PODCAST · science
This Week in Virology
by Vincent Racaniello
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
Episodes
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TWiV 1365: Andes Virus Up Close
TWiV travels to Porto, Portugal for the annual meeting of the European Society for Clinical Virology, where he speaks with Catherine and Corinne about their work on the Andes virus outbreak on the MV Hondius. Host: Vincent Racaniello Guests: Catherine Houlihan and Corinne Guerts van Kessel...
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TWiV 1364: Clinical Update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss their continuing struggle to understand the ongoing outbreak of cyclospora, decimation of US public health including 30% or greater loss of personnel from the CDC, continuing measles outbreaks here and aboard, a mumps...
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TWiV 1363: A Cauldron of Bats
TWiV explains a study testing how 16 hypothesized social and environmental drivers impact disease outbreaks, concluding that infectious disease spillover and emergence are multi-causal, and that no one-size-fits-all strategy can prevent epidemics and pandemics, and an analysis of Myotis bats…
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TWiV 1362: Clinical Update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello continue their ongoing exasperation over 5 deaths in Pennsylvania associated with measles infections, the absurdity of RFK Jr.'s statement that AI is better informed than physicians, the outbreak of cholera, more deaths by raw...
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TWiV 1361: Ancient Viral Sword and Shield
TWiV explains discovery of a previously unknown mechanism of RNA-guided DNA recognition for genetic control that possibly predates the emergence of CRISPR pathways, and the possibility that Alzheimer's Disease neuropathology evolved as a host defense response to microbial infection in the brain....
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TWiV 1360: Clinical Update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello frustration continues over the increasing number of measles infections, Kennedy's undermining of vaccines, perpetuation of autism- vaccine, autism-tylenol myths, an outbreak of hepatitis A virus in the US, the Ebola outbreak in...
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TWiV 1359: SSPE, the Long Shadow of Measles
Roberto Cattaneo and Kalpana Yadav join TWiV at the 2026 meeting of the American Society for Virology to discuss how the absence of measles virus receptors in the brain selects for hyperfusogenic variants that spread neuron-to-neuron and cause subacute sclerosing panencephalitis, a rare but fatal...
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TWiV 1358: Clinical Update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are angered by the continuous reporting of measles deaths in the US and around the world, the Ebola outbreak in Uganda, changes in reporting of virus infection and vaccine recommendations, establishing an NIH research center on...
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TWiV 1357: Furin, Naturally with Paul Bieniasz
Paul Bieniasz joins TWiV to discuss his lab's discovery that the coronavirus nuclease NSP15 cuts viral RNA into oligonucleotides that are reinserted elsewhere in the viral RNA, generating insertion mutations at a frequency above 10⁻³ per genome, including new furin cleavage sites at the spike…
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TWiV 1356: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello delve into dengue virus infections in Florida, recent human rabies infections in the US, proposed changes in biomedical funding including "converting" the Department of War into NIAID, the continuing controversy over the deaths…
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TWiV 1355: Four billion years of AI training data
TWiV reviews a landmark paper reporting the first generative design of complete viral genomes using AI, producing 16 viable bacteriophages that overcame antibiotic-resistant bacteria where natural phages could not, and a study suggesting that recombinant shingles vaccination reduces the risk of...
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TWiV 1354: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello remember Dolly Parton and her patronage of science, especially development of the COVID-19 vaccines, if the shingles vaccine protect against cardiovascular events as well as dementia, the continued national cyclosporiasis and...
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TWiV 1353: Phage bet-hedging and EBV antibodies
TWiV explores how bacteriophages enable bet-hedge against bacterial immune defenses, and how transgenic mice engineered to produce human antibodies yielded potent anti-EBV candidates targeting gp350 and gp42, a promising step toward Epstein-Barr therapeutics. Hosts: Vincent Racaniello, Rich…
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TWiV 1352: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are disheartened by the suggested change in federal vaccine recommendations, how Florida rolled back 4 childhood vaccine school requirements, results from a clinical trial suggesting that IPV can be used for outbreak control in...
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TWiV 1351: Ebola Virus Brains and Contagious Catfish Cancers
TWiV describes a human cerebral organoid model for Ebola virus persistence, and brown bullhead catfish melanoma, a novel transmissible cancer. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support...
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TWiV 1350: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are perplexed by the state of global public health as malaria, cholera and other infectious diseases are spread by civil warfare, the lack of manpower at the CDC to implement Congressional health programs, the first cancer mRNA...
