All Episodes
Clinical Chemistry Podcast — 1000 episodes
Alpha-Synuclein-Specific RT-QuIC As a Tool for the Differential Diagnosis of Neurodegenerative Diseases Using Peripheral Tissues
Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy
Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma
Audio Summary September 2026
Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial
Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction
Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility
Audio Summary August 2026
From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians
Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis
Audio Summary July 2026
DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping
Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions
Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine
Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring
Audio Summary June 2026
Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?
Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis
Audio Summary May 2026
Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets
Scientific Fraud at Scale: Challenges for Trust in Published Data
Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing
Endogenous Lithium Levels and Alzheimer Disease
Audio Summary April 2026
PREEMPT'ing Overreliance on Peripheral Blood-Based ColoRectal Cancer Screening
A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready?
Audio Summary March 2026
Global IVD: Barriers, Trends, and Future
Uterus Transplantation—Current Evaluation, Monitoring, and Emerging Diagnostics
Audio Summary February 2026
Unmet Clinical Needs and Remaining Challenges of Pregnancy Reference Intervals
From Diagnosis to Delivery: A Look at the Continuing Gap in Maternal Testing
Audio Summary January 2026
Per se driving under the influence of cannabis statutes and blood delta-9-tetrahydrocannabinol concentrations following short-term cannabis abstinence
Regulatory Fragmentation in Europe and Its Risks for Patient Access and Safety: Subcontracting Work Flow Steps of In-House Diagnostic Procedures
Transdermal GFR Signals a New Horizon in Renal Diagnostics
Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol
Audio Summary December 2025
Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use
Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making
Diagnostic Value of Digital Estimates of Trophoblastic Mosaicism in Genome-Wide Cell-Free Fetal DNA Screening
Risk vs Prevalence: Weighing Routine DPYD Variant Testing Prior to Fluoropyrimidine-Based Chemotherapy
Audio Summary November 2025
Optimizing Estimation: Perspective on Drug Dosing Using New CKD-EPI Equations
Audio Summary October 2025
Utilizing the Stability of Individual Homeostatic Setpoints over Time - A Step Forward on the Path to Personalized Laboratory Medicine
Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic
Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis
Toward Improved Prostate Cancer Screening: Insights from the Göteborg-2 Trial
Audio Summary September 2025
Proteomic Aging Clock Predicts Mortality and Risk of Common Age-Related Diseases
Influence of Macrotroponin on the 99th Percentile Threshold in 2 High-Sensitivity Cardiac Troponin Assays
Pulse Oximeter Performance across Populations with Diverse Skin Tones
Polygenic Effects on Hb A1c May Mask Hyperglycemia and Increase Retinopathy Risk
Audio Summary August 2025
Reducing the Noise in Plasma Metagenomics to Further Define Clinical Utility
Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma
Audio Summary July 2025
Robotic Process Automation in Laboratory Medicine
HOPEing That a PEACEful Resolution for the Clinical Utility of High-Sensitivity Cardiac Troponin in the Ambulatory Setting Will Improve Laboratory Testing
Audio Summary June 2025
The Slow Progress in Developing Better Long-Term Cardiovascular Risk Assessment in Women Continues
Pediatric vaccine-induced antibody thresholds: Rethinking pre-immunosuppression serologic testing and revaccination implications
Reevaluating the threshold for low total testosterone
Help Us to Help You: Recommendations for Continued Enforcement Discretion for Common Infectious Disease Test Modifications under the FDA Final Rule
Audio Summary May 2025
New Clinical Practice Guidelines for Vitamin D Supplementation and Testing
Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations
Cardiac Biomarkers and Malnutrition Incidence in Community-Dwelling Older Adults without Cardiovascular Disease: The Seniors-ENRICA-2 Cohort
Pharmacogenetic Analysis of CYP2C19 for Clopidogrel: Ready for Prime Time
Audio Summary April 2025
A Multianalyte Machine Learning Model to Detect Wrong Blood in Complete Blood Count Tube Errors in a Pediatric Setting
An AI Model (LORIS) to Predict Immune Checkpoint Blockade Response in Cancer: A Clinical Data Science Perspective
Audio Summary March 2025
New American Society of Hematology Thrombophilia Guidelines Could Provoke Surge in Laboratory Testing
Xylazine Pharmacokinetics in Patients Testing Positive for Fentanyl and Xylazine
Rethinking Albuminuria in Low-Risk Patients and a Call for Urine Albumin Standardization
Audio Summary February 2025
From the Perspective of the Child: Ethical Considerations for the Implementation of Genomic Sequencing into Neonatal and Pediatric Care
Overcoming Barriers to Genomic Medicine Implementation
Clonality Determination by Detecting Unmodified Monoclonal Serum Free Light Chains Using On-Probe Extraction Coupled with Liquid Chromatography-High-Resolution Mass Spectrometry
Audio Summary January 2025
Untargeted Metabolomics for Inborn Errors of Metabolism: Development and Evaluation of a Sustainable Reference Material for Correcting Inter-Batch Variability
Novel In-Line Hemolysis Detection on a Blood Gas Analyzer and Impact on Whole Blood Potassium Results
Forever Chemicals, Endless Testing? Expert Advice to Be Prepared for Per- and Polyfluoroalkyl Substances
Audio Summary December 2024
Alzheimer disease blood-based biomarkers: Translation from research into clinical use
Deconvolution of human urine across the transcriptome and metabolome
Niacin and Risk of Cardiovascular Events: Deciphering the Paradox
Audio Summary November 2024
Approval of the First CRISPR-Cas9 Gene Editing Therapy for Sickle Cell Disease
Personalized Reproductive Hormone Monitoring in Sweat
Reference Intervals Revisited: A Novel Model for Population-Based Reference Intervals, Using a Small Sample Size and Biological Variation Data
Beyond the Screen: Navigating Remote Work within Medicine
Audio Summary October 2024
ChatGPT vs Medical Professional: Analyzing Responses to Laboratory Medicine Questions on Social Media
Congenital Syphilis: An Emerging, Preventable Public Health Crisis
The Era of Early Detection and Treatment of Brain Amyloid Deposition in Asymptomatic Individuals?
Audio Summary September 2024
Clinical Laboratories Confront a New Wave of Drug Overdose Deaths
Audio Summary August 2024
Osmotic Demyelination Syndrome in Hyponatremia: Does the Rate of Sodium Correction Matter?
Breaking Boundaries: Exploring Performance Enhancement and Anti-Doping Testing in Sports
Use of Maternal Race and Weight Provides Equitable Performance in Serum Screening for Open Neural Tube Defects
Audio Summary July 2024
Biological Insights from Cell-Free DNA Methylome Analysis in Preeclampsia
Microbiome-Based Diagnostics for Disease: Where Are We Now and Where Are We Headed?
Biomarkers vs Machines: The Race to Predict Acute Kidney Injury
Audio Summary June 2024
Evaluation of Nanopore Sequencing on Polar Bodies for Routine Pre-Implantation Genetic Testing for Aneuploidy
Challenges Associated with the Effective Implementation of New Laboratory Tests—The International Experience
Time to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals?
Audio Summary May 2024
Large Language Models for Scientific Publishing: Please, Do Not Make Them a Foe
Eye Catching Advancement for Creutzfeldt–Jakob Disease Diagnostics
More Than a Decade of Rapid Genomic Sequencing: Where Are We Now?
Audio Summary April 2024
Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification
The Next Clinical Decision Frontier: How to Efficiently and Safely Combine Machine Learning and Human Expertise
Clinical Decision Support in Laboratory Medicine
Audio Summary March 2024
New Sepsis Diagnostics and Their Impacts on Clinical Decision-Making and Treatment Protocols
Transport of Full-Length Proteins through a Nanopore: One Step Closer to Single-Molecule Proteomics
Automating the Detection of IV Fluid Contamination Using Unsupervised Machine Learning
Screening in Multiple Myeloma and Its Precursors: Are We There Yet?
