All Episodes
JALM Talk Podcast — 167 episodes
An Overview of Allowable Total Error in the Clinical Laboratory
Toward Sustainable Clinical Chemistry: Waste Quantification and Reduction Strategies from Testing on 4 Commonly Used Automated Analyzers
Design and Analytical Evaluation of an Immunoassay for Long Forms of Cardiac Troponin T
Assessing and Resolving Findings of Sex Chromosome Discordance in Genetic Testing
ADLM Guidance Document on Laboratory Testing for Drugs of Misuse to Support the Emergency Department
Concurrent Anti-PR3 Immunoassay and cANCA Indirect Immunofluorescence Testing Provide Complementary Information for Clinical Laboratory Detection of Antineutrophil Cytoplasmic Antibodies
Blood Utilization and Waste Following Implementation of Thromboelastography
ADLM Guidance Document on Coagulation Testing in Patients Using Direct Oral Anticoagulants
Handling Hemolytic Blood Samples from High-Risk Clinical Areas: A Call to Action
SBC-SHAP: Increasing the Accessibility and Interpretability of Machine Learning Algorithms for Sepsis Prediction
MedPromptExtract (Medical Data Extraction Tool): Anonymization and High-Fidelity Automated Data Extraction Using Natural Language Processing and Prompt Engineering
Rapid Whole-Genome Sequencing as a First-Line Test Is Likely to Significantly Reduce the Cost of Acute Care in a Private Payer System
The 2024 PhD Board-Certified Clinical Chemist Compensation Survey
Fetal Fraction Methodologies and Their Clinical Use: Results of a College of American Pathologists Exercise
Is the 99th Percentile Cutoff Still Relevant? A Single-Center Assessment of Different Thresholds for Diagnosing Antiphospholipid Syndrome
Price Variability of Eight Common Laboratory Tests across All Licensed Tennessee Hospitals
Comparison of 2 Sets of Immunoassays Used in Modified 2-Tiered Testing Algorithms for the Diagnosis of Lyme Disease
High-Sensitivity Cardiac Troponin Assays: From Implementation to Resource Utilization and Cost Effectiveness
Total Prostate-Specific Antigen (PSA) Testing in Capillary Samples: Proof-of-Principle and Feasibility Study for Home Self-Testing for Prostate Cancer
Clinician-Ordered Peripheral Smear Review by a Pathologist Has Low Clinical Utility—A Reference Laboratory Perspective
Developing Benchmarking Metrics for Appropriate Ordering of Vitamin D, Thyroid Testing, and Iron Workups
Survey of Laboratory Stewardship Governance at US Academic Medical Centers
One Size Fits Small: The Narrow Utility for Plasma Metagenomics
An Introduction to the Complete Blood Count for Clinical Chemists: Platelets
Cardiac Troponin to Adjudicate Subclinical Heart Failure in Diabetic Patients and a Murine Model of Metabolic Syndrome
Recent Recall of Iron Reagent—Investigation of Potential Reagent Contamination and Assay Improvement Strategy
Glycated Albumin to Predict Adverse Neonatal Outcomes among Women with Diabetes and Overweight or Obese Body Mass Index
ADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins
Performance of fentanyl immunoassays in an ED patient population
Breaking the Chain: Navigating the Pitfalls of Total Laboratory Automation
Utility of Cystatin C-based Equation for the Estimation of Glomerular Filtration Rate in a Pediatric Population
Implementation of a Self-Audit Tool Improves Regulatory Compliance for Point-of-Care Respiratory Virus Testing in the Emergency Department
ADLM Guidance Document on Laboratory Diagnosis of Respiratory Viruses
Not Carfentanil—A Case of Unexpected Xylazine Detection
A Mathematical Algorithm for Dried Blood Spot Quality Assessment and Results concerning Quality from a Newborn Screening Program
Development of a Rapid Qualitative Screen for Anticoagulant Presence
Immunoassay Testing of Alpha-Gal Specific Immunoglobulin-E: Data from a National Reference Laboratory
The Role of Artificial Intelligence for Providing Scientific Content for Laboratory Medicine
Elucidating the Clinical Interpretation and Impact of a Positive Plasma Cell-Free DNA Metagenomics Test Result—A Single Center Retrospective Study
Point: The Need for Additional FDA Regulations in Laboratory Medicine; Counterpoint: Why the FDA Should Not Regulate Laboratory-Developed Tests
Clinical Utility and Long-Term Feasibility of Exome and Genome Reanalysis: From the Perspectives of a Clinical Laboratory
When Positive is Negative: Health Literacy Barriers to Patient Access to Clinical Laboratory Test Results
