APS Publications Podcast

In this podcast, coauthors Gaurab Bhaduri and Anchin Kalia discuss their recently published review, ‘The Mitochondrial–Autophagy Axis in MASLD: Mechanisms, Crosstalk, and Therapeutic Targets’. The review integrates contemporary evidence regarding mitochondrial dysfunction and autophagic regulation in metabolic dysfunction–associated steatotic liver disease (MASLD).  The Mitochondrial–Autophagy Axis in MASLD: Mechanisms, Crosstalk, and Therapeutic Targets Gaurab Bhaduri, Anchin Kalia, Banshi Saboo, Sanjay Bandyopadhyay Comprehensive Physiology 2026 16:3, e70155 https://doi.org/10.1002/cph4.70155

In this podcast, author Daniela Negrini discusses the recently published review, ‘The Thoracic Lymphatic Vasculature: Inter-Organ Strategies to Achieve an Optimal Tissue Function’. The article highlights the important but often overlooked role of vascular lymphatic system and the contribution of lymphatic vasculature to the control of extracellular fluid volume and composition as it applies to the majority of the body tissues.    The Thoracic Lymphatic Vasculature: Inter-Organ Strategies to Achieve an Optimal Tissue Function Daniela Negrini, Eleonora Solari, Cristiana Marcozzi, Andrea Moriondo Comprehensive Physiology 2026 16:2, e70143 https://doi.org/https://doi.org/10.1002/cph4.70143

In this episode of The APS Publications Podcast, featuring AJP-Regulatory, Integrative and Comparative Medicine, author Laura Oller discusses her recent article, "Molecular shifts induced by pseudohypoxia in gray seal blubber: an ex vivo approach." This study explored how blubber regulates responses to chemically induced pseudohypoxia. This study showed a faster, but sustained, increase in molecular markers of hypoxia. It documents downstream molecular responses to those hypoxia-induced changes, revealing important adaptations in mechanisms that induce and sustain the hypoxia response in blubber.   Molecular shifts induced by pseudohypoxia in gray seal blubber: an ex vivo approach Laura Oller, Joel Rocha, Holly Clare Armstrong, Simon E. W. Moss, Ailsa J. Hall, and Kimberley Ann Bennett American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026 330:4, R317-R335

In this podcast, Nguyen Duc Huy Hoang discusses his recently published article, ‘Mechanosensory Silence During Cardiac Stress’. He asks the question, "Why does mechanosensory stress in the heart so often remain perceptually silent?" and hopes his group's new conceptual gating framework, Cardiac Mechanoafferent Silencing Model, will shed some light on the topic and support the prioritization of future experimental and translational investigations.   Mechanosensory Silence During Cardiac Stress Nguyen Duc Huy Hoang Comprehensive Physiology 2026 16:2, e70122 https://doi.org/10.1002/cph4.70122 

In this podcast, coauthors Yuan Li and Mingming Liu discuss their recently published article, ‘Functional segregation of pancreatic microcirculation reveals sex-dependent microhemodynamic signatures’. The article used a multi-scale approach to investigate pancreatic microhemodynamics in healthy male and female mice. Authors identified sexual dimorphism in pancreatic microhemodynamics that was restricted to the exocrine compartment, where blood vessels expressed different levels of CD31 and estrogen receptor ERβ. These sex-specific vascular patterns were linked to distinct systemic steroid hormone profiles, leading to fundamentally different mechanisms of blood‑flow regulation in males and females. Overall, the work identified pancreatic microvasculature as a key site where hormonal differences shape sex‑specific organ physiology.   Yuan Li, Yingyu Wang, Bing Wang, Qin Ouyang, Weiqi Liu, Xiang Xu, Xu Zhang, Mingming Liu, Ruijuan Xiu Comprehensive Physiology 2026 16:2, e70130 https://doi.org/10.1002/cph4.70130

In this podcast, coauthors Yifeng Bu and Imanuel Lerman discuss their recently published review, ‘A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action’. The review overviews VNS mechanisms and their translational relevance, and thus serves as a foundational resource for advancing the science and clinical deployment of precision neuromodulation and bioelectronic medicine. A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried-Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman Comprehensive Physiology 2025 16:2, e70109 https://doi.org/10.1002/cph4.70109

In this podcast, coauthors Yujie Xu, Han Wu, Ru Mu, Lu Yang, Yixuan Li, and Xian Ma discuss their recently published review, 'Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO–HPT–HPA Axes in Perimenopausal Reproductive Health’. The findings highlight the multi-axis pathophysiology of perimenopausal endocrine disorders and suggest therapeutic potential for treatments targeting kisspeptin neurons as part of individualized, multi-axis approaches. Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO–HPT–HPA Axes in Perimenopausal Reproductive Health Yujie Xu, Han Wu, Ru Mu, Lu Yang, Yixuan Li, Xian Ma Comprehensive Physiology 2026 16:1, e70115  https://doi.org/10.1002/cph4.70115