Eight Misconceptions about Prostate-Specific Antigen
Cancer Screening, Incidental Detection, and Overdiagnosis
Audio Summary February 2024
Reevaluating the Role of High-Density Lipoprotein Cholesterol: New Perspectives on Cardiovascular Disease and Alzheimer Disease
Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age
Audio Summary January 2024
Sensitive Blood-Based Detection of HIV-1 and Mycobacterium tuberculosis Peptides for Disease Diagnosis by Immuno-Affinity Liquid Chromatography–Tandem Mass Spectrometry: A Method Development and Proof-of-Concept Study
Audio Summary December 2023
Early and Accurate Diagnosis of Parkinson Disease May Be Rooted in Seed Amplification Assays
AI Chatbots in Clinical Laboratory Medicine: Foundations and Trends
Generalizability of a Machine Learning Model for Improving Utilization of Parathyroid Hormone-Related Peptide Testing across Multiple Clinical Centers
Audio Summary November 2023
Confirmation of Insertion, Deletion, and Deletion-Insertion Variants Detected by Next-Generation Sequencing
Generative Artificial Intelligence: More of the Same or Off the Control Chart?
Short Timeframe Prediction of Kidney Failure among Patients with Advanced Chronic Kidney Disease
Audio Summary October 2023
Reference Interval Harmonization: Harnessing the Power of Big Data Analytics to Derive Common Reference Intervals across Populations and Testing Platforms
A Machine Learning Model for the Routine Detection of "Wrong Blood in Complete Blood Count Tube" Errors
In-Hospital Manufacturing of Cellular Therapies Using Automated Systems
Audio Summary September 2023
Feasibility of Targeted Next-Generation DNA Sequencing for Expanding Population Newborn Screening
Abatacept as a Mimic of Gamma Heavy Chain Disease
Assessing the Accuracy and Clinical Utility of ChatGPT in Laboratory Medicine
Audio Summary August 2023
Machine Learning in Laboratory Medicine: Recommendations of the IFCC Working Group
Driving Under the Influence of Cannabis: Impact of Combining Toxicology Testing with Field Sobriety Tests
Tissue Mass Spectrometry: How Solid Is Our Future?
Audio Summary July 2023
Polygenic Risk Scores: Genomes to Risk Prediction
Rapid Rule-Out of Myocardial Infarction Using a Single High-Sensitivity Cardiac Troponin I Measurement Strategy at Presentation to the Emergency Department: The SAFETY Study
Using Biomarkers for Traumatic Brain Injury: Are There Lessons That Can Be Learned from Implementing Cardiac Troponin?
Audio Summary June 2023
The Present and Future of Lipid Testing in Cardiovascular Risk Assessment
Multiplexing Homocysteine into First-Tier Newborn Screening Mass Spectrometry Assays Using Selective Thiol Derivatization
Lab Medicine in Space
Audio Summary May 2023
FDA Regulation of Laboratory Clinical Decision Support Software: Is It a Medical Device?
The Genotype—Phenotype Conundrum for Antimicrobial Susceptibility Testing
Psychedelics for Medicinal Use: How Will This Alter the Collective Laboratory Consciousness?
Audio Summary April 2023
Clinical Perspective on Use of Long-Read Sequencing in Prenatal Diagnosis of Thalassemia
Effects of Supplemented Mediterranean Diets on Plasma-Phospholipid Fatty Acid Profiles and Risk of Cardiovascular Disease after 1 Year of Intervention in the PREDIMED Trial
A Spotlight on Disruptors and Innovators
Audio Summary March 2023
Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis
Laboratory Preparedness for the Current Monkeypox Outbreak
Within-Person and Between-Sensor Variability in Continuous Glucose Monitoring Metrics
A Translational Tool to Facilitate Use of Apolipoprotein B for Clinical Decision-Making
Audio Summary February 2023
Neutral-Coating Capillary Electrophoresis Coupled with High-Resolution Mass Spectrometry for Top-Down Identification of Hemoglobin Variants
One Bad Apple Can Spoil the Bunch: The Impact of Contamination in the Clinical Laboratory
Can Rapid Nanopore Sequencing Bring Genomic Testing to the Bedside?
What is the Importance of Analyzing Tumor Tissues and Blood Cells in the Study of Circulating Tumor-Derived DNA?
Audio Summary January 2023
Rising to the Challenge: Shortages in Laboratory Medicine
Ceramide Risk Scores Can Bring Lipidomics to Clinical Medicine
Audio Summary December 2022
Identifying Clinically Relevant Bacteria Directly from Culture and Clinical Samples with a Handheld Mass Spectrometry Probe
Macrotroponin—Analytical Anomaly or Clinical Confounder
The PROVE-HF Study: Additional Proof for the Inclusion of the Manufacturer's Name When Reporting B-Type Natriuretic Peptide Results
Clinical Laboratory Informatics and Analytics: Challenges and Opportunities
Audio Summary November 2022
Cardiac Troponin as a Marker of Heart Failure Risk in Diabetes
Estimated Atherosclerotic Cardiovascular Disease Risk Score: An Automated Decision Aid for Statin Therapy
Harmonization Status of Serum Ferritin Measurements and Implications for Use as Marker of Iron-Related Disorders
Audio Summary October 2022
Differences between Educational and Regulatory External Quality Assurance/Proficiency Testing Schemes
Pan-Cancer Detection and Typing by Mining Patterns in Large Genome-Wide Cell-Free DNA Sequencing Datasets
Rh Blood Group D Antigen Genotyping Using a Portable Nanopore-based Sequencing Device: Proof of Principle
Direct-to-Consumer Testing for Routine Purposes
Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern
Audio Summary September 2022
Reproducibility: Has Cancer Biology Failed beyond Repair?
Public Misinformation and Science Communication in Times of Public Health Crises
Women in Laboratory Medicine: A Q&A on Diversity and Inclusion
Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus
Critical Roles of Clinical Laboratorians in Translational Research and Applied Sciences—Experts' Insights and Experiences
Machine Learning to Assist in Large-Scale, Activity-Based Synthetic Cannabinoid Receptor Agonist Screening of Serum Samples
The Need to Develop Clinical Guidance for the Use of High-Sensitivity Cardiac Troponin in Pediatric and Neonatal Patients
Audio Summary August 2022
Audio Summary July 2022
Evaluation of Neutralizing Antibodies against SARS-CoV-2 Variants after Infection and Vaccination Using a Multiplexed Surrogate Virus Neutralization Test
Angiogenic Biomarkers for Risk Stratification in Women with Preeclampsia
A Novel Approach to Improve Accuracy of CYP2D6 Enzyme Activity and Drug Response Predictions
Audio Summary June 2022
Toward Clinical Application of Leukocyte Counts Based on Targeted DNA Methylation Analysis
How Not to Introduce Laboratory Tests to Clinical Practice: Preimplantation Genetic Testing for Aneuploidy
New Equations for Estimating Glomerular Filtration Rate
A Paradigm Shift: Engagement of Clinical Chemistry and Laboratory Medicine Trainees by Innovative Teaching Methods
Glycated Albumin: Added Value or Redundancy in Diabetes Care?
Interpreting EQA—Understanding Why Commutability of Materials Matters
How Can We Ensure Reproducibility and Clinical Translation of Machine Learning Applications in Laboratory Medicine?
Audio Summary May 2022
Pregnancy in the Time of COVID-19: What Are the Challenges for Maternity Care?
Audio Summary April 2022
Alternative Sample Matrices Supporting Remote Sample Collection during the Pandemic and Beyond
Galaxy Is a Suitable Bioinformatics Platform for the Molecular Diagnosis of Human Genetic Disorders Using High-Throughput Sequencing Data Analysis: Five Years of Experience in a Clinical Laboratory
Audio Summary March 2022
Chest Pain Assessment: What Is Our Endgame?
