PODCAST · education
Translational Medicine
by Oxford University
Research in Medicine needs to ultimately translate into better treatment of patients. Researchers at the Nuffield Department of Medicine, University of Oxford, collaborate to develop better care and improved preventive measures. Findings in the laboratory are translated into changes in clinical practice, from Bench to Bedside.
Episodes
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Artemisinin Resistance
Artemisinins are very poweful tools in the treatment of malaria, and the emerging loss of their activity has the potential to create a major public health problem. MALARIA TREATMENT Dr Charlie Woodrow is based at MORU in Bangkok, Thailand, where he coordinates clinical and laboratory studies on...
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A deep breath in
Asthma and COPD (chronic obstructive pulmonary disease) are common conditions that affect the lives of many people. Dr Mona Bafadhel studies the pathophysiology of COPD (chronic obstructive pulmonary disease). There are broadly two inflammatory phenotypes of COPD that are clinically...
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Chemistry, epigenetics and drugs
Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug. Professor Paul Brennan research focusses on epigenetics: the mechanisms that control…
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The genetics of metabolic diseases
A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function. Professor Wyatt Yue explores how genetic defects lead to disease at the molecular level, by determining 3D structures and biochemical properties of enzymes and...
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Getting the dose right
Too high a dose can result in toxicity and side-effects, too low a dose can cause the illness to come back and at worse develop resistance. Professor Joel Tarning is Head of Clinical Pharmacology in our MORU Unit in Bangkok, Thailand. He's working towards drug dose-optimisation using novel...
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Biological imaging
Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data. Professor Jens Rittscher has a joint appointment between the Ludwig Institute for Cancer Research, the Target Discovery Institute and the Department of Engineering Science. His...
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Pharmacogenomics
Dr Sebastian Nijman develops new approaches to study signalling networks in cancer cells and uncover specific weaknesses, particularly in breast and lung cancer. This can be used to develop more effective drugs and to better guide treatment decisions. In the context of cancer, genetic diversity...
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Microbiology in Thailand
Microbiology in Thailand Acurately diagnosing infections is particularly challenging in tropical environments. Researchers at the Mahidol Oxford Tropical Medicine Research Unit (MORU) are working to develop effective and practical means of diagnosing and treating malaria and other neglected...
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Infectious diseases in South East Asia
Infectious diseases in South East Asia The Mahidol Oxford Tropical Medicine Research Unit (MORU) is a collaboration between the University of Oxford and Mahidol University, and was established with the Wellcome Trust in 1979. MORU aims to fight the infectious tropical diseases affecting rural...
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Rickettsial Disease
Daniel Paris: Rickettsial Disease Rickettsial diseases such as scrub typhus are important causes of fever in southeast Asia especially in rural communities. Discovered quite recently and not big killers, these diseases are among the most under-reported and under-diagnosed illnesses that are both...
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Human Genetics
Professor Peter Donnelly tells us how genetics helps us to understand common diseases and develop new drugs. Understanding which variations in our DNA affect susceptibility to diseases can provide new insights into the disease process and lead to new treatments. Professor Peter Donnelly leads…
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The Global Health Network
Dr Trudie Lang tells us how the Global Health Network facilitates collaboration and resource sharing. Clinical trials establish the evidence base for prevention and treatment of disease and are critically important in the field of Global Health. Dr Trudie Lang leads the Global Health Clinical...
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Artemisinin therapy for malaria by Professor Nick White
Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness…
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Respiratory Medicine
Dr Najib Rahman talks about his research on respiratory medicine. The Pleura are thin membranes that cover the surface of the lungs. Dr Najib Rahman specialises in areas of respiratory medicine including pleural disease and the conduct and analysis of respiratory trials. Dr Rahman is currently...
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Psychiatric genetics
Professor Jonathan Flint talks about his research on psychiatric genetics. It is now known that genetic variants can form the basis of psychiatric disorders, such as depression and anxiety. Professor Jonathan Flint is investigating the genetics behind psychiatric disorders, in particular the...
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Development of chemical probes
Professor Stefan Knapp tells us how the development of chemical probes helps us to find new drugs. The role of proteins in cellular signalling and disease is best studied through the development of highly specific chemical inhibitors, which can serve as a tool molecule for functional studies....
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Can we block malaria transmission
Dr Sumi Biswas talks about the development of a vaccine aimed at the mosquito stage of the malaria parasite cycle. Malaria transmission-blocking vaccines aim to induce immunity against the parasites that infect mosquitoes. Such vaccines will prevent malaria transmission on a wider scale, focusing...
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Membrane proteins and drug development
Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins;...
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Fiona Powrie
Professor Fiona Powrie talks about the importance of our guts, and her research in gastroenterology.
