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All Episodes

Mendelspod Podcast — 546 episodes

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Title
1

Solexa Co-Inventor Shankar Balasubramanian on Six-Base Sequencing and What's Next in Genomics

2

The Next Frontier in Biology: Physics? Erdinc Sezgin of the Karolinska Institute

3

The Case for a 6-Base Genome with Peter Fromen, CEO of Biomodal

4

The Eligible But Under-Tested: Genomic Medicine in 2026 with Damon Hostin, Illumina

5

Spatial Transcriptomics Is Changing How We Do Biology: Fei Chen, The Broad Institute

6

Beyond GLP-1: Why Peptides Are Back at the Center of Drug Discovery with Charlie Johannes and Tomi Sawyer

7

From the Archives: Inventor Mark Kokoris Debuts Roche’s New SBX Sequencer

8

Why Do Some Animals Live Ten Times Longer? Pursuing the Science of Aging with Steve Austad

9

MRD Testing: From Residual Disease to Real Decisions with Chris Hourigan and Gary Pestano

10

Early vs Late Recurrence: How Multimodal AI Is Changing Breast Cancer Prognosis with George Sledge, Caris Life Sciences

11

The Dark Genome with Author Sudhakaran Prabakaran

12

Illumina's New Mapped Read Technology Provides Insights into Rare Disease: Stephen Kingsmore, Olivia Kim-McManus and Ali Crawford

13

CareDx’s Second Act with CEO John Hanna

14

Inside GP2: Building a Global Genetic Map of Parkinson’s with Andrew Singleton and Ignacio Mata

15

A Simple Sponge, a Big Shift in Cell Therapy with Yev Brudno, UNC

16

How Cellanome Is Changing the Way We Study Cell Function with Matthew Spitzer and Pier Federico Gherardini

17

From Hereditary Risk to Residual Disease: Natera’s Integrated Vision for Precision Oncology with Adam ElNaggar, MD

18

The Rise of Geroscience with Alan Landay and Tom Blackwell, UTMB

19

Unlocking the RNA Revolution: How Self-Replicating RNA Could Transform Vaccines and Therapeutics with Andrew Geall, Replicate Bioscience

20

From Targets to Hits: The Emerging AI Ecosystem in Drug Discovery with Aqib Hasnain, Mithrl and Cheng Hu, Technetium Therapeutics

21

Most Popular Show of 2025: How Certis Is Rewriting Cancer Models with CEO Peter Ellman

22

Building the Front-End for Every Sequencer with Volta Labs CEO Udayan Umapathi

23

A New Foundational Platform for Biology: Cellanome’s Debut with CEO Omead Ostadan

24

The Best of Times, the Worst of Times: Former NHGRI Director Eric Green on a Shaken NIH and Surging Genomic Science

25

From the Archives: Next-Gen MRD Testing: Foresight’s Leap in Sensitivity with Jake Chabon and Dave Kurtz

26

Petter Brodin of Karolinska: How Spatial Interactomics Could Transform Autoimmune Therapy

27

From GWAS to EWAS: Chirag Patel and and Gary Miller on the Rise of Exposomics

28

Agilent Partners with PacBio to Speed Adoption of Long Reads into Diagnostic Testing

29

How AI Is Doing Science with Vivek Adarsh, CEO of Mithrl

30

Inventor Mark Kokoris on Roche’s New Sequencing by Expansion

31

From Brewing Sake to Brewing Science: Takara Bio’s Bold New Chapter with CSO Andrew Farmer

32

How Pathologists Can Lead in Precision Medicine with David Braxton

33

From DNA to Proteins: Illumina Makes Its Proteomics Play - with Krishna Morampudi

34

Theranos Had the Vision. Truvian Has the Execution. Our Chat with CEO Jay Srinivasan

35

Physicians Don't Want a Laundry List of Genes says Premal Shah, CEO of Myome

36

The Customer Case for iconPCR with Stefan Green and Yann Jouvenot

37

Alex Dickinson on Long Read Sequencing, Multi Omics, and the Next Frontier in Genomics

38

Rapid Answers for Rare Disease: Katherine Stueland on GeneDx’s Mission

39

Moran Snir's Vision for Making Genomic Care Routine across the U.S.

40

How Certis Is Rewriting Cancer Models with CEO Peter Ellman

41

Myriad’s Next Chapter: New CEO Sam Raha on Growth, AI, and MRD Testing

42

Next-Gen MRD Testing: Foresight’s Leap in Sensitivity with Jake Chabon and Dave Kurtz

43

Bodour Salhia and Danielle Goldberg: Rethinking Cancer Research with Illumina's 5-Base Solution

44

Reinventing PCR: Pranav Patel, N6 Tec

45

Making Whole Genome Sequencing the Universal Genetic Test - with David Ledbetter, Pediatric Rare Disease Institute, FSU

46

Remembering Atul Butte with Marina Sirota, Chirag Patel and Mike Snyder

47

The Age of Digital Pathology with Andy Beck, PathAI

48

What’s New for Regulatory Informatics in the Age of AI? Not Much—And That’s the Point with Raju Rayavarapu of DNAnexus

49

From Illumina to Advocacy: Mike Kreitzinger on the Future of Clinical Genomics

50

Amplifying the Expert: Jing Gao on Illumina's Connected Insights

51

The End of Animal Testing? Vivodyne Scales Human Tissue with CEO Andrei Georgescu

52

How Liquid Biopsy Is Becoming Standard of Care with Rita Shaknovich, CMO, Agilent

53

Tracking GMOs in the Gene Editing Era: Frédéric Debode on the Science of GMO Detection

54

From Discovery to Translation: Bruker's Bold New Play in Spatial with Joe Beechem and Oliver Braubach

55

Tagomics Wins NHS Grant, Unveils De-Methylation Platform for Early Cancer Testing with Rob Neely, CSO

56

From Paris to the Pentagon: Sophie Peresson Maps Biosecurity’s New Landscape

57

From Mitochondria to Protein Degradation: Mike Kiebish on BPGbio’s "Biology First" Vision

58

The Grammar of RNA: Gavin Knott on Gene Editing and Structural Biology in the Age of AI

59

The Third Way: Christian Schafmeister’s Spiroligomer Revolution

60

Can Math and AI Replace Some Biology in Drug Discovery? with Aridni Shah, Immunito AI