Deadly Pathogens, Transformative Technologies, and Protracted Pandemics: Challenges and Opportunities in Laboratory Medicine
At-Home Testing for Infectious Diseases: The Laboratory Where You Live
Audio Summary February 2022
A Push for Real Normal: Mass Screening for COVID-19
Audio Summary January 2022
Challenges in Translating Clinical Metabolomics Data Sets from the Bench to the Bedside
Digital Microfluidic Hemagglutination Assays for Blood Typing, Donor Compatibility Testing, and Hematocrit Analysis
Circulating Ceramides and Sphingomyelins and Risk of Mortality: The Cardiovascular Health Study
Molecular Approaches to Transplant Monitoring; Is the Horizon Here?
Audio Summary December 2021
Liquid Biopsy Hotspot Variant Assays: Analytical Validation for Application in Residual Disease Detection and Treatment Monitoring
Programmed Cell Death Ligand 1-Expressing Circulating Tumor Cells: A New Prognostic Biomarker in Non-Small Cell Lung Cancer
The European Biological Variation Study (EuBIVAS): Biological Variation Data for Coagulation Markers Estimated by a Bayesian Model
Perspectives on Identifying and Treating Familial Hypercholesterolemia in Childhood
Audio Summary November 2021
Can High-Sensitivity Troponins Help to Level the Playing Field in Cardiovascular Disease Prevention between Women and Men?
TOP-Plus is a Versatile Biosensor Platform for Monitoring SARS-CoV-2 Antibody Durability
Audio Summary October 2021
High-Sensitivity Cardiac Troponin T for the Detection of Myocardial Injury and Risk Stratification in COVID-19
Cardiac Biomarkers in Pediatrics: An Undervalued Resource
Audio Summary September 2021
AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 EUA and LDT Serologic Testing in Clinical Laboratories
How Well Do Laboratories Adhere to Recommended Guidelines for Cardiac Biomarkers Management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) Study of the European Federation of Laboratory Medicine Task Group on Cardiac Markers
Big Data Strikes Again: Future Utilization of the UK Biobank as a Resource for Clinical Laboratories
Case-Control Study of Individuals with Discrepant Nucleocapsid and Spike Protein SARS-CoV-2 IgG Results
Serum Prostate-Specific Antigen Testing for Early Detection of Prostate Cancer: Managing the Gap Between Clinical and Laboratory Practice
Audio Summary August 2021
Associating SARS-CoV-2 Serological Assays with Protection: Where the Field Stands
Laboratory Action Plan for Emerging SARS-CoV-2 Variants
Audio Summary July 2021
Centralized vs Decentralized Molecular Infectious Disease Testing
Is it Time to move on? Reexamining Race in Glomerular Filtration Rate Equations
Limitations of Accelerated Stability Model Based on the Arrhenius Equation for Shelf Life Estimation of In Vitro Diagnostic Products
Interoperability: COVID-19 as an Impetus for Change.
Audio Summary June 2021
Audio Summary May 2021
Development of an LC-MS/MS Proposed Candidate Reference Method for the Standardization of Analytical Methods to Measure Lipoprotein(a)
Clinical Protein Analysis by Mass Spectrometry: A New Higher Order
Audio Summary April 2021
Towards an SI-Traceable Reference Measurement System for Seven Serum Apolipoproteins Using Bottom-Up Quantitative Proteomics: Conceptual Approach Enabled by Cross-Disciplinary/Cross-Sector Collaboration
Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation
The Dynamic and Multifaceted Nature of Cardiovascular Disease and Using Genetic Testing to Inform Clinical Care: An International Perspective
Audio Summary March 2021
The Vitamin D Metabolite Ratio is Independent of Vitamin D Binding Protein Concentration
Audio Summary February 2021
Nonfasting Lipid Profile for all Patients?
B-Type Natriuretic Peptide Is Associated with Favorable Left Ventricular Function in General Population
Audio Summary January 2021
Deus ex machina? Predicting SARS-CoV-2 Infection from Lab Tests Using Machine Learning.
SARS-CoV-2 Whole Genome Amplification and Sequencing for Effective Population-Based Surveillance and Control of Viral Transmission
Cautionary Note on Contamination of Reagents Used for Molecular Detection of SARS-CoV-2
Genomic Prediction of Antimicrobial Resistance: Ready or Not, Here It Comes!
The Faces of Women in AACC - A Historical Reflection on AACC Leadership and Awards
Audio Summary December 2020
Cell-free DNA fragmentomics: the new "omics" on the block
Audio Summary November 2020
Examining Laboratory Medicine's Role in Eliminating Health Disparities
Proportion of Donor Specific Cell-Free DNA in Blood as a Marker of Transplant Rejection: Not an Absolute
Patient-Based Real Time QC
Evaluation of the Risk of Laboratory Microbial Contamination During Routine Testing in Automated Clinical Chemistry and Microbiology Laboratories
Audio Summary October 2020
In-Depth Analysis of Molecular Heterogeneity of Circulating N-Terminal pro-BNP: Does Detailed Characterization of Analyte Structure Really Matter for its Diagnostic Use?
Throughput Considerations for a Sample-Multiplexed LC-MS/MS Assay: Is the Ability to Double the Injection Throughput Always a Time Saver?
Recognition of the Pre-hospital Preanalytical Phase: Collaborative Efforts between Laboratory Medicine and Emergency Medicine to Ensure Quality Testing
Clinical Performance of Two SARS-CoV-2 Serologic Assays
Audio Summary September 2020
Machine Learning for the Biochemical Genetics Laboratory
Audio Summary August 2020
IFCC Working Group Recommendations for Correction of Bias Caused by Noncommutability of a Certified Reference Material Used in the Calibration Hierarchy of an End-User Measurement Procedure
Fecal Microbiota Transplantations: Where Are We, Where Are We Going, and What Is the Role of the Clinical Laboratory?