Robust Response of the Clinical Laboratory to the COVID-19 Pandemic despite Significant Challenges
Analytical Performance Evaluation of Three Point-of-Care CBC Analyzers for Management of Clozapine Therapy in Ambulatory Psychiatry Clinics
Cardiac Troponin T Degradation in End-Stage Renal Disease Patients Appears to Occur in Vivo
Global Heatwaves Threaten Integrity of Patient Test Results: A Dire Warning for the Lab Medicine Community
Raising the Dead Volume: Analysis of Microsamples Diluted and Corrected with Near Infrared Tracer
AACC/NKF Guidance Document on Improving Equity in Chronic Kidney Disease Care
Inverse Associations between Measures of Adiposity and Glycated Albumin in US Adults, NHANES 1999–2004
Pediatric Reference Value Profiling of Essential Trace and Toxic Elements in Healthy Children and Adolescents Using High-Resolution and Triple Quadrupole Inductively Coupled Plasma Mass Spectrometry
Clinical Laboratory Approaches for Diagnoses of Sleep-Disordered Breathing and ADHD-Like Behavior in Children
AACC Guidance Document on the Clinical Use of Procalcitonin
Clinical Validation of the sFlt-1:PlGF Ratio as a Biomarker for Preeclampsia Diagnosis in a High-Risk Obstetrics Unit
Comparison of a Novel Thin-Walled 25-gauge Needle Push Button Blood Collection Set to a Standard 23-gauge Needle in a Cancer Patient Population
AACC Guidance Document on Cervical Cancer Detection: Screening, Surveillance, and Diagnosis
Deceptively Simple: Can Urine Samples from CLIA-Waived Urine Drug Screen Devices Be Reused for Confirmatory Testing?
On Developing Better Practices for Reproducible Data Analysis in Laboratory Medicine
End to End Data Automation for Pooled Sample SARS-CoV-2 Using R and Other Open-Source Tools
Risk Analysis for Quality Control Part 2: Theoretical Foundations for Risk Analysis
CRP and High-Sensitivity CRP: "What's in a Name?"
Overprediction of Carbapenemase-Containing Isolates by an Automated AST Instrument's Computer Algorithm
It's VALID, but Is It Rational?
Decreasing the Lower Limit of Quantitation for Urine Albumin Improves Clinical Utility
The Biological Variability of Plasma Ceramides in Healthy Subjects
Reference Intervals for Clinical Chemistry Analytes for Transgender Men and Women on Stable Hormone Therapy
AACC Guidance Document on the Use of Point-of-Care Testing in Fertility and Reproduction
Point-of-Care: Roadmap for Analytical Characterization and Validation of a High Sensitivity Cardiac Troponin I Assay in Plasma and Whole Blood Matrices
Contemporary Challenges in Clinical Flow Cytometry: Small Samples, Big Data, Little Time
Predicting Direct-Specimen SARS-CoV-2 Assay Performance Using Residual Patient Samples
Utilizing Longitudinal Within-Individual Changes of Serum Creatinine, Cystatin C, and/or eGFR to Optimize Clinical Sensitivity and Eliminate Race and Gender Corrections
Impact of the AACC Global Laboratory Quality Initiative in Partnership with Professional Societies and Universities in Latin America and the Caribbean
Engaging Laboratory Staff in Stewardship: Barriers Experienced by Medical Laboratory Technologists in Canada
Development and Implementation of One-Step, Broad-Spectrum, High-Sensitivity Drug Screening by Tandem Mass Spectrometry in a Pediatric Population
Evaluation of Three Anti-SARS-CoV2 Serologic Immunoassays for Post-vaccine Response
Correlation of ANA Characteristics with pANCA IFA Interference
Anti-Nuclear Antibody Quantitation: Calibration and Harmonization Adjustment via Population Interrogation
The 2021 PhD Board-Certified Clinical Chemist Compensation Survey
AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury
More than Just Contaminants: Frequency and Characterization of Polymicrobial Blood Cultures from a Central Clinical Microbiology Laboratory Serving a Large Healthcare System
Validation of a Commercial Reagent for the Depletion of Biotin from Serum/Plasma: A Rapid and Simple Tool to Detect Biotin Interference with Immunoassay Testing
Use of a Daratumumab-Specific Immunofixation Assay to Assess Possible Immunotherapy Interference at a Major Cancer Center: Our Experience and Recommendations
A Multicenter Evaluation of a Point-of-Care Blood Glucose Meter System in Critically Ill Patients
Rapid Quantification of Plasma Creatinine Using a Novel Kinetic Enzymatic Assay
AACC Guidance Document on Laboratory Testing for the Assessment of Preterm Delivery
How SARS-CoV-2 Transformed the Clinical Laboratory: Challenges and Lessons Learned.