In this podcast, coauthors Chrysi Keskinidou and Nikolaos S. Lotsio discuss their recently published research article, ‘Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells’. The article describes the authors' deep dive into the interactions between AQP1 and TGFB1 in human pulmonary vascular endothelial cells, and and provide a novel perspective on the interactions of the BMP/TGF-β signaling pathway.  Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells Chrysi Keskinidou, Nikolaos S. Lotsios, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Ioanna Dimopoulou, Anastasia Kotanidou, David Langleben, Stylianos E. Orfanos, Alice G. Vassiliou Comprehensive Physiology 2025 15:6, e70066 https://doi.org/10.1002/cph4.70066

In this podcast, corresponding author Yuan-Yuan Zhang discusses the recently published review, ‘Insulin as an Accelerator and Brake of Aging: From Molecular Landscape to Clinical Interventions’. Here, Dr. Zhang describes key findings, key takeaways, and key gaps that relate to our understanding of the role of insulin in aging and how it can be leveraged for anti-aging therapies. Listen here to learn why her and her co-authors argue that the secret to healthier aging lies with insulin and in helping it find the perfect rhythm.  Shi-Cheng Chen, Xiao-Dong Sun, Yuan-Yuan Zhang Comprehensive Physiology 2025;15(6):e70079 https://doi.org/10.1002/cph4.70079 

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, coauthors Suzanne Estaphan, David Kramer, and Harry Witchel discuss their recently published article, “Navigating the frontier of AI-assisted student assignments: challenges, skills, and solutions.” This paper presents a framework to effectively design take-home assessments in the generative artificial intelligence (AI) era with four key recommendations to navigate the challenges and opportunities posed by generative AI. From codeveloping AI literacy to fostering human-AI collaboration, the strategies empower educators to promote authentic learning, critical thinking, and ethical AI use. Adaptable to various contexts, these insights help prepare students for an AI-driven future while maintaining academic rigor and integrity. Navigating the frontier of AI-assisted student assignments: challenges, skills, and solutions Suzanne Estaphan, David Kramer, and Harry J. Witchel Advances in Physiology Education 2025 49:3, 633-639

In this episode of the APS Publications Podcast, featuring an article from Advances in Physiology Education, authors Declan McLaughlin, Aisling Keane, and Joe Quinn discuss their recently published article, “The chick embryo model as an educational tool to explore the effect of alcohol on cardiovascular development.” This study explores the use of the chick embryo model as a teaching aid to illustrate connections between anatomy and physiology during development. Providing direct observation opportunities, the model allows students to witness organ formation and the impact of teratogens, focusing on cardiovascular abnormalities associated with fetal alcohol syndrome. The paper outlines practical methodologies to assess developmental outcomes. Its adaptability, affordability, and ability to spark discussions make the model a valuable resource for diverse educational environments. The chick embryo model as an educational tool to explore the effect of alcohol on cardiovascular development Declan McLaughlin, Aisling Keane, Joe Quinn, and Nuala Tipping Advances in Physiology Education 2025 49:2, 438-460 

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, coauthors Madyson Hintz and Aisya Ahmad Zamri discuss their recent article, “Associations between heart size and anthropometric and cardiovascular indicators: an undergraduate physiology teaching laboratory.” They share how a hands-on undergraduate lab lets students observe heart measurements with ultrasound, collect body and cardiovascular data, and explore how factors like age, sex, body size, and hand palm diameter relate to heart health.   Associations between heart size and anthropometric and cardiovascular indicators: an undergraduate physiology teaching laboratory Madyson O. Hintz, Aisya S. Ahmad Zamri, Elizabeth W. Erickson, Frosina Barlev, Sean Coffey, and Regis R. Lamberts Advances in Physiology Education 2025 49:2, 508-516

In this podcast, Dr. Rashmi Chandel discusses the recently published article, "Jigsaw technique: Will it help Gen Z nursing students?" This study examines the effectiveness of the jigsaw technique (JST) as a student-centered learning strategy for engaging Generation Z undergraduate nursing students. Recognizing Gen Z learners’ distinct cognitive styles and preferences, the research compares JST with conventional lectures across four physiology modules using a crossover design. Results showed significantly higher pretest, posttest, and retention scores with JST in most modules, along with strong positive student feedback regarding engagement, understanding, communication, and peer interaction. Overall, the findings suggest that integrating JST into nursing education can enhance learning outcomes while fostering essential interpersonal and professional skills in future nurses. Jigsaw technique: will it help Gen Z nursing students? Rashmi Chandel, Anumeha Bhagat, Anita S. Malhotra, Ravi Rohilla, Gurjit Kaur, and Kiran Prakash Advances in Physiology Education 2025 49:2, 304-313

