All Episodes

Episode: 85 - Daniel Chen on Building Multi-Target Drugs with Logic Gating

Episode: 84 - Martin Pacesa on BindCraft: An Automated Pipeline for De Novo Protein Binder Design

Episode: 83 - Patrick Baeuerle and Jeffrey Miller on T Cell and Immune Cell Engagement

Episode: 82 - PANEL DISCUSSION: Future of Biologic Therapeutics: Will Half-Life Extended Peptides Replace Multispecific Antibodies?

Episode: 81 - Laszlo Radvanyi on Pushing Boundaries in Cancer Immunotherapy Research

Episode: 80 - Vibha Jawa Discusses the Impact of Biologic Molecules and the Future of Immunogenicity

Episode: 79 - Conversation with Bahija Jallal on the Biggest Anticipated Transformations and Breakthroughs

Episode: 78 - Shamit Shrivastava on an Interdisciplinary Approach to Antibody Biophysics and Developability

Episode: 77 - Derek Lowe on AI and the US Biotech Ecosystem

Alexey Lugovskoy Shares Decades of Experience in Starting Out and Founding Companies

Episode: 75 - Are Licensing Fees Required or Gatekeeping?

Episode: 74 - Keith Flaherty, President-Elect of AACR, on Public and Private Collabs, AI Optimism, and More

Episode: 73 - PANEL DISCUSSION: Near-Term Challenges for AI/ML in Biotherapeutic R&D

Episode: 72 - Pamela Barney on HR Lessons to Meet the Needs of Biotech

PEGS Young Scientist Keynote Jessica Stark on the Role of Glycans in Cancer Research

Episode: 70 - Views on Machine Learning and AI in the Antibody and Protein Engineering Space

Episode: 69 - Conversation with Sir Greg Winter on the 50th Anniversary of the Milstein and Köhler Paper

Episode: 68 - Changing the Game of Protein-Protein Interactions With Randolph Lopez

Episode: 67 - Anthony Tolcher Discusses Oncology, Dual-Payload Technology, and the ADC Field

Episode: 66 - John Lambert on Antibody Drug Conjugates Then, Now, & Beyond

Episode 65- Tariq Ghayur on the Renaissance of Bispecifics and ADCs, AI, and More

Episode: 64 - Peyton Greenside on AI’s Role in Antibody Engineering, Optimization, and More

Episode: 63 - Discussing Protein Signaling and Structural Biology With Andrew Kruse

Episode: 62 - AI/ML in Antibody Discovery and Engineering: Reality, Hope, Future, and Hype

Episode: 61 - Tomoyuki Igawa Discusses Leadership and His Experiences in Discovery and Development

Episode: 60 - Lesley Millar-Nicholson on Technology Licensing, Navigating Patents, and Building Teams

Episode: 59 - Gabriel Rocklin on Protein Biophysics and Protein Design

Episode: 58 - Janine Schuurman Reflects on the Key Lessons and Accomplishments of Her 20-Year Career

Episode: 57 - The Future of Bispecific Antibody Drug Conjugates With Rakesh Dixit, Ph. D.

Episode: 56 - Thomas Sakmar on the Golden Age for the Application of Biologics to GPCR Pharmacology

Episode: 55 - Tala Fakhouri Discusses AI/ML for Biologics Drug Discovery & Development

Episode: 54 - Enkelejda Miho on the Current State of AI: Drug Development, Research, and the Future

Episode: 53 - Jonathan Sockolosky on Breaking Into Biotech and Making Real Progress in Ovarian Cancer Treatments

Episode 52: Entrepreneurship in Immunotherapy: Capstan’s Adrian Bot on Teambuilding

Episode: 51 - Setting the Right Strategy to Drive Engineering Parameters for Solid Tumor-Targeting T Cell-Engagers

Episode: 50 - Pivoting Research with Antibody Drug Conjugates

Episode: 49 - Building a Next Generation Bioproduction Platform

Episode: 48 - A Conversation with Peter Tessier: Classifying Antibodies to Assess Biologics Developability Features Early in the Discovery Process

Episode: 47 - Bonus Episode with PEGS Young Scientist Keynote Dr. Andrew Anzalone on Engineering Prime Editor Proteins for Therapeutic Applications

Episode: 46 - Leveraging Albumin and IgG FcRn-Mediated Regulation in Therapeutic Development

Episode: 45 - Advances in Targeted Protein Degradation

Episode 44: Structure Forward: Using Structural Biology Pipelines to Achieve Favorable Antibody Responses