Plasma Protein Profiling by Proximity Extension Assay Technology Reveals Novel Biomarkers of Traumatic Brain Injury – A Pilot Study
Engaging Pathology Residents in Clinical Chemistry: The Essential Ingredient Is a Committed Teacher
Comparison of Two Automated Immunoassays for the Detection of SARS-CoV-2 Nucleocapsid Antibodies
A Shared Diagnostic Stewardship Approach toward Improving Autoimmune Encephalopathy Send-out Testing Utilization
On the Basis of Race: The Utility of a Race Factor in Estimating Glomerular Filtration
The Medical Students' Perspective of Health Disparities and a Raced Based Curriculum: Addressing Disparities in Medical Education
Recognizing Laboratory Medicine's Collaborative Role in Identifying and Eliminating Health Disparities
Impact of COVID-19 Pandemic on Laboratory Utilization
Ten-Month Evaluation of the Routine Application of Patient Moving Average for Real-Time Quality Control in a Hospital Setting
Liquid biopsy to detect circulating tumor cells: is it ready for a value proposition in laboratory medicine?
Detection of Intravascular Hemolysis in Newborns Using Urinary Carbonic Anhydrase I Immunoreactivity
Intelligent Liver Function Testing: Working Smarter to Improve Patient Outcomes in Liver Disease
Demand for Interpretation of a Urine Drug Testing Panel Reflects the Changing Landscape of Clinical Needs; Opportunities for the Laboratory to Provide Added Clinical Value
Current Practices When Reporting Quantitative Human Chorionic Gonadotropin Test Results
Correlation of Chemical Urinalysis to Microscopic Urinalysis and Urine Culture: Implications for Reflex Urinalysis Workflows
Unexpected Troponin Elevation in a Patient Treated with Atorvastatin
AACC Guidance Document on Biotin Interference in Laboratory Tests
Volumetric Microsampling of Capillary Blood Spot vs Whole Blood Sampling for Therapeutic Drug Monitoring of Tacrolimus and Cyclosporin A: Accuracy and Patient Satisfaction
Bridging the Gap: Acute Neurology and a Metabolic Acidosis
Cannabinol (CBN) Cross-Reacts with Two Urine Immunoassays Designed to Detect Tetrahydrocannabinol (THC) Metabolite
The 2018 AACC/SYCL PhD Clinical Chemist Compensation Survey
Unleashing the Power of Laboratory Developed Tests: Closing gaps in COVID diagnosis and beyond
Contingency planning in the clinical laboratory: lessons learned amidst COVID-19
A Laboratory Risk Assessment during the Coronavirus (COVID-19) Pandemic
Clinical Laboratory Detection of a High-Level Hemoglobin Abnormality in a Patient with Suspected Recreational Drug Ingestion
Rapid Diagnosis, Triage, and Treatment of a 59-Year-Old Man with Sudden-Onset Right-Sided Weakness and Difficulty Speaking
Bad Tests Die Slowly: The Myelin Basic Protein Example
Reproducible Research and Reports with R
Practical Approach to Eliminate Bilirubin Interference in Icteric Samples for Creatinine Measurement
Laboratory Test Utilization and Repeat Testing for Inpatients of Age 80 and Over in Australia
A Multicenter Assessment of the Sensitivity and Specificity for a Single High-Sensitivity Cardiac Troponin Test at Emergency Department Presentation for Hospital Admission
Development of Reference Materials for Noninvasive Prenatal Aneuploidy Testing by Massively Parallel Sequencing: A Proof-of-Concept Study
Isotyping of Paraprotein Irresolvable by Routine Immunofixation Electrophoresis
D-dimer: Common Assay, Challenges Abound, Caution Advised
It's Not Just a Needlestick: Exploring Phlebotomists' Knowledge, Training, And Use of Comfort Measures in Pediatric Care to Improve the Patient Experience
Analytical Concordance of Diverse Point-of-Care and Central Laboratory Troponin I Assays
Case of Sudden Acute Coma Followed by Spontaneous Recovery
AUC-Based Monitoring of Vancomycin: Closing the Therapeutic Window
