All Episodes

ImmunoepigeneticsVIII. Protective immunotolerant neonate Th1 inactivity involves IL-12 p35subunit promoter methylation. DJGPhD.23.12.22. Authentic Biochemistry Podcast

Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB.

Holiday Ethanol Use VII. EtOH exposure precipitates chromatin methylation associated MCH and chemokine involvement linking arousal, reward and inflammation. DJGPhD.21.12.22 Authentic Biochem.

Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast

Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast

Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health.

Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem.

Holiday Ethanol Use III. In utero fetal cardiac muscle development is corrupted by maternal EtOH exposure via metabolic, bioenergetic and epigenetic means involving fatty acid and folate redox poise.

Holiday EtOH Lecture II. Ethanol ingestion permanantly corrupts myelin lipid composition while altering MET and Folate metabolism leading to epigenetic syntactic and semantic chromatin errors.DJGPhD.

Immunoepigenetics VII. MicroRNA mediated feedback control over signalling response toward inflammation.DJGPhD. 10Dec22. Authentic Biochemistry

ImmunoepigeneticsV!. TLR's and TCR's use membrane lipid raft signal transduction to obtain transcription factor mediated cell fate via epigenetic modification. DJGPhD.09 Dec.22

ImmunoepigeneticsV. TCR activation and the integration of cell senescence with epigenetic authorship and reading-mediated tumorigenesis. DJGPhD.07Dec22. Authentic Biochemistry

ImmunoEpigeneticsIV. Membrane lipid raft components dynamically mediate Tcell reception, hippocampal pyrimidal neuron endocytosis, and lung cancer cell mesenchymal to endothelial transition.DJGPhD.

Immunoepigenetics 3. EtOH abuse interrupts membrane lipid raft -mediated TCR signaling by decreasing the TF NFAT nuclear translocation and IL-2 transcription.DJGPhD.04.DEC.22.Authentic Biochemistry.

Immunoepigenetics 2. Treg and ILC differentiation and the evolution of lymphocytic response specificity incl. B cell class switch recombination and somatic hypermutation deamination.DJGPhD.2.12.22

Membrane Biochemistry 86/Immunoepigentics1. The complex divergent roles of Inhibitor of DNA (Id) binding proteins in terminal differentiation and disease states. DJGPhD.01.12.22.Authentic Biochemistry

Membrane Biochemistry 85. EBV latent membrane protein induction of haemopoietic proliferative disease and Id repressor protein transcriptionally mediated terminal differentiation.DJGPhD.30.11.22.

Membrane Biochemistry 84. Isolation of membrane protein using non-ionic detergents exposes the prescence of cellular lipid raft domains. DJGPhD. 29.11.22. Authentic Biochemistry.

Membrane Biochemistry 83. Countercurrent distribution theory of membrane lipid raft mediated endomebranous sequence ontology. DJGPhD.26.11.22

Membarne Biochemistry 82. Coda in absentia. Redux of the epistemological lens and the membrane lipid raft resurfaces. Dr. Daniel J. Guerra. 23.11.22. Authentic Biochemistry Podcast

Membrane Biochemistry 81. Synopsis. Logical judgment and square of opposition applied to lipids as transcription factors and membrane sequence derivatives respectively. DJGPhD19.11.22.Authentic Bioch

Membrane Biochemisty.Steroidogenic endo-nuclear sphingolipid metabolism involving ganglioiside turnover mediates transcription factor de-repression via DAG kinase.DJGPhD.18.11.22.

Membrane Biochemistry 79. Sphingolipids and cyclic phosphatidic acid control PPAR isoform-mediated gene transcription over lipid metabolism and inflammation. DJGPhD.16.11.22. Authentic Biochemistry

Membrane Biochemistry 78. Nuclear sphingolipid metabolism controlling cAMP response element-mediated transcription promoting proinflammation and anti-inflammation temporally and spatially.DJGPhD.

Membrane Biochemistry 77. Membrane lipid mediated IGF-I in contextual expression within discrete organ systems controls an inflammatory valence DJGPhD. 9 November 2022 Authentic Biochemistry

Membrane Biochemistry 76. Introduction to SubCellular-Distribution Mechanisms and Function of Nuclear-Localized Lipids. DJGPhD.06Nov22b.Authentic Biochemistry Podcast

Membrane Biochemistry75. Rational judgment as the epistimological prolegomena to research science:isoprenoid lipid biosynthesis guided event ontologies.DJGPhD.6NOV22.Authentic Biochemistry.

