:42 How the structure of neuron cultures shapes performance19:19 Bees vs elephants: why bigger brains aren’t always better21:37 Growing hippocampal place cells in a dish24:12 Teaching neurons Morse code28:27 The Free Energy Principle — cups, predictions and surprise32:29 Where Brett disagrees with Friston37:03 The dog treat problem — how do you reward a neuron?39:40 Complexity as a hidden driver of intelligence41:53 His baby daughter’s obsession with fractals43:57 Defining agency — the three orders of information processing50:33 Change how you change over time53:27 Why scientists are incentivised to be vague instead of wrong59:42 J.D. Bernal’s 1929 vision for brains beyond bodies1:02:38 Standing on the shoulders of iPSC pioneers1:03:14 Can neurons play chess? Moravec’s Paradox1:04:12 No AI can walk into your kitchen and make tea1:05:16 Augmenting what silicon is bad at1:06:35 Is general intelligence even possible for silicon?1:09:40 Why 200,000 neurons beat 800,0001:11:16 Complexity and structure matter more than scale1:11:58 Could biological neurons end up in your laptop?1:13:36 Edge robotics and the future of biological computing...Email for sponsorship enquiries: [email protected]

Do you really inner speak? Join my Skool community and find out: https://www.skool.com/the-giants-shoulder-6526/aboutCharles Fernyhough is the world's leading Inner Speech Researcher, Cambridge-trained Psychologist, and author of *The Voices Within*. His three decades of research have uncovered something most people never suspect: the voice in your head isn't a monologue — it's a compressed conversation between internalised versions of everyone you've ever spoken to, and when that compression fails, you hear voices.Expect to learn why inner speech is a Swiss army knife you use against yourself as often as you use it to plan your day, what "thinking in pure meanings" actually feels like when language gets stripped away, why spontaneous inner speech lights up completely different brain regions than scientists expected, how the dialogic structure of your inner voice explains human creativity, why 1 in 7 fiction readers hear characters as vividly as a real person in the room, what experiential crossing is and why a reader walked into Starbucks as Mrs Dalloway, why prayer might just be a specific kind of inner speech, and much more…Timestamps: 00:00 Intro02:30 Inner Speech as a Swiss Army Knife05:39 Is Inner Speech the Same as Thinking?06:58 Why We Should Abolish the Word "Thinking"08:42 Chess Experts Don't Use Language to Think10:03 Evan's 10-Week DES Experiment with Hurlburt12:19 Condensed Inner Speech vs Unsymbolized Thinking17:11 What Brain Scans Actually Show About Inner Speech20:58 Spontaneous vs Elicited Speech Light Up Different Areas25:16 Does It Matter How Much Inner Speech You Have?30:02 When Inner Speech Becomes a Weapon Against Yourself32:41 Are People Without Inner Speech NPCs?36:02 It's Not How Much You Speak — It's What You Say38:44 Why People Refuse to Believe Others Think Differently42:26 Neurodiversity and the Inner Speech Revolution44:35 The Dialogical Inner Speech Model Explained49:55 Multiple Identities Inside Your Inner Dialogue52:00 Prayer as Inner Speech with a Spiritual Being54:20 Hearing Voices Without Being Mentally Ill57:17 1 in 7 Readers Hear Characters Like Real People58:34 Experiential Crossing — Walking Into Starbucks as Mrs Dalloway59:48 Do Writers Actually Hear Their Characters?1:01:57 Predictive Processing and Fictional Selves1:04:20 Why Children Create Imaginary Companions...Email for sponsorship enquiries: [email protected]

Do you really inner speak? Join my Skool community and find out: https://www.skool.com/the-giants-shoulder-6526/aboutBen Alderson-Day is a hallucination researcher, Professor of Psychology at Durham, and author of the award-winning book *Presence*. His work reveals that the line between your inner voice, hearing voices, and deliberately creating a mind inside your own head is far thinner than anyone assumed.Expect to learn why not as many people truly inner speak as you might think, how your parents' voices became the voice in your head, why writers hear their characters talk back, what tulpamancers are and how they build autonomous minds, what really separates inner speech from hallucination, what Evan's LSD experience revealed about the voice in his head, and much more…Timestamps: 00:00 Intro03:20 What everyone should know about their inner speech05:39 Is my inner speech really me?07:30 Why some people have no inner speech at all11:13 How your parents' voices became the voice in your head13:34 The age your brain learns to think in words15:25 What 10 weeks of sampling your own mind reveals18:13 Peep Show and