Episode: 43 - Evolution of Antibody Technologies

Episode: 42 - Machine Learning Informatics for Antibody Discovery

Episode: 41 - Introduction and Evolution of the Antibody Patent Landscape

Episode 40: Exploring Developability Concepts with Bispecific Antibodies

Episode 39: René Hoet on Antibody Discovery and Following Your Heart

Episode 38: Pivoting to Meet Protein Purification Needs with TriAltus

Episode 37: Flashback Friday: COVID-19 Science-Sequence-Structure for Pandemic Preparedness

Episode 36: Quality Control from Molecule to Organization

Episode 35: NK Cells and the Science of Innate Immunity w/ Éric Vivier

Episode 34: Antibody and Vaccine Development for COVID-19 – Panel Discussion

Episode 33: Tackling COVID-19 Drug Discovery with Structural Genomics

Episode 32: Young Scientist Spotlight: Cryo-EM to Uncover Structures of Coronavirus Spike Glycoproteins

Episode 31: The Role of Tags in Your Purification Toolbox w/ Dennis Karthaus

Episode 30: Recombinant Methods to Generate Antibodies Against COVID-19 – Roundtable Discussion

Episode 29: Efficient Chromatography Devices for Purification Requirements

Episode 28:  Chasing Interleukin-2 from Academia to Industry w/ Willem Overwijk

Episode 27: Human VH Domains – Finding Antibodies to Treat COVID-19 and Beyond

Episode 26: Science Commune: Role of Regulation in an Age of Acceleration

Episode 25: Innovations in Antibody Engineering to Generate Novel Cancer Immunotherapies

Episode 24: Taking Risks and Setting Precedent in Bioanalytical Assays for Cell & Gene Therapies

Episode 23: Undruggable No More - Biologists & Engineers Unite to Successfully Deliver Potent RAS-Cleaving Enzyme

Episode 22: Science Commune: Embracing the Complexity of Glycobiology

Episode 21: Science Commune: Inspiration and Growth from the Early Days of Microbiology

Episode 20: Science Commune: Problem-Solving and Innovation at the Intersection of Science and Engineering

Episode 19: Developing a Novel Self-Cleaving Tag Technology while Learning From Both Success and Failure

Episode 18: Courage & Creativity: Entrepreneur of the Year Shares her Journey from Academia to Industry

Episode 17: Diagnostic Testing Approaches to the Coronavirus

Episode 16: Suppressing the Spread of Coronavirus from a Public Health Perspective

Episode 15: Cancer Immunotherapy Trends to Impact Patients and R&D

Episode 14: Science Commune: Biologists, Engineers, Artists, and Aha Moments w/ Bruce Keyt & Daniel Chen

Episode 13: When Gene Editing Goes Too Far w/ Hank Greely

Episode 12: A Fireside Chat with Kathryn Hastie & Jamie Spangler - Part 2

Episode 11: A Fireside Chat with Kathryn Hastie & Jamie Spangler - Part I

Episode 10: Intelligent Data Flow through Biotherapeutic Protein Development w/ Cenk Ündey, PhD

Episode 09: Engineered Multi-Specific Antibodies for Targeted Inhibition of Cancer Metastasis w/ Jamie Spangler

Episode: 08 - Democratizing Cell-Free Protein Synthesis w/ Javin Oza, PhD

Episode: 07 - From Sequence to Product: Exploring Role of Aggregation and Developability in Biologics Product Development with Paolo Arosio, PhD

Bonus Episode: Versatope and the Universal Influenza Vaccine with Christopher Locher, PhD

Bonus Episode: Research Technologies for Synthetic Immunology with Sai Reddy, PhD

Episode: 06 - Progress with Bispecific Vγ9Vδ2-T Cell Engagers w/ Dr. Paul Parren

Episode 05: Hot Topics in Continuous Chromatography for Protein Purification w/ Dr. Massimo Morbidelli

Episode 04: Toward in silico Lead Discovery – the Advent of AI and Machine Learning w/ Lars Linden, PhD, Head, Protein Biochemistry, Biologics Research, Bayer

Episode 03: Science Stories and the Return of Cell-Free Synthesis with Dr. Marco Casteleijn

Episode 02: Science Commune with Daniel Chen and Teemu Junttila

Episode 01: International Collaboration Yields Therapeutic Protein with Genome Engineered CHO Cells. Bjørn Voldborg, Technical University

Episode 0: Welcome to The Chain