61

$10 Genome, $8 Coffee: Rethinking the Economics of Life Science Tools with Stephane Budel, DeciBio

62

Quantum Scale: A New Era for Single-Cell Analysis with Giovanna Prout

63

Building Intuition at the Nanoscale: Steve McCloskey of Nanome on the VR Future of Science

64

Beyond the $100 Genome--the Everyday Sequencing Revolution You Missed: Mark Budde, Plasmidsaurus

65

What Next for LDTs? A Conversation with Sarah Overton of Velsera

66

AI’s Quiet Revolution in the Pharma Supply Chain with Chris Petersen, Scientist.com

67

We've Been Misclassifying Childhood AML for Years: Jeffery Klco, St. Jude's

68

Aaron Viny: A 21-Year Leukemia Survivor on the Frontlines of Epigenetic Cancer Research

69

Toward Disease Sub-typing with Ben Busby, DNAnexus

70

Synthetic Biology Ready for Its ChatGPT Moment: A Preview of SynBioBeta 2025 with John Cumbers

71

Beyond the Parts List: Chris Mason and Simon Fredriksson on Mapping the Immune System in Space and Cancer with Cell Surface Proteomics

72

DNA Is Still Where It's At: Christian Henry, CEO of PacBio, on Watershed Year in 2024

73

A New Sequencing Technology Has Entered the World: Keith Robison Reviews AGBT and New Tech in our Annual Sequencing--er, Multi-Omics Show

74

Unlocking the Future of Forensic Genetics with Mirna Ghemrawi

75

Public Science in Peril: Hank Greely of Stanford on Funding, Fishing, and the Fight for Knowledge

76

Breaking the ‘Undruggable’ Barrier with AI and Synthetic Biology: Eswar Iyer, CEO of Aikium

77

"They're not cutting a branch. They're cutting the whole tree." Laura Hercher Defends DEI in Genomic Research and Medicine

78

Early Detection for Lung Cancer with Susan Tousi, DELFI Diagnostics

79

Big RNA with Brendan Frey of Deep Genomics

80

Genome Informatics in the Age of AI With Ben Busby, DNAnexus

81

AI & the Future of Genetic Testing: Ezra Cohen, CMO of Tempus

82

PredxBio and the Promise of Spatially Intelligent Biology

83

Surprise: Our Most Popular Show of 2024 Was on Genomic AI

84

New Startup Launches Epigenetic Screening: Mohamad Takwa, CEO, Epigenica

85

AI Powered Multiomics: Joachim Schmid on Data Analysis at Illumina

86

Renowned GI Oncologist Discusses MRD Testing and the Future of Cancer Detection

87

Precision Medicine Then and Now: We Talk with the Retiring President of the Personalized Medicine Coalition, Ed Abrahams

88

MicroRNA: A New Era in Biomarker Discovery with Tim Williams and Paola Ulivi

89

Somatic Genomics: A Revolution in Biology with Jacob Rubens

90

Exploring the Future of Single Cell Technology with Mauro Muraro, CEO, Single Cell Discoveries

91

Grail and Verily Alum on Billion Dollar Startup Bringing AI to Drug Development: A Discussion with Vik Bajaj

92

Singular Genomics Introduces a Dual-Purpose Platform Capable of Both NGS and Spatial Multiomics: Drew Spaventa, CEO & Founder

93

The Evolving Future of Genetic Counseling with Ellen Matloff, CEO, MyGeneCounsel

94

As Sequencing Continues to Scale, Volta Labs Improves Sample Prep: Udayan Umapathi, CEO

95

What’s Next for Large-Scale Proteomics? With Chris Whelan, Janssen

96

Will this At-Home Blood Collection Device Transform Medicine? Ben Casavant, Tasso

97

Geneticist Kevin Mitchell Attempts to Naturalize Free Will in New Book

98

ctDNA Testing Could Lead to New Ways of Staging Cancer Patients, Says Ben Weinberg, MedStar Georgetown

99

14th Season Opener: Michael Levin on ‘The New Biology’

100

The Success of ctDNA Testing in Colorectal Cancer: Adham Jurdi, Natera

101

Henrik Zetterberg on the Current Excitement Around Alzheimer’s Research

102

The Reboot of Consumer Genomics? with Kian Sadeghi, Nucleus Genomics

103

From Geospatial to Biospatial: Avi Veidman of Nucleai

104

New Proteomics Technology Brings Unprecedented Sensitivity and Scale: Yuling Luo, CEO, Alamar Bio

105

Diagnostic Trends in 2024 with Mara Aspinall, Illumina Ventures

106

The Actionable Epigenome with Bret Barnes, Illumina

107

Not All Prenatal Screens Are the Same: Jennifer Hoskovec, Billion to One

108

Harvard's Marc Lipsitch on the New White House Policy Regulating Risky Pathogen Research

109

Liquid Biopsy Goes Beyond Cancer: Diana Abdueva and Maggie Louie, Aqtual

110

Cell Therapy Will Transform Medicine as We Know It, Says Jason Bock, CTMC

111

Two Industry Leaders on Dealing with the Growing Complexity of Genomic Cancer Data

112

Single Cell Spatial Proteomics with Filip Karlsson, Pixelgen

113

The Precision Medicine Optimist: Damon Hostin, Illumina

114

An Ethics First Approach to Genetic Research and Drug Development with Sarah LeBaron von Baeyer

115

How Do You Train Genomics AI? On Natural Selection Itself, Says VP of Illumina’s AI Lab, Kyle Farh

116

The Pre-Symptomatic Space with Patrick Short, Sano Genetics

117

Systemwide Implementation of Precision Medicine at UCHealth with David Kao

118

Is this New Tech a Game Changer for Spatial Biology?