why we think thinking means talking21:04 What Evan's inner experience was actually like23:00 The field was written by people who talk to themselves25:32 Why people refuse to believe other minds work differently28:39 Why you get furious when a character's voice is wrong in a film34:22 Reader Bank — find out what type of reader you are37:53 Can you train yourself to have richer inner speech?40:20 Writers who hear their characters speak42:27 What is a tulpamancer and how did this start?45:36 How to create a sentient being in your own mind50:20 "This sounds like you're channelling psychosis"52:45 "It's just like hearing a voice in the room"55:50 The time Evan didn't recognise his own voice on LSD58:31 Would a hallucination researcher ever try tulpamancy?...Email for sponsorship enquiries: [email protected] mentioned:Russell Hurlburt (Round 1): https://youtu.be/j0gKl-g3DNgRussell Hurlburt (Round 2): https://youtu.be/N9tO1OLdJtoGualtiero Piccinini: https://www.youtube.com/watch?v=YIkDIPLIuRg

Get A Full Breakdown Of Your Own Conscious Inner Experience (100% Free): https://www.skool.com/the-giants-shoulder-6526/aboutMatthias Michel is an MIT philosopher and co-founder of the MIT Consciousness Club who has developed one of the most provocative theories of consciousness in recent years: Perceptual Reality Monitoring. He argues your brain runs a constant reality check on every signal it receives — deciding what's real and what's noise — and that this mechanism IS consciousness.Expect to learn how your brain tells the difference between perception, memory, imagination and noise, why conscious vision lags 400 milliseconds behind reality, why every fast action you've ever taken was driven entirely unconsciously, why fish probably have no conscious visual experience at all, how aphantasics may have mental imagery they can't consciously access, why conscious mental imagery might actually be a bug in the system, what blindsight patient GY's experience reveals about unconscious vision, and much more…Timestamps: 0:00 Matthias Michel — What Is Perceptual Reality Monitoring?2:58 How does the brain tell reality from imagination?5:30 Snake fear in Malaysia: when prediction systems misfire6:22 Blood vessel shadows and the stuff your brain erases7:50 Motion-induced blindness: your brain deleting real objects9:50 Is schizophrenia a broken reality monitor?11:02 Where does reality monitoring happen in the brain?12:53 Can you be conscious without a frontal cortex?15:49 Mark Solms and brainstem consciousness18:15 What does it mean to see without conscious vision?18:40 "Tell me what it's like to see behind your head" — blindsight patient GY20:48 Do fish have conscious vision?22:05 Why conscious vision is 350-400ms too slow for action24:07 Two visual systems: one conscious, one not25:30 The hollow face illusion fools your eyes but not your hand26:21 Binocular rivalry: your eyes know things you don't29:24 Sensory horizons: why water limits conscious vision33:17 Could coral reef fish or octopuses be the exception?37:31 Are fish complete zombies? (60% confidence)39:18 Should we still protect fish even if they're unconscious?42:47 Aphantasia through the lens of reality monitoring46:00 Why conscious imagery might be a "bug"48:06 Blank access: using imagery without experiencing it50:17 What is an unconscious visual representation?55:54 The strongest counterevidence to unconscious imagery58:50 Pupil dilation and Joel Pearson's results1:01:18 How do we falsify unconscious imagery?1:04:30 The PRM explanation for aphantasia: threshold differences1:07:50 The future of consciousness and aphantasia research1:10:29 Vividness is multidimensional — lessons from Russell Hurlburt1:13:35 Brain imaging limitations and the next breakthrough...Email for sponsorship enquiries: [email protected] GS Episodes MentionedMark Solms — https://youtu.be/nMWaQ1U6dccAdam Zeman — https://youtu.be/SgA2up6-BokRussell Hurlburt (R1) — https://youtu.be/j0gKl-g3DNgRussell Hurlburt (R2) — https://youtu.be/TfSuvAJB3JUMerlin Monzel — https://www.youtube.com/watch?v=g21AqnSV1X4Joel Pearson — https://www.youtube.com/watch?v=_I_7HrWYMQ0Alfredo Spagna - https://www.youtube.com/watch?v=k8SBHefDnEk