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, Stephen Fitzjohn and Frances MacMillan discuss their recently published article, “Active learning to improve numeracy skills and confidence using quizzes in first-year biomedical science undergraduates.” They share how thoughtfully designed, gamified quizzes in Blackboard helped students practice numeracy skills, build confidence, and achieve significant improvement. The conversation highlights a practical and adaptable teaching approach that can be easily applied to subjects beyond numeracy, offering valuable insights for educators looking to enhance student learning and confidence. Active learning to improve numeracy skills and confidence using quizzes in first-year biomedical science undergraduates Stephen M. Fitzjohn, Alice M. Semenenko, and Frances M. MacMillan Advances in Physiology Education 2025 49:3, 680-685

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, James Davis discusses their recently published article, “From anonymity to engagement: the benefits of early-semester student-instructor meetings.” This study shows that brief, early-semester student-instructor meetings foster stronger connections, increase student participation, and improve self-reported academic performance in large lecture courses. The following article demonstrates how a simple, scalable strategy can transform student-instructor relationships and enhance learning outcomes. From anonymity to engagement: the benefits of early-semester student-instructor meetings James T. Davis, Abigail P. Sondreal, Frederick Bauer, and Joseph T. Cornelius Advances in Physiology Education 2025 49:3, 605-610

In this podcast, co-first author Jonathan Hyde discusses the recently published article, ‘Pulmonary Vascular Endothelial Dysfunction is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model’. The study used an in vivo large animal model combined with ex vivo and in vitro studies to investigate pulmonary vascular endothelial cell dysfunction associated with the Glenn procedure. The results suggest that low, non-pulsatile flow associated with Glenn physiology plays a pivotal role in development of endothelial cell dysfunction. Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model Jonathan Hyde, Michael A. Smith, Naveen Swami, John H. Hwang, Yenchun Chao, Jason Boehme, Gary W. Raff, Casper Noah Nilsson, Wenhui Gong, Gail H. Deutsch, Eric G. Johnson, Ting Wang, Stephen M. Black, Sanjeev A. Datar, Emin Maltepe, Jeffrey R. Fineman Comprehensive Physiology 2025 15:6, e70071   https://doi.org/10.1002/cph4.70071

In this episode of the APS Publications Podcast, Dr. Ralph Rühl discusses his team’s new article in Physiological Genomics, “Transcriptome-driven Health-status Transversal-predictor Analysis for health, food, microbiome and disease markers for understanding of lifestyle diseases.” The article outlines the development of a novel artificial intelligence approach based on machine-learning to predict general health and food-intake parameters. This novel technique, which is based on PBMC transcriptomics from human blood, can predict a wide range of health-related markers.   Todt T, van Bussel I, Afman L, Brennan L, Ivanova DG, Kiselova-Kaneva Y, Thomas EL, Rühl R. Transcriptome-driven Health-status Transversal-predictor Analysis for health, food, microbiome and disease markers for understanding of lifestyle diseases. Physiol Genomics. 2025 Nov 19. doi: 10.1152/physiolgenomics.00026.2025. PMID: 41259124.

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, David Van Reyk discusses their study on "The use of AI large language models by university students for assignment preparation." Over 50% used AI for idea generation and drafting. PRC students showed improvements in their grades with the use of AI, while Australian students’ grades remained unchanged. Students support institutional guidance and access for responsible AI use. The use of AI large language models by university students for assignment preparation Hui Chen, David Van Reyk, and Brian G. Oliver Advances in Physiology Education 2025 49:2, 517-525

In this episode of the APS Publications Podcast, featuring Advances in Physiology Education, coauthors Christine Bell and Oana Birceanu discuss their recently published article, “Educators’ experience and guide to scaffolding generative AI applications throughout a physiology and pharmacology undergraduate laboratory course.” The paper presents a two-pronged approach to reduce GenAI confusion and build AI literacy, research, and critical thinking skills. Educators’ experience and guide to scaffolding generative AI applications throughout a physiology and pharmacology undergraduate laboratory course Christine E. Bell and Oana Birceanu Advances in Physiology Education 2025 49:3, 721-728 

In the latest APS Publications Podcast, featuring Advances in Physiology Education, John Zubek discusses, “From virtual to reality: evaluating student attitudes through VR dissection preparations: a use case.” VR vs. live dissections: how do students learn best? We explored their experiences to see how tech can complement STEM & healthcare training. From virtual to reality: evaluating student attitudes through VR dissection preparations: a use case Sarah Shine, Julia Warznie, Guoli Zhou, and John Zubek Advances in Physiology Education 2025 49:3, 611-620 

In this episode of the APS Publications Podcast, featuring Advances in Physiology Education, coauthors Serena Kuang and Nora Laban discuss their recently published Illuminations paper “From compliance to moduli: clarifying basic mechanical properties of biological tissues.” This article advances physiology education by clarifying the basic mechanical property-related terms in physiology, introducing two fundamental terms in material science that are often missing in physiology education, and revealing the interrelationships among these terms. It serves as a handy tool kit for physiology educators, researchers, as well as clinicians to select and apply these terms appropriately based on their needs. From compliance to moduli: clarifying basic mechanical properties of biological tissues Nora Laban, Radwa Dawood, and Serena Y. Kuang Advances in Physiology Education 2025 49:3, 651-658