119

Synthetic Biology in 2024 with John Cumbers

120

Illumina Scales Variant Calling and Genome Interpretation to Improve Gap in Genetic Testing with Sam Strom

121

The Renaissance in DNA Synthesis Continues: Cosimo Ducani, CEO, Moligo

122

Jennifer Wipf of Ginkgo Bioworks on RNA Therapeutics and Cell Therapy

123

Precision Medicine for Dogs: Christina Lopes, OneHealth

124

Taking Gene Therapy to the Next Level: Rahul Kakkar of Tome

125

Christian Henry of PacBio on Long Reads at Scale, Next Moves

126

Robert Michel, Editor at The Dark Report, on Gap in Genetic Testing

127

Turning to Next Gen Proteomics for Novel Biomarkers: Jon Brudvig and Bruce Wilcox

128

What Have We Learned from the Brain Map Project So Far? with Tom Nowakowski, UCSF

129

Quality Healthcare Should Not Depend on Which Book Club You Attend, Karen Tumulty of the Washington Post

130

Real Probiotics: Colleen Cutcliffe, CEO, Pendulum Therapeutics

131

Todd Druley of Mission Bio on Single Cell Multi-Omics

132

Kevin Davies on Gene Therapy in 2023

133

History and State of Proteomics 2023 with John Yates

134

New Philosophy of Biology Series on PBS: A Preview with Host Robert Lawrence Kuhn

135

Mapping the Meta Proteome: John Shon, CTO, Serimmune

136

Supercharged Killer Cells Effective Against Alzheimer’s: Paul Song, CEO, NKGen Biotech

137

Chris Hall and Rich Chen of Personalis on Next Gen MRD Testing

138

State of Sequencing 2023: Shawn Baker and Keith Robison

139

Newborn Sequencing 2023 Part II: What Evidence Is Enough?

140

Lincoln Nadauld on the State of Precision Medicine in 2023

141

Nothing Is "Undruggable:" Alex Federation, CEO, Talus Bio

142

Mass Spec Advances in a New Age of Proteomics: Rosy Lee, Thermo Fisher Scientific

143

This Is Very Cool: Treating Cancer with Sound

144

The Future of Clinical Proteomics with Jenny Van Eyk and Daniel Hornburg

145

Elinor Karlsson on Darwin’s Ark

146

Long DNA for Difficult Applications: Dan Lin-Arlow, CEO, Ansa Biotech

147

Next Gen CRISPR Therapies with Trevor Martin, CEO of Mammoth Biosciences

148

13th Season Opener: Mike Snyder on Microsampling and Multi-Omic Profiling

149

Gene Patent Decision at 10 Years, State of Genetic Testing with Ellen Matloff, My Gene Counsel

150

Proteomics Bigger than Genomics, It’s Just Taking Time, Says Jeff Hawkins, CEO, Quantum-SI

151

Biden, AI, and DeSci: John Cumbers Previews SynBioBeta 2023

152

Proteomics Today Where Genomics Was in the 80s: Margaret Donovan and Asim Siddiqui of Seer on Landmark Study

153

Is This New Platform an Answer to the Reproducibility Crisis? with Guy Rohkin

154

Elegen Pioneers Long DNA Subindustry with CEO Matt Hill

155

Nevermind the $200 Genome, Element CEO Molly He Says Core Chemistry Capable of Much More

156

3D Genomics Solves Cancer Case Where Sequencing Came Up Short: Anthony Schmitt, Arima Genomics

157

New Spatial Company Maps Cell Surface Proteome without Imaging

158

John Greally on His Latest Review of Epigenomics

159

President of ASHG on Eugenics Apology, Diversity Initiative

160

23andMe Launches New Personalized Healthcare Initiative with Amy Sturm

161

Converting Digital to Biological: John Gill, Telesis Bio

162

50% Not Tested: Precision Oncology with Jerome Madison, Invitae

163

Paul Freemont on Synthetic Biology in the UK

164

The Bioengineered Hangover Cure: Changing the Conversation around GMOs with Zack Abbott of ZBiotics

165

Lance Baldo of Freenome on their Approach to Early Cancer Detection

166

Mara Aspinall on COVID

167

Terry Lo of Vizgen on Spatial Genomics

168

Proteomics at Scale Empowers Genomics in New Ways: Dale Yuzuki, Olink

169

A New Tool in the Genomics Kit with Ivan Liachko of Phase Genomics

170

Paul Kruszka of GeneDx/Sema4 on Groundbreaking Newborn Sequencing Study

171

Is PGx Having a Moment? Kristine Ashcraft, Invitae

172

Christian Henry on Revio, Onso and the New Vision at PacBio

173

The Revolution in Single Molecule Sequencing Continues: Vijay Ramani, UCSF

174

Will Hwang of Mass General on Discovery of Novel Pancreatic Cancer Cell Subtype

175

Going Beyond Time Barriers: Arutha Kulasinghe on the Power of New Spatial Biology Tools

176

Invitae’s Data Manager, Farid Vij, on New Genome Management Platform

177

Satellite Bio out with a New Tissue Based Approach to Regenerative Medicine

178

We Have to Get Sequencing Back to Moore’s Law: Gilad Almogy, Ultima Genomics

179

RNA Therapeutics: A New Paradigm for Drug Development? Tim Mercer, BASE Lab, U of Queensland

180

The System is Working. We Need More Engagement, Says ClinVar Champion Heidi Rehm of Mass General in Her Update on the State of Genomic Medicine in 2022

181

The Promise of Exosomes Now Realized, Says Paul Billings, CEO, Biological Dynamics

182

Lee Cronin on Origin of Life, Genomics, Aliens and More

183

Eric Green on the Future of the NHGRI

184

5-Base Sequencing: Jonas Korlach and Tomi Pastinen

185

More Cancer Patients Die from Infections than Cancer, Says Alec Ford, CEO of Karius

186

Some of the Lowest Hanging Fruits in Precision Medicine: Michelle Whirl-Carrillo on Pharmacogenomics

187

John Nelson of GE Research Talks Vaccines on Demand, Enzymatic Synthesis, and the Era of Writing DNA

188

A New Generation Comfortable Doing a Thousand Things at a Time Is Reinventing Life Science Says Joe Beechem of NanoString

189

Enabling a New Age of Unbiased Proteomics Discovery: Omid Farokhzad, Seer Inc.

