All Episodes

Episode 92: Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Episode 91: Reddit Trending — “It’s Like You’re Trying to Defuse a Bomb”: <i>Fear, Responsibility, and Shame in Young Men’s Sexual Lives</i>

Episode 90: Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition

Episode 89: Reddit Trending — Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse

Episode 88: GPCR antagonism via rewiring of receptor trafficking and degradation

Episode 87: Reddit Trending — Did Donald Trump Receive a Mandate for Sweeping Change in 2024?

Episode 86: Specific targeting of MR1-antigen complexes using nanobodies

Episode 85: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

Episode 84: Reddit Trending — Predictors and prevalence of support for white nationalism in the United States

Episode 83: Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex

Episode 82: Reddit Trending — Substantial under-detection of human rabies cases in the United States

Episode 81: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability

Episode 80: Reddit Trending — Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata

Episode 79: Reddit Trending — Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study

Episode 78: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation

Episode 77: Reddit Trending — People prefer to negotiate with women, even when outcomes are identical and gender is unknown

Episode 76: Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors

Episode 75: Reddit Trending — A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone

Episode 74: Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow

Episode 73: Reddit Trending — Work from Home and Disability Employment

Episode 72: From free speech advocates to critics: The Trump administration’s new rhetoric promotes support for censorship among Trump voters

Episode 71: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial

Episode 70: Language Modeling Materializes a World Model of Protein Biology

Episode 69: Novel bispecific T-cell engagers overcoming acquired EGFR resistance

Episode 68: The lived experience of rejection sensitivity in ADHD - A qualitative exploration

Episode 67: Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery

Episode 66: The political polarization of health outcomes in the USA

Episode 65: Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager

Episode 64: Climate-driven depopulation and adaptation realities in America’s coastal ground zero

Episode 63: Engineering of acidic pH-responsive anti-CD3 binding antibodies

Episode 62: Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study

Episode 61: Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

Episode 60: A trophoblast glycoprotein specific 5 T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies

A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity

Language models cannot reliably distinguish belief from knowledge and fact

Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade

Guidelines for Early Food Introduction and Patterns of Food Allergy

Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design

A genetic common factor underlying self-reported math ability and highest math class taken

Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition

The impact of CD3 affinity-attenuation on T cell engaging bispecific antibodies: is it really that simple?

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy

AlphaEarth Foundations: An embedding field model for accurate and efficient global mapping from sparse label data

Single-Chain Fab Chain-Exchange (scFab-PACE) converts targeted prodrugs into functional T cell engagers on tumor cells

Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement

Navigating protein landscapes with a machine-learned transferable coarse-grained model

Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions

Predicting human decisions with behavioural theories and machine learning

Tuning antibody stability and function by rational designs of framework mutations

Lying increases trust in science

Soil and cherry bacterial communities predict flavor on coffee farms

What Is It Like to Be a Bat?

3 Papers on Antibody Tumor Penetration and Clearance

Why people follow rules

Cross-tissue multicellular coordination and its rewiring in cancer

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity

Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease

Adversarial testing of global neuronal workspace and integrated information theories of consciousness

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

A natural experiment on the effect of herpes zoster vaccination on dementia

The end of the genetic paradigm of cancer

Embodied large language models enable robots to complete complex tasks in unpredictable environments

Sequencing by Expansion (SBX) – a novel, high-throughput single-molecule sequencing technology

CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells

AlphaFold prediction of structural ensembles of disordered proteins

A second-generation M1-polarized CAR macrophage with antitumor efficacy

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice

Deep learning enhances the prediction of HLA class I-presented CD8+ T cell epitopes in foreign pathogens

Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation

Prior vaccination prevents overactivation of innate immune responses during COVID-19breakthrough infection

Accelerated enzyme engineering by machine-learning guided cell-free expression

Discovery of a new class of cell‑penetrating peptides by novel phage display platform

Learning the language of antibody hypervariability

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans

Recombinant venom proteins in insect seminal fluid reduce female lifespan

Autonomous mobile robots for exploratory synthetic chemistry

A mechanism for hypoxia-induced inflammatory cell death in cancer

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Decomposing causality into its synergistic, unique, and redundant components

Probiotic neoantigen delivery vectors for precision cancer immunotherapy

Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies

The hallmarks of cancer immune evasion

In vivo dendritic cell reprogramming for cancer immunotherapy

Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor

Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion

Neutrophil profiling illuminates anti-tumor antigen-presenting potency

Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma

Sequence clustering confounds AlphaFold2