Live from Stage 4: MBC News for Us, by Us

Every year, Living Beyond Breast Cancer (LBBC) brings together hundreds of people living with metastatic breast cancer for one of the most anticipated events in the MBC community, the Thriving Together MBC Conference. This year marked a milestone: the 20th anniversary.In this episode, the members of the podcast team Abigail Johnston, Dr. Jill Tirabassi, Dr. Ellen Landsberger, and Victoria Goldberg, all MBC patients themselves, sit down for an honest, heartfelt recap of the 2026 conference. They share what moved them, what they learned, and what keeps them coming back year after year.Topics covered include:The emotional experience of walking into a room full of people living with MBC — for the first time and the tenthHighlights from the scientific sessions, including insights from Dr. Virginia Borges and Dr. Seth Wander on personalized medicine, ctDNA, and the explosion of new treatment optionsThe power of patient-centered programming and why Thriving Together hits differently than ASCO or SABCSFavorite sessions: expressive writing, reading scans and research, and the Spinning Science workshopThe growing presence of caregivers and families at the conferenceSuggestions for future programming, including tracks for long-term survivors and pre-conference prep for the newly diagnosedA look at LBBC's Hear My Voice advocacy program, Project Life, and what the next 20 years might bringWhether you've been to Thriving Together ten times or have never heard of it, this episode will make you want to be in that room.Resources mentioned:Living Beyond Breast CancerProject LifeSpinning Science (via Project Life)Hear My Voice Advocacy Program (LBBC)Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

Hair loss is one of the most emotionally complex side effects of cancer treatment — and in this episode of Symptom Spotlights, Abigail Johnston and Melanie Sisk are joined by Lisa Backus and Jill Tirabassi for an honest, practical conversation about navigating it.From complete hair loss due to chemotherapy (multiple times) to gradual thinning from hormone therapy and targeted treatment, each woman shares her unique experience — and the tips, products, and mindset shifts that have helped along the way.In this episode, we cover:The difference between hair thinning and full hair loss — and how to know which you're experiencingWigs vs. soft hats, scarves, and beanies: what actually worksCold capping, Minoxidil, biotin, vitamin panels, and other interventions to discuss with your care teamHenna head tattoos, silk pillowcases, volume shampoos, and other creative solutionsThe psychological toll of visibly "looking sick" — and why hair loss is never a small thingHow hair can grow back differently in color, texture, and curl after treatmentThis conversation is full of peer wisdom, humor, and heart. Links to products and interventions mentioned are in the show notes.Nothing shared in this episode constitutes medical advice. Always consult your care team before trying new products or supplements.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

What happens when breast cancer spreads to the brain — and what can actually be done about it? In this episode, host Victoria Goldberg sits down with Dr. Nancy Lin, medical oncologist at Dana-Farber Cancer Institute and one of the country's leading experts on metastatic breast cancer and brain metastasis.Dr. Lin breaks down the current treatment landscape for all subtypes — HER2+, ER+, and triple negative — covering everything from antibody drug conjugates like T-DXd and sacituzumab, to oral agents like tucatinib, to advances in focused radiation techniques. She also shares her nuanced take on the HER2 CLIMB-05 trial, why the brain metastasis prevention data were disappointing, and what the Patina trial data tells us about CDK4/6 inhibitors.Then we go deeper — into the blood-brain barrier itself. Dr. Lin explains why it's been called an enigma, what the "blood-tumor barrier" actually means for treatment, and what cutting-edge technologies like focused ultrasound and receptor-mediated transcytosis could change about drug delivery to the brain. Plus: should patients with metastatic breast cancer be getting routine brain MRIs? Dr. Lin's answer may surprise you.In this episode:New treatment options for brain mets across subtypesWhat tucatinib does — and doesn't — do for preventionThe blood-brain barrier vs. the blood-tumor barrierFocused ultrasound and microbubbles: science fiction becoming realityDrugs being designed from the ground up to cross the blood-brain barrierRoutine brain MRI screening: is the pendulum shifting?A preview of upcoming research, including the LMD registryThis podcast is for informational purposes only and does not constitute medical advice. Visit livefromstage4.org for transcripts, resources, and deeper explanations of everything discussed.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

If you've ever heard the words "palliative care" and incorrectly assumed it meant the end was near — this episode is for you.Abigail Johnston and Amy Parliament sit down with Dr. Mary Busowski, a palliative care physician at Orlando Health, to bust one of the most persistent myths in cancer care: that palliative medicine is the same as hospice.Dr. Busowski brings a rare perspective — she trained as a neonatal ICU nurse, went to medical school, completed an infectious disease fellowship, and was among the first physicians to receive board certification in palliative medicine when the American Board of Internal Medicine officially recognized it as a specialty in 2008.In this conversation, you'll learn:The real difference between palliative care and hospiceWhy getting palliative care involved early — not just at end of life — can change your entire treatment experienceHow palliative medicine addresses more than just painWhat to look for when choosing a palliative care providerWhy Dr. Busowski calls herself a "joyful practitioner" — and what that means for her patientsDr. Busowski also shares a deeply personal story about navigating her husband's Parkinson's disease journey without palliative support — and how that experience now shapes the care she gives every patient.Whether you're newly diagnosed, deep in treatment, or supporting someone you love, this episode offers clarity, comfort, and a new way to think about the care you deserve.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

