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All Episodes

Paper Talk — 1000 episodes

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Title
1

1582-The Pan-Cancer Single-Cell Multimodal Regulatory Atlas

2

1581-Long-Read Sequencing of Melanoma Subclonal Evolution

3

1580-Multi-modal Tumor Profiling in Ovarian Cancer

4

1579-Genomic Architecture and Viral Adaptation in Bats

5

1578-AGENTEX: Automated Prototyping of Genetic Codes

6

1577-Malva: Reference-Free Sequence Discovery in Single-Cell

7

1576-Mapping Significantly Mutated Protein Regions in Cancer

8

1575-Stem-like Lymphoid Niches in HCC Immunotherapy

9

1574-Fifteen Challenges for Generative AI in Cell Biology

10

1573-Milk Osteopontin Regulation of Neonatal Lung Immunity

11

1572-Targeting 5-HT2AR to Enhance Colorectal Cancer Immunity

12

1571-Spatial Hi-C-RNA Maps 3D Genom&Transcriptome in Tissue

13

1570-Microbial Synthesis for Cardiometabolic Health

14

1569-cMAF Program in Brain Perivascular Macrophages

15

1568-Synthetic Transcription Factors for CAR T Cells

16

1567-RNA Structures Regulate Norovirus Replication

17

1566-Multimodal Brain Cell Atlas of Adult Macaque Lifespan

18

1565-Spatial Remodeling of Skin Cancer Microenvironment

19

1564-Intestinal Muscle Plasticity and Regulation of Gut Size

20

1563-Metabolic Atlas of Human Cortical Development

21

1562-Cellular Landscapes of Cognitive Decline in ALS

22

1561-Polyamines Buffer Labile Iron to Suppress Ferroptosis

23

1560-ULTRA: AI-Driven 3D Histology for Glioma Mapping

24

1559-Embryo Contractility Drivers Implantation Failure

25

1558-Stromal Cell Senescence and Haematopoietic Fitness

26

1557-Reversible Epiblast Regionalization in Pluripotency

27

1556-SecAct: Inferring Secreted Protein Signaling Activities

28

1555-Decoding Mechanoregulation with Biomimetic kpiCells

29

1554-CellTune for Precise Spatial Proteomics Classification

30

1553-Siibra: Tool Suite for Human Brain Atlasing

31

1552-Spatialproteomics for Multiplexed Image Analysis

32

1551-SpaMTP for Spatial Metabolomics&Transcriptomics

33

1550-Characterizing Microbial Dark Matter with MetaSBT

34

1549-Mapping the Druggable Proteome-wide CRBN Interactome

35

1548-Mapping Mesenchymal Diversity in Human Small Intestine

36

1547-RAD51 stabilizes Neutrophil Extracellular Trap

37

1546-Bacterial Sense Phage-Induced Genome Degradation

38

1545-Virome-Wide Discovery of Diverse Viral UbiquitinLigases

39

1544-De Novo Design of Fluorophore-Binding Proteins

40

1543-Biomni: Autonomous Artificial Intelligence Agent

41

1542-Wake-Activated Neuron Regulating Sleep Drive

42

1541-Skull Bone Marrow Lymphoid Structures in CNS

43

1540-Psilocybin Reorganizes Brain Activity into Context

44

1539-Astrocyte CD40&MHC-II Presentation in CNS Autoimmunity

45

1538-Maturation of Long-Term Human Brain Organoids

46

1537-GOOSE: for Functional Intrinsically Disordered Proteins

47

1536-Bacterial STAND Receptors Sense the Core Phage Proteome

48

1535-NextGen DepMap: A 3D Cancer Model Dependency Resource

49

1534-Stem Cell Multipotency Switching

50

1533-Principles of Human&Bacterial Antiviral Immunity

51

1532-Foundations of LLM Safety and Security in Healthcare

52

1531-Immunological Foundations of mRNA-LNP Vaccine

53

1530-Circadian Regulation of OPC Metabolism in Aging

54

1529-Neural Circuit for Compulsive Eating

55

1528-Dopaminergic Acorss Development to Degeneration

56

1527-Deep Learning Control of Human Visual Cortex Activity

57

1526-C1-vlPAG Circuit: Brainstem Hub for Anxiety Regulation

58

1525-Spatiomolecular Atlas of the Human Nucleus Accumbens

59

1524-Rapid Reversal of Hippocampal-Neocortical Interplay

60

1523-Latent Effector T Cells in Bone Marrow Malignancies

61

1522-Targeting PIKfyve-ER Stress Axis in Prostate Cancer

62

1521-Mining Tumor-Infiltrating Plasma Cells for Therapy

63

1520-Optimizing CAR NK Potency

64

1519-Tunneling Nanotubes-Fourth Pillar of Brain Connectivity

65

1518-Models of Neurodevelopment in Humans and Machines

66

1517-Neural Systems of Social Cognition and Relationship

67

1516-Network Similarity for Precision Functional Mapping

68

1515-CURBD: Inferring Brain-Wide Interactions

69

1514-Microglial Senescence and DLK Drive Brain Aging

70

1513-Genomic Insights into Seed-Size Variation in Buckwheat

71

1512-Co-option Promotes Antibody Diversification

72

1511-Spatial Atlas of the Human Brain Vasculature

73

1510-GasderminE-Viral Pyroptosis to Lethal Hepatic Steatosis

74

1509-Metabolic Atlas of the Developing Human Cortex

75

1508-Context-Dependent Action Encoding in Human Cortex

76

1507-DANDELION to Prioritize Asthma Drivers

77

1506-Spatial Immune Remodeling in Skin Cancer

78

1505-Architect of Apicomplexan Redox&Metabolic Adaptation

79

1504-Targeting 5-HT2AR to Enhance Antitumor Immunity in CRC

80

1503-Intestinal Muscle Plasticity Instructs Gut Size

81

1502-Gut Microbiome Protection Against Respiratory Illness

82

1501-Dusp5&Zfp219 to Rejuvenate Aged Antitumor Immunity

83

1500-Arginine Availability Controls MHC-I Translation

84

1499-Cellular Phenotypes of Language in ALS

85

1498-Intrinsic Cardiac Nervous System in Heart Function

86

1497-Structural Principles of CNNM4 Magnesium Transport

87

1496-VIDA: Protease-Initiated Antiviral mRNA Therapy

88

1495-Whole-Transcriptome Isoform-Resolved Spatial Imaging

89

1494-Viral ORFeome for Host-Pathogen Interaction Screening

90

1493-ULTRA: Rapid AI-Driven 3D Histology

91

1492-Oncoformer: Multimodal for Clinical Predictions

92

1491-Glutaminergic Neuromodulation of Skin Aging

93

1490-GTP-Driven Resource Allocation in Bacteria

94

1489-Circular Axonal Architecture in the Mouse Cortex

95

1488-Maternal TVA and Neonatal Immune Imprinting

96

1487-A 3D Molecular Atlas of the Lamprey Brain and Evolution

97

1486-CD4+ T Cells Combat Tumors via Vascular Destruction

98

1485-Zonated Mechanosensing Controls Liver Regeneration

99

1484-Synapse Loss Driven by Neuronal Activity

100

1483-Structure-Guided Design of Minimal RNA-Guided Nucleases

101

1482-Iron-Catalyzed Ferroptosis in Cyanobacterial Blooms

102

1481-TranscriptFormer: Model for Evolutionary Cell Biology

103

1480-Synthetic Wnt Organizers Pattern Human Kidney Organoids

104

1479-Mapping Genetic Regulation of Human Transcriptome

105

1478-NEDD8 and SUMO2 Regulation of Epithelial Homeostasis

106

1477-A Cellular Blueprint of the Human Hormone Cell Atlas

107

1476-ILC2 Regulates Pancreatic Fibroblast Progenitor Niches

108

1475-Restoring Macrophage Clearance to Limit Aging

109

1474-Neural Circuits for Valence Updating in Social Memory

110

1473-CARM1 Inhibition: Enhancing Cancer Immunotherapy

111

1472-Cryo-EM Structures of Human Cone Visual Pigments

112

1471-αKG-ON Biosensor: Mitochondrial-Nuclear Signaling

113

1470-Molecular Basis of Human Daylight Vision

114

1469-IL17RA Recognition and the Development of Vδ7 γδT Cells

115

1468-Dendritic Cells as Orchestrators of Cancer TLS

116

1467-Antibiotic-Induced Horizontal Protein Transfer

117

1466-Single-Cell Multiomics of Neuronal Activation

118

1465-Solubilizing Membrane Proteins via De Novo WRAP Design

119

1464-Metabolic Reprogramming in Ischemic Stroke

120

1463-Circular RNA FCHO2 Drives Airway Remodeling

121

1462-Hypoxia-Induced Sorafenib Resistance in HCC

122

1461-Arginine Deprivation Enhances GB Radiosensitivity

