The Harry Glorikian Show
by Harry Glorikian
At The Harry Glorikian Show, I, Harry Glorikian, am your host. In short, I have talks with leaders in the healthcare & life sciences industry about the ongoing data-driven transformation of their industry.From new ways to diagnose & treat patients, bring down costs & creating new value, all the way to AI algorithms that increase efficiency & accuracy, better data is revolutionizing healthcare.I turn to doctors, hospital administrators, IT directors, entrepreneurs, & others for help mapping out the changes & their impact on everyone from patients to researchers.Welcome to the show!
Episodes
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Butterfly Network's Next Chip: Joe DeVivo Returns on AI, Ultrasound & the Path from Prototype to Product
Three years after his first appearance, Butterfly Network CEO Joe DeVivo returns to catch Harry up on the roadmap. Butterfly's ultrasound-on-a-chip has evolved from a single handheld device into a foundational semiconductor platform that third parties can build on. The most dramatic example:...
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Dr. David Albert and The AI Revolution in Cardiology
🎙️ In this episode, we discuss: 00:00 The Journey of an Innovator 06:27 The Birth of a Smartphone ECG 11:29 Overcoming Resistance in Digital Health 16:20 The Evolution of ECG Technology 23:43 The Importance of Early Detection in Cardiac Care 26:20 Innovations in 12-Lead ECG Technology 29:00 AI…
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Kyle Kiser is Using AI to Make Your Patient Experience Better
🎙️ In this episode, we discuss: 00:00 The Origin Story of Arrive Health 06:04 Rebranding and Evolving Mission 11:50 Real-Time Patient-Specific Drug Costs 18:08 Tackling Prior Authorization Challenges 22:56 Leveraging AI for Healthcare Efficiency 25:36 Understanding Scale and Impact 28:04...
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Making better real-time clinical decisions with AI
🎙️ In this episode we discuss: 01:06 The founding story of Retina AI 03:56 Why ophthalmology is uniquely suited for AI solutions 06:27 Recent Series B funding and what it means for the company 08:31 How AI integrates into real-world clinical workflows 12:04 AI alerts and notifications for…
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Future of Ultrasound: Innovations Ahead
Chapters 00:00 Introduction and Company Updates 02:49 The Digital Transformation of Ultrasound Imaging 06:00 Advancements in Technology and Market Growth 09:03 AI Integration in Medical Imaging 14:50 Impact on Global Health and Humanitarian Efforts 20:55 Challenges in Mainstream Adoption of...
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Revolutionizing Cardiovascular Care with AI
00:00 Introduction and Overview of Caristo Diagnostics 09:08 The Technology Behind Carry Heart 18:00 Clinical Implications and Risk Assessment 27:27 Actionable Steps for Patients 30:34 Optimizing Cardiovascular Drug Dosing 32:31 AI in Cardiovascular Medicine 33:50 Leveraging Historical Data for...
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Al's Transformative Role in Pharma ConcertAl CEO Jeff Elton
In this episode of The Harry Glorikian Show, host Harry Glorikian welcomes back Jeff Elton, CEO of Concert AI, to discuss the latest advancements in AI-driven healthcare solutions. They reflect on the recent JP Morgan Healthcare Conference, highlighting the optimism surrounding AI's role in...
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Raffi Krikorian Says "We Don't Have Much Time Left" to Rein in AI
Harry's guest this week is Raffi Krikorian, chief technology officer and managing director at Emerson Collective, the social change organization founded by Laurene Powell Jobs. Krikorian is the former vice president of engineering at Twitter (now X), where he was responsible for getting rid of…
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How ActiveLoop Is Building the Back End for Generative AI
Generative AI is going to change how we do things across the entire economy, including the fields Harry covers on the show, namely healthcare delivery, drug discovery, and drug development. But we’re still just starting to figure out exactly how it’s going to change things. For example, AI is...