Modification of In Vitro Diagnostic Devices: Leveling the Playing Field
Audio Summary July 2020
July 2020 Summary Peddu
July 2020 Summary Caswell
July 2020 Summary Pitella-Silva
July 2020 Summary Lau
July 2020 Summary Jensen
July 2020 Summary McGrath
June 2020 Summary Benoist
June 2020 Summary Min
June 2020 Summary Crawford
June 2020 Summary Tafess
June 2020 Summary Trouillet-Assant
June 2020 Summary Pan
Audio Summary June 2020
SARS-CoV-2 Serology: Much Hype, Little Data
Development, Validation, and Regulatory Considerations for a Liquid Biopsy Test
Audio Summary May 2020
May 2020 Summary Clouet-Foraison
May 2020 Summary Liu
May 2020 Summary Guo
May 2020 Summary Heider
May 2020 Summary Hicks
May 2020 Summary Colak
Calibrating from Within: Multipoint Internal Calibration of a Quantitative Mass Spectrometric Assay of Serum Methotrexate
Audio Summary April 2020
April 2020 Summary Silveira
April 2020 Summary Lam
April 2020 Summary Korecka
April 2020 Summary Moncrieffe
April 2020 Summary Lyngbakken
April 2020 Summary Jongejan
April 2020 Summary Chu
Mass Spectrometry for Identification, Monitoring, and Minimal Residual Disease Detection of M-Proteins
Clinical Relevance of the 99th Percentile Upper Reference Limit for High-Sensitivity Cardiac Troponin Assays
Emergence of a Novel Coronavirus Disease (COVID-19) and the Importance of Diagnostic Testing: Why Partnership between Clinical Laboratories, Public Health Agencies, and Industry Is Essential to Control the Outbreak [Chinese Translation]
Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank
Development and Clinical Validation of a Sensitive Lateral Flow Assay for Rapid Urine Fentanyl Screening in the Emergency Department
Emergence of a Novel Coronavirus Disease (COVID-19) and the Importance of Diagnostic Testing: Why Partnership between Clinical Laboratories, Public Health Agencies, and Industry Is Essential to Control the Outbreak
Audio Summary March 2020
March 2020 Summary Guo
March 2020 Summary Hoffman
March 2020 Summary Blesa
March 2020 Summary Sun
March 2020 Summary Lam
March 2020 Summary Apple
Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia [Chinese Translation]
Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia
February 2020 Summary Pruner
February 2020 Summary Jin
February 2020 Summary Malka
February 2020 Summary Vigneron
February 2020 Summary Ge
February 2020 Summary Starnberg
February 2020 Summary Li
February 2020 Summary O'Malley
Audio Summary February 2020
Circulating Tumor DNA for Modern Cancer Management
Microbiome Diagnostics
Unconventional Diagnosis Based on Somatic Findings through Germ Line Whole-Exome Sequencing
Predictive and Precision Medicine with Genomic Data
Molecular Diagnostics: Going from Strength to Strength
Audio Summary January 2020
January 2020 Summary Coelho-Lima
January 2020 Summary Wu
January 2020 Summary Profaizer
January 2020 Summary Zucha
January 2020 Summary Chandler
January 2020 Summary Gotway
January 2020 Summary Ge
January 2020 Summary Song
January 2020 Summary Lin
January 2020 Summary Joosse
January 2020 Summary Lampignano
Ethics for Laboratory Medicine
Laboratory Measurement's Contribution to the Replication and Application Crisis in Clinical Research
Audio Summary December 2019
December 2019 Summary Sorensen
December 2019 Summary Meisterzheim
December 2019 Summary Weber
December 2019 Summary Salamin
December 2019 Summary Sun
December 2019 Summary Yang
December 2019 Summary Wussler
December 2019 Summary Hughey
December 2019 Summary Costenbader
Circular RNAs as Urinary Biomarkers
ProBNP That Is Not Glycosylated at Threonine 71 Is Decreased with Obesity in Patients with Heart Failure
An Intact ACTH LC-MS/MS Assay as an Arbiter of Clinically Discordant Immunoassay Results
Audio Summary November 2019
November 2019 Summary Bansal
November 2019 Summary Nestelberger
November 2019 Summary Boeddinghaus
November 2019 Summary Yang
November 2019 Summary O' Leary
November 2019 Summary Shi
November 2019 Summary van Faassen
November 2019 Summary Potter
A View on the Interrelationship between Obesity and Natriuretic Peptide Measurements: Can Dysregulation in pro–B-type Natriuretic Peptide Glycosylation Explain Decreased B-type Natriuretic Peptide Concentrations in Obese Heart Failure Patients?
Urinary Amino-Terminal Pro–C-Type Natriuretic Peptide: A Novel Marker of Chronic Kidney Disease in Diabetes
Role of BNP vs NT-proBNP Testing in the Age of New Drug Therapies: Sacubitril-Valsartan
Once-Per-Visit Alerts: A Means to Study Alert Compliance and Reduce Repeat Laboratory Testing
Detection of Neprilysin-Derived BNP Fragments in the Circulation: Possible Insights for Targeted Neprilysin Inhibition Therapy for Heart Failure
Audio Summary October 2019
October 2019 Summary Hoq
October 2019 Summary Takahashi
October 2019 Summary van Tol
October 2019 Summary Kolling
October 2019 Summary Sun
October 2019 Summary Garrel
October 2019 Summary Chan
October 2019 Summary Prickett
October 2019 Summary Feygina
Optimal Use of Biomarkers for Chronic Kidney Disease
September 2019 Summary Lynch
September 2019 Summary Ma
September 2019 Summary Cassinari
September 2019 Summary Lampasona
September 2019 Summary Lampignano
September 2019 Summary Szymanski
September 2019 Summary Lewis
September 2019 Summary IIkezaki
Audio Summary September 2019
Patient-Based Real-Time Quality Control: Review and Recommendations
The National Glycohemoglobin Standardization Program: Over 20 Years of Improving Hemoglobin A1c Measurement
Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling
Audio Summary August 2019
August 2019 Summary Chen
August 2019 Summary Kuusisto
August 2019 Summary Carobene2
August 2019 Summary Hjort
August 2019 Summary Sepiashvili
August 2019 Summary Body
August 2019 Summary Roraas
August 2019 Summary He
Audio Summary July 2019
July 2019 Summary Cheng
July 2019 Summary JLi
July 2019 Summary Tan
July 2019 Summary Boeddinghaus
July 2019 Summary Vylegzhanina
03 Summary Lyngbakken
July 2019 Summary Whitman
July 2019 Summary Grammer
Low HDL Cholesterol and High Risk of Autoimmune Disease: Two Population-Based Cohort Studies Including 117341 Individuals
Inspiring Minds-: Patrick Bossuyt
What the Protecting Access to Medicare Act Means for Clinical Laboratories
A Message to Medical School Promotion Committees: Proper Credit for Peer-Reviewed Online Educational Materials
Generation of Highly Biomimetic Quality Control Materials for Noninvasive Prenatal Testing Based on Enzymatic Digestion of Matched Mother–Child Cell Lines
Audio Summary June 2019
June 2019 Summary Li
June 2019 Summary Burkve
June 2019 Summary Zelniker
June 2019 Summary Matin
June 2019 Summary Zhang
June 2019 Summary Mendelian Randomization Group
Increased Clinical Sensitivity and Specificity of Plasma Protein N-Glycan Profiling for Diagnosing Congenital Disorders of Glycosylation by Use of Flow Injection–Electrospray Ionization–Quadrupole Time-of-Flight Mass Spectrometry
Privacy in Direct-to-Consumer Genetic Testing
Parameters for Validating a Hospital Pneumatic Tube System
May 2019 Summary Farnsworth
May 2019 Summary Hartley
May 2019 Summary Sans
May 2019 Summary Yu
May 2019 Summary Chen
May 2019 Summary Madsen
Audio Summary May 2019
Can Mendelian Randomization Shift into Reverse Gear?
Challenges in the Assessment and Diagnosis of Polycystic Ovary Syndrome
A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease
Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS
Which Methods for Determining Glomerular Filtration Rate Most Strongly Associate with Risk of Progression of Kidney Disease?