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TWiV 1349: Smallpox and mummies
TWiV explains how liquid–liquid phase separation and a phage-encoded inhibitor cooperatively drive transcriptional transition during phage SPO1 infection, and the first smallpox virus genomes from an early outbreak in South America. Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and…
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TWiV 1348: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are troubled by the latest executive order changing routine childhood vaccine recommendations, the call for nominations to join the Advisory Committee for Immunization Practices, West Nile virus transmission in South Carolina, a...
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TWiV 1347: No Short Answers for Long COVID
TWiV explains research showing that Long COVID is associated with reactivation of numerous chronic viruses, including herpesviruses and anelloviruses, and with the production of autoantibodies that target neurological tissues. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe...
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TWiV 1346: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are distressed by Erica Schwartz' confirmation as CDC director, the GAO proposed pandemic preparedness plans, the national cyclospora outbreak and resulting two deaths, new screwworm and the scale of the Ebola outbreak in the...
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TWiV 1345: Rocky Mountain Virology High
TWiV travels to Colorado State University in Ft. Collins, where he speaks with Angela Bosco-Lauth, Rebekah Kading, and Mark Stenglein about their careers and their virology research. Host: Vincent Racaniello Guests: Angela Bosco-Lauth, Rebekah Kading, and Mark Stenglein Subscribe (free): Apple...
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TWiV 1344: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the numerous attempts by states to roll back vaccine laws, the recent surge of Dengue virus cases in Sri Lanka, the national cyclospora outbreak, new screwworm and Legionnaires cases, launching of the CHaT-Ox Ebola…
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TWiV 1343: Batting averages and stolen bases
TWiV explains research which shows that Per os infectivity factors are essential for bracovirus infection and wasp parasitism, and that periodic shifts in viral load increase risk of Hendra virus spillover from Pteropus bats. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe...
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TWiV 1342: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello explore the source/not source of the national cyclospora outbreak, trust in the FDA to correctly identify the source, new screwworm, Legionnaires and cyclosporasis cases, the Ebola outbreak in the Congo and development of a…
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TWiV 1341: Phage breaks and COVID origins
TWiV explains research that reveals dual activity of a phage-encoded lysin that modulates infection dynamics in a mycobacteriophage, and refutes a proposed link between the SARS-CoV-2 furin cleavage site and mouse-adapted MERS-coronavirus MA30. Hosts: Vincent Racaniello, Kathy Spindler, Angela...
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TWiV 1340: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello debate if Senator Mitch McConnell's recent hospitalization is due to post-polio syndrome or just old age, how air quality from Maine to Chicago has been affected by the Ontario wild fires, new screwworm, Legionnaires and...
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TWiV 1339: Ebola up close with Tom Ksiazek
Tom Ksiazek, a world-renowned virus expert with 40 years of experience on the front lines of some of the worst outbreaks the world has ever seen, joins TWiV to discuss his career, ebolaviruses in general, and the current outbreak of Bundibugyo ebolavirus in Africa. Hosts: Vincent Racaniello, Rich...
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TWiV 1338: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are dismayed over the military deaths due to the voluntary influenza vaccination policy, FDA's first vaccine recommendations since 2023, the efficacy of influenza vaccines, new screwworm, Legionnaires and cyclosporiasis cases…
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TWiV 1337: The whitefly and the Red Queen
TWiV explains research that reveals an an alternative evolutionary path of antiviral signalling in a sea anemone, and how a bacterial symbiont and a plant virus enhance insect fitness by inducing physical defenses against fungal parasites. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit...
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TWiV 1336: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello lament about the new ACIP charter, how administration of the HPV vaccine has eliminated cervical cancer deaths in young women, the global economic burden of infectious disease, restoring trust in vaccinology, new screwworm…
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TWiV Special: Albert Sabin with Karen Torghele
Vincent speaks with Karen Torghele about her recently published biography of polio vaccine pioneer Albert Sabin, the first ever written. Host: Vincent Racaniello Guest: Karen Torghele Subscribe (free): Apple Podcasts, RSS, email Links for this episode Karen Torghele's website Purchase Albert…
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TWiV 1335: TldR, bacterial hot rods and nullifying norovirus
TWiV explains research showing how temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling, and that IgA antibody is necessary and sufficient to prevent norovirus infection in mice. Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe...
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TWiV 1334: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end…
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TWiV 1334: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end…
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TWiV 1333: STING like a nanoparticle, float like HIV
TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection. Hosts: VVincent Racaniello, Alan Dove, Rich Condit, and Brianne...
