PODCAST · technology
Training Data
by Sequoia Capital
Join us as we train our neural nets on the theme of the century: AI. Sonya Huang, Pat Grady and more Sequoia Capital partners host conversations with leading AI builders and researchers to ask critical questions and develop a deeper understanding of the evolving technologies—and their implications for technology, business and society. The content of this podcast does not constitute investment advice, an offer to provide investment advisory services, or an offer to sell or solicitation of an offer to buy an interest in any investment fund.
Episodes
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David Silver and Lasse Espeholt of Ineffable Intelligence: A Superlearner for the Age of Experience
David Silver spent two years building AlphaGo on human data. When he removed human data altogether building AlphaGo Zero, the AI surpassed AlphaGo in under two days. He left DeepMind to run that same bet in pursuit of superintelligence. David and Lasse Espeholt, co-founders of Ineffable...
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Google's AI Infrastructure Chief, Amin Vahdat, on the Physics & Economics of Frontier AI
At 100,000-accelerator scale, something fails multiple times an hour, which is why Google's Chief Technologist for AI Infrastructure Amin Vahdat thinks FLOPS is a vanity metric. The metric that matters is what he calls goodput: the useful work a workload actually delivers through real failures....
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Box's Aaron Levie: On Reinventing Yourself in the AI Age and Enterprise Diffusion
Starting a company is hard. Reinventing your company for AI as a public company with quarterly earnings results is even harder. Aaron Levie has pulled off the transition with Box and offers hard-won advice for founders. The cofounder and CEO of Box argues the value isn't only in the model; it's…
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Making Cities Awesome: Peregrine’s Nick Noone & Ben Rudolph
Most public safety technology companies grow by collecting more data. Peregrine inverted the model: no sensors, no new data, a business built on connecting the data and information cities already own. Co-founders Nick Noone and Ben Rudolph received more than two dozen no's before San Pablo PD let...
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Parallel’s Parag Agrawal: Building a New Web for AI Agents
Parag Agrawal is making a bet that goes against two decades of web search: agents will query the web a thousand times more than humans ever have, and the infrastructure built around human clicks is wrong for them. The former Twitter CEO, now founder and CEO of Parallel Web Systems, explains why...
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Rich Sutton and Khurram Javed: Why AI Models Stop Learning, and How to Start It Again
Rich Sutton, who helped pioneer reinforcement learning and wrote the seminal AI essay The Bitter Lesson, has now cofounded Oak Lab with his former student Khurram Javed. Their goal: to build agents that continuously learn from their own experience rather than from us. Rich doesn't think he holds…
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Chai Discovery's Bitter Lesson: Drug Design Is Another Scaling Problem
Most people treat biology as a bespoke, messy science. Josh Meier and Matt McPartlon, co-founders of Chai Discovery, treat it as an engineering problem. They make the case that drug design obeys the bitter lesson: scale data, models, and compute, and the model can learn what a hand-built pipeline...
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Building the Automated AGI Lab: Core Automation's Jerry Tworek and Rohan Anil
Jerry Tworek led reasoning at OpenAI, convinced that scaling reinforcement learning was the path to AGI. Rohan Anil co-led Gemini pre-training and built the Shampoo optimizer. Now they've teamed up at Core Automation on a contrarian premise: the transformer has carried us as far as it can, and…
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Factory's Matan Grinberg: The Coming ‘Dark Factory’ Where Software Builds Itself
Factory started building fully autonomous coding agents in April 2023, two years before enterprises were ready. Matan Grinberg now says this is indistinguishable from being wrong. The Factory co-founder and CEO explains how the company survived its "journey in the desert," including the decision…
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Anthropic's Katelyn Lesse & Angela Jiang: Building an Ecosystem, not a Walled Garden
Katelyn Lesse and Angela Jiang lead the team building Anthropic's developer platform - the layer that both outside builders and Anthropic's own products run on top of. Angela frames the platform as a three-layer stack: knowledge, execution, and coordination. She argues the real leverage is what’s...
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Inside Zipline's Autonomous System: 140M Miles, Zero Incidents
The largest commercial autonomous system on earth isn't a robotaxi fleet — it's Zipline, which has flown 140 million autonomous miles with zero safety incidents. Co-founder Keller Rinaudo Cliffton and Eric Watson, who leads systems engineering and safety, explain why the drone itself is only 15%…
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Why Hardware-Software Co-Design Is AI's Real 100x: Dylan Patel of SemiAnalysis
Dylan Patel, founder of SemiAnalysis, argues the biggest gains in AI don't come from faster chips, they come from software-hardware co-design. Optimizing the model, the kernels, and the silicon together turns a 2x here and a 2x there into 100x. He explains why DeepSeek's experts were shaped for...