Dr. Alfredo Spagna is a Cognitive Neuroscientist at Columbia University who discovered the Fusiform Imagery Node — the brain region that activates every time you imagine anything. But when he scanned people with aphantasia using an ultra-high-field 7T brain scanner, the node was firing perfectly — it just wasn't connected to the frontal lobe, suggesting that consciousness itself might depend not on what your brain computes, but on what it connects.Expect to learn how imagination hijacks the brain's perceptual system, why aphantasia shattered 40 years of assumptions about mental imagery, what the "visualizer fallacy" is and why it affects everything from therapy to education, how a painter with aphantasia creates art without ever seeing it in his mind, why your brain imagining a lemon makes you salivate even though there's no lemon, what the 7T brain scanner revealed about the architecture of imagination, how aphantasia may support the Global Neuronal Workspace theory of consciousness, why Olympic athletes spend hours visualizing routines they never physically perform, and much more…Timestamps00:08 What Happens in the Brain When You Imagine01:02 Where Imagination and Perception Diverge03:44 Would Perfect Imagination Be Hallucination?05:49 Voluntary vs Involuntary Imagination06:50 Why Do People with Aphantasia Still Dream?07:33 What Is Aphantasia — The Discovery That Changed Everything09:30 The Dissociation That Frightened Scientists11:06 The Visualizer Fallacy12:01 How Aphantasics Solve Problems Without Images14:31 Evan's Sister Discovers Aphantasia at 3116:55 Could Imagery Be Unconscious in Aphantasia?18:19 The Architect Who Lost His Imagination21:11 Eric the Painter — Creating Art Without Seeing It24:51 The Inner Speech Fallacy and Neurodiversity29:02 "I Can't Visualize My Mom's Face"29:57 Why Aphantasia Breaks Psychotherapy33:06 Empathy, Conflict and How Inner Experience Shapes Society36:42 The Chemistry Exam Problem39:09 Is Hypervisualization Actually a Disadvantage?41:21 Imagination as a Double-Edged Sword43:37 What Is the Fusiform Imagery Node?46:10 The Cafeteria Conversation That Started It All50:07 Three Bombshells From One Meta-Analysis52:23 Domain-General vs Domain-Specific Imagination54:05 The Brain Still Imagines in Aphantasia — It Just Disconnects56:36 Is Aphantasia a Disconnection Syndrome?58:59 Step-By-Step: What Your Brain Does When You Imagine an Apple1:05:05 Non-Visual Imagination — Taste, Touch, Sound1:09:38 What Aphantasia Reveals About Consciousness1:13:26 Does This Support IIT or Global Workspace Theory?1:15:49 Can Aphantasia Be Trained Away?1:18:53 The Olympic Skier Who Visualized Gold1:22:25 $10 Billion to Solve Imagination — Where Would You Spend It?...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Bryan L. Roth is a drug receptor scientist who solved the crystal structure of LSD inside a serotonin receptor and took $26.9 million from DARPA to build a non-hallucinogenic psychedelic — a compound that hits the same receptor as psilocybin, produces antidepressant effects in mice, and doesn't cause a trip.Expect to learn how his mother's schizophrenia launched a 40-year career in pharmacology, why Salvia divinorum has zero serotonin activity and works entirely through the kappa opioid receptor, why serotonin and opioid receptors converge in the claustrum, why DARPA funded non-hallucinogenic alternatives for soldiers, how his lab screens a trillion compounds that don't physically exist, why only 100 of 26,000 protein targets have ever been drugged, and much more…Timestamps: 00:00 Bryan L. Roth — The Man Who Builds Non-Hallucinogenic Psychedelics02:41 Falling Into Receptor Science by Accident04:58 When Only 5 People on Earth Studied Psychedelic Receptors06:07 Why "Psychedelic" Was Banned From Research Grants07:28 The 2016 Papers That Changed Everything08:26 The Scientist Friend Who Got "Cured" by Psilocybin10:41 The Vietnam Vet With a Gun in His Mouth — Ibogaine's Power12:50 What Is Ibogaine and Why Can It Kill You?18:06 Why the Kappa Opioid System Breaks Reality19:07 The Hidden History of Psychotomimetic Opioids22:16 Why Opioid Researchers Deny Kappa Causes Hallucinations23:18 The Claustrum: Where Serotonin and Opioid Receptors Meet24:14 Multiple Entry Points Into Reality-Altering Brain Systems28:35 Why Psychedelic Experiences Feel So Meaningful29:58 DMT: "More Real Than Reality" — And Nobody Knows Why31:28 Salvia: Becoming Plaid on a Wall33:48 Trump's $50M Psychedelic Order Won't Buy One Clinical Trial35:33 No Other Psychedelic Touches the Kappa Receptor38:10 The Real Reason He Built a Non-Hallucinogenic Psychedelic41:33 DARPA: More Psychiatric Casualties Than Physical in the Military44:48 Biased Agonism: Stripping the Trip From the Therapy47:19 How GPCRs Work and Why Drug Design Is Still Trial and Error49:50 People Who Will Never Touch a Psychedelic But Do Cocaine Weekly52:27 "I Don't Discuss That" — Whether He's Taken Psychedelics52:47 Screening a Trillion Drugs That Don't Exist55:02 The Real Bottleneck: 26,000 Targets, Only 100 Drugged...