123

1460-Age-Related Lymphocyte Pathways&Mechanisms in Sepsis

124

1459-LCP2 Deficiency Drives Chemoresistance in Lymphoma

125

1458-NAT10-Mediated ac4C Acetylation Drives Renal Senescence

126

1457-MRPL3 Driven Early Hepatocellular Carcinoma Recurrence

127

1456-JMJD3 Modulates Benign Prostatic Hyperplasia

128

1455-Multi-omics Profiling of Cervical Cancer Evolution

129

1454-β-Catenin Signaling in Toxoplasma gondii Infection

130

1453-CFTR Potentiates Immune Microenvironment Reprogramming

131

1452-Adenosine Disequilibrium: Fingerprint of Embryo Quality

132

1451-Decoding the CAF–TAM Axis in the Tumor Microenvironment

133

1450-SUMOylation of CORO1C in Lung Adenocarcinoma

134

1449-Organelle Contact Sites in Cancer Cells

135

1448-Senescent Cancer Cells in Antitumor Immunity

136

1447-Human Retinal Organoid Model for AMD Drug Screening

137

1446-NIK Deletion Accelerates Pancreatic Cancer Progression

138

1445-Conserved Role of Atx2 in JNK Pathway Activation

139

1444-Breast Cancer Brain Metastasis progression

140

1443-Cristae: Bioenergetic Hubs in Mitochondrial Homeostasis

141

1442-Enhancing chemotherapy efficacy for Gastric Cancer

142

1441-Lactylation Switch in Cancer Resistance

143

1440-ANGPTL2 Regulation of Macrophage Mitophag&Pyroptosis

144

1439-The Brain as a Dynamic Immunological Interface

145

1438-PGE2-Driven Dendritic Cell Dysfunction in Breast Cancer

146

1437-MIF-p38-GSDMD in UVB-Induced Cutaneous Lupus

147

1436-Hypothalamic GABAergic Circuits Drive Neuroprotection

148

1435-GABAergic Inhibitory Dysfunction in Spinal Muscular

149

1434-Lipid Rafts and TRPA1 in Pancreatic Cancer

150

1433-miR-424(322)~503 Impairs PTEN-Deficiency

151

1432-RNASEH2C Regulation in Liver Cancer Immunity

152

1431-Intratumoral Microbiota Remodeling and Immunotherapy

153

1430-Th17-like Cells and M2 Macrophages in Sarcoma

154

1429-Organelle Dynamics in Cancer Cell Pyroptosis

155

1428-Decoding Neddylation in Malignancies

156

1427-TIGIT Blockade Enhances BCMA-CAR-T Efficacy in Myeloma

157

1426-YTHDF3 Promotes HPV Carcinogenesis

158

1425-mTORC1-Independent Glycogen Storage in TSC

159

1424-Somatic Kitl Facilitate Meiotic Prophase I

160

1423-NRF1 Upregulation via ER Stress Inhibition

161

1422-Mechanisms of First-Line Drug Resistance in HCC

162

1421-Hallmarks of Polyglutamine Spinocerebellar Ataxias

163

1420-Ferroptosis in Systemic Lupus Erythematosus

164

1419-EFHD2 Drives DNA Repair in Radioresistant Cancer

165

1418-DHA Potentiates Regorafenib and Anti-PD-1

166

1417-ZBP1-Driven Macrophage Pyroptosis in Sepsis

167

1416-Nrf2 Signaling Mechanisms in Acute Ischemic Stroke

168

1415-GLI1 Palmitoylation in Sonic Hedgehog Medulloblastoma

169

1414-CD23 Regulation of NKT17 Homeostasis

170

1413-LSD1-GLS2 Drives Subtype-Specific Chemoresistance

171

1412-IGFBP5+ Endothelial Drives Colorectal Cancer Metastasis

172

1411-RelB/ILF2–GM-CSF Loop Sustains Cancer Immunosuppression

173

1410-The BMP7-TGM2 Axis in Preeclampsia Pathogenesis

174

1409-E2F6/SH3GL2/HMGB1 Axis in Glioblastoma Resistance

175

1408-Glutamine Drives PARP Inhibitor Resistance

176

1407-Pathogenesis of Neurodevelopmental Proteasomopathies

177

1406-The PLAU-ITGB1-TGF-β Axis in OSCC Immunosuppression

178

1405-Atp8a2: Regulator of Neuronal Integrity and Survival

179

1404-Restoring CD226 to Overcome Refractory Breast Cancer

180

1403-Roles of PKM2 in Retinal Homeostasis and Survival

181

1402-NINJ1 Role During Lung Injury

182

1401-Targeting STAT3 to Overcome Chemoresistance in AML

183

1400-Mitochondrial-Driven Resistance in Osteosarcoma

184

1399-Broadly Neutralizing HIV Antibodies

185

1398-Generative AI for Controllable Protein Sequence Design

186

1397-Generative AI for Efficient Large Molecule Design

187

1396-DiffPharma: 3D Molecular Generation

188

1395-Druggable Kinases in Neuropathic Pain Management

189

1394-Sinonasal Carcinoma Therapeutic Vulnerabilities

190

1393-Tumor Infiltrating Lymphocytes in Glioblastoma

191

1392-Comparative Framework for Human&Mouse Neuron

192

1391-Connectomic Basis of Neuromuscular Network Formation

193

1390-RareLink: for Rare Disease Data Interoperability

194

1389-Stem Cell Models of Leukodystrophies

195

1388-Geno4ME: Implementing Population Health Genomics

196

1387-Microglial Vascular Pruning via the PD-1 Signaling Axis

197

1386-Modular In Vivo Antibody-ADC Click Therapy

198

1385-Ketogenic diet mediates intestinal tumorigenesis

199

1384-A Queen Odour Mediates Reproductive Suppression

200

1383-SGLT2i Improves Diastolic Dysfunction in hiPSC Heart

201

1382-Primate Spermatogonia Generation from Stem Cells

202

1381-Patient-derived Organoids Reveal Ductal Dysfunction

203

1380-SPACE-seq: Spatial CRISPR Lineage Tracing

204

1379-Vitamin C Decelerates Primate Bone Marrow Aging

205

1378-Epithelial-to-Mesenchymal: Engine of Tumor Plasticity

206

1377-Oncogenic Phenoscape of Colonic Stem Cell Polarization

207

1376-Pathway Level Subtyping of Colorectal Cancer Phenotypes

208

1375-Bacteriocin-Mediated Colonization of BB in Human

209

1374-TCA Cycle Rewiring in Pluripotency Transitions

210

1373-DEERS: for Cancer Drug Sensitivity Prediction

211

1372-Whole-Cell Digital Twin Simulations of Organelle

212

1371-TOP1-Mediated Genomic Damage in ALS

213

1370-Evolution of the Coral Symbiosome

214

1369-4D Molecular Mapping of Hair Follicle Organogenesis

215

1368-Neural Mapping of Mouse Visual System Change Detection

216

1367-Whole-Transcriptome Isoform-Resolved Spatial Imaging

217

1366-Boron-Bridged GIPCs Stabilize Cell Wall Anchoring

218

1365-Sprox-seq: Multi-modal Spatial Profiling

219

1364-Systematic Discovery of Pathogen Effector Functions

220

1363-Cell State Dynamics in Colorectal Cancer

221

1362-Cytoskeletal Oscillator Establishes Neuronal Polarity

222

1361-Spatial Mapping of Species-Specific Erythroid Niches

223

1360-Cellular and Genetic Drivers of Bone Disease

224

1359-Modern Perspectives on Alzheimer’s Pathogenesis

225

1358-GABA-Driven Immunotherapy Resistance in Tumors

226

1357-Intratumoral B Cell Dynamics and Stress Responses

227

1356-Next-Generation ADCs: Path Toward Precision Medicine

228

1355-Diet–Microbiome Synergy in Immunotherapy Efficacy

229

1354-Stress-Induced Intratumor Phage-Fibroblast-B Circuit

230

1353-Chronic Stress and Glioblastoma

231

1352-Menin Inhibition Targets Pathogenic Megakaryopoiesis

232

1351-GABA Inhibition of TLS in Cancer Immunotherapy

233

1350-Menin in normal and malignant megakaryopoiesis

234

1349-The MDK-Targeted EV-Photoimmunotherapy Platform

235

1348-Detecting Cancer Signals via cfDNA Language Models

236

1347-A Foundation Model for Cell Biology

237

1346-Competing Programs of Cortical Sensorimotor Axis

238

1345-Chromatin Landscape and Epigenetic Heterogeneity of AML

239

1344-Non-Genotoxic Epitope Editing

240

1343-A Quantitative Spatially Resolved Map of Human Proteome

241

1342-TGF-β1 Signaling in Aging BBB Leakage

242

1341-Fast Circuitry of Mechanical Nociceptive Pain

243

1340-Sensitize Liver Cancer for Immunotherapy

244

1339-Phage-Fibroblast-B Circuit in Stressed Tumor Growth

245

1338-Ductal Dysfunction and CFTR Responses in Pancreatitis

246

1337-Predictive Corticospinal Model for Pain Perception

247

1336-Fragmentia-AI: Detecting Cancer

248