In this podcast, coauthors Mary Pelkowski and Gabi Waite discuss their recently published Illuminations article, “Implementing core concept teaching in an integrated, clinical presentation model medical school curriculum”.  They outline a practical approach to incorporating physiology core-concept teaching into an integrated, team-taught medical curriculum—combining a clinical presentation model with flipped classroom learning. Implementing core concept teaching in an integrated, clinical presentation model medical school curriculum Mary M. Pelkowski, Xiaojun Qi-Lytle, and Gabi N. Waite Advances in Physiology Education 2025 49:3, 659-666 

In this podcast, coauthors Maria Magdalena Quetglas-Llabrés and Manuel Jiménez-García discuss their recently published article, ‘Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High-Fat Diet Model in Rats.' The article investigated the effect of exercise, alone or with dietary modifications, on high fat diet–induced outcomes in rats of both sexes. Authors overview the methodological approach and discuss key takeaways and next steps.   Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High-Fat Diet Model in Rats Manuel Jiménez-García, Maria Magdalena Quetglas-Llabrés, Maria Del Mar Ribas-Taberner, Antoni Sureda-Gomila, David Moranta-Mesquida, Silvia Tejada-Gavela Comprehensive Physiology 2025;15(6):e70074  https://doi.org/10.1002/cph4.70074 

In this episode of the APS Publications Podcast, featuring Advances in Physiology Education, coauthors Anna Smith, Fran der Weduwen, and Thomas Powell discuss their recently published Illuminations paper “The practical skills passport: a co-curricular program to enhance lab skills confidence in undergraduate neuroscience and biology students”. The COVID-19 pandemic limited in-person lab opportunities, impacting students’ skills and confidence. This episode explores the development, implementation, and evaluation of a co-curricular lab skills program designed to help students regain confidence during their return to in-person learning. Findings show that participation in the program had a positive impact on student lab confidence.   The practical skills passport: a co-curricular program to enhance lab skills confidence in undergraduate neuroscience and biology students Anna E. Smith, Fran der Weduwen, Thomas Powell, and Gayle Doherty Advances in Physiology Education 2025 49:3, 696-703

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, Prof. S. Mehran Hosseini discusses the study, “Misconception about the application of Dalton’s Law in respiratory physiology.” Dalton’s Law may provide a good example for students to highlight the existence of misconceptions and their effect on gaining new knowledge. The awareness of students about this misconception may improve their learning styles. Misconception about the application of Dalton’s Law in respiratory physiology S. Mehran Hosseini Advances in Physiology Education 2025 49:3, 646-650

In this special episode of the APS Publications Podcast, the founding of Physiological Genomics is discussed in a series of interviews with Drs. Allen W. Cowley, Jr., Bina Joe, and Hilary Coller. These interviews were organized and conducted in September 2025 by Oluwatosin Mautin Akinola (PhD candidate in Molecular Medicine at the University of Toledo, Toledo, OH, United States; https://www.researchgate.net/profile/Oluwatosin-Akinola-2). Full videos of these interviews are available as Supplemental Material in the article. Joe B, Cowley AW, Garrett MR, Kriegel AJ, Prokop JW, Lee EC, Akinola OM, Coller HA. Connecting Genes to Physiology: The First 25 Years of Physiological Genomics. Physiol Genomics. 2025 Oct 29. doi: 10.1152/physiolgenomics.00207.2025. PMID: 41159925.

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, Dr. Raju Suresh Kumar discusses a novel, hands-on simulation designed to teach auditory physiology. By experiencing unilateral conductive hearing loss, students gain deeper insight into auditory masking and sound lateralization. This simple, cost-effective method enhances conceptual understanding and clinical skills, offering strong potential for integration into medical education. Enhancing auditory physiology: simulating unilateral conduction defects to improve understanding of Rinne’s and Weber’s tests Raju Suresh Kumar, M. Ganesh Kamath, Rekha Prabhu, and Mohamed Eldigire Ahmed Advances in Physiology Education 2025 49:3, 689-695

In this podcast, coauthors Liz Simon, Flavia Souza-Smith, Megan Donovan, Eden Gallegos, Kaitlin Couvillon, and Patricia Molina summarize their recently published review article, "Physiological Mechanisms Vulnerable to Alcohol-Induced Alterations: Role in Chronic Comorbidities." The article describes alcohol's multi-systemic physiological effects on the gastrointestinal, cardiovascular, and immune systems, as well as on energy metabolism that contribute to multiorgan injury and disease burden.   Physiological Mechanisms Vulnerable to Alcohol-Induced Alterations: Role in Chronic Comorbidities Liz Simon, Kaitlin E. Couvillion, Meagan E. Donovan, Eden M. Gallegos, Flavia M. Souza-Smith, Patricia E. Molina Comprehensive Physiology 2025 15:5, e70057   https://doi.org/10.1002/cph4.70057