Audio Summary April 2019
April 2019 Summary Jones
April 2019 Summary Yin
April 2019 Summary Jung
April 2019 Summary Franken
April 2019 Summary Fredsoe
April 2019 Summary Norman
Inflammatory Biomarkers and Clinical Judgment in the Emergency Diagnosis of Urgent Abdominal Pain
Type III Hyperlipoproteinemia: The Forgotten, Disregarded, Neglected, Overlooked, Ignored but Highly Atherogenic, and Highly Treatable Dyslipoproteinemia
March 2019 Summary Anand
March 2019 Summary Braga
March 2019 Summary Riethdorf
March 2019 Summary Rackow
March 2019 Summary Boeddinghaus
March 2019 Summary Mohammadi-Shemirani
March 2019 Summary Toes-Zoutendijk
March 2019 Summary Freed
Audio Summary March 2019
Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease
Using Machine Learning to Aid the Interpretation of Urine Steroid Profiles
Audio Summary February 2019
February 2019 Summary Wood
February 2019 Summary Hansen
February 2019 Summary Boot
February 2019 Summary Breidthardt
February 2019 Summary Salameh
February 2019 Summary Jin
February 2019 Summary Kong
February 2019 Summary Myrick
Assessment of Digital PCR as a Primary Reference Measurement Procedure to Support Advances in Precision Medicine
Differences in Health Outcomes between Men and Women: Biological, Behavioral, and Societal Factors
Male Contraceptive Development: Update on Novel Hormonal and Nonhormonal Methods
Redesigning Prostate Cancer Screening Strategies to Reduce Overdiagnosis
Updates on Screening, Prevention, Treatment, and Genetic Markers for Preeclampsia
CRISPR Methods for Nucleic Acid Detection Herald the Future of Molecular Diagnostics
Audio Summary January 2019
January 2019 Summary Winston-McPherson
January 2019 Summary Marrone
January 2019 Summary Srinivasan
January 2019 Summary Mikkelsen
January 2019 Summary SoRelle
January 2019 Summary Jayasena
Direct Comparison of Cardiac Troponin T and I using a Uniform and a Sex-specific Approach in the Detection of Functionally Relevant Coronary Artery Disease
Influence of Molecular Testing on Influenza Diagnosis
Decmeber 2018 Summary Huang
December 2018 Summary Kiehl
December 2018 Summary Folch
December 2018 Summary Liu
December 2018 Summary Milosevic
December 2018 Summary Hejl
December 2018 Summary Smith
December 2018 Summary Neumann
Audio Summary December 2018
Audio Summary November 2018
November 2018 Summary Parker
November 2018 Summary Eisenhofer
November 2018 Summary Sharma
November 2018 Summary Mansukhani
November 2018 Summary Ibrahim
November 2018 Summary Welsh
November 2018 Summary Mueller
November 2018 Summary Wilkes
Current and Emerging Trends in Point-of-Care Technology and Strategies for Clinical Validation and Implementation
Commutability Assessment of Candidate Reference Materials for Pancreatic α-Amylase
October 2018 Summary Zavridou
October 2018 Summary Li
October 2018 Summary Joosse
October 2018 Summary Lee
October 2018 Summary Delatour
October 2018 Summary Beck
October 2018 Summary Kabe
October 2018 Summary Andini
Audio Summary October 2018
September 2018 Summary Wald
September 2018 Summary Aarsand
September 2018 Summary Myhre
September 2018 Summary Caironi
September 2018 Summary Boeddinghaus
September 2018 Summary Silva
September 2018 Summary Guo
September 2018 Summary Darebna
Audio Summary September 2018
Validation of an Expanded Carrier Screen that Optimizes Sensitivity via Full-Exon Sequencing and Panel-wide Copy Number Variant Identification
Toward a Global Overview of HbA1c Test Performance
Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research
Association of Tryptophan Metabolites with Incident Type 2 Diabetes in the PREDIMED Trial: A Case–Cohort Study
Characterization of Human Salivary Extracellular RNA by Next-generation Sequencing
RNA Profiles of Circulating Tumor Cells and Extracellular Vesicles for Therapy Stratification of Metastatic Breast Cancer Patients
Quantifying Atherogenic Lipoproteins: Current and Future Challenges in the Era of Personalized Medicine and Very Low Concentrations of LDL Cholesterol. A Consensus Statement from EAS and EFLM
Audio Summary August 2018
August 2018 Summary Gai
August 2018 Summary Kim
August 2018 Summary Cannaert
August 2018 Summary Yu
August 2018 Summary Tobias
August 2018 Summary Deprez
August 2018 Summary EurA1C Group
Full-Size Cardiac Troponin I and Its Proteolytic Fragments in Blood of Patients with Acute Myocardial Infarction: Antibody Selection for Assay Development
Audio Summary July 2018
July 2018 Summary Rasmussen
July 2018 Summary Katrukha
July 2018 Summary Alimohamed
July 2018 Summary Li
July 2018 Summary Ludwig
July 2018 Summary Hogan
July 2018 Summary Keup
July 2018 Summary Than
Clinical Utility of Transcriptome Sequencing: Toward a Better Diagnosis for Mendelian Disorders
Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison Study
Clinical Evaluation of a Blood Assay to Diagnose Paucibacillary Tuberculosis via Bacterial Antigens
Audio Summary June 2018
June 2018 Summary Schirmer
June 2018 Summary Waalkes
June 2018 Summary Wu
June 2018 Summary Willemse
June 2018 Summary Cannaert
June 2018 Summary Ismail
Clinical and Genomic Insights from Metastatic Cancers
From DESI to the MasSpec Pen: Ambient Ionization Mass Spectrometry for Tissue Analysis and Intrasurgical Cancer Diagnosis
Evaluating Rapid Rule-out of Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay at Presentation
Audio Summary May 2018
May 2018 Summary Hilderink
May 2018 Summary Selvin
May 2018 Summary Haselmann
May 2018 Summary Greenslade
May 2018 Summary X Liu
May 2018 Summary Rejali
May 2018 Summary C Liu
Advanced Whole-Genome Sequencing and Analysis of Fetal Genomes from Amniotic Fluid
Comparing Measures of HDL: On the Right Path with the Wrong Map
The Biological Variation Data Critical Appraisal Checklist: A Standard for Evaluating Studies on Biological Variation
Audio Summary April 2018
April 2018 Summary vanderGugten
April 2018 Summary Kim
April 2018 Summary Mao
April 2018 Summary Amr
April 2018 Summary Topbas
April 2018 Summary Masi
April 2018 Summary deRond
Non-invasive Detection of Cocaine and Heroin Use Using Single Fingerprints
Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe
Plasma Steroid Metabolome Profiling for Diagnosis and Subtyping Patients with Cushing Syndrome
IFCC Working Group Recommendations for Assessing Commutability
Evaluation of Thyroid Function during Pregnancy: Have We Taken a Wrong Turn?
March 2018 Summary Badertscher
Audio Summary March 2018
March 2018 Summary Pavo
March 2018 Summary Eisenhofer
March 2018 Summary Tijms
March 2018 Summary Frobel
March 2018 Summary Kim
March 2018 Summary Greiner
March 2018 Summary El Heliebi
March 2018 Summary Zhou
March 2018 Summary Aarsand
March 2018 Summary Matera
Audio Summary February 2018
February 2018 Summary Walter
February 2018 Summary Moen
February 2018 Summary Prickett
February 2018 Summary Ruel
February 2018 Summary Hill
February 2018 Summary Camunas-Soler
February 2018 Summary Dharajiya
February 2018 Summary Decraene
February 2018 Summary Aalipour
February 2018 Summary Markou
February 2018 Summary Westgard
February 2018 Summary Farrokhi
Dietary Fat: Friend or Foe?