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Andrés Gómez Emilsson runs research at the Qualia Research Institute and thinks consciousness has a literal mathematical shape. We walk through the six geometric levels of DMT, why phenomenal space goes hyperbolic at high doses, why bad trips are competing symmetries fighting for territory in your visual field, and why he thinks AI on silicon will never be conscious.Expect to learn why pleasure is symmetry, what makes DMT phenomenologically alien at the topological level, why your breath being out of phase with your heartbeat might be most of what anxiety is, where the free energy principle stops being a theory of consciousness, and why a swimming pool full of logic gates breaks every computational theory of the mind.Timestamps00:00 The 6 Geometric Levels of DMT 02:30 Can Subjective Experience Be Studied Like Physics?03:58 Mapping Experience as a Hypergraph09:33 Introducing the Symmetry Theory of Valence12:19 What Symmetry Actually Is (And Why Physics Cares)19:21 Why Energetic Blockages Feel Bad — Yoga, Jhanas and Wave Propagation23:06 Is Pleasure Necessarily Symmetrical?26:31 The Annealing Metaphor: Healing a Broken Cymbal29:18 Symmetries in the World vs Symmetries in the Brain32:54 The Bucket Brigade: Why Coupled Oscillators Have to Be in Phase36:27 Where the Free Energy Principle Stops Being a Theory of Consciousness39:33 Marr's Levels: Why Friston Describes But Doesn't Explain42:12 What's Actually Symmetric in the Brain? (Thalamus and Biorhythms)47:52 Anxiety as Hyperpressurisation50:13 Connectome Harmonics and the Brain as a Musical Instrument52:18 The Six Levels of DMT — Threshold, Symmetry Hotel, Magic Eye55:06 The Magic Eye Level Explained57:31 Crystal Worlds and the Waiting Room59:48 The Breakthrough: When Topology Itself Changes01:01:43 Why Bad Trips Are Competing Symmetries, Not Missing Ones01:04:35 Square vs Hexagon Universes Fighting for Territory01:05:54 The LSD Christianity Example01:07:32 Andrew Gallimore's Alien Worlds — Pre-Configured Reality?01:09:04 Beam Splitter Holography and the Brain as a Non-Linear Optical Computer01:10:21 Why DMT Feels So Real — Cross-Modal Coherence and the Tactile Field01:12:48 The Coupling Kernel and Opposite-Phase Oscillators01:13:53 DMT Archetypes and the Specificity of Encounters...🔗 GS Episodes ReferencedAndrew Gallimore (DMT, alien worlds): https://www.youtube.com/@thegiantsshoulder/search?query=GallimoreElizabeth Margulis (music neuroscience): https://www.youtube.com/@thegiantsshoulder/search?query=MargulisMark Solms (homeostatic theory of valence): https://www.youtube.com/@thegiantsshoulder/search?query=Solms 🔗 Andrés Gómez EmilssonQualia Research Institute: https://qri.orgQualia Computing (blog): https://qualiacomputing.comSubstack: https://andrsgmezemilsson.substack.comEmail for sponsorship enquiries: [email protected]

Andrew Gallimore is a neurobiologist, pharmacologist and chemist who developed the DMTx protocol — a technology that extends the most intense psychedelic experience known to science from minutes to hours. He is the author of Alien Information Theory, Reality Switch Technologies and Death by Astonishment, and is Director of Noonautics, a nonprofit dedicated to the scientific exploration of consciousness. He currently lives and works in Tokyo.Expect to learn why your brain builds alien worlds on DMT, what thalamocortical loops and attractor states actually are, why DMT may have once been an ancient neurotransmitter, why 94% of users encounter non-human entities, what Jungian archetypes can and can't explain about DMT, where Andrew disagrees with Robin Carhart-Harris on the reality of entities, what the DMTx extended state protocol is and how it works, why DMT is the only psychedelic that doesn't produce tolerance, what happens when entities deny you access to the DMT world, what darkness retreats and breathwork have to do with endogenous DMT, and much more...Timestamps:0:00 Trailer2:11 What Is the Building Alien Worlds Thesis?4:06 What Makes DMT Unique Among Psychedelics?6:57 World Space Landscape and Consensus Reality8:11 DMT Entities — Prevalence and Types11:04 Consistency of Entity Interactions13:31 Is the DMT World Real or a Hallucination?17:34 Thalamocortical Loops and World-Model Construction20:34 Attractor States Explained24:21 Why DMT’s Stability Suggests an Evolutionary Role27:25 Parallel Lives — The DMT Sleep Cycle Hypothesis28:36 What Was the Evolutionary Purpose of the DMT World?33:35 Melatonin, Serotonin and DMT — Pharmacological Cousins35:57 Is DMT Still Doing Something Important in the Brain?36:36 Noonautics and Endogenous DMT Research38:43 Debunking DMT Breathwork Courses and Pineal Myths40:45 What Does a Stable Pattern of Brain Activity Actually Look Like?43:53 Order Within Chaos — Chris Timmermann’s DMTx Findings47:16 Robin Carhart-Harris and the Jungian Archetype Debate48:37 What Jungian Archetypes Actually Are53:36 Why Archetypes Can’t Explain Alien Entities54:32 The Directed World Model — Do Entities Control Access?56:55 DMT Lockout — When Entities Deny You Entry58:30 Can You See Entities in Brain Scans?1:00:06 Future Brain Scanning Technology1:01:24 The Speed of the Switch as Evidence1:04:40 Dimensionality and Topology of the DMT World1:06:39 DMTx — What Is the Extended State Protocol?1:09:03 Target-Controlled Intravenous Infusion Explained1:11:23 Sending Specialists Into DMT Space1:13:35 Time Perception on DMT1:16:16 Surprises from DMTx Experiments1:18:15 The Future of DMT Consciousness Research1:19:12 Andrés Gómez Emilsson and the Mathematics of DMT Space...