Clinical Effect of Expedited Pathogen Identification and Susceptibility Testing for Gram-Negative Bacteremia and Candidemia by Use of the Accelerate PhenoTM System
Elimination of 72-Hour Quantitative Fecal Fat Testing by Restriction, Laboratory Consultation, and Evaluation of Specimen Weight and Fat Globules
Algorithms Used in Ovarian Cancer Detection: A Minireview on Current and Future Applications
The (Sun)Light and Dark of 25-Hydroxyvitamin D Testing
Creation of a Professional Development Program for Women in a Major US Medical School Pathology Department
Interventions That Can Help Reduce Diagnostic Errors
False Positive Carbamazepine Results by Gas-Chromatography Mass Spectrometry and VITROS 5600 Following a Massive Oxcarbazepine Ingestion
Keeping Up with Fentanyl: Failure to Do So Is Not an Option
Automated Laboratories: When Technology Needs a Human Touch
Thrombophilia: Women-Specific Reference Ranges Can Prevent Misdiagnosis in Women
High-Throughput LC-MS/MS Method for Determination of the Alcohol Use Biomarker Phosphatidylethanol in Clinical Samples by Use of a Simple Automated Extraction Procedure—Preanalytical and Analytical Conditions
Genotype–Phenotype Correlations of G6PDt Variants Throughout an Activity Distribution
Expanding the Utility of High-Sensitivity Dried Blood Spot Immunoassay Testing with Single Molecule Counting
A Paradigm Shift: Considerations in Prenatal Cell-Free DNA Screening
Medical Cannabis and Pain Management
Reflections of Two Pain Medicine Clinicians in the Era of the Opioid Crisis
Pharmacogenetics of Opioid Use and Implications for Pain Management
Executive Summary: American Association of Clinical Chemistry Laboratory Medicine Practice Guideline—Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients
Therapeutic Monoclonal Antibodies in the Clinical Laboratory
Biological Variation of Donor-Derived Cell-Free DNA in Renal Transplant Recipients: Clinical Implications
The Importance of Verifying Reference Intervals for Calculated Results
Transforming Laboratory Utilization Review into Laboratory Stewardship: Guidelines by the PLUGS National Committee for Laboratory Stewardship
Sandwich Immunoassay for Bioactive Plasma Adrenomedullin
Automated Sample Preparation Enables LC-MS/MS as a Routine Diagnostic Analysis for Serum Testosterone
The Era for High-Sensitivity Cardiac Troponin Has Begun in the US (Finally)
Serum Free Light Chain (FLC) Analysis: A Guiding Light in Monoclonal Gammopathy Management
Creation of a Universal Sample Bank for Determining the 99th Percentile for Cardiac Troponin Assays
Comparison of the Alere i and BD Veritor Assays for the Rapid Detection of Influenza A and B Viruses
Effect of Preanalytical Factors on the Stability of Maternal Serum Biomarkers and Calculated Risk for Trisomy 21, Trisomy 18, and Open Neural Tube Defect
Sickle Cell Trait in the Blood Supply
Quality Monitoring Approach for Optimizing Antinuclear Antibody Screening Cutoffs and Testing Work Flow
Myocardial Ischemia on Exercise Stress Echocardiography Testing Is Not Associated with Changes in Troponin T Concentrations
Are Heart Failure Management Recommendations and Guidelines Followed in Laboratory Medicine in Europe and North America?
Point-of-Care vs Central Lab "Discrepancies"
To Delta Check or Not to Delta Check? That Is the Question
The Importance of Effective Communication
Defying Gravity
Persistently Elevated Human Chorionic Gonadotropin in a Menopausal Woman
Lipoprotein Biomarkers and Risk of Cardiovascular Disease
Moving Latin American Laboratories Forward by Giving Back
α-Glutathione S-Transferase: A New Biomarker for Liver Injury?
The Food and Drug Administration: Overseeing, Overarching, Overreaching
Analytical and Clinical Evaluation of the NOWDiagnostics ADEXUSDx Human Chorionic Gonadotropin Test Using Whole Blood
Utility of Antinuclear Antibody Screening by Various Methods in a Clinical Laboratory Patient Cohort