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Memory and Continual Learning: Engram's Dan Biderman and Jessy Lin
Dan Biderman and Jessy Lin, co-founders of Engram, are building a neolab around memory and continual learning, which they call two sides of the same coin. Their contrarian premise: instead of stuffing ever-larger prompts into the context window or bolting on RAG, bake a team's knowledge directly...
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Simulating Humans at Scale: Simile's Joon Sung Park
The race to build superintelligence is producing models that keep getting better at objective problems, but not at behaving like actual people. Joon Sung Park, founder and CEO of Simile and creator of Stanford's "Smallville" generative agents study, argues that simulating human society requires a...
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Google DeepMind's Logan Kilpatrick: Why the Model Eats the Harness
The entire startup ecosystem is racing to build agent harnesses. Logan Kilpatrick, who leads Google AI Studio and the Gemini API, argues that scramble has a roughly 12-month shelf life. Models will absorb the scaffolding and run it natively, so the edge moves elsewhere. Google's own bet runs in...
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LIVE: Jensen Huang on Building the Dynamo of the Intelligence Age
Jensen Huang, founder and CEO of NVIDIA, makes the case that computing is undergoing its biggest shift in 60 years: from retrieval, where data centers store files we look up, to generation, where every word, image, and video is produced in real time and customized for whoever is asking. He…
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Knowing What Your Customers Want, All the Time: Listen Labs' Alfred Wahlforss
Alfred Wahlforss, co-founder and CEO of Listen Labs, is building an AI agent that interviews your customers at a scale no focus group ever could—thousands of voice conversations at once, drawn from an audience of 30 million people. A year after launch, Listen serves hundreds of Fortune 100s to...
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How Cursor Trained Composer on Fireworks: Distributed Infrastructure for High-Performance RL
Cursor's Federico Cassano and Fireworks' Dmytro Dzhulgakov explain how they collaborated to build Composer as a specialized foundation model. The core insight: models have finite capacity in their weights, and allocating all those bits to the singular task of software engineering in Cursor frees...
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Rebuilding IT From the Ground Up for the AI Age: Serval's Jake Stauch
Jake Stauch, founder and CEO of Serval, is building a ServiceNow for the AI era. His most contrarian bet is that the product should look like boring old enterprise software, but with unlimited intelligence. Serval's architecture splits work between two agents: an admin agent that uses code...
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Suno's Mikey Shulman: Everyone Can Make Music Now
Most music platforms assume you're a listener. On Suno, 90% of daily users make something. Founder and CEO Mikey Shulman explains why that flips the model: the act of creating IS the entertainment, with closer parallels to gaming and Claude Code than to Spotify. He breaks down the technical bets...
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ElevenLabs' Mati Staniszewski: How Voice Becomes the Interface for Everything
Mati Staniszewski, co-founder and CEO of ElevenLabs, joins Sequoia partner Andrew Reed at AI Ascent 2026 to talk about how a four-year-old company built a frontier audio AI business with just over 400 people and over $400M in revenue. He explains why audio was overlooked in 2022 when the rest of…
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Anthropic's Boris Cherny: Coding's Printing Press Moment
Boris Cherny, creator of Claude Code at Anthropic, joins Sequoia partner Lauren Reeder at AI Ascent 2026 to talk about where coding goes from here. He explains why he hasn't written a line of code in 2026, why he now ships dozens of PRs a day from his phone, and why he believes coding is...
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Waymo's Dmitri Dolgov: 20 Million Rides and the Road to Full Autonomy
Dmitri Dolgov, co-CEO of Waymo, joins Sequoia partner Konstantine Buhler at AI Ascent 2026 to talk about the 20-year arc from the DARPA Grand Challenge to fully autonomous service in eleven cities and counting. He explains how Waymo persisted through every AV hype cycle by treating safety as the...
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OpenAI's Greg Brockman: Why Human Attention Is the New Bottleneck
Greg Brockman, co-founder and president of OpenAI, joins Sequoia partner Alfred Lin at AI Ascent 2026 for a conversation that spans the full OpenAI stack. He explains why the company will never have enough compute, why he believes we're 80% of the way to AGI, and why the agentic coding tools that...
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Demis Hassabis on Building DeepMind, AlphaFold, and the Final Stretch to AGI
Demis Hassabis, co-founder and CEO of Google DeepMind and 2024 Nobel laureate in chemistry for AlphaFold, joins Sequoia partner Konstantine Buhler at AI Ascent 2026 for a wide-ranging conversation about the path to AGI and what comes after. He explains why he believes AGI is achievable by 2030…
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Andrej Karpathy: From Vibe Coding to Agentic Engineering
Andrej Karpathy (co-founder of OpenAI, former head of AI at Tesla, and now founder of Eureka Labs) talks with Sequoia partner Stephanie Zhan at AI Ascent 2026 about what's changed in the year since he coined "vibe coding." He explains why he's never felt more behind as a programmer, why agentic...