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Dr. Matt Hill is one of the world’s leading cannabis neuroscientists, former president of the International Cannabinoid Research Society, and a researcher with over 21,000 citations studying how the endocannabinoid system regulates the brain and body.Cannabis affects different people in completely opposite ways — calming one person while causing crippling anxiety in another — and Hill explains why the biology makes this inevitable, why both sides of the cannabis debate are getting it wrong, and why legalisation in Canada accidentally destroyed the very research that could have answered our biggest questions.Expect to learn why CB1 is the most widely distributed receptor in the brain yet almost nobody has heard of it, how endocannabinoids work backwards across the synapse unlike any other signalling system, why low-dose THC calms the amygdala but high-dose THC causes paranoia and anxiety, why women get higher than men on the same dose of cannabis due to a liver enzyme difference, why only a third of people genuinely benefit from medical cannabis while a third get nothing, how cannabis triggers schizophrenia in genetically vulnerable people without actually causing the disease, why Canadian legalisation killed cannabis clinical trials through a bureaucratic GMP-versus-GPP standoff, what the real cardiovascular risks of chronic cannabis use are, why cannabis users paradoxically have lower obesity rates, and much more…Timestamps: 00:00 Trailer02:00 Dr. Matt Hill — Cannabis Neuroscientist02:25 The Endocannabinoid System: Your Body’s Own Cannabis04:23 Every Biological Function It Controls06:30 The Most Distributed Receptor Nobody’s Heard Of07:20 Why Cannabis Science Is So Politically Toxic09:35 Both Sides Are Wrong: The Three Blind Men Problem10:23 The Frustrating Polarity of the Cannabis Debate12:37 Your Personal Experience Doesn’t Generalise16:25 Why Cannabis Feels Like a Different Drug for Different People17:52 Retrograde Signalling: How Cannabis Works Backwards20:08 Low Dose Calms, High Dose Causes Paranoia — Here’s Why22:24 Women Produce More 11-Hydroxy-THC Than Men25:52 Why Receptor Distribution Makes Cannabis Unpredictable27:11 The PET Scan Problem: Why We Can’t Map Your Receptors29:04 Why Cannabis Companies Don’t Fund Real Research31:25 How Legalisation Accidentally Killed Cannabis Science34:46 The GMP vs GPP Bureaucratic Disaster38:09 David Nutt: Drug Policy Driven by Politics Not Science43:01 Why You Can’t Standardise Cannabis Dosing Like Alcohol49:44 The Three Thirds Rule: Benefit, Side Effects, or Nothing53:05 The Best Evidence: Where Cannabis Actually Works53:36 Schizophrenia Risk — It’s a Trigger, Not a Cause55:52 Cardiovascular Risk: The Under-Discussed Real Danger57:02 Does Exercise Cancel Out Cannabis Heart Risk?58:14 The Obesity Paradox: Why Cannabis Users Are Thinner01:01:03 Chronic Pain, MS, Epilepsy and PTSD — The Medical Evidence01:03:18 Final Thoughts and a Plea for Billionaire Stoners...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderDr. Elizabeth Margulis is a professor of music cognition at Princeton University and author of Transported: The Everyday Magic of Musical Daydreams.When strangers listen to the same unfamiliar music, they independently imagine the same vivid stories — down to specific words like "frolic" and "pirates." This may be one of the most surprising findings in modern cognitive science, and it challenges everything we assume about the privacy of our own thoughts.Expect to learn why strangers imagine the same stories when listening to identical music, how a cross-cultural experiment between the US and rural China revealed completely different imagined worlds to the same sounds, how repeated speech spontaneously transforms into song, the surprising link between psychedelic therapy and modern music therapy, why the Mozart Effect misled state legislatures, what makes certain songs irresistibly groovy, and much more…Timestamps: 00:00 Intro02:45 From Concert Pianist to Cognitive Scientist06:27 What Does a Brain Look Like Listening to Music?09:04 How Musical Processing Differs from Speech10:53 The Irresistible Urge to Dance16:18 Can Animals Keep a Beat? The Snowball Experiment23:42 Why Repetition Changes How You Feel About Music26:31 The Speech-to-Song Illusion32:05 Is Music Evolutionary? The Case for Social Bonding36:36 Psychedelics and Music: What's Really Driving the Healing?42:28 The Mozart Effect Myth47:42 How to Raise a Musical Prodigy49:25 Musical Daydreams: Why Strangers Imagine the Same Stories53:11 The China Experiment: Same Music, Different Stories1:06:57 Psychedelic Hallucinations and Musical Archetypes1:16:17 Can Music Teach Us About Consciousness?...