1335-Tumoroid-on-a-Chip for Precision Drug Testing

249

1334-TIGIT-IL-12 Fusion Protein for Tumor Immunotherapy

250

1333-SAMT-247 Synergizes with SIV Vaccination Immunity

251

1332-Spatial Transcriptomics for Precision Bladder Cancer

252

1331-Light-Driven Hydrogel Nanomodulators for Tumor Therapy

253

1330-CAR-NK Cell Therapy: Breakthroughs and Challenges

254

1329-Indolelactic Acid Restores Skin Barrier

255

1328-Synergistic Radiopharmaceutical for Neuroblastoma

256

1327-Islet Transplantation: Tolerance Versus Immune Evasion

257

1326-Metabolomic Refine Metabolic Risk Stratification

258

1325-Targeting FAM3D to Alleviate Atherosclerosis

259

1324-DNA TFO Liposomes for Pulmonary Fibrosis Gene Therapy

260

1323-T Cell Dynamics in Gastric Cancer Response

261

1322-Spatiomolecular Mapping of the Human Nucleus Accumbens

262

1321-Reconstituting Human Gastrulation

263

1320-Emergent Disease-Associated Motor Neuron State in ALS

264

1319-Geometric Constraints on Mammalian Cortical Connectomes

265

1318-PIEZO1-SLC7A11-Glutamate Axis in Chronic Bladder Pain

266

1317-Iron-Catalyzed GSDMD in Allergic Airway Inflammation

267

1316-Arc Packaging Mediates Intercellular Tau Transmission

268

1315-Whole-Cell Digital Twin Simulations

269

1314-Genomic Instability in Neurodegenerative Disorders

270

1313-Spatiotemporal Dynamics of Hair Follicle Organogenesis

271

1312-LEF1 and Niche Factors Regulating T Cell Stemness

272

1311-Homogeneity & Sex Estimation of Homo naledi Enamel

273

1310-GMP Expansion & Engineering for Cellular Immunotherapy

274

1309-Trimodal Imaging of Neuronal Gene Expression

275

1308-Cuproptosis-Immunity Crosstalk

276

1307-CANVAS: AI-Driven Spatial Profiling

277

1306-eORFeome: Discovery of Pathogen Effector Functions

278

1305-AI-Driven Subtyping from CNS Tumor Histology

279

1304-Multiomic Profiling of Acute Myeloid Leukemia

280

1303-Nodal B Cell Lymphoma: Stromal Reprogramming

281

1302-A Single-Cell Atlas of Crohn’s Disease Pathogenesis

282

1301-Clusterin Enhancers for Alzheimer’s Disease Therapy

283

1300-Single-Nucleus Epigenomic Profiling of Adult Human CNS

284

1299-Transcriptomic Landscape of Neocortical Development

285

1298-Conditional Gap for Single-Cell Perturbation Modelling

286

1297-Multimodal Foundation Model for Cardiac Health

287

1296-Hippocampal Ripples Tune Cortical Responses

288

1295-Atlas of Cerebrovascular Fibrosis in Brain Aneurysms

289

1294-Landscape of Posterior Brain Organoid Development

290

1293-Cerebellar Disinhibition Gates & Fiber Learning

291

1292-Spatial Proteomics of Microglial States in AD

292

1291-Genoarchitecture & Organization of Mouse Basal Ganglia

293

1290-Developmental Cell & Atlas of Embryonic Chronology

294

1289-Transcription Senescence Promotes Rapid Tissue Healing

295

1288-Antibiotics Drive Infant Gut Malassezia Expansion

296

1287-Unmasking Lipid Nanoparticle Protein Corona

297

1286-Meniscus Scaffolds for Pediatric Airway Reconstruction

298

1285-Lentiviral Gene Therapy for ARC Syndrome Treatment

299

1284-Spatial Biomarkers of Chemotherapy Resistance

300

1283-Glial to Neuromesenchymal Transition in MPNST

301

1282-CODA: Integrative Spatial Transcriptomics Alignment

302

1281-hiPS Cell Model for Holistic Study of EMT Transitions

303

1280-Tumor Heterogeneity in Hepatocellular Carcinoma

304

1279-Noninvasive Phenotyping for Liver Cancer Prognosis

305

1278-Multi-Omics for Pulmonary Adenocarcinoma Grading

306

1277-SLC Transporters in Cancer Metabolism

307

1276-Models for Drug-Drug Interaction Prediction

308

1275-Predicting Anticancer Drug Interactions

309

1274-IMIREG: Regulon Signature of Immunotherapy Response

310

1273-GZMK+ T Cells as Biomarkers for Immunotherapy Response

311

1272-Mapping Invasive-Front Signature of Bladder Cancer

312

1271-AI for Rational Polypharmacology drug design

313

1270-SQLE as a Diagnostic and Prognostic Biomarker for LIHC

314

1269-Blood Proteomic Signatures of NSCLC Surgical

315

1268-Deep Learning Biomarkers for Gastric Cancer Prognosis

316

1267-STIL as a Key Driver of Li-Fraumeni Syndrome

317

1266-CBX2 Phase Regulates EV Biogenesis in tumor Metastasis

318

1265-VDAC2 Pan-Cancer Analysis: Decoding Tumor Evolution

319

1264-Prostate Cancer Neuroendocrine Differentiation

320

1263-AI-Driven Body Composition Atlas in NSCLC

321

1262-Deep Learning Pathomics Signature for Gastric Cancer

322

1261-MARCKS Reprograms Immunosuppressive Microenvironment

323

1260-Prostate Cancer: Genomic Landscape & Precision Therapy

324

1259-Overcoming Midostaurin Resistance in AML

325

1258-Cellular Differentiation Trajectories in Gastric Antrum

326

1257-AI-Driven Nanoplatforms for Targeted Ovarian Cancer

327

1256-AI Prediction of Prostate Cancer Molecular Subtypes

328

1255-Multi-Omics Framework for Colorectal Cancer Prognosis

329

1254-Pan-Cancer Tumour Segmentation in Whole-Slide Images

330

1253-APOLLO11: AI Framework for Precision Lung Oncology

331

1252-Advancing Ovarian Cancer Care via Immunotherapy

332

1251-Ovarian Spatiotemporal Atlas of Folliculogenesis

333

1250-Mapping Microglial Morphology in the Aging Brain

334

1249-Subtyping AD and PD Using Longitudinal Health Records

335

1248-scMORE: Mapping Trait-Relevant eRegulons

336

1247-Organ-Specific Proteomic Aging Clocks

337

1246-Reversible mTOR Mechanisms in Alzheimer’s Disease

338

1245-Mapping the Aging Mammary Landscape

339

1244-Loss of Transcriptional Coordination in Human Aging

340

1243-Nonlinear Dynamics of Multi-omics During Human Aging

341

1242-A Spatiotemporal Atlas of Human Ovarian Aging

342

1241-RNA Reinforces Mutant ENL Condensate Nucleation

343

1240-TimeVault: A Molecular Time Machine for Single Cells

344

1239-Quantum Biology: From Mechanisms to Medicine

345

1238-Integrated Stress Response Drives Cancer Evolution

346

1237-DRP1&MID49 Diffusion Dynamics in Mitochondrial Fission

347

1236-TEAD1 Condensates: Inactive Storage Sites

348

1235-ERO1α Regulation of MAM Dynamics in Glioblastoma

349

1234-Nanodomain Partitioning in Lipid Droplet Targeting

350

1233-Meg3+ Stem Cells in Immune Ageing

351

1232-Rapid-onset senescence is integral to healing

352

1231-Metabolomic of Microglia, Astocytes, and Neurons

353

1230-Confined Neuronal Migration Induces DNA Damage

354

1229-Prognostic Human Brain Network for Midline Glioma

355

1228-GEMINI for Cellular Histories

356

1227-GIFT: Single-Cell Genotyping in Fixed Transcriptomes

357

1226-VIPerturb-seq: Genome-Wide Single-Cell CRISPR Screening

358

1225-ExpiMap: for Single-Cell Reference Mappingc

359

1224-ROAST: Reference-Free Supertranscriptome Assemblies

360

1223-Host Immune Dynamics After CAR T Therapy in GBM

361

1222-Cellular Origins of Checkpoint Inhibitor

362

1221-NF2 Loss Mediates Resistance to Immunotherapy

363

1220-First Multi-Organ Pig-to-Human Xenotransplantation

364

1219-Glioblastoma Organoids for Precision Oncology

365

1218-SPACE-seq: Spatial Lineage Tracing

366

1217-Irg1/Itaconate Rewires Macrophage and Tumor Metabolism

367

1216-Microbiota-Immunity Axis in Cancer Checkpoint Blockade

368

1215-Mitochondrial Tracing of Innate Immune Clonal Dynamics

369

1214-Prognostic Atlas for Pancreatic Cancer

370

1213-Oncofetal Cell Plasticity in Early Colorectal Cancer

371

1212-The Cartography of KRAS Inhibitor Resistance

372

1211-STING Unlocks CD4+ T Cell Immunity in Pancreatic Cancer