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TWiV Special: Ebola virus and Andes virus with John Dye
Vincent travels to ASM Microbe in Washington DC to speak with John Dye of the United States Army Medical Research Institute of Infectious Diseases about the recent outbreaks of Bundibugyo ebolavirus in Africa and Andes virus on a cruise ship. Host: Vincent Racaniello Guest: John Dye Subscribe...
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TWiV 1332: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello express concern about vaccine policy and ACIP, scaling back of the CDC's role in global public health, shingles vaccine and dementia, new screwworm cases, the Ebola outbreak in the Congo and Uganda and where the hantavirus...
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TWiV 1331: A drug for cervical cancer
TWiV explains research showing that dairy cows are infected with low doses of influenza A(H5N1) and do not transmit efficiently to other animals, and covalent inhibitors of human papillomavirus type 16 E6 protein that restore p53 function and suppress growth of HPV-driven tumors in vivo. Hosts:...
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TWiV 1330: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello opine on the recent executive order on the routine childhood vaccination schedule, the Ebola outbreak in the Congo and Uganda including the fast track trials for 2 vaccine candidates and antivirals, recent Hantavirus infections,...
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TWiV 1329: How HIV-1 goes nuclear
TWiV explains research showing limited transmission of cervid prions to nonhuman primates, and the finding that cone-shaped HIV-1 capsids are transported through intact nuclear pores. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a...
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TWiV 1328: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello opine on the recent executive order on the routine childhood vaccination schedule, the Ebola outbreak in the Congo and Uganda including the fast track trials for 2 vaccine candidates and antivirals, recent Hantavirus infections,...
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TWiV 1327: Influenza viruses in the MIST
TWiV explains research on human influenza virus transmission that reveals heterogeneous expulsion of infectious virus into air, and how gut bacteriophages dictate inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease. Hosts: Vincent Racaniello,...
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TWiV 1326: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello comment on incidences of locally transmitted malaria in the US, mpox diagnostics, the latest developments surrounding hantavirus infections, and the Ebola outbreak in the Congo and Uganda including vaccine candidates before Dr....
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TWiV 1325: Sticky flu with Hannah Rowe
Vincent travels to Oregon State University in Corvallis to meet up with Hannah Rowe to talk about her career and her work demonstrating how the interaction of influenza A virus and Streptococcus pneumonia influences transmission. Hosts: Vincent Racaniello Guest: Hannah Rowe Subscribe (free)…
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TWiV 1324: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss withdrawal of the ACIP charter published in April 2026, the first council meeting on antibiotic resistant bacteria, the latest developments surrounding hantavirus infections, and the Ebola outbreak in the Congo and…
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TWiV 1323: One influenza infection, two patients
TWiV explains mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines, and how toll-like receptor 7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity, Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): Apple...
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TWiV 1322: Clinical update with Dr. Daniel Griffin - Hantavirus special
In his weekly clinical update, Daniel Griffin and Vincent Racaniello reviewed the latest developments surrounding the hantavirus outbreak, including new interim guidance from the Centers for Disease Control and Prevention for the management of infectious cases, whether the CDC may be downplaying...
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TWiV 1321: Phage cross talk and cross reactions
TWiV explains how cross-reactive anti-prophage antibodies and bacterial heteroresistance is implicated in phage therapeutic failure, and how phages communicate across species to shape microbial ecosystems. Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free):...
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TWiV 1320: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the outbreak of Hantavirus on a cruise ship and its potential for person-person transmission, how cessation of funding for global health by the Trump administration has compromised American health and well being, as well as...
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TWiV 1319: An earful of SARS-CoV-2
TWiV explains the emergence of vaccine-derived poliovirus strains from the novel oral polio vaccine in the Central African Republic, and the infection of spiral ganglion neurons in the inner ear by SARS-CoV-2, which may explain hearing loss in humans. Hosts: Vincent Racaniello, Alan Dove, and…
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Frequently Asked Questions
How many episodes does This Week in Virology have?
This Week in Virology currently has 1000 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is This Week in Virology about?
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
How often does This Week in Virology release new episodes?
This Week in Virology releases new episodes frequently with a large back catalog of 1000 episodes. Check the episode list for recent publication dates.
Where can I listen to This Week in Virology?
You can listen to This Week in Virology on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts This Week in Virology?
This Week in Virology is created and hosted by Vincent Racaniello.
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