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderTim Maudlin is a philosopher of physics at NYU and founder of the John Bell Institute for the Foundations of Physics. In 1989 he published a paper proving that consciousness cannot arise from computation — thirty-five years before the world started panicking about whether ChatGPT can think.Expect to learn why no computer programme will ever be sufficient for consciousness, why large language models operate nothing like human brains, the critical difference between intelligence and consciousness that the AI industry keeps collapsing, why Penrose's arguments about consciousness are wrong, why quantum mechanics has nothing to do with the mind, why the mind-body problem may be the most intractable problem in all of science, and much more…Timestamps:00:00 Why Consciousness Is Not Computable02:35 Maudlin's 1989 Paper: Computation and Consciousness06:01 The Thought Experiment: Beer Cans, Windmills and Conscious Machines08:11 Why Running a Programme Can't Be Enough for Consciousness10:36 Counterfactuals: What the Machine Would Have Done13:56 The Cog and Wheel Machine: Stripping It Down16:18 The Strange Anaesthesia: Jamming the Gears19:10 Why Computational Structure Is the Wrong Level20:08 Is This For or Against Computationalism?23:01 The 2026 AI Consciousness Debate25:06 Why the Turing Test Is Trivially Defeatable27:00 Neural Nets Are Nothing Like Brains29:12 Why the Brain Is Far More Than Neurons31:01 HAL 9000 and How Children Actually Learn33:27 The Car Wash Question That Breaks ChatGPT35:18 Defining Intelligence and Consciousness37:53 Twin Earth: Why Definitions Don't Work the Way You Think43:06 Locked-In Syndrome and the Lobster Problem47:08 Computation Can't Explain Pain Either48:01 Intelligence vs Consciousness: Why You Must Separate Them50:45 Can Anything Be Intelligent Without Being Conscious?53:09 Is the Turing Machine Argument About Intelligence Too?54:04 What Does Memory Actually Mean?57:00 Can Mathematics Capture the Structure of Qualia?01:00:02 Scott Aaronson's Demolition of Integrated Information Theory01:03:26 Why Formalising Consciousness Is a Fetishisation of Maths01:09:00 Why There Is No Simple State Space for Vision01:13:22 Does Quantum Mechanics Explain Consciousness?01:18:25 The Problem with Penrose and Hameroff's Microtubule Theory01:21:31 How Do We Actually Make Progress on Consciousness?01:24:45 Does the Body Matter or Is It All in the Brain?01:27:00 The Mysterian View: Why the Mind-Body Problem May Be Unsolvable01:29:47 Could Someone Invent a New Explanatory Framework?01:31:13 Why Pain Hurts: The Evolutionary Story01:33:12 What Newton Would Think of General Relativity...Email for sponsorship enquiries: [[email protected]](mailto:[email protected])❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderDr. György Buzsáki is one of the world’s most influential neuroscientists and the author of The Brain from Inside Out — a radical rethinking of how the brain generates perception, memory, and consciousness.We’ve been asking the wrong questions about the mind. Memory isn’t storage. Perception isn’t passive. Time and space aren’t sensed — they’re constructed. And the rhythms of our own bodies may be the hidden scaffolding behind everything we think, feel, and remember.Expect to learn why the brain doesn’t record the world but predicts it, how neural rhythms act like syntax to structure our thoughts, why time is not an input but a product of the brain’s internal cycles, how space and memory emerge from the same temporal code, why consciousness might just be a performance built from nested oscillations, what happens when brain–body rhythms fall out of sync, how we can think about memory as musical replay not archival storage, how rhythm breakdown may underlie mental disorders, and much more…Timestamps: 00:00 Intro01:22 The Evolution of Neuroscience Techniques05:13 Understanding Feedforward Inhibition08:13 The Paradigm Shift in Brain Function12:07 The Role of Rhythms in Prediction14:28 Overcoming Technological Barriers in Research16:45 Mapping the Hippocampus and Microcircuitry25:30 The Complexity of Brain Connectivity26:24 The Future of Connectomics34:36 The Inside Out Brain: A New Framework42:28 The Brain's Survival Mechanism45:00 Local and Global Brain Interactions48:47 Evolution of Brain Complexity52:56 Inside-Out Thinking in Neuroscience59:32 The Importance of Body Rhythms01:17:42 The Interconnectedness of Mind and Body01:26:43 Understanding Brain Dynamics in Psychiatric Disorders01:29:04 The Future of Diagnosing Mental Health Conditions01:32:56 The Role of Technology in Neuroscience01:35:47 Exploring the Nature of Memory02:06:25 Consciousness and Its Complexities...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Upgrade Your Shaving Experience With Henson (100 FREE BLADES): https://hensonshaving.com/thegiantsshoulderDr Wendy Suzuki is a Neuroscientist and Professor at New York University whose lab was the first to capture neurons firing as new memories are born. Her TED talk has over 65 million views, and she's the author of Good Anxiety and Healthy Brain, Happy Life.The hippocampus isn't just where memories are stored — it's the structure that builds your internal model of reality, imagines futures you've never lived, and may be the engine that constructs your sense of self.Expect to learn how place cells and grid cells map your world inside your skull, why people without a hippocampus can't imagine a tropical beach, how memories become models and models become selves, what the default mode network reveals about consciousness, how exercise physically grows new brain cells even into your 90s, why the boundary between memory and imagination is far blurrier than you think, and much more…Timestamps: 04:31 The Hippocampus: The Brain Structure That Makes You You07:01 Patient H.M.: The Most Famous Brain Surgery in History11:28 Place Cells, Grid Cells, and the Nobel Prize for Mapping Reality17:18 The Patients Who Can't Imagine a Tropical Beach20:41 Is Memory Just a Type of Imagination?24:44 Aphantasia: The People With No Mind's Eye28:55 The People Who Can't Forget Anything36:39 Reconsolidation: Why Remembering Makes Memories Vulnerable42:46 Marian Diamond and the Discovery of Brain Plasticity46:53 Autocatalytic Closure: How Memories Become Ideas51:44 Time Cells: How Your Brain Tracks "When"55:42 What the Hippocampus Does While You Sleep59:34 The All-Nighter Experiment: From A Grades to F Grades01:03:47 Does the Brain Replay Emotions During Sleep?01:07:01 The Amygdala, Fear Conditioning, and Joy Conditioning01:13:13 What Is Consciousness and Does the Hippocampus Create It?01:14:38 Clive Wearing: New Consciousness Every Seven Seconds01:19:30 The Dream Experiment and Optimizing Your Brain for Life...

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeDr. David E. Nichols is a pharmacologist, medicinal chemist, and widely regarded as the greatest living psychedelic scientist. He personally synthesized the psilocybin, MDMA, and DMT used in the most landmark psychedelic studies ever conducted — and founded the institute that funded most of them. He is 81 years old, has published nearly 300 scientific papers, and there is no one alive who can replace him.Expect to learn how he made a kilogram of MDMA for $4,000 and changed the course of psychiatry, what his first LSD trip revealed about the function of the universe, why psilocybin may be the most effective depression treatment we have, how his research was stolen and turned into street drugs that killed people, why the DMT pineal gland theory is scientifically impossible, whether consciousness lives in the brain at all, and much more…Timestamps:00:00 The Greatest Living Psychedelic Chemist05:09 Making MDMA for $4,000 and Changing Psychiatry08:25 How Do You Explain a Kilo of MDMA to Your University?10:50 What Was Known About MDMA in the 1980s?12:06 The LSD Trip That Showed Him the Function of the Universe14:52 A Psychedelic Healed His Relationship With His Abusive Father19:26 MDMA, PTSD, and a New Paradigm in Healing21:17 Psilocybin for Alcohol Addiction: The Stories That Changed Everything24:30 Why Is Psychedelic Research Still So Painfully Slow?30:05 Big Alcohol, Big Pharma, and the Economics of Prohibition33:24 The Paradigm Shift Happening in Real Time39:35 What Psychedelics Actually Do to Your Perception of Life42:06 Music and Psychedelics: Why Lyrics Can Ruin a Trip44:56 Can You Separate Real Insight From Hallucination?46:19 Is Consciousness in the Brain at All? The Transducer Theory52:36 His Wife's Paranormal Prediction of Her Father's Death55:56 Eating Disorders, OCD, and the Untapped Frontier59:25 Why Psychedelics Work Like Rebooting Your Computer01:00:08 The Bureaucratic Nightmare of Studying