373

1210-SenCat: Atlas for Decoding Human Cell Senescence

374

1209-Gate of Moment-to-Moment Memory Accessibility

375

1208-Epigenetic Control of Microglial Immunity in Alzheimer

376

1207-Single-Cell Proteome Atlas of Aging Mouse Microglia

377

1206-Gut-Brain Identity Coding

378

1205-Dopamine Circuit Mechanisms Gating Chronic Pain

379

1204-Zn-Cu Therapy for Post-Infarction Cardiac Repair

380

1203-Epigenetic Routes to Cancer Cell Camouflage

381

1202-PathPrism: for Histopathology Biomarker Discovery

382

1201-Two Causes of Human Pre-implantation Embryonic Arrest

383

1200-circ-arRNA Guided Exon Skipping for DMD Therapy

384

1199-Modeling Primate Embryogenesis from Totipotency

385

1198-Senescence States and Brain-Barrier Development

386

1197-Nuclear MAP1B Regulates Neural Stem Cell Fate

387

1196-Protein Epigenetic Switch for Adaptation

388

1195-Spatial Pharmacobiology of Antibody Delivery

389

1194-Perturb-DBiT: CRISPR Screening in Native Tissue

390

1193-Mapping MDD Risk Genes via In Vivo Perturb-seq Analysis

391

1192-CytoSignal: Decoding Cellular Communication Dynamics

392

1191-Spatially Single-Cell Atlas of Human Meningioma

393

1190-Inflammatory Cytokines and Induced Cancer Dependencies

394

1189-MAPK and WNT Dynamics in Intestinal Cancer

395

1188-Human Brain Network for Diffuse Midline Glioma

396

1187-Mitochondrial Interaction with Nuclear Pore Complex

397

1186-TADShop: Identification of Chromatin Domains

398

1185-Evolution and Speciation of the Brassica A Genome

399

1184-Decoding Regulatory Networks in Metabolic Liver Disease

400

1183-Cellist: Cell Segmentation for Spatial Transcriptomics

401

1182-Spinal Cord Stimulation for Post-Stroke Motor Recovery

402

1181-Interferon-α Gene Therapy for Glioblastoma

403

1180-Microglial Transitions at Amyloid-Tau Inflection Point

404

1179-KRAS Phase Separation in Colon Cancer

405

1178-SPAC-seq: Spatial CRISPR Screening

406

1177-A Spatiotemporal Atlas of Developing Human Meninges

407

1176-CytoCommunity: Decoding Tissue Cellular Neighborhoods

408

1175-Cell-Type Resolution of Genetic Variation in IBD Risk

409

1174-SMC-Derived Progenitors Drive Vascular Remodeling

410

1173-Pathogenesis Profiling of DLBCL Proteogenotypes

411

1172-Hypoxia-Driven Therapeutic Response in Metastatic ccRCC

412

1171-Mitotrek: Mapping Human Tumor Myeloid Origins

413

1170-D&D-seq: Single-Cell DNA-Protein Interactions

414

1169-Deep-Phase: Decoding Biomolecular Condensate Morphology

415

1168-Plasma Signatures for Early Lung Cancer Risk Prediction

416

1167-Regional Principles of Neuronal Protein Clearance

417

1166-A Core Peptide Signaling for Pollen Cold Resilience

418

1165-Centromeric DNA in ALT Cancer Telomeres

419

1164-Spermine Suppressing Ferroptosis

420

1163-Ecotypes and Archetypes of TNBC chemotherapy Response

421

1162-Predictable Evolution on Antibody Affinity Landscape

422

1161-Mapping Spatial Tumor-Immune Interactions

423

1160-DeepSpaCE: for Super-Resolution Spatial Transcriptomics

424

1159-Starfysh: Integrating Spatial & Histology data

425

1158-Optimizing Cellular Neighbor Preference Analysis

426

1157-ISG Atlas: Functional Map of Antiviral Innate Immunity

427

1156-Knowledge and Research Sustainability in the AI Era

428

1155-Renoir: Charting Spatial Ligand-Target Activity

429

1154-Type I interferon in amyloid beta in nervous system

430

1153-Confounding Noise in Multiplexed Enhancer AAV Screening

431

1152-Visual Attention via Bidirectional Recurrent Gating

432

1151-The NHGRI Archive: for Genomic Innovation

433

1150-Map of Cilia-Associated Proteins in Fallopian Tube

434

1149-Chromatin Remodeling in Cancer Dedifferentiation

435

1148-High Amylase Gene Copy Number in Indigenous Andeans

436

1147-Microbiota-Gut-Brain and Habitual Coffee Consumption

437

1146-Emergent Tissue Properties from Spatial Profiles

438

1145-Kasumi: Learning Persistent Patterns in Spatial Data

439

1144-scNiche: Decoding Multi-View Cell Niches

440

1143-Spatial Heterogeneity of Triple-Negative Breast Cancer

441

1142-Spatial Cell Interactions in HER2+ Breast Cancer

442

1141-HBV HBx Protein Subversion of Host Epigenetic Control

443

1140-Evaluating Feature Reduction Methods for Drug model

444

1139-Interpretable Drug Synergy Prediction

445

1138-SiamCDR: for Enhanced Anti-Cancer Drug Prioritization

446

1137-CTDPathSim2.0: Mapping of Cell Lines to Patient Tumors

447

1136-Deep Learning Architectures for Drug Synergy Prediction

448

1135-Drug Response Models for Personalised Cancer Therapy

449

1134-Reliable Drug Sensitivity Prediction and Prioritization

450

1133-MutliSyn: for Drug Combination Synergy Prediction

451

1132-Astrocytic Sodium Homeostasis in Mouse Brain

452

1131-Recurrent Multiplicity of TGFβ Domains in Vertebrates

453

1130-The Microbiota-SNHG9-MAS Axis in Liver Protection

454

1129-VEGFR2 Requirements in Lymphatic Sprouting

455

1128-DrEval: Evaluation of Drug Response Prediction Models

456

1127-Dual Targeting Mechanisms of Tetracyclines

457

1126-Key Microbial Allies for Coral Resilience

458

1125-Multi-Modal Profiling of Antigen-Specific CD4+ T Cells

459

1124-Pericytes Regulates Tissue Morphogenesis

460

1123-Carrageenan Catabolism in Ruminant Microbiomes

461

1122-Patient-Derived Xenograft Models in Cancer Therapy

462

1121-Alternative Splicing in Cardiac Disease

463

1120-eIF4G2 Buffering of Chromatin Regulators

464

1119-Regenerative Skin Remodeling in Systemic Sclerosis

465

1118-Dopamine Drives Remodelling of Maternal Brain

466

1117-Restoring Visual Function Optic Nerve Transplantation

467

1116-Epigenetic Phase Variation in the Gut Microbiome

468

1115-SPART: Regulator of Orthoflavivirus Uncoating

469

1114-Memory Reservoirs in Ovarian Tumor-Draining Lymph Nodes

470

1113-Monoclonal Antibodies Targeting Measles Proteins

471

1112-Gut Microbiota & Cancer Immunotherapy

472

1111-Dietary sulfur amino acids enhance anti-tumor immunity

473

1110-The Immunology of Exercise

474

1109-IFN-I & TREM2 Dysregulation in Neurodevelopment

475

1108-FastGxC: Context-Specific Gene Regulation

476

1107-TPPP/p25 Amyloid Seeding Activity for MSA

477

1106-Amygdala-Like Organoids for Modeling Stress Circuitry

478

1105-Coronavirus Interactome Mapping in Bat and Human Cells

479

1104-Spatial CRISPR Screening with SPAC-seq

480

1103-Synthetic Rewriting of the IGH Locus

481

1102-VEGFR2 for VEGF-C Driven Lymphatic Sprouting

482

1101-Computational Engineering for PET Recycling

483

1100-Human Nuclear-Embedded Mitochondrial DNA Dynamics

484

1099-Comparative Transcriptomics of Demyelination Models

485

1098-Exome-Wide Lipid Association in 1.1 Million Individuals

486

1097-Mosaic Chromosomal Alterations in Aging Blood Genome

487

1096-Ketogenesis-Ferroptosis Axis in Leukemic Stem Cell

488

1095-Stem Cell Subtypes Determine Venetoclax Resistance

489

1094-Cardiac Fibrosis Clearance and Myocardial Regeneration

490

1093-Hyocholic Acids: Metabolic Mediators of Immunity

491

1092-Endocytic Evasion & Drug Resistance

492

1091-Human Sinoatrial Node-Cardiac Plexus Assembloids

493

1090-Temporal Architecture of Seminiferous Epithelial Cycle

494

1089-The Essential lncRNA Landscape of Human Transcriptome

495

1088-Interferon-inflammaging links epigenetic age

496

1087-ProtoCloud: Explainable Model for Single-Cell Analysis