In this podcast, coauthors Simon D. Pouwels and Brady Rae discuss their recently published research article, "Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System." The article describes development of a novel unidirectional millifluidic multi-organ-on-chip device to study the communication between human lung epithelial cells and colorectal cells following a toxic stimulus. Authors additionally discuss the versatility of the device to study communication across other cell types.     Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System Brady Rae, Verena Bood, Hye-Jin Dijk, Gwenda F. Vasse, Barbro N. Melgert, Anika Nagelkerke, Janette K. Burgess, Dirk-Jan Slebos, Irene H. Heijink, Simon D. Pouwels Comprehensive Physiology 2025 15:5, e70051 https://doi.org/10.1002/cph4.70051

In this episode of the APS Publications Podcast, featuring an article from AJP–Regulatory, Integrative and Comparative Physiology, author Periklis Marnas discusses inhalation exposure of adult D. melanogaster to cigarette smoke and changes in physiological parameters and the expression of COPD-associated orthologous genes. The study found that transcriptomic responses were more profound in females, indicating sex-specific responses to inhaled toxicants. Furthermore, enrichment analyses of the differentially expressed genes in females pointed to biomolecules associated with response to nicotine and detoxification. D. melanogaster thus provides a powerful model system to test the efficacy of new potential drugs for COPD treatment.   Marnas P, Lüpold S, Giannakou L, Giannopoulos AS, Hatzoglou C, Gourgoulianis KI, Zarogiannis SG, Rouka E. Modeling COPD in Drosophila melanogaster by cigarette smoke inhalation: functional changes and alterations in the expression of COPD-relevant orthologous genes. Am J Physiol Regul Integr Comp Physiol. 2025 Jul 1;329(1):R13-R19. https://doi.org/10.1152/ajpregu.00056.2025

In this episode of the APS Publications Podcast, featuring an article from AJP–Regulatory, Integrative and Comparative Physiology, authors Ziba Taherzadeh and Claire Kissell discuss the influence of race and sex and Cardiac autonomic function. Their study found that non-Hispanic Black adults living in the United States are more likely to develop cardiovascular disease compared with their non-Hispanic White adult counterparts. These results support that reduced cardiac autonomic function does not manifest early in life among young non-Hispanic Black adults, but rather non-Hispanic Black men had greater spontaneous cardiac baroreflex sensitivity and heart rate variability compared with non-Hispanic White men. No differences were found among women.   Taherzadeh Z, Kissell CE, Young BE, Alhalimi TA, Stephens BY, Kaur J, Kao Y, Brothers RM, Fadel PJ. Cardiac autonomic function in young, healthy adults: Influence of race and sex. Am J Physiol Regul Integr Comp Physiol. 2025 May 1;328(5):R611-R618. https://doi.org/10.1152/ajpregu.00288.2024

In this episode of the APS Publications Podcast, featuring an article from AJP–Regulatory, Integrative and Comparative Physiology, authors Andrea Zsombok, Lucie Desmoulins, and Adrien Molinas discuss the role of estradiol treatment in regulating metabolism and glucose homeostasis. In their study with middle-aged, high-fat diet-fed, ovariectomized female mice, the authors found that liver-related neurons in the hypothalamus became more excitable. Estradiol treatment reduced this excitability, suggesting that midlife estradiol therapy may support healthier brain-liver metabolic regulation.   Molinas AJR, Desmoulins LD, Dugas CM, Williams GL, Kamenetsky S, Felintro de Souza V, Maroteaux MJ, Davis RK, Daniel JM, Schrader LA, Zsombok A. Midlife estradiol treatment reduces the firing rate of liver-related PVN neurons in ovariectomized high-fat diet-fed mice. Am J Physiol Regul Integr Comp Physiol. 2025 Aug 1;329(2):R245-R252. https://doi.org/10.1152/ajpregu.00117.2025

In this episode of The APS Publications Podcast, coauthors Matthew A. Hadiono, Alexis B. Kazen, Fatima A. Aboulalazm, and John R. Kirby discuss their recent study, "Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure," published in AJP–Regulatory, Integrative and Comparative Physiology. The authors explore how the gut microbiome, a thermogenic biomass, plays a critical role in regulating energy expenditure. Their study shows that the composition of the microbial community, influenced by both xenobiotics and bacterial metabolites, can impact metabolic function. They found that treatment with reutericyclin counteracts the suppression of anaerobic energy expenditure caused by risperidone. These findings suggest that reutericyclin may offer a new therapeutic approach for managing obesity. Tune in to learn more about the gut microbiome’s role in energy balance and the potential for microbiota-targeted therapies.   Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure Matthew A. Hadiono, Alexis B. Kazen, Fatima A. Aboulalazm, Colin M. L. Burnett, John J. Reho, Tammy L. Kindel, Justin L. Grobe, and John R. Kirby American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:6, R741-R757