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How Caristo is Using AI to Reduce Heart Attack Risk
If you learned that radiologists looking at CT scans for the traditional signs of coronary artery disease catch only 20 percent of the people who actually have a high risk of a heart attack, and if you learned that there’s a new AI-based test that can catch subtle signs of inflammation in the…
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Why Deep Origin Is Betting on Both Physics and AI for Drug Discovery
Investors and companies in the life science industry have been betting a lot of money over the last few years on a single idea: that computation will help us get a lot better at developing new drugs. But the word “computation” covers a pretty broad range of techniques. And the reason that there…
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How ConcertAI Came to Lead in Cancer Data
If you look back at all the health-tech and drug development companies Harry has hosted on the show, an interesting pattern starts to emerge: a very large number of those companies have gone on to enormous growth and success in their markets. It could be that being on the podcast is like a…
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T Cell Engagers: The New Cancer Drug?
One of the most amazing successes in the battle against cancer over the last two decades has been the introduction of antibody drugs that harness the body’s own immune system to kill tumor cells. Finding those drugs may sound like a biology problem rather than a machine learning or a big-data...
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How Pangea Is Using AI to Find New CNS Drugs in Nature
The combination of better data and more powerful computing is helping researchers reinvent the process of discovering new drugs. Within 5-10 years, we’ll likely see a huge wave of new medicines that were either discovered or designed using AI—drugs that will finally help us get control of our…
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AI and Microbiomes 101 with Jona
There are about 30 trillion human cells in your body, but there are about 38 trillion bacterial cells, mostly hanging out in your large intestine. And that’s not even counting all the viruses, fungi, protists, and other microbial cells that live on your skin, in your bloodstream, and all around...
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Modicus Prime Safeguards Drug Manufacturing
Quality control is one of those things that only a select few people pay attention to—until something goes wrong, then everyone cares. That's especially true in the drug manufacturing industry, where episodes like cross-contamination in a drug factory can shut down a production line and create...
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AI Isn't Magic, But It Can Save Lives, says HDAI's Nassib Chamoun
There’s a lot of talk out there about how artificial intelligence will change the way doctors and nurses take care of patients; you hear some of it right here on this show. But all of that still feels like a forecast rather than a present reality. When you look really closely, it’s hard to find...
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We Can All Live to 120...and Beyond
There’s a good chance that we’re all going to live a lot longer than we think. Or at least, that’s what Harry's guest Sergey Young argues in his book The Science and Technology of Growing Young. Young is an investor who leads a $100 million venture capital fund called the Longevity Vision Fund…
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Scott Penberthy & Google AI for Healthcare
It's practically the theme of our show that AI is going to change almost everything about the way drugs get developed and the way healthcare gets delivered. But there’s probably nobody better placed to see how this transformation is already happening than Harry's guest this week, Scott Penberthy....
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How to Build a Medtech Startup in High School
Building any kind of startup is hard. Starting a business in healthcare or medical technology is even more challenging, given the long timelines for product development and all the regulatory requirements companies have to meet. But imagine how much harder it would be to start a company if you…
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How exponential growth is changing the world
If you’re looking for help thinking about the implications of exponential change in all areas of technology, one of the best people you can turn to is Azeem Azhar. He's a writer, entrepreneur, and investor who publishes the incredibly popular and influential Substack newsletter Exponential View,...
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How to make Generative AI in Healthcare Safe, with Huma.ai's Lana Feng
It’s been less than a year since OpenAI opened up ChatGPT to the general public, and less than six months since OpenAI introduced GPT-4, the large language model that currently powers ChatGPT. But in that brief time, the new crop of generative AI tools from OpenAI and competitors like Google and...
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Handheld Ultrasound by Butterfly Network: Faster, Cheaper, Better
Harry's guest this week is Joe DeVivo, the new CEO of Butterfly Network. The company's goal is to make it radically easier for doctors or medical technicians to perform an ultrasound exam on any part of the body, and radically cheaper for a patient to get one. The companyt makes an FDA-cleared,...
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AHA: Ask Harry Anything!
This week Harry's guest is....Harry! We're flipping the script and giving Harry a chance to wax eloquent about AI in healthcare and drug research, the growing role of personal health monitoring devices, the unique features of the Boston life science ecosystem, the meaning of the recent downturn…
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Debunking large language models in healthcare with Isaac Kohane
Harry's guest this week is Dr. Isaac Kohane, chair of the Department of Biomedical Informatics at Harvard Medical School and co-author of the new book The AI Revolution in Medicine: GPT-4 and Beyond. Large language models such as GPT-4 are obviously starting to change industries like search,...