190

The Rise of MRD Testing and the Field of Fragmentomics with Sugganth Daniel, Invitae

191

The Invention of Enzymatic DNA Synthesis with Sylvain Gariel, DNA Script

192

Akoya Biosciences Launches New Integrated Spatial Platform: Our First Interview with CEO Brian McKelligon

193

Harlan Robins on How T-cell Focused COVID Vaccines Can Move Us Toward Endemicity

194

Twist Bioscience: A New Kind of DNA Synthesis Company

195

Going High Resolution with 10X Genomics: Michael Schnall-Levin

196

George Church and Ben Lamm on the Launch of Colossal Biosciences

197

We Might Be the Comeback Kids of the Universe: Chris Mason on His Plan for the Next 500 Years

198

Invitae and PacBio CEOs Share Details of Clinical Sequencing Partnership

199

Building on the Knowledge Base of Developer Community, LuminexPLORE Lab Offers Custom Insights: Jackie Surls, Director

200

DNA Script Takes DNA Synthesis Back to the Bench with Enzymatic Tech: Thomas Ybert, CEO

201

Tumor Evolution in Context with Christina Curtis

202

The History of mRNA Vaccines with Elie Dolgin

203

Hundreds of Thousands of Biological Molecules Undiscovered in Plant Chemical Space Says Founder of New Drug Discovery Company

204

Quantitative Pathology with David Rimm, Yale

205

The State of Comprehensive Genomic Profiling at One of America’s Largest Health Systems with Carlo Bifulco

206

Inside the World of Genome Engineering at Amyris with Kirsten Benjamin, VP of R&D

207

Clinical Genetics 2021 Highlights: Laura Hercher, Host of the Beagle Landed Podcast

208

A New Way to Phenotype Life: Chris Mason Talks Spatial Biology, His New Book

209

The Impact of Spatial Technology on Childhood Cancers with David Steffin, Texas Children's

210

Robert Green: Newborn Sequencing Is the Goal Here in the U.S.

211

The Studies Are In—Optical Mapping Can Replace Traditional Cytogenetics Tests

212

Amy Sturm of Geisinger on FH Testing and New Implementation Science

213

Out of the Reductionist Trap: Brad Gray of NanoString on Spatial Biology

214

Precision Oncology at the Community Level with Lee Schwartzberg

215

Daniel Kraft on the Digitome and COVID

216

Orchid Health Is 1st in the World to Offer Whole Genome Couple's Report

217

PacBio and Labcorp Team Up on a Global Pan-Pathogen Surveillance Network

218

Will High Sensitivity Proteomics Enable a New Paradigm in Precision Health? with Kevin Hrusovsky, Quanterix

219

A Liquid Biopsy Technology that Doesn't Degrade the Sample: Raj Krishnan of Biological Dynamics

220

The Future of Big Biology: Bionano at AGBT

221

Playing Catch Up--Viral Surveillance in the U.S. with Will Lee of Helix

222

The Coronavirus, A Year On with Carl Zimmer

223

Spatial Biology Enables The Cancer Immunome Project

224

The CRISPR Saga with Kevin Davies

225

PacBio’s Never Been Stronger: New CEO, Christian Henry, Shares His Vision

226

Keith Robison on the State of Sequencing: 2020 Edition

227

Halloween with Nathan and Laura: The Spooky and Creepy of Genomics

228

When and Why Whole Genome Sequencing Should Be Standard of Care: Stephen Kingsmore of Rady Children’s

229

Limited Genetic Diversity Affects Us All

230

Genomics England Making Significant Strides in System Built on Trust in NHS

231

September 2020 Review with Nathan and Laura: Vaccine Choice, Dwarfism, Research Volunteerism

232

Bob Nussbaum on the State of Genetic Testing: 2020 Edition

233

SynBioBeta 2020 with John Cumbers

234

Mapping Intracellular Context: Garry Nolan on Spatial Biology

235

August 2020 Review: Radical Shift on LDT Policy, First Pan-Cancer Liquid Biopsies, and New Alzheimer’s Test

236

Using CRISPR Genome Editing Tools, Willow Biosciences out with First Synthetic Cannabinoid

237

The Pros and Cons of Expanded Carrier Screening with Mary Norton, UCSF

238

Is This A Unique Time for Science? We Ask Sci-fi Writer Kim Stanley Robinson

239

May 2020 with Nathan and Laura: Vaccine News, Notre Dame Argument, COVID Genetic Targets

240

Matt Loose on "Read Until" or Adaptive Sequencing

241

The Current State of Coronavirus Vaccines with Jeff Stein, Cidara Therapeutics

242

April 2020 Review with Nathan and Laura: Ioannidis Scandal, Antibody Testing, Ethics Questions

243

Lab Director Speaks to the Challenges of COVID-19 Testing: Elaine Lyon, HudsonAlpha

244

FDA in the Time of Coronavirus: Understanding the New VALID Act with Turna Ray, GenomeWeb

245

March 2020 Review with Nathan & Laura: Corona Gets Personal, Where Are the Tests?, the VALID Act, Some non-Corona Science

246

90% Go Undiagnosed, Says Geisinger’s Amy Sturm of FH Patients

247

Lisa Alderson on Her Telegenetics Firm, Genome Medical, Also Speaks to the DTC Downturn

248

February 2020 Review with Nathan and Laura: Coronavirus, Medicare for All, and Live from AGBT

249

Pouria Sanae on the DTC Slowdown and His New Precision Health Testing Platform

250

January 2020 Review: Genetic Counselors vs ACMG, 23andMe Layoffs, Privacy

251

End-of-Decade Review, What's Next? with Nathan and Laura

252

Ewan Birney on Race, UK Genomics

253

November 2019 with Nathan and Laura: Happy Birthday CRISPR Babies, 23andMe for Embryo Selection, and Golden Rice, Almost

254

Learning from the Field's Mistakes, Ancestry.com Rolls out Physician Ordered Health Testing

255

The Gene Edited Babies Saga - A Year Later with Hank Greely

256

Improving Quantitative Evidence for Genetic Tests: Carlos Araya, Invitae

257

The Meteoric Rise of Twist Bioscience and the Wild Demand for DNA: Emily Leproust, CEO

258

October 2019 Review with Nathan and Laura: Prime Editing, Vertex Win, and ASHG

259

Should We Increase Panel Testing for All Breast Cancer Patients?