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From SEO to Agent-Led Growth: Profound’s James Cadwallader
James Cadwallader, co-founder and CEO of Profound, makes the case that we are living through the biggest platform shift in marketing history. The front door of the internet hasn't changed, but the visitor walking through it has. Where consumers once clicked blue links, AI agents now crawl the web...
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How Autonomous Labs Will Transform Scientific Research: Ginkgo Bioworks’ Jason Kelly
Jason Kelly founded Ginkgo Bioworks in 2008 with a simple but radical idea: DNA is code, and cells are programmable. Sixteen years later, AI is finally making that vision real in ways that could reshape science itself. Jason describes a landmark collaboration with OpenAI in which a reasoning…
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Greetings, Earthlings: Philip Johnston of Starcloud on Data Centers in Space
Philip Johnston, founder and CEO of Starcloud, explains why space will become the primary location for AI compute infrastructure within the next decade. After witnessing SpaceX's massive manufacturing scale at Starbase, Philip realized that declining launch costs would make space-based data…
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Physics Gets a Vote: Nominal Cofounders on Hardware Development in an AI World
Nominal’s cofounders (Cameron McCord, Jason Hoch and Bryce Strauss) realized that the new age of reindustrialization requires a new approach to hardware engineering and testing that’s closer to how software is developed. They founded Nominal with the insight that while SpaceX, Tesla, and Anduril...
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Building the GitHub for RL Environments: Prime Intellect's Will Brown & Johannes Hagemann
Will Brown and Johannes Hagemann of Prime Intellect discuss the shift from static prompting to "environment-based" AI development, and their Environments Hub, a platform designed to democratize frontier-level training. The conversation highlights a major shift: AI progress is moving toward...
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What’s the Future of Vertical SaaS in an AGI World? Jamie Cuffe, CEO of Pace
Jamie Cuffe is solving one of AI's hardest problems: getting conservative, regulated industries to trust autonomous agents with mission-critical work. At Pace, he's building AI that replaces traditional BPOs in insurance, handling everything from email triage to claims processing with 50-75% cost...
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Making the Case for the Terminal as AI's Workbench: Warp’s Zach Lloyd
Zach Lloyd built Warp to modernize the terminal for professional developers, but the rise of coding agents transformed his company's trajectory. He discusses the convergence of IDEs and terminals into new workbenches built for prompting and agent orchestration, and why he thinks "coding will be...
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Context Engineering Our Way to Long-Horizon Agents: LangChain’s Harrison Chase
Harrison Chase, cofounder of LangChain and pioneer of AI agent frameworks, discusses the emergence of long-horizon agents that can work autonomously for extended periods. Harrison breaks down the evolution from early scaffolding approaches to today's harness-based architectures, explaining why...
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How Ricursive Intelligence’s Founders are Using AI to Shape The Future of Chip Design
Anna Goldie and Azalia Mirhoseini created AlphaChip at Google, using AI to design four generations of TPUs and reducing chip floor planning from months to hours. They explain how chip design has become the critical bottleneck for AI progress -- a process that typically takes years and costs...
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Training General Robots for Any Task: Physical Intelligence’s Karol Hausman and Tobi Springenberg
Physical Intelligence’s Karol Hausman and Tobi Springenberg believe that robotics has been held back not by hardware limitations, but by an intelligence bottleneck that foundation models can solve. Their end-to-end learning approach combines vision, language, and action into models like π0 and...
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Why the Next AI Revolution Will Happen Off-Screen: Samsara CEO Sanjit Biswas
Sanjit Biswas is one of the rare founders who has scaled AI in the physical world – first with Meraki, and now with Samsara, a $20B+ public company with sensors deployed across millions of vehicles and job sites. Capturing 90 billion miles of driving data each year, Samsara operates at a scale...
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The Rise of Generative Media: fal's Bet on Video, Infrastructure, and Speed
fal is building the infrastructure layer for the generative media boom. In this episode, founders Gorkem Yurtseven, Burkay Gur, and Head of Engineering Batuhan Taskaya explain why video models present a completely different optimization problem than LLMs, one that is compute-bound…
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Why IDEs Won't Die in the Age of AI Coding: Zed Founder Nathan Sobo
Nathan Sobo has spent nearly two decades pursuing one goal: building an IDE that combines the power of full-featured tools like JetBrains with the responsiveness of lightweight editors like Vim. After hitting the performance ceiling with web-based Atom, he founded Zed and rebuilt from scratch in...