Membrane Biochemistry 74. ER-Phosphatidylcholine biosynthesis regulates neuritigenesis and the use of logical judgment in research science. DJGPhD. 03Nov22. Authentic Biochemistry

Membrane Biochemistry 73. Pathogenic membrane associated phosphatidylcholine and sphingomyelin metabolism is linked to skeletal and CNS pathology. DJGPhD.02NOV22. Authentic Biochemistry

Membrane Biochemistry72. DHEA and the steroidogenic pathways as biochemical prolegomena to logical judgments. Dr. Daniel J. Guerra.29.10.22b.Authentic Biochemistry

Membrane Biochemistry 71. Intracellular-endomembranous cholesterol trafficking and estrogen biosynthesis is under epigenetic control. DJGPhD.29.10.22.Authentic Biochemistry.

Membrane Biochemistry 70. Ketogenesis and cholesterologenesis are mediated by mitochondrial bioenergetics and the ER+Peroxisomal metabolism of VLCPUFA's via membrane domain event ontology.DJGPhD

Membrane Biochemistry 69. Distilled electrochemical potential mediated Inner mitochondrial membrane redox and the introduction to sterol involvement.DJGPhD.27.10.22. Authentic Biochemistry

Membrane Biochemistry 68. Elevatum Hypostasis. Dr Daniel J. Guerra. 22.10.22b Authentic Biochemistry

Membrane Biochemistry 67. VDAC oligimerization inhibition can block mitochondria-mediated apoptosis and NLRP3 inflammasome activation. DJGPhD.22.10.22.Authentic Biochemistry.

Membrane Biochemistry 66. Staph aureus infection, autoimmune disease, biliary cholangitis, and neurodegeneration involve NLRP3 Inflammasome activation with core bioenergetic involvement. DJGPhD.

Membrane Biochemistry 65. The integration of pro-inflammatory signaling from a plenum of molecular membranous events: The NRLP3 Inflammsome. DJGPhD. 19.10.22. Authentic Biochemistry.

Membrane Biochemistry 64. Prelude to Biochemical Metaphysics and the Mitochondrial Membrane Damage Response I. Dr. Daniel J. Guerra.18.10.22.Authentic Biochemistry Podcast

Membrane Biochemistry 63. The TCR:APC Chemokine receptor Trigger for Cytokine Stimulation. DJGPhD. 16 Oct 2022 Authentic Biochemistry Podcast

Membrane Biochemistry 62. The T cell receptor mechanism II. Dr. Daniel J. Guerra. 14.10.22 Authentic Biochemistry

Membrane Biochemistry 61. The Tcell membrane :APC synapse I. Dr Daniel J. Guerra 13.10.22 Authentic Biochemistry

Membrane Biochemistry 60. Human neocortical membrane lipid evolution and the links to cognition,fasting, and neurodegeneration. Dr Daniel J. Guerra. 03Oct2022.Authentic Biochemistry.

Membrane Biochemistry 59. Back to the Basics.Dr Daniel J. Guerra 30 September 2022.Authentic Biochemistry

Membrane Biochemistry 58. Cardiolipin biosynthesis involves a PC-linoleic acid requiring maturase and a unique phosphatidylglycerol phosphate phosphatase. DJGPhD.25.9.22.Authentic Biochemistry

Membrane Biochemistry 57. c-Fos osteoclastogenesis and control over acetyl ceramide mediated apoptosis.Dr Daniel J.Guerra.22.9.22 Authentic Biochemistry

Membrane Biochemistry 56. Membrane Associated Cholesterol hydroxylation leads to bile acid conjugate- promoting human breast cancer stem cell proliferation. DJGPhD.19.9.22 Authentic Biochemistry.

Membrane Biochemistry 55. A phosphoglycerolipid primer. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 16 Sept. 2022.

Membrane Biochemistry 54. De-phospho TYR cFos doubles the VMax of specific glycolipid and phospholipid biosynthetic enzymes via ER stabilization.Dr Daniel J. Guerra. Authentic Biochemistry.14.9.22

Membrane Biochemistry 53. cFos correlates with light-induced retinal membrane retailoring without de novo transcription. Dr Dan Guerra. 13.9.22.Authentic Biochemistry Podcast

Membrane Biochemistry 52. Epigenetic modifications in pathophysiology and the synthesis of nascent membrane lipid in cell cycle progression. DJGPhD.12Sept22. AUthentic Biochemistry

Membrane Biochemistry 51. The BRD4 epigenetic reader control over cardiac mitochondrial function via bioenergetic gene expression may be corrupted in oncogenic pharmacotherapy driven BETi. DJGPhD.

Membrane Biochemistry L (50). SCFA's work via membrane free fatty acid receptors through transcription factor Nrf2 to reduce ROS with an epigenetic mark-up.DJGPhD.7Sept22.Authentic Biochemistry.