Use of Metabolomics in Improving Assessment of Dietary Intake
Bad Breaks and Metabolic Effects of Bariatric Surgery
New Therapies for Treating Hepatitis C Virus: Impact on Laboratory Testing Recommendations and Clinical Management
High-Resolution, Accurate-Mass (HRAM) Mass Spectrometry Urine Steroid Profiling in the Diagnosis of Adrenal Disorders
January 2018 Summary Ahmad
January 2018 Summary Varbo
January 2018 Summary Castillo
January 2018 Summary Ndumele
January 2018 Summary Astley
January 2018 Summary Mendelian Group
Audio Summary January 2018
Clinical Case Study: Unusual Cause of Abdominal Pain and Anemia
Using Biomarkers to Guide Heart Failure Therapy
Audio Summary December 2017
December 2017 Summary Silbernagel
December 2017 Summary Jagodzinski
December 2017 Summary Tolbus
December 2017 Summary McCudden
December 2017 Summary Durant
December 2017 Summary Taylor
December 2017 Summary Hines
The Role of Procalcitonin in Diagnosis of Sepsis and Antibiotic Stewardship: Opportunities and Challenges
Audio Summary November 2017
November 2017 Summary Diao
November 2017 Summary Costa
November 2017 Summary Noceti
November 2017 Summary Ferencik
November 2017 Summary Langsted
November 2017 Summary Cao
November 2017 Summary Pan
High-Sensitivity Troponin: Star Player but No Lone Hero
Implementing a Reference Measurement System for C-Peptide: Successes and Lessons Learned
Audio Summary October 2017
October 2017 Summary DeGrande
October 2017 Summary Gool
October 2017 Summary Pryor
October 2017 Summary Lam
October 2017 Summary Ladas
October 2017 Summary Sandoval
October 2017 Summary Bredemeier
Overinterpretation of Research Findings: Evidence of "Spin" in Systematic Reviews of Diagnostic Accuracy Studies
Patient Privacy and Clinical Laboratory Data
When Gender Identity Doesn't Equal Sex Recorded at Birth: The Role of the Laboratory in Providing Effective Healthcare to the Transgender Community
Audio Summary September2017
September 2017 Summary Carobene
September 2017 Summary Cardenas-Gonzalez
September 2017 Summary Do
September 2017 Summary Ebai
September 2017 Summary Kahaly
September 2017 Audio Summary Kahraman
September 2017 Audio Summary Zhang
Facilitating Prospective Registration of Diagnostic Accuracy Studies: A STARD Initiative
August 2017 Audio Summary
August 2017 Audio Summary Eggers
August 2017 Audio Summary Wang
August 2017 Audio Summary Sillence
August 2017 Audio Summary Bietenbeck
August 2017 Audio Summary Christenson
August 2017 Audio Summary Liao
August 2017 Audio Summary McGrath
Harmonization: Its Time Has Come
Temporal Biomarker Profiling Reveals Longitudinal Changes in Risk of Death or Myocardial Infarction in Non–ST-Segment Elevation Acute Coronary Syndrome
July 2017 Audio Summary
July 2017 Audio Summary Schrock
July 2017 Audio Summary Harada
July 2017 Audio Summary Liao
July 2017 Audio Summary Ong
July 2017 Audio Summary Thienpont
July 2017 Audio Summary Duprez
July 2017 Audio Summary Wildi
July 2017 Audio Summary Chan
Thrombin-Mediated Degradation of Human Cardiac Troponin T
Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry
June 2017 Audio Summary
June 2017 Audio Summary Kobylecki
June 2017 Audio Summary Carobene
June 2017 Audio Summary Lian
June 2017 Audio Summary Liu
June 2017 Audio Summary Lewis
June 2017 Audio Summary Dieplinger
June 2017 Audio Summary Katrukha
Fifty Shades of Yellow
May 2017 Audio Summary
Association of Blood Eosinophil and Blood Neutrophil Counts with Asthma Exacerbations in the Copenhagen General Population Study
FullIssueSummary April2017
Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair
Are THC Levels in Oral Fluids and Blood Plasma Comparable after Oral Ingestion of Edibles Containing Cannabis or THC?
High Glycated Albumin and Mortality in Persons with Diabetes Mellitus on Hemodialysis
Bone Turnover Markers in the Diagnosis and Monitoring
Clinical Chemistry's Commitment to Education: Stronger than Ever
Patient Consent and the Commercialization of Lab Data
FullIssueSummary February2017
Diurnal Rhythm of Cardiac Troponin: Consequences for the Diagnosis of Acute Myocardial Infarction
Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases
Short-term variability of vitamin D-related biomarkers
Early rule-out and rule-in strategies for myocardial infarction
Interpreting Cardiac Biomarkers in the Setting of Chronic Kidney Disease
Biomarkers for Clinical Decision-Making in the Management of Pulmonary Embolism
Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I
Myocardial Infarction Type 2 and Myocardial Injury
Trimethylamine N-oxide and Risk Stratification after Acute Myocardial Infarction
FullIssueSummary January2017
Alcohol consumption and cardiac biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study
Is the $1,000 genome as near as we think? A cost analysis of next-generation sequencing
Optimization of a Moving Averages Program Using a Simulated Annealing Algorithm
A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources
Comprehensive Assessment of M-Proteins Using Nanobody Enrichment Coupled to MALDI-TOF Mass Spectrometry
A Study of Hypermethylated Circulating Tumor
What Can a Clinical Chemist Learn from Aviation?
FullIssueSummary September16
Full Audio Summary September16
Can't Touch This! Contamination of Laboratory Equipment with Bloodborne Pathogens
Discordance with 3 Cardiac Troponin I and T Assays: Implications for the 99th Percentile Cutoff
Ready, Set, Type! Proteomics vs Agglutination for Escherichia coli H Antigen Confirmation
The Promise-and Pitfalls-of Computerized Provider Alerts for Laboratory Test Ordering
Classifying Germline Sequence Variants in the Era of Next-Generation Sequencing
A 30-Year-Old Patient Who Refuses to Be Drug Tested
Full Audio Summary July16
Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial
Incorporating Clinical Considerations into Statistical Analyses of Markers: A Quiet Revolution in How We Think About Data
Smartphones Can Monitor Medical Center Pneumatic Tube Systems
Postmarket Surveillance of Point-of-Care Glucose Meters through Analysis of Electronic Medical Records
Pharmacists in the Laboratory Space: Friends or Foes?
FullIssueSummary June2016
Different Susceptibility of B-Type Natriuretic Peptide (BNP) and BNP Precursor (proBNP) to Cleavage by Neprilysin: The N-Terminal Part Does Matter
Soluble CRTC3: A Newly Identified Protein Released by Adipose Tissue That Is Associated with Childhood Obesity
Effect of Dried Blood Spot Quality on Newborn Screening Analyte Concentrations and Recommendations for Minimum Acceptance Criteria for Sample Analysis
FullIssueSummary May2016
Nonfasting Sample for the Determination of Routine Lipid Profile: Is It an Idea Whose Time Has Come?
Mass Spectrometry–Based Adrenal and Peripheral Venous Steroid
Paper-Based Quantification of Male Fertility Potential
FullIssueSummary April2016
Clostridium difficile—Diagnostic and Clinical Challenges
Paper-Based Quantification of Male Fertility Potential
FullIssueSummary March2016
Impact of Implementing Preanalytical Laboratory Standards on the Diagnosis of Gestational Diabetes Mellitus: A Prospective Observational Study
Effect of Vitamin D or Activated Vitamin D on Circulating 1,25- Dihydroxyvitamin D Concentrations
Serum Total Testosterone Concentrations in the US Household Population from the NHANES 2011–2012 Study Population
FullIssueSummary February2016
Measurement by a Novel LC-MS/MS Methodology Reveals Similar Serum Concentrations of Vitamin D–Binding Protein in Blacks and Whites
US Food and Drug Administration Perspectives on Clinical Mass Spectrometry
Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements
Clonotypic Light Chain Peptides Identified for Monitoring Minimal Residual Disease in Multiple Myeloma without Bone Marrow Aspiration
High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes
Protein-Specific Glycoprofiling for Patient Diagnostics
Mass Spectrometry Selectivity, Specifically
FullIssueSummary January2016
Performance of Cystatin C– and Creatinine-Based Estimated Glomerular Filtration Rate Equations Depends on Patient Characteristics
"Big Data" in Laboratory Medicine
Optimizing Early Rule-Out Strategies for Acute Myocardial Infarction: Utility of 1-Hour Copeptin
Obese Nondiabetic Pregnancies and High Maternal Glycated Hemoglobin at Delivery as an Indicator of Offspring and Maternal Postpartum Risks:
STARD 2015: An updated list of essential items for reporting diagnostic accuracy studies
FullIssueSummary November2015
Extreme Nonfasting Remnant Cholesterol vs Extreme LDL Cholesterol as Contributors to Cardiovascular Disease and All-Cause Mortality in 90000 Individuals from the General Population
Nonfasting Lipid Profiles: The Way of the Future
Clopidogrel and CYP2C19: Pharmacogenetic Testing Ready for Clinical Prime Time?
Next-Generation Microfluidic Point-of-Care
FullIssueSummary October2015
Difference in Bias Approach for Commutability Assessment: Application to Frozen Pools of Human Serum Measured by 8 Direct Methods for HDL and LDL Cholesterol.
FullIssueSummary September2015
Pediatric Lipid Screening Rates in the US Are Low: What Can Labs Do to Help?
