Reversing Heart Disease: The Science of LDL and Lipoprotein(a) with Dr. Steven Nissen

EPISODE · Nov 19, 2025 · 1H 21M

Reversing Heart Disease: The Science of LDL and Lipoprotein(a) with Dr. Steven Nissen

from The Ultimate Asset · host Velocity Health

Heart disease remains the #1 killer worldwide, but are we doing enough to prevent it?In this episode of The Ultimate Asset, Dr. Deep sits down with Dr. Steven Nissen, Chief Academic Officer of the Heart and Vascular Institute at the Cleveland Clinic and one of the most influential cardiologists in medical history. Dr. Nissen has led the landmark trials that changed the way the FDA approves drugs and how we treat cholesterol today.We dive deep into the "Lower for Longer" philosophy, the truth about statin denialism, and the groundbreaking new therapies for Lipoprotein(a)—a genetic risk factor that traditional tests often miss.In this episode, we discuss:* The Traverse Trial: The real impact of Testosterone Replacement Therapy (TRT) on heart health.* Vioxx & Avandia: The "Good Trouble" Dr. Nissen got into while exposing dangerous drug side effects and forcing FDA transparency.* The Reversal & Asteroid Trials: Can you actually regress coronary plaque? The data on intensive LDL lowering.* Lipoprotein(a) Explained: Why this "noxious particle" is 3-6x more atherogenic than standard LDL and how new RNA-interference drugs are aiming for a 95% reduction.* Statin Denialism: Addressing the "Internet cults" and why evidence-based medicine remains the gold standard for saving lives.* The 77-Year-Old Work Ethic: Dr. Nissen shares his personal health "stack" for longevity, including his take on supplements vs. pharmaceutical prevention.*About Dr. Steven Nissen:* Dr. Nissen is a world-renowned cardiologist, researcher, and patient advocate. His work has been instrumental in establishing the requirement for cardiovascular outcome trials (CVOT) for new medications, ensuring patient safety across the globe.Resources Mentioned:* The Traverse Trial (TRT Safety)* The Reversal Trial (Plaque Regression)* The SPORT Trial (Dietary Supplements vs. Statins)* Clinicaltrials.govConnect with Velocity Health:Website: www.velocityhealthclinic.comInstagram: https://www.instagram.com/velocity_health/Twitter/X: https://x.com/join_velocityPrecision Medicine Consults: https://velocityhealthclinic.com/book-your-private-consultation/Disclaimer: This video is for educational purposes only and does not constitute medical advice. Always consult with your physician before starting new medications or supplements.#HeartHealth #Cardiology #DrStevenNissen #LDL #LipoproteinA #Statins #Longevity #PrecisionMedicine #ClevelandClinic #HeartDiseasePrevention

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Reversing Heart Disease: The Science of LDL and Lipoprotein(a) with Dr. Steven Nissen

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