260

Genomics Going from a Passive to an Active Science: John Stuelpnagel on the “Write” Revolution

261

Why Isn’t Personalized Medicine Being Mentioned by the Presidential Contenders? Ed Abrahams on Drug Pricing, Genetic Testing, and the State of the Industry in 2019

262

Karen Miga on the Next Era of Genomics

263

September 2019 Review with Nathan and Laura: Same-Sex Genetics, Mosquitos, and Another DTC Scandal

264

We Can See Tumor Heterogeneity. Now What? We Ask Cathy Smith, UCSF

265

Hallelujah! A Universal Flu Preventative and Therapy with Jeff Stein, Cidara

266

'The Movement:' John Cumbers Previews the Rapidly Growing SynBioBeta 2019

267

Anya Prince on Our Current Vulnerability to Genetic Discrimination

268

Do Long Reads Hold Answers for Alzheimer’s? with Mark Ebbert, Mayo

269

With Nanopore Sensing Beyond Sequencing, Ontera Takes 'Lab' to the Field

270

Mark Chaisson on Two New Structural Variation Papers

271

Early Cancer Detection: Is This Company Ahead of Grail?

272

June 2019 Review with Nathan and Laura: Gene Patents, Grail, Dr. Lynch

273

Should Genomic Screening Be Standard of Care? with Adam Buchanan, Geisinger

274

May 2019 Review with Nathan and Laura: Gene Therapies, DTC Shifts, Gender and Sports

275

Toward the Human Pan Genome with Adam Phillippy, NHGRI

276

Laura Hercher on the DTC Genetic Testing Landscape

277

Arcadia Biosciences Pivots to Bring Us Non-GMO, High Fiber GoodWheat and Better Cannabis

278

April 2019 Review with Nathan and Laura: uBiome Raided by FBI, PRS for Obesity, and a Gene Therapy Cure

279

The Era of the Social Genome with Rodrigo Martinez, Veritas Genetics

280

Reassessing Alzheimer’s with Larry Goldstein, UCSD

281

Family Surprises Care of the Home DNA Test with Brianne Kirkpatrick

282

March 2019 with Nathan and Laura: Old Envelopes, Wooly Mammoth DNA, and the Night King

283

Single Cell Analysis Shows Important New Detail in Key Clinical Study of AML: Koichi Takahashi, MD Anderson

284

Science Communication in a Post Fact World with Erik Clausen

285

February 2019 Review with Nathan and Laura: Family Surprises, IQ Profiling, and Chinese Surveillance

286

Heretic No Longer? Meet Michael Joyner, Precision Medicine’s Critic-in-Chief

287

The Internet of Biology Revolution-For Real This Time, with Brett Goldsmith, Cardea

288

January 2019 Review with Nathan and Laura: Cloning, CRISPRing, DTC, and Paleogenomic Overreach

289

Cara O'Neill of the Cure Sanfilippo Foundation Tells Her Story

290

PregSource: The NIH’s Crowdsourcing Project for Pregnancy Data with Caroline Signore

291

Meet Christian, Janos, and the New World of 3D Oncology

292

Has Computational Modeling for Cancer Genomics "Arrived?" with Shirley Liu, Dana Farber

293

Amy Harmon of the NYT on Race & Genetics, Women in Science

294

CRISPR or Not, You Can't Genetically Enhance Humans, Says Sci-Fi Author Kim Stanley Robinson

295

The New World of Infectious Disease Diagnosis: Out in the Field with David Hong of Karius

296

California Life Science Industry Steps to New Heights - the 2019 Edition with Sara Radcliffe

297

Nathan and Laura on CRISPRed Babies and Other November 2018 Stories

298

Ellen Matloff on a New Digital Genetic Counseling Product for DTC Customers

299

Connecting the Dots for a Community of Rare Disease Patients: Terri Klein, MPS Society

300

Keith Robison and Shawn Baker on Illumina Buyout of PacBio

301

October 2018 Review with Nathan and Laura: ASHG Does Race, Parents Do Gene Therapy, Unsung Demons

302

A Point-of-Care CBC Test Based on a Few Drops of Blood—Is This the Real Thing? with Danny Levner, Sight Diagnostics

303

It’s a Gold Rush in Single Cell Genomics, Says Joachim Schultze, U of Bonn

304

A Market Solution for Biospecimen Quality Standards with Matt McLoughlin, Scientist.com

305

September 2018 with Nathan and Laura: Studying the Same Genes and the Matt Fender Story

306

Single Cell Sequencing Tailor Made for Nephrology, Says Vivek Bhalla, Stanford

307

It’s the Social Factors, Stupid! Lisa Suennen on Healthcare, Her Career, Digital Health Investing, and . . . Just Being Herself

308

Concerned About DTC Test Quality? Ask Two Questions, Says Daryl Pritchard, PMC

309

August 2018 Review with Nathan and Laura: The polygenic month

310

An International Perspective on How to Improve Biobanking with Kirstin Goldring

311

A Seqster Preview with Founder Ardy Arianpour

312

Detective Stories from the Genomic War Room with Ramesh Hariharan

313

Should Biobanking Come Under CLIA? Shannon McCall, Duke

314

Pharma Stepping Up, Footing the Bill for Genetic Testing & Counseling: Jordanna Mora, Alnylam

315

Are We Asking Too Much of Genomics in Cancer Research? Tony Letai, Dana Farber

316

I Won’t Rest Until We Have Quality Standards in Place for Biospecimens: Carolyn Compton, ASU

317

May 2018 with Nathan and Laura: The Free Exome, California Database, and Mosaicism

318

Has Diagnostic Testing Plateaued? Alka Chaubey, Greenwood Genetic Center

319

A New Way for DTC? Nathan Pearson, Root Deep Insight

320

Genetic Testing in the Age of Trump: Hank Greely, Stanford

321

Genetic Testing is Dead, Long Live Genetic Testing: Sean George of Invitae

322

April 2018 with Nathan and Laura: Golden State Killer and the Cancer Prediction Space

323

Liquid Biopsy for Infectious Disease with Mickey Kertesz, Karius

324

Nanopore Sequencing and the Future of Cancer Research with Chia-Lin Wei, JAX

325

A New Method for Long Reads: Hanlee Ji of Stanford on Cancer Genomics Tech 2018

326

March 2018 in Genomics with Nathan & Laura: DTC BRCA and Revisiting All of Us

327

With More Tools in the Box, Lon Cardon Says We’re in a New Age of Drug Development

328

Personalized Medicine in the Trump Era with Edward Abrahams

329

Eric Schadt and Sema4 Try the Consumer Model with Newborn Screening Panel

330

February 2018 in Genomics with Nathan & Laura: 23andMe Goes for the Gold, Trump Year One