Membrane Biochemistry 49. linking membrane reception and endocrine steroid lipid signaling to disease and longevity.DJGPhD.06Sept22

Membrane Biochemistry 48.Coxsackievirus B enterovirus causes myocarditis in young men due to lack of estrogen-receptor-mediated control of mitochondrial fission/fusion & inflammation. DJGPhD.3Sept22

Membrane Biochemistry 47. AMPK is regulated by steroid hormone activating kinases and calcium. DJGPhD. 02September2022, Authentic Biochemistry Podcast

Membrane Biochemistry 46. Lung and endometrial cancer vs neurodegersative disease in steroid-sex-hormone NK cell biochemistry.DJGPhD.31.8.22. Authentic Biochemistry.

Membrane Biochemistry XXXXV. Female NK Cytotoxicity due to Membrane Surface Receptors may Obtain Reduced Pathogen Infection Rates and Cancer in Women v. Men.DJGPhD.30.8.22 Authentic Biochemistry.

Membrane Biochemistry 44. Synthesis of Lectures Video. Part One. Attached in show notes. Dr. Daniel J. Guerra. 29.8.22 Authentic biochemistry Podcast.

Membrane Biochemistry 43. Action potentials and the mechanisms of electrochemical communication in biological systems. DJGPhD.26.8.22. Authentic Biochemistry

Membrane Biochemistry XXXXII. Basic Electrobiochemistry of Biological Membranes. Dr Daniel J. Guerra. 24.8.22b Authentic Biochemistry Podcast Audio Lectures.

membrane Biochemistry XXXXI. A priori Synthesis of Sex-linked Biochemical Dimorphism and Canonical Membrane Event Ontology. Dr. Daniel J. Guerra. 24.8.22.Authentic Biochemistry Podcast.

Membrane Biochemistry XXXX. Immunological Response to Molecular Sex-linked Pattern Dimorphism Includes the Presentation of Differential Autoinflammatory Diseases. DJGPhD 22.8.22b.Authentic Biochem.

Membrane Biochemistry XXXIX. Maternal Inheritance of Mitochondrial DNA and the Heterozygous XY Chromosomal Contributions to Sexually Dimorphic Biochemical Processes.DJGPhD.22.8.22. Authentic Biochem.

Membrane Biochemistry XXXVIII. Sexual Biochemical Dimorphism Epigenetic Involvement in Early Infant CRF/HPA Axis and Subsequent Adult Neuropsychiatric Disease. DJGPhD.19.8.22. Authentic Biochemistry.

Membrane Biochemistry XXXVII. CRF Receptor Studies in Pre-Clinical Research as Bootstrapped to Human MDD, GAD, PTSD and Addiction.DJGPhD.19.8.22. Authentic Biochemistry

Membrane Biochemistry XXXVI. Sexual Differential CRF Signaling Accorded to Downstream Processing and Associated Neuropsychiatric and Phyiological Disorders.DJGPhD.17.8.22 Authentic Biochemistry.

Membrane Biochemistry XXXV. Lipocortin-1 induces cortisol thus suppressing phospholipase A2, blocking eicosanoid and leukocyte inflammatory events. DJGPhD.16.8.22. Authentic Biochemistry

Membrane Biochemistry XXXIV. Assymetric Glucocorticoid Pharmacotherapy in Rheumatoid Autoimmune Disease with T2Diabetes and the Fear Axis.DJGPhD.Authentic Biochemistry 15.8.22

Membrane Biochemistry XXXIII> Are Oxytocin and Corticotropin Releasing Factor Antiinflammatory, Analgesic and Anxiolytic? Dr Daniel J. Guerra. 14.8.22. Authentic Biochemistry

Membrane Biochemistry XXXII. The Subcortico-limbic network in Fear Conditioning as seen through the Dialectical Event Ontology lens. DJGPhD.10.AUG.22. Authentic Biochemistry

Membrane Biochemistry XXXI. Corticotropin Releasing Factor and "Fear" Neurobiochemical Correlates in the CNS. Dr Daniel J. Guerra. 9Aug2022. Authentic Biochemistry Podcast

Membrane Biochemistry XXX. Nociception as component of Subcortical-Limbic Involvement of the Conditioned Fear Response in Mammals. DJGPhD. 8Aug22. Authentic Biochemistry

Membrane Biochemistry XXIX. Final discussions on serum albumin and membrane disruption mediated inflammatory modulation. Dr. Daniel J. Guerra. 7bAug22.Authentic Biochemistry.

Membrane Biochemistry XXVIII. Serum Albumin as an arbiter of neuronal inflammation or peripheral removal of circulating endogenous Danger/Damage-Associated Molecular Patterns. 7Aug22. DJGPhD.

Membrane Biochemistry XXVII. Traumatic Brain Injury and Ischaemic Stroke associated neuroinflammation is mediated through membrane caveolae. Dr Daniel J. Guerra.3Aug22. Authentic Biochemistry.

