All Episodes

BioMedical Portrait V C.5 Periodontitis-linked CVD. DJGPhD. 30.10.31

BioMedical Portrait V. c7. NETs and the combined activities of elastase,NOX2,MPO and IP3 PTEN phosphatase potentiate inflammation-linked pathologies of lung and pancreas. DJGPhD.31.10.23 and

BioMedical Portrait V C.6 P. gingivalis Two Component System assembly and activation mediate infection court involvement in subsequent host vector pathology.DJGPhD. 30.10.23b.

BioMedical Portrait Vc4 Two component signal system pathogenic bacterial responses to host immunity and the gigipain cysteine protease opposing serum secretory IgA mediated phagocyte activation.DJGPhD

BioMedical Portrait V.c3. The categorical analysis of Neutrophil involvement in multiple pathophysiologies requires cellular signaling to derivatize pleiotropic disease ontologies. DJGPhD.26.10.23

BioMedical Portrait V. The neutrohil oxidative burst and the roles of Phox generating superoxide and peptide arginine deiminase in phagocyte defense against pathogens and contrarion disease promotion.

BioMedical Portrait V. Introductory alethic unfolding of neutrophil glycolysis associated hyperinflammatory restraint.

Continuing dialectical event ontology of epistemological requirements for validation of biochemical research. DJGPhD.23.10.23. Authentic Biochemistry Podcast

All reciprocity in not disinterested so phenomena must be in equilibrium. But phenomena at equilibrium are invisible so reciprocity must be uncertain. DJGPhD.22.10.23. Authentic Biochemistry

BioMedical Portrait IV. Postcript DJGPhD. 21 October 2023. Authentic Biochemistry Podcast

BioMedical Portrait IV. 13b. Magnetic Resonance Imaging as a non-invasive tool in Neurodegenerative Diseases. DJGPhD.19.10.23 Authentic Biochemistry.

BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast

BioMedica; Portrait IV Coda II.c12. Biochemical Concatenations-the spatiotemporal sequences of molecular-cellular events of FTD's from proteinopathies to signalling and antigen recognition. DJGPhD.

BioMedical Portrait IV c11. FTLD-tau is correlated with microglial and astrocytic inflammation and subsequent neural degeneration. DJGPhD. 16.10.23 Authentic Biochemistry.

BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast

BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23

BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23.

BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry

BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD

BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation

BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic.

BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol.

BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD.

BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry.

BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD

BioMedical PortraitIII. c13b.Immune cell metabolic dialectical usurpation of architechtonic control over inflammation and cell fate obtained from senescence and obesity.-linked dyslipidaemia.DJGPhD.

BioiMedical Portrait III. NLRP3 Inflammasome and senescence-associated heterochromatic foci in macrophages, Kuppfer Cells and Liver sinusoidal endothelial cells contibute to liver/adipose disease

BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD.

BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD.

BioMedical Portrait III. c10. Ribosomal collision frequency is attenuated by ZAK and GCN2 via mutually exclusive signalling events, DJGPhD. 25.9.23. Authentic Biochemistry Podcast

BioMedical Portrait III. c9. Amino acid deprivation-linked fall of polypeptide synthetic fidelity triggers downstream ribosomal stress response phenomena including kinase mediated cell fate sequalae.

BioMedical Portrait III. c8. Unique mRNA upstream open reading frames direct both the integrated stress response and rare selective up-regulation of stress-correcting protein synthesis.DJGPhD.21.9.23

BioMedical Portrait III.c.7 Elementary polypeptide synthesis-translation. Lecture 1. DJGPhD.20.9.23.Authentic Biochemistry Podcast.

BioMedical Portrait III. c6. Adipokine and the succinate receptor systems in obese adipose inflammation as regulated by AMPK.DJGPhD.19.9.23. Authentic Biochemistry Podcast

BioMedical Portrait III.c.5. Adipokine mediated adipose inflamation is linked to the hypothalamic control over metabolism and systemic inflammation.DJGPhD.18.9.23.Authentic Biochemistry Podcast

BioMedical Portrait III. c.4. Adipose tissue macrophages express galectin binding proteins which alter immunosuppression and polarization;adipokines mediate the inflammatory response. DJGPhD.17.9.23

BioMedical Portrait III. Immunometabolic disease 3c.Reactive N and O interconversions in obese adipose exacerbate systemic inflammation. 17.9.23. DJGPhD. Authentic Biochemistry Podcast.

BioMedical Portrait III. Immunometabolic disease. The obesity-compromised adipose poise to hyperinflammation. DJGPhD. 15.9.23. Authentic Biochemistry.

BioMedical Portrait III. c1. Immuno-metabolic disease. Dr. Daniel J. Guerra. 14.9.23. Authentic Biochemistry Podcast.