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Non-standard Amino Acids in the Development of New Medical Therapies
In the same way that written English is built around an alphabet of just 26 letters, all life on Earth is built around a standard set of just 20 amino acids, which are the building blocks of all proteins. And just as we've invented special characters like emoji to go beyond our standard letters…
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Dog Cancer Cure: Fidocure by Christina Kelly Lopes
Owning a dog can be a joy, but one sad downside is that dogs are highly prone to cancer—six million of them are diagnosed with the disease in the U.S. each year. Harry's guest this week, Christina Lopes, is co-founder and CEO of a company called One Health that's working to improve cancer…
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How Beacon Biosignals Brings Precision Medicine in Neurology to the Brain
Unlike cancer, brain diseases like epilepsy, Alzheimer’s disease, or depression don't tend to have easily measured biomarkers that could help doctors tailor treatments, or that could help researchers develop more effective drugs. So in neurology and psychiatry, the precision medicine revolution...
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Your Next Doctor is a Chatbot? Language Models, Google Researchers, & MedPaLM-2
Large language models are already changing the business of search. But now they’re about to change the practice of medicine. Harry's guests, Vivek Natarajan and Shek Azizi, are both researchers on the Health AI team at Google, where they're pushing the boundaries of what large language models can...
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Going Boldly into Biomanufacturing and Bioeconomy with Inscripta
Harry's guests this week are Sri Kosaraju, the CEO of Inscripta, and Richard Fox, a former Inscripta scientist who just rejoined the company as its SVP of Synthetic Biology. In reabsorbing Infinome—the Inscripta spinout Fox described to Harry in a spring 2021 episode of the show—Inscripta is...
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Drug Discovery with 1910 Genetics: Knowing Your Tools
Harry's guest this week, Jen Nwankwo, is the founder and CEO of a drug discovery company in Boston called 1910 Genetics. Her PhD is in pharmacology, which shows through in her practical focus on fixing the drug discovery process to get more and better therapies into the hands of doctors. To hear...
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Cry Me a Biomarker: Using Tears to Screen for Cancer
Tears are a signal of more than just our emotions. The liquid in tears comes from blood plasma, and contains a lot of the same proteins and other biomolecules that circulate in the bloodstream. But what this liquid doesn’t have are a lot of the extra components like antibodies that would get in…
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Insilico Brings Generative AI to Drug Development and Discovery
It may feel like generative AI technology suddenly burst onto the scene over the last year or two, with the appearance of text-to-image models like Dall-E and Stable Diffusion, or chatbots like ChatGPT that can churn out astonishingly convincing text thanks to the power of large language models....
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Raphael Townshend on The Power of Small Molecule Drugs
There have been a lot of stories in the news over the last few months about AI chatbots like ChatGPT that can respond to your questions with convincing and well-written answers. These so-called large language models can tell you how to build a treehouse, how to bake a cake, or how to sleep…
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How the Glaucomfleckens are Humanizing Medicine, One Laugh at a Time
The medical news publication STAT calls Will Flanary “the Internet’s funniest doctor.” The guests we bring on the show usually talk about how technology is changing healthcare, but Will and his wife Kristin are changing healthcare in a very different way—through comedy. A former standup comic who...
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Stephen Kingsmore's Quest to Test Every Baby with Genome Sequencing
There's a quiet revolution happening in the field of genetic screening of newborns. Within the last couple of years it’s become possible to sequence the entire genome of a newborn baby, all six billion base pairs of DNA, and diagnose potential genetic disorders in about 7 hours. That’s already...
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Arterys Medical Imaging Jumpstarts the AI Revolution in Radiology
Last October, medical imaging company Arterys announced that it had been acquired by healthcare AI giant Tempus. That caught our attention here at The Harry Glorikian Show, because back in the fall of 2018—exactly 100 episodes ago, as it turns out—we welcomed Arterys co-founder and CEO Fabien...
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Measuring brain activity - Ryan Field on the Harry Glorikian Show
You can wear an Oura ring or a WHOOP armband to tell you how your body is adapting to exercise. A continuous glucose monitor can send your phone information about your blood sugar levels are changing. And during the pandemic, a lot of people bought home pulse oximeters to monitor their blood...