In this episode of The APS Publications Podcast, coauthors John J. Durocher and Ezra Mutai discuss the Editorial Focus titled "Sleep tight with vitamin D’s might" published in AJP–Regulatory, Integrative and Comparative Physiology. The conversation centers on a recent study by Culver et al., which examines the relationship between vitamin D levels and reduced sleep variability. Tune in to hear how these findings shed light on the potential link between vitamin D status and consistent sleep patterns.   Sleep tight with vitamin D’s might John J. Durocher and Ezra Mutai American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:5, R557-R558

In this episode of The APS Publications Podcast, coauthors Alexander A. Buelow and J. Mikhail Kellawan discuss their recent study, "Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults," published in AJP–Regulatory, Integrative and Comparative Physiology. They explore how functional sympatholysis, which has traditionally been considered independent of nitric oxide and prostaglandins, may actually involve endothelial CYP450 pathways. Their findings show that inhibition of CYP450-2C9 reduces sympatholytic responses during dynamic handgrip exercise combined with lower body negative pressure. This suggests that CYP450 plays an important role in regulating blood flow during exercise in healthy individuals. Tune in for insights into vascular physiology, research methodology, and the broader implications of these findings for cardiovascular research.   Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults Alexander A. Buelow, Jacob E. Matney, Sarah M. Skillett, John D. Ashley, Jiwon Song, Chris Mixon, Amir Akbari Fakhrabadi, Matthew Stanford, Debra A. Bemben, Daniel J. Larson, and J. Mikhail Kellawan American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:6, R642-R650

In this podcast, coauthors Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Somayeh Darzi, Charles K Thodeti, and Sailaja Paruchuri talk about their recently published review, "Leukotrienes: bridging the inflammatory gap in asthma and inflammatory bowel diseases (IBD)." The review highlights how altered leukotriene biosynthesis and signaling contribute to the pathogenesis of both asthma and IBD, and considers the therapeutic implications of targeting leukotriene pathways for patients with concurrent asthma and IBD.   Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD) Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Somayeh Darzi, Charles K Thodeti, Sailaja Paruchuri Comprehensive Physiology 2025 15:3, e70022 https://doi.org/10.1002/cph4.70022 

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, join coauthors Maurizio Costabile and Layla Mahdi as they discuss their study, “Leveraging computer-based simulations and immersive software technologies for enhanced student learning in laboratory medicine.” They share how these digital tools were integrated across a 4-year laboratory medicine degree and how they significantly improved student engagement and understanding. Tune in to hear how this innovative approach can be applied beyond laboratory medicine to benefit a wide range of disciplines. Leveraging computer-based simulations and immersive software technologies for enhanced student learning in laboratory medicine   Maurizio Costabile, Connie Caruso, Chris Della Vedova, Sheree Bailey, and Layla Mahdi Advances in Physiology Education 2025 49:2, 338-351

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, join coauthors Helena Carvalho and Patricia Halpin as they discuss DramaZoom is a teaching tool paired with a pretest to activate memory. It promotes learning for both medical students and undergraduate students with different majors in the study cohort. DramaZoom creates an opportunity for a fun learning experience that promotes knowledge gain in physiology regardless of whether the teaching setting is face to face or completely virtual. Future research will be done to investigate the long-term retention of content.   Introducing and validating DramaZoom as a teaching tool for diverse student populations Helena Carvalho, Patricia A. Halpin, Elke Scholz-Morris, Rosa de Carvalho, and Daniel Contaifer Jr. Advances in Physiology Education 2025 49:2, 386-393 

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, coauthor Katelyn Cooper highlights the meeting reports titled “Meeting report: an interdisciplinary approach to addressing anxiety in undergraduate active learning biology courses.” She explains that anxiety is a common emotional condition marked by feelings of tension, worry, and physical symptoms like restlessness and fatigue.  Among college students, anxiety is the most reported mental health concern and is linked to lower motivation, engagement, and academic performance. Biology students may be particularly affected due to the rigor and competitiveness of their courses, with high anxiety levels contributing to reduced academic success and increased attrition in the field. Meeting report: an interdisciplinary approach to addressing anxiety in undergraduate active learning biology courses   Katelyn M. Cooper, Sara E. Brownell, Elisabeth E. Schussler, Virginia R. Downing, Logan E. Gin, Kelly K. McDonald, Randolph M. Nesse, Carly A. Busch, Benjamin J. England, LaToya Grigler, Samantha A. Maas, Marco Molinaro, Nicole L. Nieset, Amy L. Pate, Jed Rasmussen, Jessica L. Schleider, Amina Y. Simmons, Shawn L. Spurgeon, Cynthia M. Stonnington, and Michael Trobiano Advances in Physiology Education 2025 49:2, 405-415 