Biochemical Energetics. Elementary Considerations chapter2. DJGPhD. 13.9.23 Authentic Biochemistry Podcast

Biochemical Energetics I Elementary Considerations. DJGPhD 12Sept23. Authentic Biochemistry Podcast.

BioMedical Portrait II. Hashimoto's Thyroiditis prevalence in women linked to mitochondrial electron transport chain activity, ATP/ADP translocation, and potent autoantibodies to thyroid peroxidase.

BioMedical Portrait II. c.14. Predominance of Hashimoto's Thyroiditis in Women: is there a link to the decreased expression of TLR7 and the AMPK-alpha/Id3 axis on CD8+TE and Treg activity?

BioMedical PortraitII. c13. Female prevalent autoimmune RA-macrophage STAT3(TF) and NaMPT(NAD+ salvage pathway) promote rheumatoid arthritis & primer on thyroiditis

BioMedical Portrait II. C12. Lupus is far more common in women than men due to TLR7 enhancement and Rheumatoid Arthritis is more common in women due to macrophage bioeneregtic phenomenaDJGPhD.7Sept23

BioMedical Portrait II.c11. Autoimmune diseases like lupus are far more prevalent in women due to the lack of X chromosomal allelic inactivationof TLR7's. DJGPhD.7Sept23.Authentic Biochemistry.

Biomedical Portrait!!,c.10 Older women have more reactive oxygen and fewer functional mitochondria and DNA content than older men or younger women.DJGPhD.5Dept2023. Authentic Biochemistry Podcast.

BioMedical Portrait II. c9. Autoimmune diseases are more common in women than men: immune response triggering and the possible role of bioenergetics.DJGPhD.3sept23.Authentic Biochemistry.

BioMedical Portrait II. C.8. Alterations in sphingosine metabolism linked to breast cancer staging in women and progression of NAFLD to NASH and HCC is much lower in women until menopause.DJGPhD.

Biomedical Portrait II. C.7. Serum sphingolipid molecular speciation in women differs from men but association with tissue endomembranous lipid components fail to be addressed.DJGPhD. 31.8.23

BioMedical Portrait II. Metabolic and Bioenergetic distinction between men and women includes lipid deposition and utilization mechanisms.DJGPhD.30.8.23.Authentic Biochemistry Podcast.

BioMedical Portrait II, c.5. Muscle fibre sexual dimorphism obtains networks of genetic, epigenetic, and biochemical events.DJGPhD.29.8.23 Authentic Biochemistry Podcast

Biomedical PortraitII.C.4 THe sexual dimorphism of bioenergetics: introduction to carbon utilization. Video lecture link

BioMedical Portrait II. Chapter 3. Mitochondrial gene expression, lipid metabolism and cell fate are at least partiatially mediated by Fragile X protein competency. DJGPhD.24.8.23

BioMedical Portrait II. The Fragile X Syndrome. Discovery and subsequent association with the FMR1 gene. Premature Ovary Failure I vs. heritable intellectual disabilities DJGPhD.22.8.23

BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation

BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23

Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP.

BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD

BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry

BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD.

BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23

BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD

BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD.

BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD

Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB.

BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection.

BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23

BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23

BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry

From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast

The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast

ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry

ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast.

ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD

ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression.

ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23

ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23

Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast.

ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23

ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry

ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA.

ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD.

ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry.

ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry

Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast.

Primer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast Productions

PhotosynthesisV. Photorespiration and synthesis of this holiday arc: fait accompli. DJGPhD.08July23b. Authentic BiochemistryPodcast.

Photosynthesis 4. Chlorophyll and carotene biosynthesis and some further detail on the mechanism of the Mn-H20 splitting complex of p680 PSII and diatomic molecular oxygen (O2) evolution.DJGPhD. 7July

Photosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productions

Unique Lecture Post holidayIV. Photosynthesis 2. DJGPhD.05July23b Authentic Biochemistry Podcast production.

Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast.

Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions)

Unique Lecture Series . Holiday Time. 4th of July 2023! Hydrocarbons.

ImmunoEpigenetics 89. Final synthesis of statin drug mediated alteration of metabolism in T lymphocytes. DJGPhD.6.30.23. Authentic Biochemistry Podcast.

ImmunoEpigenetics 88. Statin treatment of early progenitor T cell acute lymphoblastic leukemia could pose biochemical impositions on healthy lymphocyte populations. DJGPhD.29.6.23.Authentic Biochem.

ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture.

ImmunoEpigenetics86. Could regimented titrating statin pharmacotherapy be useful in controlling early T lymphoid progenitor cell ETP-ALL via an epigenetic mechansim? DJGPhD.27.6.23. Authentic Biochem

ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23

ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD.