GRACEcast cover art

All Episodes

GRACEcast — 299 episodes

#
Title
1

FCR vs. BR - Is One Better?

2

Basics of Small Cell Lung Cancer

3

Adjuvant Chemotherapy for Elderly and Frail Patients

4

Rachel Sanborn - Adjuvant Chemotherapy for Early Stage NSCLC Patients, part 1

5

New Trials of Targeting Therapies to Treat Leptomeningeal Carcinomatosis

6

ASCO 2016 LC RT Vid 8 - Promising Early Results for Treatments

7

Immuno-oncology Developments - Combinations and Use as First-Line Therapy

8

Does Current Evidence Support Favoring Proton-Beam Radiation

9

J-Alex Trial: Should Alecensa Replace Xalkori as First-Line ALK Therapy?

10

Are There Less Toxic Alternatives to the Extreme Regimen

11

Promising Early Data for Oral Inhibitor Buparlisib

12

Using Immunotherapy as First-Line Treatment and in Combinations

13

Keynote 55 Pembrolizumab for Heavily Pre-Treated Patients

14

Using Biomarkers in Immunotherapy

15

Common Side Effects of PD-1 Inhibitors

16

Data from Keynote 12 Nivolumab and Pembrolizumab

17

How Promising Are The Results From Checkmate 141?

18

Local Consolidation Therapies for Oligomatastases

19

The Immune System and PD-1 Inhibitors

20

Urine or Blood Testing Instead of Lung Biopsy Shows Promise for Finding EGFR Mutations

21

Can Online Patient Groups Speed New Targeted Therapies?

22

Rova-T Shows Promise in Small Cell Lung Cancer

23

Significance Of IGHV Mutations & How They Are Assessed

24

Immunotherapy Combinations

25

Immunotherapy as First-Line Treatment

26

Lung Cancer Screening - Process and Potential Benefits

27

Bronchoscopy and EBUS

28

Maintenance Therapy for Advanced NSCLC

29

Rociletinib/Osimertinib for EGFR T790M-negative NSCLC

30

Are There Clinically Significant Distinctions Between PD-1 and PD-L1?

31

Histology-Specific Recommendations - Large-Cell Neuroendocrine

32

Histology-Specific Regimens - Squamous

33

Histology-Specific Regimens - Adenocarcinoma

34

What is the Role of Bevacizumab in Stage IV NSCLC?

35

Platinum-Based Chemo Doublets: Backbone for NSCLC Treatment

36

Timing of Second Generation ALK Inhibitors: First Line vs. Treatment after Acquired Resistance

37

CNS Disease in ALK-Positive NSCLC: Monitoring and Systemic vs. Radiation Therapy

38

Ceritinib and Other Second Generation ALK Inhibitors for Acquired Resistance in ALK-Positive NSCLC

39

Crizotinib for First Line Treatment of ALK or ROS1 Rearrangements

40

ROS-1 Rearrangements: What Are They?

41

ALK Rearrangements: What Are They, and Who Has Them?

42

Multiplex Testing for Rare Mutations: What Are the Potential Benefits?

43

The Role of Targeted Therapy Post-Resection

44

What Is a Standard Adjuvant Chemotherapy Regimen?

45

Why Give Adjuvant Chemotherapy, and to Which Patients?

46

Zoledronate or Denosumab for Lung Cancer with Bone Metastases

47

How Rate of Progression Can Affect Treatment Decisions

48

Platinum-Based Doublets As the Cornerstone of First Line Treatment

49

What are the Goals of Treating Advanced NSCLC?

50

Video-Assisted Thorascopic Surgery vs. Open Thoracotomy

51

What Is the Significance of Mediastinal Node Sterilization After Neoadjuvant Therapy?

52

What Is a Sleeve Resection?

53

What Is a Mediastinoscopy?

54

How Do Thoracic Surgeons Assess Fitness for Surgery?

55

The Surgical Decision: Assessing and Discussing the Patient's Options

56

Is There a Role for PCI in Locally Advanced NSCLC?

57

Can Immunotherapy Play a Role in Locally Advanced NSCLC?

58

Appropriate Chemo Regimens with Radiation for Locally Advanced NSCLC

59

Is Targeted Therapy Feasible As Consolidation in Locally Advanced NSCLC?

60

Is There a Role for Induction or Consolidation Chemotherapy Before/After Chemo/Radiation?

61

Chemoradiation as a Standard of Care for Unresectable NSCLC

62

What is Stage III Unresectable NSCLC?

63

Trends in Lung Cancer Demographics and Changes in Histology

64

Lung Cancer Risk Factors

65

Lung Cancer Demographics/Epidemiology

66

Are There Significant Genetic Risks for Lung Cancer?