In this episode of The APS Publications Podcast, corresponding author Han-Kyul Kim provides an overview of the study titled "Exercise pressor reflex function is augmented in rats with chronic kidney disease," recently published in AJP–Regulatory, Integrative and Comparative Physiology. Dr. Kim discusses how the research team uncovered exaggerated blood pressure responses triggered by the exercise pressor reflex (EPR) in a chronic kidney disease (CKD) animal model. The study highlights how both the muscle mechanoreflex, activated through passive stretch and the muscle metaboreflex, stimulated by intra-arterial capsaicin, contribute to this hypertensive effect. Tune in to learn more about how sympathetic overactivation and altered reflex function could play a key role in cardiovascular risk for individuals with CKD.   Exercise pressor reflex function is augmented in rats with chronic kidney disease Han-Kyul Kim, Juan A. Estrada, Ayumi Fukazawa, Amane Hori, Gary A. Iwamoto, Scott A. Smith, Masaki Mizuno, and Wanpen Vongpatanasin American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:4, R460-R469

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, coauthors Jynx Pigart, Tasneem Mohammed, and Katelyn Cooper discuss their study, “Premed pressure: examining whether premed students experience more academic stress compared to non-premeds.” Their research investigates the common perception that premedical students experience higher levels of academic stress than their non-premed peers. The findings revealed no statistically significant differences in reported academic stress between the two groups. However, the study did show that students with lower GPAs were significantly more likely to leave the premed track than those with higher GPAs.   Premed pressure: examining whether premed students experience more academic stress compared to non-premeds Jynx Pigart, Tasneem F. Mohammed, Theresa Acuña, Shurelia Baltazar, Connor Bean, Michayla Hart, Katelyn Huizenga, Amaris James, Hayleigh Shaw, Kimberly Zsuffa, Carly A. Busch, and Katelyn M. Cooper Advances in Physiology Education 2025 49:2, 280-290

In this episode of The APS Publications Podcast, we hear from coauthor Casey G. Turner about the study, "Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating." Published in AJP–Regulatory, Integrative and Comparative Physiology, this study investigates the effect of OCP phase on in vivo microvascular endothelium-dependent vasodilation and explores underlying mechanisms. Present findings suggest OCP phase does not affect overall microvascular endothelium-dependent dilation but does affect the underlying mechanisms. In women using OCP, there is a robust reliance on EDHF pathways and the COX pathway moderates basal microvascular blood flow and demonstrates a phase-dependent restraint of the NO pathway.   Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating Casey G. Turner, Anna E. Stanhewicz, Karen E. Nielsen, Jeffrey S. Otis, Rafaela G. Feresin, and Brett J. Wong American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:3, R374-R385

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education. The authors present their study on the Indonesian Medical Physiology Olympiad (IMPhO). This article outlines key strategies for building a successful team in a physiology competition, including effective use of resources, mentorship, teamwork, and faculty guidance. These approaches not only enhance performance in competitive settings but can also be adapted to strengthen study techniques for medical students. Preparation strategies for physiology competition: lessons learned from participants of Indonesian Medical Physiology Olympiad Mohammad Nizar Maulana, Agde Muzaky Kurniawan, Raden Argarini, Rimbun Rimbun, and Eka Arum Cahyaning Putri Advances in Physiology Education 2025 49:2, 352-355

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education, we hear from Dr. Himel Mondal about his recently published paper entitled “Evolving resource use for self-directed learning in physiology among first-year medical students in a classroom setting.” This study reports a shift in educational resource use for self-directed learning (SDL) among medical students after introduction of large language model (LLM) chatbots. Students use multiple sources, with digital tools like search engines and LLM chatbots nearly matching each other as the most preferred resources. Despite the accessibility and efficiency of digital tools, traditional resources like textbooks remain relevant, though less frequently chosen.   Evolving resource use for self-directed learning in physiology among first-year medical students in a classroom setting Himel Mondal Advances in Physiology Education 2025 49:2, 394-397

In this episode of the APS Publications Podcast, featuring Physiological Genomics, join coauthors Ibra Fancher and Malak Alradi as they discuss, “A long-term high-fat diet induces differential gene expression changes in spatially distinct adipose tissue of male mice.” This study explores how a long-term high fat diet affects gene expression in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in male mice.   A long-term high fat diet induces differential gene expression changes in spatially distinct adipose tissue of male mice. Malak Alradi, Hassan Askari, Mark Shaw, Jaysheel D. Bhavsar, Brewster F. Kingham, Shawn W. Polson, and Ibra S. Fancher Physiological Genomics 2024 Dec 1;56(12):819-832. https://doi.org/10.1152/physiolgenomics.00080.2024