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Clinical Trials in Gastroenterology
Dr Simon Travis tells us how clinical trials bring tomorrows treatments to patients today. Before translating basic research into the clinic it is important first to undergo clinical trials in order to identify safe treatments and therapies for disease. Led by Dr Simon Travis the Gastroenterology...
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Can we eradicate HIV?
Dr John Frater talks about his research into finding a cure for HIV. It is increasingly apparent that highly active antiretroviral therapy (HAART) may not be the long-term solution to the management of HIV infection, and that other avenues need to be explored. As a result of various recent cases,...
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Multiple Sclerosis
Professor Lars Fugger talks about his research on multiple sclerosis. Professor Lars Fugger focuses on translational studies in multiple sclerosis and uses a multidisciplinary approach. He is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with...
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Immune System in the Gastrointestinal tract
Dr Holm Uhlig talks about the role of the immune system in our gastrointestinal tract. Dr Holm Uhlig is based at the Translational Gastroenterology Unit and studies defects in the immune response and regulation leading to immunopathology. Dr Uhlig is interested in children with inflammatory bowel...
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Autoimmunity
Professor Richard Cornall tells us about his research on autoimmunity. Professor Richard Cornall aims to understand the causes of autoimmune diseases. Autoimmunity occurs when the immune system which is normally designed to attack pathogens ends up attacking the body. Professor Cornall is also...
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Progress in Malaria Vaccine Research
Dr Simon Draper tells us about his progress in malaria vaccine research. Dr Simon Draper's research interests include studies of vaccine induced malaria immunity. His group focuses on translational medicine. They will take their most promising vaccine candidates and manufacture them as clinical...
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Diabetes in Young Adults
Dr Katharine Owen talks about the different types of Diabetes in young adults. There are more forms of diabetes than the commonly known type 1 and type 2. Dr Katherine Owen investigates the different characteristics of monogenic diabetes with the aim of creating systematic diagnostics for…
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Diabetes and Genomics
Professor Mark McCarthy tells us how genomics helps us understand diabetes. Professor Mark McCarthy (Robert Turner Professor of Diabetes) leads a multidisciplinary research team including clinicians, nurses and lab-based research staff. One of their major focuses lies in translating gene...
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Malaria vaccine for P. vivax
Dr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax. Dr Reyes Sandoval aims to develop a novel malaria vaccine against Plasmodium vivax, one of the four malaria parasites that affect humans. P. vivax is found in Africa, Asia, Latin America and the Western...
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Wider Statin Use Saves Lives
Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives.
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HIV Vaccine Development
Professor Tomas Hanke tells us about his research on HIV vaccine development. The long term aim for Professor Tomáš Hanke is to develop a safe, effective and accessible HIV-1 vaccine. His group tests novel ideas and vaccine strategies, and focusses on a safe but rapid translation of the most...
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Personalised Diabetes Treatment
Professor Stephen Gough talks about the development of personalised diabetes treatment. Prof. Stephen Gough believes that you cannot give every patient affected by diabetes the same treatment; where people react differently to treatments provides a background to his research. Prof. Gough aims to...
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Statistical Genetics
Professor Gil McVean tells us how statistical genetics helps us understand and treat disease. Prof Gil McVean is the Head of Bioinformatics and Statistical Genetics at the Wellcome Trust Centre for Human Genetics. His research covers several areas in the analysis of genetic variation, combining…
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Liver Fat Metabolism
Dr Leanne Hodson talks about her research on liver fat metabolism. Dr Leanne Hodson's research focuses on fatty liver disease, defined as having over 5 percent liver fat, and a 'silent disease' as many people are not diagnosed. Dr Hodson aims to find targets for new medications which will help...
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Metabolism of Fatty Acids
Dr Barbara Fielding talks about her research on the metabolism of fatty acids. Dr Barbara Fielding believes that nutritional advice should be based on a thorough understanding of metabolic responses to food ingestion, and that it is important to investigate the metabolism of dietary fat after…
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Lowering cholesterol in chronic kidney disease
The largest trial investigating the benefits of cholesterol lowering in kidney patients. The Study of Heart and Renal Protection (SHARP) concluded that around a quarter of all heart attacks, strokes, and operations to open blocked arteries could be avoided in people with chronic kidney disease by...
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Genetics and Diabetes
Dr Anna Gloyn talks about her research on the genetics of Diabetes. The research undertaken by Dr Anna Gloyn focuses on using naturally genetic variants identified in humans as tools to identify critical regulatory pathways for insulin secretion and action. Current research projects are focused…
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The treatment of severe malaria
Prof. Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Prof Arjen Dondorp is the Deputy Director and Head of Malaria Research at the Mahidol-Oxford Tropical Medicine Research Unit in Bangkok, Thailand. His main research interests include the...