497

1086-ChromBERT: A Foundation Model for Regulatory Networks

498

1085-CRISPR Activation Mapping of Cancer Glycome Landscape

499

1084-AI Decoding Autism via Brain Transcriptomics

500

1083-CRISPRa Mapping of Cancer Glycome and Immune Evasion

501

1082-Hist2Cell: Cellular Architectures from Histology Images

502

1081-Microbial Single-Cell Omics In Situ

503

1080-Sexual Dimorphism in the Drosophila Brain

504

1079-Precision Product Framework for MSC Therapy

505

1078-SSpMosaic: Integrating Single-Cell and Spatial Omics

506

1077-The Drosophila Central Brain Neuron Atlas

507

1076-Genetic Regulation in Lung Cancer susceptibility

508

1075-Genetic Architecture of Murine Red Blood Cell Proteome

509

1074-Spatial Topography Drivers of Interstitial Lung Disease

510

1073-EnrichSci: Transcript-Guided Targeted Cell Enrichment

511

1072-Tumor-Infiltrating B Cells Across Human Cancers

512

1071-mHDX-MS: Mapping Protein Energy Landscapes

513

1070-Engineering Electrical Synapses for Circuit Editing

514

1069-Adaptive Cellular Evolution in the Cichlid Intestine

515

1068-Cyto-temporal Gene Expression in Cortical Development

516

1067-Building Organ Intrinsic Nervous Systems

517

1066-Spatial Pan-Cancer Atlas of lncRNAs

518

1065-A Molecular Blueprint for V3-Glycan HIV Vaccine Design

519

1064-Microtubule Dynamics & Cardiomyocyte Growth Direction

520

1063-Microglia Rank Signaling: A Key Regulator of Fertility

521

1062-Tuning STAT Signaling with Trikine Immunotherapeutics

522

1061-Raf Kinase Complexes Regulating Proton Pump Activation

523

1060-High-Throughput Selection of Fast-Acting Protein Drugs

524

1059-TranscriptFormer: Atlas Across Evolutionary History

525

1058-6-OHDA Antitumor Immunity via Macrophage Remodeling

526

1057-Reg-EXTL3 Axis in Pancreatic Cancer Nerve Crosstalk

527

1056-Cilia Beating Regulates Neural Stem Cell Quiescence

528

1055-Notch2 Orchestrates Fibroblastic Specialization

529

1054-Palmitic Acid in Breast Cancer Lung Metastasis

530

1053-Spatiotemporal Transcriptomic Atlas of Chronic Colitis

531

1052-The GGPP-RAB35 Axis in Tfh Cell Regulation

532

1051-CAR-Monocytes for Cardiac Fibrosis Clearance

533

1050-Biomolecular Condensates for Protein Degradation

534

1049-LSC Subtypes Driving Venetoclax Resistance in AML

535

1048-The Ketogenesis-Ferroptosis Axis in leukemia

536

1047-Organoid Models Emulating Metastatic Niches

537

1046-Visualizing the First Steps of Tumorigenesis

538

1045-Multilayered Regulatory Control of T Cell Exhaustion

539

1044-DNA Methylation in Precision Oncology

540

1043-Deciphering Tumor Metabolites

541

1042-Microbiome in Pancreatic Inflammation and Tumorigenesis

542

1041-NK Cell Dysfunction and Cytokine Dysregulation in MKD

543

1040-The Structure and Distribution of Human Interstitium

544

1039-TxPert: Predicting Transcriptomic Perturbation Effects

545

1038-NeuroXiv: AI-Powered Brain-Wide Neuron Morphometry

546

1037-COZI: Optimizing Cellular Neighbor Preference

547

1036-Ageing and Decline of Neuronal Proteostasis Dynamics

548

1035-Whole-Genome Doubling Drives Immune Evasion

549

1034-MRx for Simultaneous Biomarker Mapping

550

1033-CSC-Driven Immune Evasion via Vesicle Signaling

551

1032-HIV-1 Signalling Remodels Nuclear Pores

552

1031-Spatial Ecotypes of Tumour Microenvironments

553

1030-RegVelo: Single-Cell Fate Decisions

554

1029-D-SPIN: Generative Regulatory Network Modeling

555

1028-VIS-seq: Multidimensional Mapping of Variant Effects

556

1027-Multimodal Clocks of Human Aging

557

1026-Ferroptosis Inhibition Enhances Organ Graft Function

558

1025-Path2Space: AI-Predicted Spatial Transcriptomics

559

1024-GATOR1 Complex role in MYC-Driven Lymphomagenesis

560

1023-Next-Generation models for Spatial Omics

561

1022-scpFormer: Foundation Model for Single-Cell Proteomics

562

1021-Adaptive Genome-Wide Sweeps in Human Gut Microbiome

563

1020-p53 Preservation Safeguards Chemical Reprogramming

564

1019-Cell Death in Cancer

565

1018-Cancer Neuroscience

566

1017-Resolving Signal & Transcript Spillover in Xenium Data

567

1016-eSIG-Net: Decoding Protein Interaction Changes

568

1015-MicroSplit enables computational multiplexing

569

1014-KIRHub: Comprehensive Profiling of Kinase Inhibitors

570

1013-Macrophage Sampling of Living Cells

571

1012-Evolution of Genome Architecture Across 1,025 Species

572

1011-Cancer Initiation and Promotion

573

1010-Spatial Atlas of Diabetic Kidney Disease

574

1009-The New Era of De Novo Protein Design

575

1008-Intelligent and Miniaturized Drug Delivery Devices

576

1007-Biofluid Biomarkers for Neurodegenerative Dementias

577

1006-When Tissue Tension Creates a Mutagenic Niche

578

1005-Activated T Cell Vesicles Boost Antigen Presentation

579

1004-Tissue tension fosters DNA damage

580

1003-The Cutaneous Wound Response Program in PDAC Malignancy

581

1002-Targeting RAS-GTP Active State in KRAS Mutant Cancer

582

1001-Immune Cellular Architecture of Cancer Brain Metastases

583

1000-Cycling Regulatory T Cells Drive Immune Escape

584

999-Redefining Tissue-Specific Cancer Drivers

585

998-Gateways for Myeloid Cell Entry into the CNS

586

997-Glucose Hypometabolism and p-Tau Drive Necroptosis

587

996-Rethinking Immune States in Brain Metastasis

588

995-HOTSCRAMBL lncRNA: A Genetic Safeguard for Stem Cells

589

994-SAMENT: Mapping Niche in Bone Metastasis

590

993-The Topographic Map of Social Odors

591

992-A Spatial Code Governs Sensory Mapping

592

991-Mapping Human Cell Genetic Interaction Network

593

990-Mechanisms of RAS Inhibitor Resistance

594

989-Biogeography of Multi-Kingdom Cancer Microbiome

595

988-Multi-Embed: Decoding Pathological Morphologies

596

987-The Metaphyseal Niche Governs Leukaemic Stem Cell Fate

597

986-Transgene-Free Human Peri-Gastrulation Embryo Models

598

985-Organellar Insights in Ageing and Longevity

599

984-Restrictions of Cell Competition in Mosaic Gastruloids

600

983-Lipid-CLEM: Visualizing Nanoscale Lipid Distribution

601

982-Testicular Mitochondrial in Testosterone Synthesis

602

981-SpaHDmap: for Multimodal Spatial Transcriptomics

603

980-Architecting Human Trunk Development

604

979-Multi-Enhancer Oncogene Regulation

605

978-LBR & LAP2: for Peripheral Heterochromatin Anchoring

606

977-CoCo-ST: for Spatial Transcriptomics Domain Detection

607

976-Microtubule Architecture in YAP/TAZ Mechanotransduction

608

975-Durotaxis as a Driver of Fibrosis and Cancer Metastasis

609

974-Atlas of First Trimester Human Amnion Development

610

973-Nuclear Envelope Budding in Muscle Cells

611

972-Skin-Hypothalamus in Heat-Induced Metabolic Dysfunction

612

971-Somatic Cancer Variants in Alzheimer’s Disease Microglia

613

970-Spatial 5mC-seq Profiling of Embryos and Decidua

614

969-Plastic Architecture of Brain-Wide Astrocyte Networks

615

968-White Matter Lesions Drive Grey Matter Inflammation

616

967-Early Fibrotic Niches Establish Tumour-Permissive TME

617

966-QuadPE: Platform for Large Genomic Insertions

618

965-SIDISH: In Silico Perturbation for Precision Medicine

619

964-Genetic and Somatic Trade-offs in Ageing and Mortality

620

963-RAS-GTP Inhibition in KRAS Mutant Cholangiocarcinoma

621

962-Engineered Metabolic Modulation of Gut-Liver-Brain Axis

622

961-Global Genetic Interaction Network of the Human Cell