Membrane Biochemistry XXVI. Lipid molecular structures and membrane morphology impacting biological activity. Dr Daniel J. Guerra. 01August2022. Authentic Biochemistry Podcast Productions.

Membrane Biochemistry XXV. From Plotinus through Kant to Membrane lipids: an a priori synthesis of research scientific event concepts. DJGPhD.Authentic Biochemistry.31.7.22

Membrane Biochemistry XXIV. Legionella- assocated TLR mediated LPS containing sialic acid interactions and the Caveolar Involvement in Pathobiochemistry.DJGPhD. 29.7.22.Authentic Biochemistry.

Membrane Biochemistry XXIII. DNA recombination and methylation associated autoimmune and cancer pathology via TLR4 and membrane lipid rafts. DJGPhD.28.7.22. Authentic Biochemistry

Membrane Biochemistry XXII*. The dialectical event ontology of caveolae-associated disease is florid with no absolute relational, quantitative, qualitative or modal conformity.DJGPhD.27.7.22

Membrane Biochemistry XX. Loss of CNS CA1-Caveolae Formation in Obese Type-2 Diabetics is Linked to insulin Resistance and Alzheimer's Disease. DJGPhD24.7.22. Authentic Biochemistry.

Membrane Biochemistry XIX. Oxysterols and LDLR in atherosclerosis: transcriptional mediation of membrane control over cholesterol homeostasis. 21.7.22. DJGPhD.Authentic Biochemistry

Membrane Biochemistry XVIII> Valproic acid and Platelt Activating Factor:Membrane lipids in Alzheimer's DiseaseDJGPhD 18.7.22 Authentic Biochemistry

Membrane Biochemistry XVII. Epoigenetic changes in protein controlled membrane lipid transport in human disease. DJGPhD.14.7.22

Membrane Biochemistry XVI. The Acid Sphingomyelinase Deficiencies. Dr Dan Guerra. 13.7.22 Authentic Biochemistry

Membrane Biochemistry XV. REST mediated gene repression and membrane function and plaque formation in atherosclerosis. DJGPhD. 11JUly22. Authentic Biochemistry

Membrane Biochemistry XIV. Apoptosis and Necroptosis review. Dr. Daniel J. Guerra. 8 July 2022. Authentic Biochemistry Podcast

Membrane Biochemistry XIII.Fatty acid induced membrane protein phosphorylation can shift pro-oncogenic to apoptotic cell fate in human breast cancer cell lines. DJGPhD. 5July 2022 Authentic Biochem.

Membrane Biochemistry XII. The specificity of membrane lipid raft molecular species and the dialectics of protein sorting. DJGPhD.3 July 2022 Authentic Biochemistry.

Membrane Biochemistry XI. Inflammasomes and omega three fatty acid involvement in various pathogenic and human disease states. DJGPhD.02.July 2022.

Membrane Biochemistry X. Dialectical Event Ontologies and the Complexity of Biological Systems. Dr. Daniel; J.Guerra 2 July 2022 Authentic Biochemistry

Membrane Biochemistry IX. Omega Three fatty acid utilization via oxygenation to control inflammation. DJGPhD. 30.6.22 Authentic Biochemistry Podcast production

Membrane Biochemistry VIII. The basics of lipid membranes. Part 1. Dr Daniel J. Guerra. Authentic Biochemistry Podacst Production. 28.6.22

Membrane Biochemistry VII. DNA methylation and histone acetylation may be at the core of memory and learning via LTP associated Integral Membrane Excitation. DJGPhD.24.6.22 Authentic Biochemistry.

Membrane Biochemistry VI. The involvement of membrane lipid omega 3 fatty acids in LTP and memory acquisition. Part 1. Dr Guerra. 23.6.22. Authentic Biochemistry

Membrane Biochemistry V. Epigenetic alteration of gene expression is predicated by free will induced synaptic plasticity as an event ontology. DJGPhD. 21.6.22 Authentic Biochemistry

Membrane Biochemistry IV. Synaptic Plasticity and Oncological Phenomena involving DNA Methylation. Dr. Daniel J. Guerra. 20.6.22 Authentic Biochemistry

CytoEpigenetics XIX. Some examples of epigenetic methylation and acetylation patterns in disease and the concept of maintenance methylation. Dr Daniel J. Guerra. 06June2022

CytoEpigenetics XVIII. Membrane lipid architectonics organized for cell cycle and both nuclear and mitochondrial biochemical mediation of gene expression. Dr. Dan Guerra. 05 June 2022

CytoEpigenetics XVII. The role of ceramide metabolism in epigenetic and bioenergetic cross talk among multiple subcellular compartments. Dr Dan Guerra. 03June2022 Authentic Biochemistry Podcast