331

State of Sequencing 2018 with Keith Robison, Omics! Omics! Blogger

332

Direct RNA-Seq Project Shows Nanopore Sequencing Can Reveal New Insights into Basic Biology: Winston Timp, JHU

333

January 2018 Review Show with Nathan and Laura: CRISPR vs The Immune System, Biotech Math, and MinION's Big Test

334

Going Beyond the Liver with RNAi: Chris Anzalone of Arrowhead Pharma

335

Vice Chancellor Keith Yamamoto on UCSF’s Role in Medicine Today

336

The Global Business of Reproductive Genetic Testing with Gary Harton, Igenomix

337

The State of Genomics 2018 with Nathan, Laura, and Misha

338

Sharon Begley of STAT News

339

A New “Middle Way” for Genomics, with Physical Chemist, Yuval Ebenstein

340

Sara Demy on Biotech CEOs

341

November 2017 with Nathan and Laura: The Stem Cell Story We’ve All Been Waiting For and a Sea Change for DTC Testing

342

Seattle Startup Takes Precision Oncology to the Next Step: Carla Grandori, CEO, SEngine

343

Immuno Oncology 2017: Looking Back, Looking Forward with Rachel Laing and Olivier Lesueur

344

Huh? 30 Million Americans Have a Rare Disease? Howard Jacob on the State of Clinical Sequencing

345

With their Own Manufacturing Facility, Seattle Children’s Goes Big into CAR-T, Rare Disease

346

With Immuno Oncology Comes a New Focus on Rare Cells

347

We've Become Too Single Variant Centric, Says Deanna Church on Genome Analysis

348

Clinicians Show High Demand for Single Cell Sequencing, Says Bobby Sebra of Mt. Sinai

349

September 2017 with Nathan and Laura: Venter Blunder, RNAi Returns, and Monthly Science Moments

350

Charting the Dark Matter of Cancer Genomes with Jim Broach

351

Why Childhood Cancers Need Their Own Gene Panel: Tim Triche

352

Exploring the Exome and the Future of Genomics with Jay Shendure

353

August 2017 Review with Nathan and Laura: CAR-T Cashes In, Embryos Edited in US, and the Invitae Incident

354

The First In-Human Gene Editing Trial in the U.S. - And It’s Not with CRISPR

355

Thermo, Pfizer, and Novartis Pull Off a First for NGS in Lung Cancer

356

Making Genetic Testing Mainstream Medicine with Sean George, Invitae

357

Need Better Standards for Your Clinical Assays? NIST Can Help

358

Turning on Your DNA with Justin Kao, Helix

359

Will This New Nano Technology Be the Microarray of Genomic Structural Variation? Barrett Bready, Nabsys

360

George Church on What Comes After CRISPR

361

Is CRISPR Controversy Science or Spin? June 2017 Review with Nathan and Laura

362

We Need a Google Maps for Metagenomics, Says Rob Knight, UCSD

363

Move Over PDL1: New Test Combo Adds RNAseq to Better Track Immune Escape

364

The Last Major Disease To Be Studied? Ron Davis of Stanford Thinks So

365

On Bioinformatics Data Sharing and Collaboration: Andrew Carroll, DNAnexus

366

Grail Merger, Genomic Autopsies, Overtreatment Alarm, and Controversy at Ancestry.com: May 2017 Review with Nathan and Laura

367

Is Population Medicine Failing Us? Michel Accad

368

Deep Omics Profiler, Mike Snyder, Now Turns to Wearables

369

Over $1 Billion Invested this Past Year: Synthetic Biology in 2017 with John Cumbers

370

Green Light for DTC, Blood Mammograms, and Ancient DNA: April 2017 with Nathan and Laura

371

With 50 Million Users, Is Academia.edu Speeding Up Science?

372

How to Improve Lab Tests in the Absence of FDA Regulation?

373

Known for Medical Devices, 116 Yr Old BD Makes a Bold Move in Genomics

374

Proposed NIH Cuts, Undermining GINA, and Game Changing Drugs: March 2017 with Nathan and Laura

375

Art in the Lab (Falling in Love with Bacteria)

376

Flint Whistleblower Says Today's Science Is to Blame for Its Own Lack of Public Trust

377

The Story of Geisinger and Doing Genomic Medicine at the Right Pace

378

In-Situ Sequencing, CRISPR Patents, and Racist Milk Drinkers: February 2017 with Nathan and Laura

379

New Pocket Size Nanopore Device Could Revolutionize Diagnostic and Other Testing

380

By Changing a Basic Lab Step, Acoustic Liquid Transfer Having a Broad Impact

381

Many Biologists Today Don’t Have Enough Computer Science to Use the Databases

382

Cardiologists Love Genomics: Euan Ashley, Stanford

383

Scientists vs Trump: January 2017 with Nathan and Laura

384

Want to Stop Smoking? Start with Epigenetic Biomarker that Tells Doc the Truth

385

When an Exome Test Is Part of the Therapy and Not a Diagnostic: John West on Personalis and Personalized Cancer Vaccines

386

People Told Us It Was Impossible: UCSC’s Mark Akeson on Nanopore Sequencing

387

When Long Reads are Double the Price of Short Reads, Short Reads Are Dead, Says Evan Eichler

388

Genomics in 2016: Nathan and Laura Name Their Top Stories

389

Hank Greely on “The End of Sex" and Other Stuff

390

How to Scale Cancer Genomics, with Marco Marra, UBC

391

What Does the Election Mean for Genomics? November 2016 with Nathan and Laura

392

The Saga Continues: Ethan Perlstein, Indie Scientist, Part 3

393

Biomarker Panel to Predict Type 1 Diabetes

394

Can You Name the World’s Largest Single Disease Research Charity?

395

Why Diversity Is the Only Path Forward: Sarah Tishkoff on African Genomics

396

October 2016 with Nathan and Laura

397

We’re Over Halfway There: Baylor's Richard Gibbs on Clinical Genetics

398

With FDA Guidance on LDTs Still Not Out, What Are Labs Doing?