623

960-Spatiotemporal Maps of Whole Mouse Embryos

624

959-The Dynamic Architecture of Meningeal Immunity

625

958-Single-Cell Spatial Atlas of Human Skin Anatomy

626

957-Mapping Plastic Astrocyte Networks Across the Brain

627

956-scAgeClock: Model for Single-Cell Human Aging

628

955-ProAPOBEC: Enhanced in vivo RNA Base Editing

629

954-How autopolyploid genomes return to a diploid state

630

953-Early Fibrotic Niches in Lung Tumour Initiation

631

952-Deconstructing the Memory Engram

632

951-Precision Neuroimaging of Human Circuit Responses

633

950-UBQLN2 Links Proteostasis in Neurodegeneration

634

949-Restoring Bimanual QWERTY Typing with Neuroprosthesis

635

948-Epigenetic Memory of Developmental Programs in Adult CNS

636

947-Competitive Interactions Shape Mammalian Brain Network

637

946-Spatiotemporal in developing postnatal prefrontal cortex

638

945-Decoding CNS Injury-Responsive Enhancers

639

944-Lecanemab attenuates Alzheimer’sAβ pathology

640

943-The Mouse Brain Atlas of Dendritic Microenvironments

641

942-Oxidized Phospholipids in Chronic Neurodegeneration

642

941-Mapping the Human Allostatic–Interoceptive System

643

940-Spatial Organization of Striatal Neuron Morphology

644

939-Hypothalamic Leptin Receptors Counteract Anxiety

645

938-C9orf72 Repeat Expansions Impair Microglial in ALS

646

937-Region-Specific Drivers of Human CSF Mobility

647

936-Psychedelics Dissociate brain function

648

935-Muscle EVs and miR-126 Regulate TDP-43 and NMJ Integrity

649

934-Plaque-Associated Microglia in Alzheimer’s Disease

650

933-Deep Drainage and White Matter Decline in Aging Brain

651

932-Thalamocortical Connectivity of Cortical Plasticity

652

931-Gyrencephalic Niche for Postnatal Interneuron Migration

653

930-Spatial Landscapes of Human Glioblastoma

654

929-Mapping Neuronal Fate in Drosophila Optic Lobe

655

928-Neural Circuits and the Encoding of Temporal Statistics

656

927-Human Blood-Brain Barrier Spatiotemporal Development

657

926-CellFluxRL: Virtual Cell Modeling

658

925-Mitochondrial Metabolism Fuels Anti-cancer cDCs

659

924-Cycling Treg & cDC2 for Breast Cancer Immune Escape

660

923-A Tumor-Driven Collapse of Systemic Homeostasis

661

922-Context-Aware Precision Oncology

662

921-Early Malignant Transition of Hepatocellular Carcinoma

663

920-Nociceptor Subsets Regulate Skin Inflammation and Itch

664

919-SMG1 Inhibition and Expansion of Cancer Immunopeptidome

665

918-Winner-Take-All Network Dynamics

666

917-Glial Circuit Governs Balanced Brain Injury Responses

667

916-Astrocyte Cell Volume Dynamics Across Cortical States

668

915-Sleep Interpreter: for Real-Time Memory Decoding

669

914-Bidirectional Brain-Fat Body Axis for Pathogen Avoidance

670

913-Brainstem Circuits Driving Opioid Placebo Analgesia

671

912-Infant Memory Schemas

672

911-B Cells Regulate Exercise Capacity

673

910-The MIND Framework for Targeted Microbiome Alteration

674

909-Progenitor Niche in Benign-to-Malignant Transition

675

908-Gene Switch for Precise Spatiotemporal Control

676

907-Spatiotemporal of Postnatal Brain Vascularization

677

906-Dual-Engram Control of Alcohol Relapse in dMSNs

678

905-The Core Neural Signature of Psychedelic Drug Action

679

904-Prefrontal TMS Therapy for Depression

680

903-Spatial Atlas of Healthy Human Liver from Live Donors

681

902-The Neural Circuitry of Maternal Aggression

682

901-Oncofetal Plasticity in Early Colorectal Cancer

683

900-Orthrus: Evolutionary Functional RNA Foundation Models

684

899-Cerebellar Development & Medulloblastoma Spatial

685

898-Remodeling of Neuronal Membrane Periodic Skeleton

686

897-3D Genome Organization and Regulation in Brain

687

896-Spatial Map of Metastatic Breast Cancer Biopsies

688

895-The Neural Hub of Sickness Behavior

689

894-Mapping Neuronal Periodic Membrane Skeleton Interactome

690

893-Molecular and Spatial Signatures of Mouse Brain Aging

691

892-RoboChem-Flex: A Democratized Self-Driving Laboratory

692

891-CellAtria: Agentic AI for Single-Cell RNA-seq Analysis

693

890-Mitochondrial Morphology and Positioning in Connectome

694

889-MitoCatch: Mitochondrial Transplantation therapy

695

888-Proteome of Brain Vasculature across the Lifespan

696

887-Spatial Atlas of the Healthy Human Liver

697

886-PerturbFate: Mapping Melanoma Drug Resistance Regulation

698

885-Neural Mechanisms of Maternal Aggression Plasticity

699

884-Two Neurons Drive Brainwide Blood Volume Changes

700

883-Oncofetal Plasticity in Early Colorectal Cancer

701

882-Map of Human Hematopoietic Stem Cell Differentiation

702

881-FrontierScience: Benchmarking Expert AI in Science

703

880-Survey of Pathway Analysis Approaches

704

879-How Metastatic Tumors Hijack Hematopoietic Macrophages

705

878-DeSCOPE: for Genetic Perturbations

706

877-Neuronal Tuning Manifolds Across the Visual Hierarchy

707

876-NeMO: Compendium for Neocortical Development Exploration

708

875-Midbrain Dopaminergic Neuron Development

709

874-Neuroanatomical and Behavioral Mapping of Alzheimer

710

873-Multimodal Mapping of Neocortical Lineage Specification

711

872-Spatiotemporal Atlas of Human Maternal-Fetal Interface

712

871-scFOCAL: Drug Sensitivity Across tumor Cell States

713

870-Personalized Brain Decoding of Spontaneous Chronic Pain

714

869-The Human-Centric Evolution of Drug Discovery NAMs

715

868-pH-Dependent Condensates Calibrate Inflammatory Response

716

867-Keplerizing the Cell

717

866-Coralysis: Multi-Level Integration

718

865-Protenix-v2: Biomolecular Structure Prediction

719

864-CompBioBench: Agentic Systems in Computational Biology

720

863-The Human Developmental Cell Atlas

721

862-Spatial VDJ: Mapping Lymphocyte Clonal Dynamics

722

861-ROCKET: Experimental Structure Determination

723

860-Quantifying Uncertainty in Protein Sequence Embeddings

724

859-Integrated Analysis of Noncoding CRISPRi Screens

725

858-Engineered Dendritic Cells for Cardiac Remodelling

726

857-Decoding ReNU Syndrome

727

856-CARE: for Whole Slide Image Analysis

728

855-Human Development Multiomic Atlas

729

854-The Human Neural Organoid Cell Atlas

730

853-Architectural Secrets of the Mouse Cytoplasmic Lattice

731

852-Overcoming T Cell Tolerance

732

851-Human Endoderm-Derived Organoid Cell Atlas

733

850-Sparcl1 I Mitigates Abdominal Aortic Aneurysm

734

849-Neuroimmunometabolic in Tumor Micro- & Macroenvironments

735

848-GASTON: Mapping Tissue Topography

736

847-Epigenomic Profiling of Human Central Nervous System

737

846-scHiCAR: Trimodal Profiling of Gene Regulatory Landscape

738

845- Engineered Autologous Esophageal Conduits

739

844-Spatial ATAC: Epigenomic Profiling in Tissue Sections

740

843-Fatigue-Resistant Myoneural Actuators

741

842-The Architecture of Intracellular Bacteriophage Assembly

742

841-The Extreme Environment Microbiome Catalog

743

840-MYC-USP10-SOX4 Axis in Thymocyte Development

744

839-Perinatal Pig Brain Multi-Omics

745

838-Isoform-Resolved Transcriptomic of Human Placenta

746

837-Immune-Deficient Bacterial Gateways to Genetic Evolution

747

836-Genetic Architecture of an Allosteric Hormone Receptor

748

835-Eco-evolutionary of cross-ecosystem colonization

749

834-BioSeq2Seq to analyze transcriptional regulation

750

833-Blood Extracellular MicroRNAs Modulate Social Behavior