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How End-to-End Learning Created Autonomous Driving 2.0: Wayve CEO Alex Kendall
Alex Kendall founded Wayve in 2017 with a contrarian vision: replace the hand-engineered autonomous vehicle stack with end-to-end deep learning. While AV 1.0 companies relied on HD maps, LiDAR retrofits, and city-by-city deployments, Wayve built a generalization-first approach that can adapt to…
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How Google’s Nano Banana Achieved Breakthrough Character Consistency
When Google launched Nano Banana, it instantly became a global phenomenon, introducing an image model that finally made it possible for people to see themselves in AI-generated worlds. In this episode, Nicole Brichtova and Hansa Srinivasan, the product and engineering leads behind Nano Banana,...
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OpenAI Sora 2 Team: How Generative Video Will Unlock Creativity and World Models
The OpenAI Sora 2 team (Bill Peebles, Thomas Dimson, Rohan Sahai) discuss how they compressed filmmaking from months to days, enabling anyone to create compelling video. Bill, who invented the diffusion transformer that powers Sora and most video generation models, explains how space-time tokens...
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Nvidia CTO Michael Kagan: Scaling Beyond Moore's Law to Million-GPU Clusters
Recorded live at Sequoia’s Europe100 event: Michael Kagan, co-founder of Mellanox and CTO of Nvidia, explains how the $7 billion Mellanox acquisition helped transform Nvidia from a chip company into the architect of AI infrastructure. Kagan breaks down the technical challenges of scaling from...
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Securing the AI Frontier: Irregular Co-founder Dan Lahav
Irregular co-founder Dan Lahav is redefining what cybersecurity means in the age of autonomous AI. Working closely with OpenAI, Anthropic, and Google DeepMind, Dan, co-founder Omer Nevo and team are pioneering “frontier AI security”—a proactive approach to safeguarding systems where AI models act...
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Why AI Will Transform Customer Experience: Cresta CEO Ping Wu and Sequoia’s Doug Leone
Ping Wu built Google's contact center business before becoming CEO of Cresta, where he's pioneering a unique approach to contact center transformation. Rather than full automation Ping advocates a dual approach, automating what's ready while using AI to assist humans with the rest. He makes the...
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Block CTO Dhanji Prasanna: Building the AI-First Enterprise with Goose, their Open Source Agent
As CTO of Block, Dhanji Prasanna has overseen a dramatic enterprise AI transformation, with engineers saving 8-10 hours a week through AI automation. Block’s open-source agent goose connects to existing enterprise tools through MCP, enabling everyone from engineers to sales teams to build custom...
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Why Businesses Are Rejecting the AI They’ve Asked For: Agency CEO Elias Torres
Elias Torres has been building AI systems since 1999, from chatbots at IBM to co-founding Drift and now Agency. He believes businesses are caught in an expectation mismatch—demanding AI while rejecting it due to imperfection anxiety. Drawing from his experience scaling HubSpot, Elias explains why...
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Building the "App Store" for Robots: Hugging Face's Thomas Wolf on Physical AI
Thomas Wolf, co-founder and Chief Science Officer of Hugging Face, explains how his company is applying the same community-driven approach that made transformers accessible to everyone to the emerging field of robotics. Thomas discusses LeRobot, Hugging Face's ambitious project to democratize...
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Deal Velocity, Not Billable Hours: How Crosby Uses AI to Redefine Legal Contracting
Ryan Daniels and John Sarihan are reimagining legal services by building Crosby, an AI-powered law firm that focuses on contract negotiations to start. Rather than building legal software, they've structured their company as an actual law firm with lawyers and AI engineers working side-by-side to...
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n8n CEO Jan Oberhauser on Building the Universal AI Automation Layer
When the AI wave hit, n8n founder Jan Oberhauser faced a critical choice: become irrelevant or become indispensable. He chose the latter, transforming n8n from a simple workflow tool into a comprehensive AI automation platform that lets users connect any LLM to any application. The result? Four...
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ABOUT THIS SHOW
Join us as we train our neural nets on the theme of the century: AI. Sonya Huang, Pat Grady and more Sequoia Capital partners host conversations with leading AI builders and researchers to ask critical questions and develop a deeper understanding of the evolving technologies—and their implications for technology, business and society.
The content of this podcast does not constitute investment advice, an offer to provide investment advisory services, or an offer to sell or solicitation of an offer to buy an interest in any investment fund.
HOSTED BY
Sequoia Capital
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