399

Reference Genome Making Major Strides in Ethnic Diversity, Says Valerie Schneider, NCBI

400

September 2016 with Nathan and Laura

401

Luke Timmerman on His New Biography of Lee Hood

402

How Personalized is Personalized Medicine? Krister Wennerberg on FIMM’s Individualized Systems Medicine

403

Digital PCR Opens Up New Liquid Biopsy Opportunity in Melanoma Treatment: David Polsky, NYU

404

Erica Ramos on Her Pioneering Role as Genetic Counselor for Industry

405

August 2016 with Nathan and Laura

406

A Maniacal Commitment to Science: Peering into Regeneron’s Genetics Center with Jeff Reid

407

The Days of Miracle and Wonder: Laura Hercher on Genetic Counseling, Part 2

408

The Days of Miracle and Wonder: Laura Hercher on Genetic Counseling, Part 1

409

A Precision Medicine Platform Comes of Age: Jonathan Hirsch, Syapse

410

FDA’s Liz Mansfield on New NGS Guidances

411

How Is the Brexit Impacting Genomics? with Clare Turnbull and Hadyn Parry

412

It’s Not Really Bulls and Bears: John Carroll on His New Gig, the Brexit, and a New Metaphor for the Market

413

June 2016 with Nathan and Laura: GMO Labeling, Misspelling CRISPR, Sequenom Patent Loss, SmidgIon

414

Know Then Thyself: Kari Stefansson, deCODE genetics

415

Sequenom Patent Loss a Threat to Personalized Medicine, Says Kevin Noonan

416

Bringing Home Some Diagnostics Gold: Brad Gray, NanoString Show How It’s Done

417

Mukherjee Mess-up, the Secret Harvard Meeting, and Success in Gene Therapy: May 2016 with Nathan and Laura

418

When Do We Move to Population Based Cancer Screening for Those with High Genetic Risk? Josh Schiffman, U of U

419

The Solid Future of Liquid Biopsies with Michael Nall, Biocept

420

Genomics Is Oversubscribed, Says Creator of BLAST

421

With 10K Genomes Sequenced, Genomics England in High Gear: Clare Turnbull, Clinical Lead

422

April 2016 with Nathan and Laura: Big Money, More CRISPR Studies, Genomic Superheroes, and a Pot Chaser

423

A Sneak Peek into the Future of Clinical Genomics with Ben Solomon, Inova

424

Preprints and the Future of Science Publishing with Jason Hoyt, PeerJ

425

Flipping Drug Development Upside Down: Niven Narain, BERG Health

426

March 2016 with Nathan and Laura: Genomic Jenga and the Creator, the Anti-Abortion Lobby and Genetic Testing, and Theranos, Again

427

Medicine and the Limits of Science with Michel Accad, MD

428

How Good are Linked Reads? Serge Saxonov, 10X Genomics

429

A Home Run on the First Hit: PacBio’s Jonas Korlach

430

Digital Pathology at Scale: Epic Sciences Takes CTC Technology to the Next Level

431

February 2016: Mosquitos, Preprints, and that Rocking White House Summit

432

BioNano Genomics Stakes Out Sequencing Territory as They Discover Lots of De Novo Variants in Reference Genome Projects

433

Is Oxitec Ready to Scale as Governments Seek Options to Control the Zika Virus?

434

Human Genome Turns 15: Mike Hunkapiller

435

January 2016: Landergate, Grail, and Cancer Moonshot

436

Frontiers of Sequencing: Putting Long Reads and Graph Assemblies to Work

437

Why Drugs Are Priced So High and Diagnostics So Low

438

Who Is John Ioannidis?

439

Cancer: Year in Review 2015 with Anna Barker

440

Sci-Fi Author Kim Stanley Robinson Talks Life Science 2015

441

Yes to FDA Regulation of LDTs, But We Need a New Framework, Says David Spetzler

442

Genomics and the Cloud Going Through “a Second Puberty,” says AWS’ Angel Pizarro

443

Hot Biotech Market Neglects Stem Cell Therapies, Says CIRM's Neil Littman

444

The Future of Diagnostics Reimbursement with Bruce Quinn

445

Framingham for the Modern Era: Josie Briggs on the Precision Medicine Initiative

446

Do Alternate Proposals to Regulate LDTs Stand a Chance?

447

Does the Reproducibility Project in Cancer Biology Offer a Model for a New Kind of Science Auditing?

448

After CMS Announcement, Peter Maag and CareDx Fight for Life

449

The Goal Is De Novo Assembly in the Clinic, Says Jim Lupski, Baylor

450

Cliff Reid Says New Supersequencer Leads the Pack for High Throughput Clinical Sequencing

451

Defending the Value of Biotech Innovation in California: Sara Radcliffe, CLSA

452

Long Read Sequencing Dramatically Improves Blood Matching: Steven Marsh, Anthony Nolan Institute

453

The World of DIY Genomics with K T Pickard

454

Sequencing in Space: Chris Mason, Cornell

455

Is the Future of Biology a Return to Chemistry? Carolyn Bertozzi, Stanford

456

Going Beyond the $1,000 Genome with Mark Gerstein

457

Creating the Foundation of Genomics: Marc Salit, NIST

458

Still Unhappy with FDA’s Plan to Regulate LDTs, Professional Lab Groups Go Direct to the Senate

459

A Diagnostic Success Story with Alka Chaubey, Greenwood Genetic Center

460

With Two New Easy-to-Use Sequencing Instruments, Thermo Readies for Primetime in the Clinic

461

Here's Looking at Euclid

462

Is This the Future of Clinical Trials for Cancer? Stanley Hamilton on the NCI’s New MATCH Trial

463

Brian Kennedy and Aubrey de Grey on their Converging Approaches to Aging Research

464

The Business of Aging and Three Reasons Why the FDA Drug Approval Rate Is So High

465

New York Genome Center’s Nathan Pearson on Public Outreach for Genomics

466

Tim Triche on Using Arrays for Cancer Research

467

Thermo’s Chris Linthwaite on Sequencing the Ebola Virus and the Future of Public Health

468

A Tool to Strengthen the Voice of Science in Online Journalism

469

Father of Child with Rare Disease Says Science Equals Medicine

470

Bina CEO Details Secret to Success in NGS Informatics

471

Cancer Researcher Tim Triche on the Staying Power of Microarrays

472

Want Answers? Look to the Non-Coding Region of the Genome, Says Cancer Researcher, Tim Triche

473

Ivan Oransky on Today's Retraction Boom

474

Genomics-Palooza, Diagnostics Fraud, and Biblical Prophets on the Future of Biotech