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education coauthor Patricia Halpin highlights the article titled "Students bypass the syllabus to utilize alternate LMS locations for assignment deadlines." Dr. Halpin highlights how the growing use of learning management systems (LMSs) has changed how students access course information—often leading them to overlook the syllabus entirely. This shift can result in confusion and missed deadlines due to reliance on inconsistent LMS postings. Tune in as she explores why it’s more important than ever for faculty to reintroduce the syllabus on day one and clearly communicate where students should go for the most accurate course information.   Students bypass the syllabus to utilize alternate LMS locations for assignment deadlines Savannah Lopez, Allison Pham, Jeremy L. Hsu, and Patricia A. Halpin Advances in Physiology Education 2024 48:3, 588-592

In this episode of The APS Publications podcast featuring Comprehensive Physiology, we hear from Dr. Lance Fortnow (Illinois Institute of Technology) about his recent Review exploring how artificial intelligence (AI) can play a role in digital twinning of interorgan communication. The human body is an extremely complex system with constant interorgan communication, and AI has been proven effective at modeling complex systems and understanding communication. A digital twin is a complete simulation of a physical process, providing a unique opportunity to simulate real-world physiology and pathophysiological conditions such as aging and various disease states. What role might digital twinning play in researching the effectiveness of therapeutic interventions? Can digital twinning provide a platform for both early career and senior researchers to take a holistic interorgan approach to treating disease? Listen now to find out.   Lance Fortnow Digital Twinning of Interorgan Communications Comprehensive Physiology, published February 9, 2025. DOI: doi.org/10.1002/cph4.70002

In this episode of the APS Publications Podcast, we’re joined by coauthors Chasity Corbin, Chowdhury Ibtida Tahmin, and Ida T. Fonkoue to discuss their research titled "Estradiol levels are differentially associated with pulse wave velocity in trauma-exposed premenopausal women with and without PTSD." The study investigates how serum estradiol (E2) levels influence pulse wave velocity (PWV) in premenopausal women exposed to trauma, with a particular focus on the impact of posttraumatic stress disorder (PTSD). The researchers discovered that E2 levels predicted PWV only in women without PTSD, even after accounting for factors like menstrual cycle phase, age, body mass index, diastolic blood pressure, and PTSD symptom severity. Additionally, the study found that E2 levels were significantly lower in women with PTSD. Tune in as our guests dive into the details of this important study.   Estradiol levels are differentially associated with pulse wave velocity in trauma-exposed premenopausal women with and without PTSD Chasity Corbin, Chowdhury Ibtida Tahmin, Chowdhury Tasnova Tahsin, Zynab Ahmed, Redeat Wattero, Azhaar Mohamed, Susan B. Racette, Daniel Duprez, and Ida T. Fonkoue American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:3, R235-R241

In this episode of The APS Publications Podcast, featuring Advances in Physiology Education coauthors  Baylee A. Edwards and Sara E. Brownell discuss their educational research titled "Students respond positively to an instructor collecting and sharing aggregated class demographic data from a survey in a high-enrollment physiology course." This study delves into undergraduate students' perceptions of a high-enrollment physiology course instructor gathering and sharing aggregated demographic data to foster inclusivity. Most students responded positively to this approach, with particular benefits noted by women, nonbinary students, and liberal-leaning students. Edwards and Brownell's findings suggest that collecting and sharing student demographic data in an aggregate form could be an effective strategy to strengthen student-instructor relationships and promote inclusion in large science courses. Tune in to hear more about this impactful research and its potential to transform high-enrollment classrooms.   Students respond positively to an instructor collecting and sharing aggregated class demographic data from a survey in a high-enrollment physiology course Baylee A. Edwards, Jude Kolodisner, Jacob P. Youngblood, Katelyn M. Cooper, and Sara E. Brownell Advances in Physiology Education 2024 48:4, 836-856  

In this episode of The APS Publications Podcast, featuring AJP-Regulatory, Integrative and Comparative Physiology, coauthors Xiaoyu Su and Nanduri R. Prabhakar dive into their recently published research titled "Adrenal Epinephrine Facilitates Erythropoietin Gene Activation by Hypoxia Through β2 Adrenergic Receptor Interaction with Hif-2α." The study explores the role of sympathetic nervous system (SNS) activation in erythropoietin (EPO) gene expression during hypobaric hypoxia, shedding light on how adrenal epinephrine, via β2 adrenergic receptors, interacts with the transcription factor HIF-2α to enhance EPO gene activation. Tune in as they highlight the breakthrough findings that deepen our understanding of the physiological mechanisms underlying hypoxia-induced gene regulation.   Adrenal epinephrine facilitates erythropoietin gene activation by hypoxia through β2 adrenergic receptor interaction with Hif-2α Xiaoyu Su, Matthew Hildreth, Srikar Rapaka, Ying-Jie Peng, Jayasri Nanduri, and Nanduri R. Prabhakar American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:1, R75-R80