67

Local Therapy for Limited Acquired Resistance

68

Elderly Patients: Selecting Appropriate Systemic Treatment Agents

69

Elderly Patients: Single Agent vs. Doublet Chemotherapy

70

The Basics of a Lung Cancer Workup

71

What Are Pulmonary Function Tests, and How Are They Used?

72

PET Scan Imaging: What Does It Tell Us?

73

How a Diagnosis of Lung Cancer is Made: The Biopsy

74

Potential Advantages, Disadvantages and Limitations of Lung Cancer Screening

75

Detecting Lung Cancer: Presenting Symptoms

76

Predictive Testing for Chemotherapy Responsiveness

77

HER2 Mutation Positive NSCLC

78

ALK Inhibitors for Acquired Resistance: Zykadia and Alectinib

79

Combinations and Other Options for Acquired Resistance in EGFR Mutation-Positive NSCLC

80

Third Generation EGFR TKIs for Acquired Resistance

81

Targeted Therapies in a Post-Operative/Adjuvant Setting

82

Induction Chemotherapy Followed by Chemo/Radiation for Stage III NSCLC

83

Management of Locally Advanced NSCLC in the Elderly and Frail

84

Defining Resectability in Stage IIIA Lung Cancer

85

Neoadjuvant Chemotherapy vs. Chemo/Radiation for Stage IIIA NSCLC

86

Overall Management for Stage IIIA Disease

87

Managing Three Compartments in Stage III Disease (Local, Distant, CNS)

88

Heterogeneity of Stage III NSCLC/Defining Resectability for Locally Advanced NSCLC

89

What is V20 and Why Do Radiation Dose & Field Size Matter?

90

High vs. Standard Dose Chest Radiation in Stage III Lung Cancer

91

SBRT for Oligometastatic Lung Cancer

92

SBRT for Medically Inoperable Stage I Lung Cancer

93

What is Stereotactic Radiosurgery/Radiation Therapy to the Brain or Body?

94

What is the Role of Molecular Marker Testing in the Adjuvant or Post-Op Setting?

95

SBRT as a Potential Alternative for Fit Patients with Early Stage Lung Cancer

96

Can Serum Tumor Markers Be Used in the Management of Lung Cancer?

97

Different Lung Cancer Subtypes - Histology

98

Immunotherapy for Small Cell Lung Cancer

99

Second Line Chemotherapy Options for SCLC

100

New Approaches to Immunotherapy

101

Novel Immunotherapies and Combinations

102

Blood-Based Mutation Testing: Circulating Tumor Cells and Tumor DNA

103

Immunotherapy Biomarkers and Patient Selection

104

What Is Next-Gen Sequencing?

105

Immunotherapy for Melanoma

106

Immunotherapy for Lung Cancer

107

Immunotherapy for Genitourinary Cancers

108

The Patient Perspective

109

Immunotherapy for First Line Therapy of Advanced NSCLC

110

Managing Immunotherapy Side Effects

111

What is the Optimal Duration of Immunotherapy?

112

The Current Role of Immunotherapy in the Treatment of Patients with Cancer

113

Panel Q&A Session on Patient Access and Survivorship

114

What is Immunotherapy & Its Mechanisms of Action?

115

Living with Lung Cancer

116

Access & Assistance for ALK+, ROS1 & EGFR Patients

117

Panel Q&A Session on Sequencing EGFR Treatments with Drs. Riely and West

118

Treatment Options for EGFR T790M Negative Acquired Resistance

119

Emerging Options for T790M-Positive Acquired Resistance

120

Individual Treatments for Individual EGFR Mutations

121

Panel Q&A Session on ALK+ and ROS1 Acquired Resistance with Drs. Horn and Owonikoko

122

The Blood/Brain Barrier for ALK Patients

123

New Ideas and New Treatment Options for Acquired Resistance for ALK/ROS1

124

Panel Q&A Session on Acquired Resistance with Drs. Riely & Horn

125

What is the Role of Immunotherapy for Patients with Advanced NSCLC and a Driver Mutation?

126

Repeat Biopsies and Emerging Techniologies for Plasma Sampling of Mutations Seen with Acquired Resistance

127

Panel Q&A Session on Acquired Resistance with Drs. Reckamp & Owonikoko

128

Time to Response to Immunotherapy and the Concept of Pseudoprogression

129

Have Your Practices Changed Regarding Prophylactic Cranial Irradiation for Extensive Stage SCLC Patients?

130

How Important is the Impact of Smoking Cessation on Survival?

131

What Are Your Current Practices for Consolidation Chest Radiation for Extensive SCLC?

132

Are There Clinically Significant Differences Among the Third Generation EGFR Inhibitors?

133

What is Acquired Resistance to Targeted Therapy, and Why Does it Occur?

134

The Central Nervous System as a Sanctuary Site: The Special Case for Brain Metastases

135

Can or Will Specific Molecular Characteristics Help Determine Which ALK Inhibitor to Choose?

136

Are There Clinically Significant Differences Among the Second Generation ALK Inhibitors?

137

Can Patients Benefit from Broad vs. Focal Genetic Testing?

138

Does the Specific EGFR Mutation (Including "Rare" Mutations) Matter When Choosing an Oral EGFR Inhibitor?

139

What Are the Treatment Choices for EGFR Mutation-Positive Acquired Resistance in Patients Without a T790M Mutation?

140

Are There Clinically Significant Differences Among the First and Second Generation EGFR TKIs (Iressa, Tarceva, Gilotrif)?

141

Immunotherapy Combinations: Is this the Future for Treating Lung Cancer?

142

Should Third Generation EGFR Inhibitors Be Used Before First Generation EGFR TKIs or After Progression?

143

What Are You Grateful For?

144

The Lung Cancer Master Protocol/SWOG 1400 as a Clinical Trial for a New Era of Molecular Oncology

145

Clinical Trial Spotlight: Targeting Brain Mets in EGFR Lung Cancer Patients

146

In Sickness and In Health

147

Clinical Trial Spotlight: Can Epigenetic Priming Improve Efficacy of Immunotherapy in NSCLC?

148

Clinical Trial Spotlight: Identifying Lung Cancer Patients Who Respond to Ponatinib

149

Postcards from Her Patients

150

Clinical Trial Spotlight: Options for EGFR Mutation-Positive Patients with T790M Mutation-Negative Acquired Resistance

151

Clinical Trials of Immune Checkpoint Inhibitors as FIrst Line Therapy for Advanced NSCLC

152

What is the Current Role of Serum Based Biomarker Testing?

153

Should Immune Checkpoint Inhibitors and Other Therapies Be Combined Concurrently or Sequentially?

154

Are Immune Checkpoint Inhibitors Sufficiently Tolerable to Recommend Them for Older or More Frail Patients?

155

Clinical Trial Spotlight: Should a Second Generation ALK Inhibitor be First Line Therapy for Patients with ALK-Positive NSCLC?

156

Is It Feasible and Clearly Beneficial to Combine Immunotherapy Approaches?

157

Do Clinical Characteristics Alter Your Enthusiasm for Immune Checkpoint inhibitors?

158

Clinical Trial Spotlight: Should a Third Generation EGFR Inhibitor be First Line Therapy for EGFR Mutation-Positive NSCLC?

159

Should PD-L1 be Used as a Biomarker for Immunotherapy in Lung Cancer?

160

Should PD-L1 Testing Be Ordered at Diagnosis or After Progression?

161

Immunotherapy for Previously Treated Advanced Non-Small Cell Lung Cancer

162

Do You Order PD-L1 Testing Before Choosing an Immune Checkpoint Inhibitor?

163

Clinical Trial Spotlight: Determining Efficacy of Immunotherapy in Stage III Lung Cancer

164

Clinical Trial Spotlight: ALCHEMIST for Early-Stage ALK+ and EGFR Lung Cancer Patients

165

Are there Clinically Significant Differences Among Immune Checkpoint Inhibitors Treating Lung Cancer?

166

Here Today Thanks to Research

167

First Line Treatment of EGFR Mutation-Positive NSCLC

168

Promising Early Results with Immunotherapy for Mesothelioma

169

Grateful for Another Great Year

170

November is Lung Cancer Awareness Month

171

Is the Survival Benefit with Avastin Added to Chemotherapy Enough to Change the Standard of Care in Mesothelioma?

172

ECOG 1505 Study: No Benefit of Post-Operative Avastin in Early Stage Lung Cancer Patients

173

Immunotherapy for Lung Cancer: General Concepts

174

Should EGFR TKI Therapy be Continued Beyond Progression?

175

The Potential Value of Repeat Biopsies in Acquired Resistance

176

Patterns of Acquired Resistance to EGFR TKIs in EGFR Mutation-Positive NSCLC

177

Are There Distinctions Among Currently Available Oral EGFR Inhibitors for EGFR Mutation-Positive NSCLC?

178

Differences Among Specific EGFR Mutations

179

What is EGFR and the EGFR Mutation?

180

What is the Value of Testing for Molecular Markers in Advanced NSCLC?

181

Radiation Management of Limited Stage SCLC

182

Prophylactic Cranial Irradiation for Extensive Stage Small Cell Lung Cancer

183

Prophylactic Cranial Irradiation for Limited Stage Small Cell Lung Cancer

184

Should Avastin be Added to EGFR TKI Therapy for EGFR Mutation-Positive NSCLC?

185

What is Maintenance Therapy for Advanced NSCLC?

186

Optimal Systemic Therapy for Bronchioloalveolar Carcinoma (BAC)

187

Reirradiation of Tumor in a Previously Radiated Field

188

Cancer Growth Rate and Managing Slow-Growing Lung Cancers

189

What is a Pancoast Tumor and How is it Best Treated?

190

Basic Principles of Managing Locally Advanced NSCLC

191

Pre-Operative/Neoadjuvant Therapy: Rationale and Indications

192

Surgery Options for Smaller, Slow-Growing Lung Cancers

193

Immunotherapy for Kidney Cancer Patients in the Front-line Setting: Coming Soon?

194

Immunotherapy for Metastatic Kidney Cancer Shows Increased Survival

195

Stereotactic Body Radiation Therapy (SBRT) for Medically Inoperable Early Stage Lung Cancer

196

Special Considerations for Lung Cancer Surgery in the Elderly

197

Challenges of Pneumonectomy Surgery

198

Types of Lung Surgery: From Wedge Resection to Pneumonectomy

199

Defining TNM Staging and Early Stage NSCLC

200

Managing Malignant Pleural Effusions: Pleurodesis

201

Managing Malignant Pleural Effusions: Tunneled Pleural Catheter

202

Managing Malignant Pleural Effusions: Thoracentesis

203

Introduction to Malignant Pleural Effusions

204

What is the Role of Memantine for Neuroprotection During Whole Brain Irradiation?

205

Palliative Radiation for Bone Metastases

206

Liquid Biopsies: Faster Results, Easier on Patients

207

BRAF: A New Target to Treat in Lung Cancer

208

Improved Survival in Malignant Pleural Mesothelioma with Avastin Added to Chemotherapy

209

Which Patients with Lung Cancer Should Receive Whole Brain Radiation Therapy?

210

Can We Do Better with a New Chemotherapy for Squamous Cell NSCLC?

211

RET in Lung Cancer: The Next Big Target?

212

Adding to Tarceva in a Broad NSCLC Population: Weighing Benefits with Risks

213

Debating EGFR Inhibitors for Squamous Cell Lung Cancer Patients

214

Small Cell Lung Cancer Patients Can Benefit from Immunotherapy

215

Immunotherapy Combinations: Best Balance of Activity and Tolerability?

216

Choices Among Immunotherapeutics May Be the Future of Lung Cancer Care

217

Immunotherapy for Non-Squamous NSCLC: Should We be Using Biomarker Selection?

218

Immunotherapy for Squamous Non-Small Cell Lung Cancer

219

Whole Brain Radiation for Brain Metastases

220

Serum Testing for Molecular Markers: Circulating Tumor Cells & Circulating Free DNA

221

Myths and Misconceptions About Bronchioloalveolar Carcinoma (BAC)

222

Bronchioloalveolar Carcinoma (BAC): What is It?

223

Questions & Answers with Drs. Pal, Luke and Wolchok about Immunotherapy for Cancer

224

Redefining Success and Failure in Cancer Immunotherapy Trials

225

The Future of Cancer Immunotherapy: Combination Treatments

226

The Right Time for Cancer Immunotherapy: Before or After Surgery?

227

Who Benefits from Immunotherapy?

228

Lung Cancer Immunotherapy Q&A

229

Benjamin Levy, MD, Hails 2015 as the Year of Lung Cancer Clinical Trials

230

Immunotherapy for Lung Cancer: Currently Enrolling Clinical Trials of Combination Therapies

231

Currently Enrolling Clinical Trials of Single Agent Immunotherapies for Patients with Lung Cancer

232

What We Know About Immunotherapy Treatments for Lung Cancer

233

Kidney Cancer Immunotherapy Q&A

234

Kidney Cancer Immunotherapy: Reasons for Cautious Optimism

235

Kidney Cancer Immunotherapy: CTLA-4 & Vaccine Clinical Trials

236

Kidney Cancer Immunotherapy: PD-1 Pathway Clinical Trials

237

Lung Squamous Cancer 201: New Promise in Treatments

238

Lung Squamous Cancer 201: Understanding Your Disease

239

Questions & Answers with Drs. Topalian and Wolchok about Immunotherapy for Melanoma

240

Melanoma Immunotherapy, Pt. 2: The End of the Beginning

241

Melanoma Immunotherapy, Pt. 1: The End of the Beginning

242

Immunotherapy for Melanoma, Pt. 2: Immune Checkpoints & the Drugs That Block Them

243

Immunotherapy for Melanoma, Pt. 1: An Overview

244

Questions & Answers with Drs. Davies and Atkins, and patient Rusty Cline

245

Why is Immunotherapy More Effective in Some Cancers Than Others? - Part 2

246

Why is Immunotherapy More Effective in Some Cancers Than Others? - Part 1

247

The Patient Perspective

248

Managing Immunotherapy Side Effects - Part 2

249

Managing Immunotherapy Side Effects - Part 1

250

Questions & Answers with Drs. Pardoll, Hellmann, and Luke; Moderated by Dr. West

251

How Immunotherapy is Administered - Part 2

252

How Immunotherapy is Administered - Part 1

253

Dr. Geoffrey Oxnard: My Top Highlight in Lung Cancer from 2014 - Liquid Biopsies

254

History of Immunotherapy in Cancer - Part 2

255

History of Immunotherapy in Cancer - Part 1

256

What is Immunotherapy and its Mechanisms of Action? Part 2

257

What is Immunotherapy and its Mechanisms of Action? Part 1

258

Donating to GRACE is Equivalent to a Dose of Hope

259

It's Possible to Live WITH Cancer

260

Novel EGFR Inhibitors in the Setting of Acquired Resistance

261

He Said, She Said - The Doctor/Patient Relationship

262

Questions & Answers with Bonnie Addario and Craig Uthe; Moderated by Dr. Jack West

263

The best thing you can do as a cancer patient...

264

Cost of & Access to Molecularly Targeted Therapies as Barriers to Optimal Care

265

The Expanding Role of Patient Self-Education & Online Communities in Molecularly Defined Subgroups

266

Leveraging Patient Engagement & the Role of Advocacy

267

Questions & Answers with Drs. Doebele and Shaw; Moderated by Craig Uthe

268

Current and Emerging Approaches to Acquired Resistance for ALK/ROS1

269

Mechanisms of ALK Resistance & Implications for Treatment

270

Questions & Answers with Drs. Blumenthal and Pennell; Moderated by Dr. West

271

Using Non/Off-Targeted Therapies in Targeted Lung Cancer Populations

272

Clinical Trial Design & Development of Highly Targeted Agents in the Molecular Era

273

Questions & Answers with Drs. Riely, Weiss and Sequist; Moderated by Dr. West

274

Repeat Biopsies & the Potential Value of Biologically-Informed Acquired Resistance Therapy

275

Life After 1st Line Targeted Therapy: What Next?

276

What is Acquired Resistance and How Does it Occur?

277

Doctors Discuss: Immunotherapy in Lung Cancer

278

Understanding Acquired Resistance in ALK+ Lung Cancer

279

Treating Brain Mets in ALK+ Lung Cancer

280

Are EGFR TKIs (Such as Tarceva) Effective in Lung Cancer Patients Who Are Wild Type EGFR?

281

Sym-004 Offers Hope for EGFR Wild Type Lung Cancer Patients

282

It's Time to Get Over the Lung Cancer Stigma

283

Molecular Testing in Early Stage Non-Small Cell Lung Cancer

284

Targeted Therapies for Stage III Non-Small Cell Lung Cancer

285

Small Cell Lung Cancer Clinical Trial: Is ECOG 2511 Right for You?

286

I'm Very Optimistic. For the First Time.

287

Do You See Advances in Treatment for Small Cell Lung Cancer in the Near Future?

288

Will HER2 Inhibitor Drugs Help Lung Cancer Patients?

289

Treating Leptomeningeal Carcinomatosis in Lung Cancer

290

What is the Northwestern Medical Developmental Therapeutics Institute?

291

How Do You Help Your EGFR Patients Make Treatment Decisions When Their Cancers Grow?

292

Immunotherapy Treatments for Kidney Cancer

293

Evaluating Biomarkers in Kidney Cancer

294

Will Combining Immunotherapies Better Fight Kidney Cancer?

295

Cabozantinib for Late Stage Kidney Cancer

296

Immunotherapy: What Has a Year’s Experience Taught Us Since ASCO 2013?

297

The Best Thing You Can Do As a Kidney Cancer Patient

298

RADIANT and SELECT: Is Adjuvant Erlotinib Effective in Early-Stage Lung Cancer?

299

Are There PD1 Biomarkers in Kidney Cancer?