FullIssueSummary August2015
Why Disruptive Innovations Matter in Laboratory Diagnostics
Intersection of DNA Privacy and Whole-Genome Sequencing
FullIssueSummary July2015
24,25-Dihydroxyvitamin D3 and Vitamin D Status of Community-Dwelling Black and White Americans
Preanalytical Considerations in the Design of Clinical Trials and Epidemiological Studies
To Monitor Dabigatran or Not: A Matter of Patient Safety
Validation of New Cancer Biomarkers: A Position Statement from the European Group on Tumor Markers
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cutpoints—a joint consensus statement from the European Atherosclerosis Society and European Feder
FullIssueSummary June2015
Investigation of 2 Models to Set and Evaluate Quality Targets for Hb A1c: Biological Variation and Sigma-Metrics
FullIssueSummary May2015
Current Evidence and Future Perspectives on the Effective Practice of Patient-Centered Laboratory Medicine
Vitamin D: The More We Know, the Less We Know
FullIssueSummary April2015
Qualitative Point-of-Care Human Chorionic Gonadotropin Testing: Can We Defuse This Ticking Time Bomb?
Adaptive learning and medical education
Validation of a Proposed Novel Equation for Estimating LDL Cholesterol
Is This a Critical, Panic, Alarm, Urgent, or Markedly Abnormal Result?
Proposed Regulatory Framework for Direct-to-Consumer Genetic Testing: Diagnostics vs Genetic Screening
FullIssueSummary March2015
Learning from Our Mistakes: The Future of Validating Complex Diagnostics
Association of 1,5-Anhydroglucitol with Diabetes and Microvascular Conditions
Moving beyond mean glycemia: 1,5-anhydroglucitol and microvascular complications of diabetes
Noninvasive Prenatal Testing for Wilson Disease by Use of Circulating Single-Molecule Amplification and Resequencing Technology (cSMART)
The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva
FullIssueSummary February2015
Clinical Exome Performance for Reporting Secondary
Next Generation Sequencing in Clinical Diagnostics: Experiences of Early
Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer
Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries
Extreme PCR: Efficient and Specific DNA Amplification in 15–60 Seconds
Total and Cause-Specific Mortality by Moderately and Markedly Increased Ferritin Concentrations: General Population Study and Metaanalysis
FullIssueSummary January2014
FullIssueSummary January2015
ClinChem 201411 Vaught
Integrative Bioinformatics Analysis Reveals New Prognostic Biomarkers of Clear Cell Renal Cell Carcinoma
Clinical Genomics: When Whole Genome Sequencing is like a Whole-body CT Scan
FullIssueSummary December2014
FullIssueSummary December2015
Emory: Experience with Ebola Patients
T2 Magnetic Resonance: A Diagnostic Platform for Studying Integrated Hemostasis in Whole Blood—Proof of Concept
Point/Counterpoint: The Quest for Clean Competition in Sports
Microfluidic Genotyping by Rapid Serial PCR and High-Speed Melting Analysis
FullIssueSummary November2014
Generation of a New Cystatin C–Based Estimating Equation for Glomerular Filtration Rate by Use of 7 Assays Standardized to the International Calibrator
Where Are All the New Omics-Based Tests?
Early Detection of Fragile X Syndrome: Applications of a Novel Approach for Improved Quantitative Methylation Analysis in Venous Blood and Newborn Blood Spots.
From Lost in Translation to Paradise Found: Enabling Protein Biomarker Method Transfer by Mass Spectrometry
FullIssueSummary October2014
Three of 7 Hemoglobin A1c Point-of-Care Instruments Do Not Meet Generally Accepted Analytical Performance Criteria
Influence of the Confounding Factors Age and Sex on MicroRNA Profiles from Peripheral Blood
Maternal Plasma RNA Sequencing for Genome-Wide Transcriptomic Profiling and Identification of Pregnancy-Associated Transcripts
Podcasts Go Platinum!
Measurements for 8 Common Analytes in Native Sera Identify Inadequate Standardization among 6 Routine Laboratory Assays
FullIssueSummary September2014
Immunoextraction - tandem mass spectrometry method for measuring intact human chorionic gonadotropin, free beta, and beta core fragment in urine
To P or not to P: that is the question
Weekly and 90-Minute Biological Variations in Cardiac Troponin T and Cardiac Troponin I in Hemodialysis Patients and Healthy Controls
FullIssueSummary August2014
Biomarkers of Brain Injury in Cerebral Infections
Novel Biomarkers for Acute Myocardial Infarction: Is MicroRNA the New Kid on the Block?
ClinChem 201406 deLemos Khalili
FullIssueSummary July2014
Harmonization of Test Results: What Are the Challenges; How Can We Make It Better?
The FDA and 23andMe: Violating the First Amendment or Protecting the Rights of Consumers?
When a “Disease-Causing Mutation” Is Not a Pathogenic Variant
Genetically Low Triglycerides and Mortality: Further Support for “the Earlier the Better”?
FullIssueSummary June2014
Low Nonfasting Triglycerides and Reduced All-Cause Mortality: A
Interlaboratory Agreement of Insulin-like Growth Factor 1 Concentrations Measured by Mass Spectrometry
Interferon γ–Release Assays for Diagnosis of Latent Tuberculosis in Healthcare Workers in Low-Incidence Settings: Pros and Cons
Development of an Immunoassay for the Kidney-Specific Protein myo-
Posttransplantation Bone Marrow Assessment by Quantifying Hematopoietic Cell–Derived mRNAs in Plasma Exosomes/Microvesicles
Sandwich Assay for Tacrolimus Using 2 Antitacrolimus Antibodies
Novel Uses for Platelet Function Testing in the Clinical Laboratory: Where Are We Now?
Publication and Reporting of Test Accuracy Studies Registered in ClinicalTrials.gov
Screening Method to Evaluate Point-of-Care Human Chorionic Gonadotropin (hCG) Devices for Susceptibility to the Hook Effect by hCG β Core Fragment: Evaluation of 11 Devices
Influence of PCR Reagents on DNA Polymerase Extension Rates Measured on Real-Time PCR Instruments
FullIssueSummary April2014
Islet autoantibodies and type 1 diabetes: does the evidence support screening?
Digital PCR as a Novel Technology and Its Potential Implications for Molecular Diagnostics
Diagnosis of Gestational Diabetes Mellitus: it is time for international consensus
Invention and Validation of an Automated Camera System That Uses Optical Character Recognition to Identify Patient Name Mislabeled Specimens
FullIssueSummary March2014
FullIssueSummary May2014
Diagnosis of Gestational Diabetes Mellitus: It Is Time for International Consensus.
Biomarkers for Acute Kidney Injury: Where Are We Today? Where Should We Go?
Genomic Test Validation for Incidental Findings
As if Biomarker Discovery wasn’t Hard Enough
FullIssueSummary February2014
High-Sensitivity Cardiac Troponin Assays: Isn't It Time for Equality?
Tumor Microenvironment–Released Peptides: Could They Form the Basis for an Early-Diagnosis Breast Cancer Test?
What’s Different about Women’s Health?