Schedule I Drugs01:06:11 The MDMA Analogue Nobody Will Fund01:08:16 A Plea to Billionaires: Fund Psychedelic Research01:09:32 Structure Activity Relationships: Sculpting Molecules to Fit Receptors01:12:07 AlphaFold, AI, and the Future of Drug Discovery01:14:36 The Golden Question: What Happens After a Drug Binds?01:17:39 DMT and the Pineal Gland: Debunking the Myth01:21:21 Is There Any Evidence DMT Is Released at Death?01:22:33 DMT Transfusions and Machine Elves01:26:09 What Excites Him About the Future of Psychedelics01:28:19 The Legacy of the Greatest Psychedelic Chemist Alive...Email for sponsorship enquiries: [[email protected]](mailto:[email protected])❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqeDr Robin Carhart-Harris is the world's leading psychedelic researcher, founder of the first Centre for Psychedelic Research at Imperial College London, and the scientist who put the first person on LSD inside a brain scanner in over 40 years.His Entropic Brain Hypothesis proposes that consciousness exists on a spectrum from order to chaos — and that psychedelics work by dissolving the brain's confidence in its own model of reality. His landmark trial in the New England Journal of Medicine showed two doses of psilocybin matched six weeks of antidepressants for depression.Expect to learn why psychedelics don't activate the brain but scramble it, what the entropic brain hypothesis actually means and why entropy may be the best biomarker for consciousness, how the default mode network holds your ego together and what happens when psychedelics melt it, the difference between DMT entity encounters and 5-MeO-DMT ego obliteration, why Robin thinks we could still get psychedelic medicine catastrophically wrong, and much more…Timestamps:00:00 Introduction to Dr. Robin Carhart-Harris03:01 The Journey into Psychedelics06:10 First Brain Scans with Psychedelics12:06 Understanding Brain Activity and Psychedelics17:49 The Entropic Brain Theory24:02 Consciousness and Brain Entropy30:10 Decoding Conscious Experience40:49 Exploring the Entropic Brain Model45:24 The Limits of Consciousness and Ego50:11 Psychedelics and Evolutionary Perspectives53:31 Shared Psychedelic Experiences and Archetypes01:00:06 The Nature of Hallucinations and Collective Unconscious01:04:34 Entropy, Connectivity, and Brain Function01:17:02 The Role of Serotonin Receptors in Psychedelic Experiences01:20:46 The Mechanisms of Psychedelics01:30:18 Cultural Perspectives on Psychedelics01:39:13 Psychedelics and Self-Understanding01:48:36 Cross-Cultural Studies in Psychedelic Research01:53:25 The Future of Psychedelics in Mental Health...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Peter Brannen is an award-winning science journalist and the author of The Story of CO₂ Is the Story of Everything — a mind-bending journey through deep time that reveals how a single molecule shaped life, climate, intelligence, and mass extinction.Carbon dioxide isn’t just a climate statistic. It’s the raw material of all biology, the original building block of your brain, and the molecule that has repeatedly rebooted life on Earth. Understanding it means rethinking everything from the origin of life to the future of civilization.Expect to learn how CO₂ helped spark the first cells at the bottom of ancient oceans, why hydrothermal vents may hold the key to alien life, how volcanoes rewrote evolution, the truth about the most catastrophic extinction in Earth’s history, how CO₂ shaped your metabolism, brain and the rise of humans, why mass extinctions can reboot evolution, why today’s climate experiment is unlike anything in the fossil record, why the planet has a natural thermostat — and how we’re breaking it, why life might be a universal process of energy dissipation, how the story of Earth challenges our ideas of uniqueness, and much moreTimestamps: 02:14 How CO₂ Became the Most Misunderstood Molecule on Earth07:31 Life as a Carbon-Fueled Energy Dissipation Machine12:45 The Origins of Life and the Vents That May Have Sparked It19:08 Why Mass Extinctions Keep Rewriting Life’s Blueprint26:27 CO₂ as Climate Stabilizer — Until It Isn’t35:40 What the Permian Extinction Tells Us About the Future42:55 Deep Time and the Psychology of Geological Thinking49:18 Why the Anthropocene Might Be a Cosmic Joke55:36 How Life Changes the Planet — And Gets Changed in Return01:04:02 The Story of CO₂ as the Story of Everything01:10:15 Is Earth’s Climate Crisis a Rehearsal of Past Catastrophes?01:15:49 Carbon, Consciousness, and Why We’re Here to Begin With01:22:06 What Would a Geologist See If They Dug Up 2024?01:27:31 Hope, Humility, and What Deep Time Teaches Us...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/