475

Ethical Issues around Editing Human Germline for the Future. Today It's about Plants and Animals, Says NYU's Art Caplan

476

We Got Research, PCSK9 Inhibitors, and Clinical Trials for Religion

477

The Multi-Platform Approach to Clinical Sequencing with Bobby Sebra, Icahn School

478

So That Happened, The Mad Genius, and Selling SynBio

479

Summer Genomics Festival, the Other Sports Genes, and Brain Surgery for Fruit Flies

480

The Sports Genes with Jeremy Koenig, Athletigen

481

Woodstock for Genomics? Richard Lumb and Carl Smith on this Month’s Festival

482

Geneticists Anonymous, the Sad State of Science Journalism, and New Kids on the Helix

483

The 9 Billion People Problem: Rod Wing on Plant Genomics

484

Should We Hold Back the Reins on Biotechnology? with Chris Gunter

485

Are We Ready to Trust Liquid Biopsies? with Milena Cankovic, Henry Ford Hospital

486

Gene and Tonic: Boxing for Cancer, Dubious Correlations, and When Should a Researcher Retire

487

New Patient Focused Genome Magazine Signing up Many Doctors Too

488

Gene and Tonic: The Decline of Pseudoscience, An Atheist for President, and What to Do with a Sexist Reviewer

489

Gene and Tonic: Sexism in Science, How to Spend an NIH Budget Increase, How Not to Spend It

490

Participation in Genomics Research a 21st Century Public Good, Says Paul Billings of Omicia

491

Gene and Tonic: Competition for 23andMe, Four Tips for Attending AACR 2015, and "Swab Stories"

492

Improving the Backbone of Clinical Genomics : Valerie Schneider, NCBI

493

Gene and Tonic: The ACA Turns Five, Ten Reasons to Have Your Genome Sequenced, and Humbled by the Ancients

494

Behind the Sequencing Bench with Dale Yuzuki

495

Gene and Tonic: The Tenth Commandment of Science, Icelandic Treasure, and TechBio Babies

496

It’s Pretty Bad: Andy Brooks of RUCDR on Sample Quality

497

Knowing More about What We Don’t Know: John McPherson on Cancer Genomics

498

Gene and Tonic: The iWatch and Research Kit, 23andMe Goes for the Big Time, No Spaceship

499

In Partnership with IBM’s Watson, Pathway Genomics Reinvents Itself

500

Affymetrix CEO, Frank Witney, on Arrays in the Age of Sequencing

501

Gene & Tonic: Disruption in Sequencing, Scientist Politicians, Some Cool Synbio

502

Changing the World with Color Changing Flowers

503

Cancer Researcher at Mayo Says Illumina Platform Maxing Out, Looks to BGI/Complete

504

Returning to Old Biotech Model, OncoMed Boasts of Seven Drugs in Clinical Trials by Mid 2015

505

Cutting through the Hype in Healthcare Innovation with David Shaywitz and Lisa Suennen

506

A Call to Consumers to Lead the Shift in Healthcare: Sharon Terry, Genetic Alliance

507

In Autoimmune Disease, Finding Clarity Beyond the Genome: Stefan Muellner, Protagen

508

Myriad Settlements Mark End of an Era: Antoinette Konski on Gene Patents

509

David Schwartz on the Future of Sequencing

510

Not a Stenographer to Power: Luke Timmerman and the New 'Timmerman Report'

511

FDA Will Take Time to Digest Comments on LDT Guidance, Says Liz Mansfield

512

Future of Personalized Medicine at Stake, says Amy Miller of PMC about LDT Regulation

513

'A Good Year' with John LaMattina

514

An Exciting Time for Mass Spec: Paul Beresford, Biodesix

515

Current Version of LDT Draft Guidance Means Much Fewer and Lower Quality Tests for Patients, Says Elaine Lyon of ARUP

516

The Sad State of Biospecimen Science with David Rimm, Yale

517

Cancer 2014: The Year in Review with Anna Barker

518

Faces of Leadership in Diagnostics: Surbhi Sarna

519

Historic Consensus Reached on Biospecimen Standards: Carolyn Compton, NBDA

520

Setting Better Expectations for Genomic Medicine: Geoff Ginsburg, Duke University

521

Test Driving Genomic Medicine: Thomas Quertermous, Stanford

522

The Silicon Valley Fantasy Trip: Sci-fi Author Kim Stanley Robinson Talks Life Science

523

Faces of Leadership in Diagnostics: Mara Aspinall

524

The Daunting Task of Managing Biospecimens at the World's Largest CRO: Diane Farhi, Quintiles

525

Janet Woodcock, FDA, on Biomarker Development and the Future of Clinical Trials

526

Biosampling Basics with Scott Jewell, Van Andel Institute

527

Faces of Leadership in Diagnostics: Bonnie Anderson, Veracyte

528

Biotech’s Gentleman Lawyer: Alan Mendelson

529

The Open Secret about the HER2 Assay with Jim Vaught

530

What a Physicist Can Tell Us about Cancer

531

'Moving Target Science:' Jonathan Brody on Pancreatic Cancer

532

The Progress of Clinical Genomics in Sweden with Ulf Gyllensten

533

Proteins Are Where It's At: Chip Petricoin, George Mason University

534

After a Decade on the Sidelines, Gene Myers Back into Sequencing, Excited about Long Reads

535

The Story of Aubrey de Grey and How the Study of Aging Became Mainstream

536

#ScienceHack with Connor Dickie, Synbiota

537

What Translational Gap? Michael Pishvaian on Advances in Tumor Profiling

538

A Dangerous Book? Science Historian Nathaniel Comfort Discusses “A Troublesome Inheritance”

539

Eric Schadt on Long Read Sequencing and Clinical Genomics

540

George Church at 60

541

Major Sequencing Projects Should Be Done with Long Reads, Says Dan Geraghty

542

Test Driving Illumina's X Ten with Shawn Baker, AllSeq

543

Short Read Sequencing Not Up to the Task of Characterizing Transcriptome Says Mike Snyder of Stanford

544

U.K. Life Science Update with Eliot Forster, MedCity

545

Paperwork, Not Algorithms the Biggest Challenge for Large Bioinformatics Projects, Says David Haussler, UCSC

546

Big Pharma Does Some Farming: Pearl Huang, GSK