The Ethical Implications of Preimplantation Genetic Diagnosis
Gestational Diabetes Mellitus
Diagnosing Diabetes Mellitus: Performance of Hemoglobin A1c Point-of-Care Instruments in General Practice Offices
FullIssueSummary December2013
Digital Droplet PCR for Rapid Quantification of Donor DNA in the Circulation of Transplant Recipients as a Potential Universal Biomarker of Graft Injury
Multiplex Picodroplet Digital PCR to Detect KRAS
MicroRNA Signature Helps Distinguish Early from Late Biochemical Failure in Prostate Cancer
FullIssueSummary November2013
Bioinformatics: What the Clinical Laboratorian Needs to Know and Prepare For
Use of MALDI-TOF for diagnosis of microbial infections
ClinChem 201310 Rifai
False Biomarker Discovery Due to Reactivity of a Commercial ELISA for CUZD1 with Cancer Antigen CA125
FullIssueSummary October2013
Scanning for cancer genomic changes in plasma: towards an era of personalized blood-based tumor markers
Automation in the Clinical Microbiology Laboratory
Automation in the Clinical Microbiology Laboratory
Point-of-Care and Over-the-Counter Qualitative Human Chorionic Gonadotropin (hCG) Devices Remain Susceptible to False-Negative Results Caused by Excess hCG β Core Fragment
Twenty-Eight Grams of Prevention Is Worth a Half Kilogram of Cure
FullIssueSummary September2013
A New Era in Prenatal Diagnosis: The Use of Cell-Free Fetal DNA in Maternal Circulation for Detection of Chromosomal Aneuploidies
Failure of Current Laboratory Protocols to Detect Lot-to-Lot Reagent Differences: Findings and Possible Solutions
ClinChem 201308 Korf
FullIssueSummary August2013
FDA Oversight of Laboratory-Developed Tests: Is It Necessary, and How Would It Impact Clinical Laboratories?
FDA Oversight of Laboratory-Developed Tests: Is It Necessary, and How Would It Impact Clinical Laboratories?
FDA Oversight of Laboratory-Developed Tests: Is It Necessary, and How Would It Impact Clinical Laboratories?
Noninvasive Prenatal Methylomic Analysis by Genomewide Bisulfite Sequencing of Maternal Plasma DNA
Gaps in the Traceability Chain of Human Growth Hormone Measurements
Newborn Screening by Sequence and the Road Ahead
Clinical Utility and Analytical Challenges in Measurement of Cerebrospinal Fluid Amyloid-β1–42 and τ Proteins as Alzheimer Disease Biomarkers
FullIssueSummary July2013
Measurement of Thyroglobulin by Liquid Chromatography–Tandem Mass Spectrometry in Serum and Plasma in the Presence of Antithyroglobulin Autoantibodies
Cobalt and Chromium Measurement in Patients with Metal Hip Prostheses
Beyond LDL-C in assessing cardiovascular risk: ApoB or LDL-P?
FullIssueSummary June2013
Are Biomarkers the Answer to the Heart Failure Readmissions Problem?
Vitamin D and Cancer: Can We Believe the Evidence from Observational Studies?
Circulating MicroRNAs: What Is Their Relevance?
Molecular detection of human H7N9 influenza A virus causing outbreaks in China
Targeting the Circulating MicroRNA Signature of Obesity
FullIssueSummary May2013
The Economic Potential of Pharmacogenomics
The Human Gut Microbiome and Body Metabolism: Implications for Obesity and Diabetes
Q&A on Pheochromocytoma
Mobile device for disease diagnosis and data tracking in resource-limited settings
MicroRNAs in Idiopathic Childhood Nephrotic Syndrome
Predicting the Cost and Pace of Pharmacogenomic Advances: An Evidence-Based Study
Communication of Scientific Information: Is It Time to Reassess?
FullIssueSummary April2013
Male Infertility and Microchips
Cannabis Effects on Driving Skills
ClinChem 201305 Nordestgaard
More Data, Please!
MALDI-TOF Mass Spectrometry: Transformative Proteomics for Clinical Microbiology
FullIssueSummary March2013
Is Early Detection of Cancer with Circulating Biomarkers Feasible?
External Quality Assessment of Point-of-Care Methods: Model For Combined Assessment of Method Bias and Single-Participant Performance by the Use of Native Patient Samples and Noncommutable Control Material
MicroRNA Analysis: Is It Ready for Prime Time?
Commercial Immunoassays in Biomarkers Studies: Researchers Beware!
Data Submission and Quality in Microarray-Based MicroRNA Profiling
Comparing Multiple Measures of Glycemia: How to Transition from Biomarker to Diagnostic Test?
FullIssueSummary Feb2013
The Riddle of Protein Diagnostics: Future Bleak or Bright?
Conquering Cancer in Our Lifetime: New Diagnostic and Therapuetic Trends
Plasma-derived Tumor DNA analysis at whole genome resolution;
Validating Serum Markers for Monitoring of Cancer
Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing
Design of Tumor Biomarker-Monitoring Trials: A Proposal by the European Group on Tumor Markers
FullIssueSummary Jan2013
Associations of Alternative Markers of Glycemia with Hemoglobin A1c and Fasting Glucose
Quantitative PCR Analysis of DNA, RNAs, and Proteins in the Same Single Cell
The Evolving Threat of Influenza Viruses of Animal Origin and the Challenges in Developing Appropriate Diagnostics;
Performance Criteria for Testosterone Measurements Based on Biological Variation in Adult Males: Recommendations from the Partnership for the Accurate Testing of Hormones
Medicine Unplugged: The Future of Laboratory Medicine
Medicine Unplugged: The Future of Laboratory Medicine
Longitudinal Studies of Cardiac Troponin I in a Large Cohort of Healthy Children
FullIssueSummary Dec2012
Determination of 19 Cardiac Troponin I and T Assay 99th Percentile Values from a Common Presumably Healthy Population
On-Site Test for Cannabinoids in Oral Fluid
ClinChem FullIssueSummary Nov2012
Ectopic Pregnancy
Exome and Whole-Genome Sequencing as Clinical Tests: A Transformative Practice in Molecular Diagnostics
More Reliable On-Site Detection of Cannabis in Oral Fluid
Room for Improvement in National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines
Applicability of the AGREE II Instrument in Evaluating the Development Process and Quality of Current National Academy of Clinical Biochemistry Guidelines
The Human Salivary RNA Transcriptome Revealed by Massively Parallel Sequencing
Noninvasive Prenatal Diagnosis of Monogenic Diseases by Targeted Massively Parallel Sequencing of Maternal Plasma: Application to β-Thalassemia
Whole-Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay
Caution Is Needed in the Interpretation of Added Value of Biomarkers Analyzed in Matched Case Control Studies
Interpreting Cardiac Troponin Results from High-Sensitivity Assays in Chronic Kidney Disease without Acute Coronary Syndrome
Thyroid Function during Pregnancy: Who and How Should We Screen?
Circulating Human Hepcidin-25 Concentrations Display a Diurnal Rhythm, Increase with Prolonged Fasting, and Are Reduced by Growth Hormone Administration
Antibiotic Resistance: How Serious Is the Problem, and What Can Be Done?
A Unique Approach to Business Strategy as a Means to Enable Change in Global Healthcare: A Case Study
Establishing Pediatric Reference Intervals: A Challenging Task
Newer Fecal Tests: Opportunities for Professionals in Laboratory Medicine
Diagnostic Accuracy of Point-of-Care Fecal Calprotectin and Immunochemical Occult Blood Tests for Diagnosis of Organic Bowel Disease in Primary Care: The Cost-Effectiveness of a Decision Rule for Abdominal Complaints in Primary Care (CEDAR) Study
The Obesity Epidemic
Altering the Landscape for Women in Clinical Chemistry: Perspectives from Multigenerational Leaders
Elementary, My Dear Doctor Watson
Clinician's Perspective: Allan Jaffe
Patents and Laboratory Medicine: What Is Required to Turn an Unpatenable Natural Phenomenon or Law of Nature into a Patenable Invention?
Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children
Inappropriate Requesting of Glycated Hemoglobin (Hb A1c) Is Widespread: Assessment of Prevalence, Impact of National Guidance, and Practice-to-Practice Variability
Genetic Susceptibility for Coronary Heart Disease and Type 2 Diabetes Complications
Catch Me If You Can: Isolating Circulating Tumor Cells from Flowing Blood
Refining Noninvasive Prenatal Diagnosis with Single-Molecule Next-Generation Sequencing
Understanding the Mechanisms That Link Alcohol and Lower Risk of Coronary Heart Disease
Microtube Device for Selectin-Mediated Capture of Viable Circulating Tumor Cells from Blood
Fluorescence Sensor for the Quantification of Unbound Bilirubin Concentrations