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Grail's Josh Ofman on the Revolution of Cancer Screening
Out of all the dozens of types of cancer that occur in humans, we habitually screen for only five: breast, cervical, colon, prostate, and lung. But what if there were a single test that could detect 50 types of cancer, based on a simple blood draw? That's exactly what's possible today, thanks to...
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Carlos Ciller – AI Is The Window To The Soul At RetinAI
These days, there's an explosion of digital imaging technology for almost every part of the body. There are the familiar types of imaging everyone knows, like CT scans, MRIs, ultrasound, and of course, X-rays. But now doctors and medical researchers are also exploring newer types of digital…
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January's Noosheen Hashemi on Preventing Diabetes by Promoting Gut Health
There are many causes for diabetes—chronicallly high blood sugar—but there’s also a growing list of ways to prevent it, or manage it once it starts. Wearable technologies like continuous glucose monitors or CGMs are high on that list. These devices have tiny needles that penetrate the skin and...
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At Univfy, Mylene Yao Is Making IVF More Predictable and Affordable
About half a million babies are born every year through IVF. That number would probably be a lot higher if the procedure were cheaper and more accessible—but making that happen would mean transforming IVF from an artisanal craft into something more like a modern automated factory, with AI helping...
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Episode 100! Illumina's Phil Febbo on the New Era of Low-Cost Genome Sequencing
For the 100th episode of The Harry Glorikian Show, Harry welcomes Phil Febbo, chief medical officer at Illumina. The San Diego-based company is the leading maker of the high-speed gene sequencing machines that are at the core of the precision medicine revolution. The company has an 80 percent...
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David Sable is Still Working on Making IVF More Accessible
In 1978, Louise Joy Brown was celebrated as the world's first "test tube baby," born as the result of in vitro fertilization (IVF). Today, Brown is 44 years old, and what was a technological triumph in 1978 is almost routine today, with half a million babies born every through IVF. But Harry's...
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How H1 Is Networking the Healthcare World, with Ariel Katz
“LinkedIn meets ZoomInfo meets Zocdoc, but for doctors." That’s how H1 co-founder and CEO Ariel Katz describes the information service his company offers. It's a response to the fact that the healthcare is incredibly fragmented, with no central database or platform that everyone can use to share...
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Erwin Seinen Says the Paper Lab Notebook Is Finally Dying with eLabNext
If you walked into a typical life science research lab at a university or a biotech startup, you might be surprised to see how much paper is still laying around. A lot of researchers still keep records of their experiments and studies in paper notebooks—in fact, along with doctor’s offices, life...
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How Rune Labs Uses Data to Improve Prospects for Parkinson's Patients
Harry's guest this week, Brian Pepin, says there haven’t really been any advances in the treatment of Parkinson’s Disease in a decade. The standard treatment is still the standard treatment—meaning various drugs to replace dopamine in the brain, since the loss of neurons that produce dopamine is...
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Proscia Pushes Pathology Down the Digital Path
In most hospitals, the practice of radiology went digital years ago. Today you'll rarely find a radiologist examining a broken bone or a fluid-filled lung on a sheet of old-fashioned X-ray film. But pathology isn't as computerized. For a variety of cultural, technical, and regulatory reasons…
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Vibrent Health - the Catalyst for Mobile Healthcare
We use our smartphones to communicate, shop, navigate, watch videos, take pictures, share our lives on social media, track our exercise, and listen to music and podcasts. So why shouldn’t they also be the main interface to our healthcare experiences? That’s the question P.J. Jain started out with...
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Life Science Labs Can't Be Automated, But They Can Be Orchestrated
Wet labs at life science companies look and work the same pretty much everywhere. They're full of incubators, refrigerators, centrifuges, liquid handlers, gene sequencers, DNA and RNA synthesizers, and all sorts of other complex equipment. And a lot of these machines are automated—but the larger...
About this show
At The Harry Glorikian Show, I, Harry Glorikian, am your host. In short, I have talks with leaders in the healthcare & life sciences industry about the ongoing data-driven transformation of their industry.From new ways to diagnose & treat patients, bring down costs & creating new value, all the way to AI algorithms that increase efficiency & accuracy, better data is revolutionizing healthcare.I turn to doctors, hospital administrators, IT directors, entrepreneurs, & others for help mapping out the changes & their impact on everyone from patients to researchers.Welcome to the show!
Hosted by
Harry Glorikian
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