751

832-Corticostriatal Neurons in Monkeys

752

831-Spatial Tumor Evolution Panorama of Ovarian Cancer

753

830-Spatial Atlas of Small Cell Lung Cancer Metastasis

754

829-SMART: Spatial Multi-omic Aggregation

755

828-PocketXMol: Unified modeling of 3D molecular generation

756

827-GYDE: AI Platform for Protein Design and Engineering

757

826-Fibroblast NF-κB Activation Drives Lung Inflammaging

758

825-3D Morphogenetic Blueprint of Breast Cancer Metastasis

759

824-SPTEdU-seq: Spatiotemporal Newborn Cell Tracking

760

823-Hydrogen improves Osteoarthritic Cartilage Repair

761

822-Pathological Barriers to In Vivo Cardiac Reprogramming

762

821-Preventing Transgene Silencing During Differentiation

763

820-Tuft Cell Paracrine Drives Gut–Brain Parasite Defense

764

819-Epigenetic Memory of Colitis Promotes Tumour Growth

765

818-Neuron GLR-9 Receptor Regulates Salt Stress Resistance

766

817-AhR: Brake on Stress Adaptation and Axon Regeneration

767

816-Spino-Brain-Spinal Cord Loop of Chronic Mechanical Pain

768

815-Epigenomic Hijack Developmental Lineages in Ependymoma

769

814-Cancer Immunity and the Origins of NMDAR Autoimmunity

770

813-Functional Hierarchy of Neocortex Across the Lifespan

771

812-Androgen Activity and Male Bias in PFA Ependymoma

772

811-ATF4 Regulates DNA Repair in CUX2 Neuron Expansion

773

810-DNA Damage and CUX2 Neuron Loss in Neuroinflammation

774

809-CHARM: 4-Omics of Mammalian Gene Regulatory Landscape

775

808-Single-Cell Spatial Atlas of Human Skin Anatomy

776

807-Multitissue Epigenomic Variation of Human Disease

777

806-Converting Tregs into Type 1 Tumor Effectors

778

805-Microglia-Glioblastoma Crosstalk Mediating Invasion

779

804-Fates and Trajectories of Human Memory CD4+T Cells

780

803-Determinants of B Cell Phenotype and Antibody Breadth

781

802-Memory T Cell Aging and Rejuvenation

782

801-Landscape of Structural Variation in Pediatric Cancer

783

800-High-Fat Diet and Lipotoxic Mitochondrial Stress

784

799-ICRAFT: for Dual-Action Cancer Targets

785

798-CREsted: Designing Cell-Type-Specific Enhancers

786

797-Quantifying Uncertainty in Protein Representations

787

796-DIAMOND DeepClust for Protein Clustering

788

795-LazySlide: for Whole-Slide Image Analysis

789

794-LongcallR: SNP Calling of Long-read RNA-seq

790

793-Hypoxia-TAM Dynamics in Glioblastoma

791

792-Spatiotemporal Modeling of Molecular Holograms

792

791-Targeting uPAR-Positive Tumor with CAR T Cell Therapy

793

790-Whole-Body Cellular Mapping of Laboratory Mouse

794

789-Hyperinnervation Inhibits Regeneration in Mammalian Skin

795

788-The MSK-50K Pan-Cancer Resource of Driver Alterations

796

787-Radiotherapy Synergizes with Inducible AAV

797

786-Genetic Drivers of Hepatocellular Carcinoma Initiation

798

785-Myofibroblast Barriers to TLS Formation in PDAC

799

784-Spatially Anatomical Niches of Human Glioblastoma

800

783-Active Learning for Transcriptomic Drug Discovery

801

782-So3D: A Comprehensive Resource for 3D Spatial Omics

802

781-Functional Dissection of Human Complex Trait Variants

803

780-The AI Scientist

804

779-Microbio-Nicotinic Acid Regulate Colon Regional Identity

805

778-CellHermes: for Multimodal Omics Integration

806

777-Precision Health in Diverse UCLA ATLAS Biobank

807

776-A Deep RNA Sequencing Atlas of Human Sensory Neurons

808

775-Rewiring STAT Signaling with Trikine Immunotherapeutics

809

774-DNA Repair in R2 Retrotransposon Transgene Insertion

810

773-Cytoskeletal Instability of Cytoplasmic Partitioning

811

772-3d-OT: Geometry-Aware Framework for Spatial Alignment

812

771-A Pan-Cancer Atlas of Double-Negative T Cells

813

770-Genes2Genes: for Single-Cell Trajectory Alignment

814

769-Benchmarking Tumor Subclonal Reconstruction Algorithms

815

768-OmicClaw: Language Framework for Multi-Omics Analysis

816

767-Defining a Cancer Dependency Map

817

766-Functional Mapping Mammalian Whole Brain via Perturb-seq

818

765-Celcomen: Spatial Causal Perturbation Modeling

819

764-X-Cell: Scaling Causal Perturbation Prediction

820

763-Maf and Jun Regulate Zeb2 to Drive Microglia Development

821

762-Regulatory Networks Governing Human Cortical Cell Fate

822

761-Spatial Tumor Evolution Panorama of Ovarian Cancer

823

760-Mapping Gene Cascades from Regulators to Traits

824

759-Logic-Gated Engagers Enhance Macrophage Killing

825

758-DNA Synthesis via Manufacturing-Aware Generative AI

826

757-scHiCAR: Trimodal Single-Cell Profiling

827

756-Microalgal Factories for Molecular Crystals Biosynthesis

828

755-PlasMAAG: Reconstructing Plasmids Using AI

829

754-Ovrlpy: Identifying 3D Signal Overlaps in Spatial Data

830

753-Customizing CRISPR PAM Specificity with Language Models

831

752-Engineered Living Glues for Inflammatory Bowel Disease

832

751-SPLISOSM: Mapping Spatial Isoform Patterns

833

750-CONCORD for Single-Cell Representation Learning

834

749-DECODE: A Universal Multiomics Deconvolution Framework

835

748-Pandemic-Scale Phylogenetics: Modeling Mutation Rates

836

747-Benchmarking Xenium In Situ Data Analysis Workflows

837

746-INSTALL: Immune Evasive Kilobase Scale Genome Writing

838

745-Ageing Promotes Lung Cancer Metastasis

839

744-PerturbDiff: for Single-Cell Perturbation Modeling

840

743-Mechanotransduction in the Nucleus

841

742-AlphaCell: for Simulating Cellular Perturbation Dynamics

842

741-EdgeMap: for Intercellular Communication Components

843

740-B Cell Imprinting in Children

844

739-Dynamic Basis of G-Protein Recognition and Activation

845

738-Multidimensional Profiling of Supratentorial Ependymomas

846

737-The Interoceptive of Age-Associated Cognitive Decline

847

736-Predicting Insulin Resistance Using Wearables

848

735-Phage–Pathogen Coevolution by Clinical Surveillance

849

734-The Tumor Microbiota

850

733-Tumor-restraining Fibroblasts Emerge to Chemotherapy

851

732-A Closed Tumor-Immune-Brain Circuit in Cancer Cachexia

852

731-SLC25A35: for Glycerolipid Synthesis

853

730-GPS: Deep Learning for De Novo Drug Discovery

854

729-An Epigenetic Atlas of the Aging Mouse Brain

855

728-The Evolution of Human Cerebellar Synaptogenesis

856

727-4D Simulations of the Genetically Minimal Cell Cycle

857

726-ChatSpatial: Agentic for Spatial Transcriptomics

858

725-Viral Evolution Preceding Zoonotic Outbreaks

859

724-Ferritin Aggregation Cell Engagers for CAR T Avidity

860

723-BHB Enhances CAR T Cell Antitumor Function

861

722-Immune-Microbiome Coordination in Healthy Humans

862

721-Optovolution: Directed Evolution of Multi-State Proteins

863

720-ROCK2 Inhibition for Treatment of Liver Fibrosis

864

719-OXGR1: A Therapeutic Switch for Rosacea Erythema

865

718-SelO Regulates Mitochondrial Homeostasis

866

717-Sildenafil as a Repurposable Therapy for Leigh Syndrome

867

716-stVCR: Spatiotemporal Single-Cell Dynamics

868

715-Connectome-seq: Neuron Mapping at Single-Synapse

869

714-CellVoyager: Autonomous AI Agent for ScRNA-seq Analysis

870

713-Parkinson’s Disease as a Somato-Cognitive Disorder

871

712-The Gut Microbiome and Cognitive Decline in Ageing Mice

872

711-Atlas-Guided Genetic Switches for T Cell Programming

873

710-Engineering Lipid Nanoparticles for Drug Delivery

874

709-Repression of a Cell-Cycle Protein Hinders Malaria

875

708-Fecal Exfoliome Sequencing for Noninvasive Profiling

876

707-Viral Evasion of Host Codon Usage

877

706-Biomolecular Profiling for Noninvasive Health Monitoring

878

705-Targeting Amyloid-β Pathology with CAR-Astrocyte Therapy

879

704-STING–NF-κB builds an influenza spillover barrier

880

703-A Negative Loop in Plant Inflorescence Indeterminacy

881

702-Structural Basis for mTORC2 & Akt Phosphorylation

882

701-Redefining Targetable CD70 Expression with HIT T Cells

883

700-Termination of the Integrated Stress Response

884

699-Organism-Wide Cellular Dynamics in Mammalian Aging

885

698-Learning Neural Redundancy in Macaque Visual Cortex

886

697-Whole-Brain Cell Atlas of Circadian Neural Activity

887

696-Tumor-Immune-Neural Circuit in Cancer Cachexia

888

695-Ecological Balance Index of Gut Microbiome Health

889

694-Cellular Basis for Mammalian Nocturnal-Diurnal Switch

890

693-Structure-Guided Discovery of Viral Sponges

891

692-In Vitro Reconstitution of Testicular Niche

892

691-FlashS: Detection for Scalable Spatial Transcriptomics

893

690-Thermal Limits & Genomic Signatures of Tropical Insects

894

689-Evo 2: A Foundation Model for All Domains of Life

895

688-Microbial Drivers of Colorectal Peritoneal Metastasis

896

687-Photoreceptor Signature in Pediatric Brain Tumors

897

686-TGFβ-Induced Atypical EMT and Immune Mechanosurveillance

898

685-Brainstem Organoid Models of DMG and GD2 CAR T Therapy

899

684-Microbial Signatures of Glioblastoma Metastases

900

683-Targeting TRBC2 for the Treatment of T Cell Cancers

901

682-SMARCA5 Control: Decoupling Pancreatic Malignancy

902

681-A Multiomic Atlas of Treatment Resistance in T-ALL

903

680-SMMILe: Spatial Quantification in Digital Pathology

904

679-TP53-Associated Spatial Atlas of Lung Adenocarcinoma

905

678-Developmental Cell Atlas of the Human Cerebellum

906

677-TabulaTIME: Pan-Cancer Landscape of Profibrotic Ecotypes

907

676-Single-Cell Profiling of Multiple Myeloma Tumor Cells

908

675-Miro2-Driven Mitochondrial Transfer

909

674-NF-κB Control Prostate Stem Cell Plasticity

910

673-Endothelial Dysfunction as a Driver of Cancer Cachexia

911

672-Plexin-B2-Mediated Glioblastoma Invasion Tracks

912

671-Neutrophil-Tumor Interactions in Breast Cancer

913

670-Evolution of IDH-Mutant Glioma Progression

914

669-Single-Cell Landscapes of Olfactory Neuroblastoma

915

668-Spatial Stem-Like Evasion in Residual Liver Cancer

916

667-A Pan-Cancer Resource of 1,294 Plasma cfDNA Methylomes

917

666-Epitranscriptomic Screens for m6A Sites in Cancer

918

665-CRTAM as a T Cell Checkpoint for Immunotherapy Toxicity

919

664-GENEVA: Modeling KRAS Inhibitor Responses

920

663-Predictors of Response to Immune therapy in TNBC

921

662-Hypoimmune CD19 CAR T Cells Evade Allorejection

922

661-Pancreatic Cancer Organoid Biobank

923

660-Stem Cell Engineering of A10 Dopamine Neurons

924

659-Reconstructing Endocrine-Complete Stem Cell Islets

925

658-Calcium Imaging in CA1 Dendrites

926

657-Neural Manifolds and the Structure of Recurrent Networks

927

656-Cellular Architecture in the Spinal Cord

928

655-Spatial Atlas of the Human Suprachiasmatic Nucleus

929

654-mFISH3D: AI-Driven Whole-Organ Spatial Mapping

930

653-Converging Dopamine Encode Exploration Decisions

931

652-Postsynaptic AMPAR Regulate Short-Term Plasticity

932

651-S100A8/A9 and Hypothalamic Regulation of Cancer Cachexia

933

650-Vascular STING Activation for NK Cell Immunity in SCLC

934

649-SPYTAC: Peptide Platform for Amyloid-β Degradation

935

648-FAScore: Model for Functional Alternative Splicing

936

647-Monod: Biophysical Modeling of Transcriptional Dynamics

937

646-Steering and Monitoring AI Models

938

645-Spatiotemporal Progenitor Zones in the Human Cerebellum

939

644-Cerebellar Tumour Origins in Fetal Programs

940

643-EMT and Cancer Stem Cells

941

642-Tumor Cell Differentiation in Medulloblastoma

942

641-A Brain–Gut Circuit Hijacked by Colorectal Cancer cells

943

640-Stalled Differentiation of Human Rhombic Lip in MB

944

639-Rhombic Lip Origins of Group 3 and 4 Medulloblastoma

945

638-The Evolution of Stem Cell Models in Medulloblastoma

946

637-Epigenetic Reprogramming of Medulloblastoma Metastasis

947

636-Evolution and Development of the Mammalian Cerebellum

948

635-The Medulloblastoma Metastatic Niche

949

634-The GPX1-OSBPL8 Axis: Pathway for In Vivo Ferroptosis

950

633-Resolving Medulloblastoma Cellular Architecture

951

632-Pyruvate is a natural suppressor of interferon signaling

952

631-Chemotherapy-Induced Tumor Immune Evasion

953

630-CAF Lipid Reprogramming Enhances T Cell Cytotoxicity

954

629-Architecture of Hantavirus Glycoprotein Tetramers

955

628-The Cellular Orchestra of CAR T Success in Myeloma

956

627-Macrophages: Next-Generation Cancer Immunotherapy

957

626-Advancing Cellular Immunotherapies for Solid Tumors

958

625-The CUBIC Organ and Body Atlas

959

624-MicrobeAtlas: Database of Earth's Microbial Ecosystems

960

623-HoloTea: 3D Flow Matching for Volumetric Transcriptomics

961

622-Functional Connectivity Gradients Across the Human Brain

962

621-Tracking Innate Immune Activation in Multiple Sclerosis

963

620-Multimodal MRI Atlas of the Human Cerebellum

964

619-Landscape of Human Fetal Cerebellar Development

965

618-Single-Cell Nuclear Compartments in Mouse Cerebellum

966

617-The Origins of Medulloblastoma

967

616-Gradients of Structural Human Cerebellar Development

968

615-Functional Mapping of the Human Cerebellum

969

614-Development of the Human Cerebellum from Birth to Five

970

613-Functional connectivity of the cerebellum

971

612-A Spatial Atlas of the Mouse Brain Complement System

972

611-Methodological Limitations in Lesion Network Mapping

973

610-Spatial Tri-omics Mapping of Brain Development

974

609-Dendritic Microenvironments for Mouse Brain Parcellation

975

608-HoloBrain and HoloGraph: Oscillatory Synchronization

976

607-Multiscale Morphometry of the Whole Mouse Brain Database

977

606-Determinants of Tissue-Specific KRAS Cancer Evolution

978

605-D-LMBmap: Automated Pipeline for Whole-Brain Mapping

979

604-Dynamic Dural Sinuses: Gatekeepers of Meningeal Immunity

980

603-Causal Regulatory Variants in Human Disease

981

602-Whole-Brain Connectivity Predicts Psychosis Risk

982

601-Stimulation mapping and whole-brain modeling

983

600-The Human Brain Metabolic Connectome

984

599-Foxf2 Maintains Brain Endothelial Function

985

598-Brain Propagations from Childhood to Adulthood

986

597-CATS Net: Modeling Human Concept Formation

987

596-Whole-brain Annotation of Drosophila

988

595-Celluar Atlas of the Entire Mouse Brain

989

594-Neural Transformations of the Second Pregnancy

990

593-VCWorld: A Biological World Model for Virtual Cells

991

592-LUMI-lab:AI-Guided Discovery Platform

992

591-The Skull Bone Marrow and Brain Tumor

993

590-PHNToM: Inference of Oncogene Mutation Function

994

589-Environment Shape the Human Immune Cell Epigenome

995

588-Human Retina Cell Atlas

996

587-The Cellular Landscape and Heterogeneity of COPD

997

586-IgG1 Plasma Cell Responses to Immune Checkpoint Blockade

998

585-Drivers of Gastric Cancer Response to Immunochemotherapy

999

584-GPLD1 and TNAP Regulation of Cognitive Function in Aging

1000

583-Y Chromosome Variation and Type 2 Diabetes Regulation