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HIV and children in Africa
Professor Sarah Rowland-Jones tells us about her work on HIV with children in Africa. Prof. Sarah Rowland-Jones' work mainly focuses on anti-viral immunity, and in particular how immune responses modify the outcome of HIV infection. Her research aims to contribute to the design of vaccines and...
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Diabetes and Insulin Secretion
Professor Patrik Rorsman talks about Diabetes and how beta cells within the pancreas control insulin secretion. Patrik Rorsman is professor of diabetic medicine in the Oxford Centre for Diabetes, Endocrinology and Metabolism. Professor Rorsman has been at the forefront of research on...
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How can we live with HIV?
Dr Lucy Dorrell tells us how our immune system controls HIV and how we can live with this virus. The aim of Dr Lucy Dorrells' research is to develop immunotherapy to reduce the dependence of those infected with HIV-1 on their current treatment - antiretroviral therapy (ART). This is because 9...
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Specific Language Impairment
Dr Dianne Newbury talks about the contribution of genetics to specific language impairment. Dr Dianne Newbury is looking for the genes that predispose to Specific Language Impairment, a complex genetic disorder. Two regions, located on chromosomes 16 and 19, are linked with this disorder....
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HIV immunology for Vaccine Design
Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV...
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Dyslexia and Genetics
Dr Silvia Paracchini talks about the influence of Genetics in Dyslexia. Dr Silvia Paracchini aims to indentify the genetic components of dyslexia and understand the underlying biology. Other disorders such as Specific Language Impairment or Attention Deficit Hyperactivity Disorder are commonly...
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Aiming for a HIV vaccine
Professor Sir Andrew McMichael tells us about recent developments in the search for a vaccine against HIV. Prof. Sir Andrew McMichael is working on human immunology and vaccines, first looking at flu virus and now HIV. His current lines of research include analysing early molecular events in HIV...
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Tropical Medicine in Kenya
Professor Kevin Marsh tells us about his research on Tropical Medicine in Kenya. Prof. Kevin Marsh has a broad research interest in child health in the tropics, with a particular focus in the immune epidemiology of malaria. Prof. Marsh is director of the KEMRI Wellcome Programme in Kenya; he also...
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Obesity and Diabetes
Professor Fredrik Karpe explores the links between obesity and diabetes. Prof. Fredrik Karpe initiated the Oxford Biobank for prospective genetic epidemiological research. Integrative physiological and genomic approaches are used to study lipid and carbohydrate metabolism. Prof. Karpe also…
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Proteomics and Biomarkers
Dr Benedikt Kessler tells us how proteomics helps find biomarkers. In most living organisms, the ubiquitin-proteasome system is responsible for the degradation of proteins, either because they're damaged or they reach the end of their life span. Ubiquitin marks a protein for elimination....
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Spondyloarthritis
Dr Paul Bowness tells us about his work on spondyloarthritis. Dr Paul Bownessis works on Ankylosing Spondylitis, the commonest form of spondyloarthritis. This rheumatic disease seems to be caused by an overacting immune system. It has a major genetic component: at least 5-10 genes are known to...
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Obesity and Genetics
Dr Cecilia Lindgren explores the links between obesity and genetics. Obesity and its consequences are major and growing challenges for health care worldwide. Over 30 genes associated with body mass index have now been identified. Dr Cecilia Lindgren uses genetic and genomic approaches to better...
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Drug Discovery
Professor Chas Bountra explains how new drugs can offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders. Professor Chas Bountra is interested in identifying and validating target proteins for drug discovery. Various technologies and strategies have...
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ABOUT THIS SHOW
Research in Medicine needs to ultimately translate into better treatment of patients. Researchers at the Nuffield Department of Medicine, University of Oxford, collaborate to develop better care and improved preventive measures. Findings in the laboratory are translated into changes in clinical practice, from Bench to Bedside.
HOSTED BY
Oxford University
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Frequently Asked Questions
How many episodes does Translational Medicine have?
Translational Medicine currently has 96 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Translational Medicine about?
Research in Medicine needs to ultimately translate into better treatment of patients. Researchers at the Nuffield Department of Medicine, University of Oxford, collaborate to develop better care and improved preventive measures. Findings in the laboratory are translated into changes in clinical...
How often does Translational Medicine release new episodes?
Translational Medicine has 96 episodes. Check the episode list to see recent publication dates and frequency.
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You can listen to Translational Medicine on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Translational Medicine?
Translational Medicine is created and hosted by Oxford University.
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