Living with metastatic breast cancer isn't just about medical treatments—it's a significant time commitment that impacts every aspect of daily life. In this episode of "S**T We Deal With Shorts," Dr. Jill Tirabassi examines a 2025 JAMA Network Open study that quantifies exactly how much time patients with metastatic breast and ovarian cancer spend managing their disease.The research reveals eye-opening statistics: patients averaged one out-of-home cancer-related visit per week, with travel and wait times often exceeding actual care time. At home, cancer-related tasks consumed a median of 209 minutes per week—from taking medications to managing medical bills and scheduling appointments. For over one-third of participants, these demands disrupted their daily activities more than half the time.While most patients in the study spent 5-15 hours per week on cancer-related care—not quite the "full-time job" often described—the burden is far from insignificant. Jill brings her dual perspective as both a physician and someone living with MBC to explore how treatment lines, side effects, and care logistics impact our time and lives.This episode validates what many in the MBC community already know: managing advanced cancer requires substantial time and energy beyond what appears on any scan or lab result.Article: Time Burden in Patients with Metastatic Breast and Ovarian Cancer From Clinic and Home Demands,JAMA Network Open, December 2025Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

What if a misdiagnosis nearly cost you your life—and AI became your second opinion? In this episode, we sit down with Steve Brown, CEO of CureWise, and Lisa Booth, both living with cancer and pioneering the use of AI to navigate their treatment journeys.Steve, a tech veteran, was diagnosed with rare blood cancer in the emergency room after months of missed symptoms. When he fed his medical records to an AI agent he'd built, it immediately spotted what his doctors had overlooked. That AI became CureWise—where Steve is CEO and patient number one, and Lisa is patient number two.Lisa has been living with metastatic breast cancer for nearly 11 years, successfully navigating seven lines of therapy and multiple clinical trials. She uses CureWise to identify trial options, understand complex treatment data, advocate with her oncologist, and even appeal insurance denials.This conversation isn't just about technology—it's about empowerment. We explore:How AI agents trained in different medical specialties can analyze your records and offer multiple expert perspectivesThe gap between elite cancer care and what most patients receiveOff-label treatments and why insurance companies often say noHow to bring AI insights to your doctor without damaging the relationshipHIPAA compliance, hallucinations, and data protectionThe future of patient advocacy in the age of AISteve believes that someday soon, doctors who don't run patients through an AI model will be considered negligent. He also thinks we'll never cure cancer without AI—and after hearing his and Lisa's stories, you might agree.If you or someone you love has ever wondered, "Is there a better treatment option out there that my doctor doesn't know about?"—this episode is for you.Guests: Steve Brown (CEO, CureWise) | Lisa Booth (Patient Advocate)Hosted by: Victoria Goldberg with Jill Terabassi, Linda Weatherby, and Abigail JohnstonLearn more: CureWiseThanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In one of the most powerful conversations we've ever recorded, Dar Finkelstein—known throughout the metastatic breast cancer community as "The Queen of Joy"—shares her decision to stop treatment and transition to hospice care.After nearly seven years with metastatic breast cancer and 20 years total since her original diagnosis, Dar opens up about the impossible choice many in the MBC community eventually face: quality of life versus quantity of time. With remarkable candor and grace, she discusses how she made this heartbreaking decision, how she told her oncologist and family, and what brought her peace.In this episode, Dar talks about:• The moment she knew it was time to stop treatment• Navigating the "honeymoon period" after ending chemo• How her faith and joy mission sustain her through this transition• Practical advice for planning end-of-life care• The importance of open conversations about death within the MBC community• Finding peace, setting priorities, and still choosing joyTrigger warning: This episode discusses end-of-life issues, hospice care, and death. It's intended for mature audiences living with or affected by terminal illness.Dar's vulnerability and wisdom offer a roadmap for others facing similar decisions. Her message is clear: death is a natural part of life, and we can face it with dignity, purpose, and yes—even joy.Hosted and produced by Abigail Johnston and Melanie Sisk.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

Join us for a moving conversation with Gary Thompson, creator of the Team Powdered Donut™️ podcast and advocate for the metastatic breast cancer community. After losing his wife Maureen to stage IV breast cancer in 2014, Gary has dedicated over a decade to cancer advocacy, keeping her memory alive through a simple yet profound tradition—powdered donuts.In this episode, Gary shares the origin of his podcast name, the challenges of raising three children as a widower, and why he's embarking on an ambitious cross-country road trip to 73 NCI-designated cancer centers. He'll capture stories from patients, caregivers, researchers, and healthcare professionals—creating what he calls "StoryCorp for cancer centers."We discuss the value of storytelling in the cancer community, sustainability in podcasting, finding your "one thing" that can create meaningful change, and how Gary is discovering himself again in the empty nest years. From his unexpected podcast guests met while Uber driving to his vision for a future retreat center, Gary reminds us that love isn't just big or small—it's always enough.Memorable quotes:"We don't have to change everything. We just have to change our one thing.""Worst club ever. Most beautiful members.""You are loved very deeply by people that you may never meet."Episode Highlights:• The powdered donut tradition and how it became a podcast• Planning a multi-year road trip to cancer centers across America• The lasting impact of cancer on caregivers and families• Why there's no such thing as too many patient stories• Advice for aspiring podcasters: start with purpose, not platformThanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this  short episode, hosts Abigail Johnston and Melanie Sisk dive deep into one of the most challenging symptoms cancer patients face: insomnia. Both hosts share their personal struggles with sleep disruption following their cancer diagnoses and explore how the cancer experience—combined with treatment side effects and life changes like menopause—can profoundly impact rest.Abigail and Melanie discuss practical strategies they've discovered for better sleep, from creating the ideal bedroom environment to establishing consistent bedtime routines. They emphasize that sleep isn't just something to push through—it's an essential part of treatment and stress management.The conversation covers a range of solutions including medication options, natural remedies like melatonin and lavender, the role of medical cannabis and hemp products, and how to work with healthcare providers to find what works best for you. They also discuss the importance of adjusting medication timing and consulting specialists beyond oncology, such as palliative care doctors and cannabis nurses.Most importantly, Abigail and Melanie remind listeners that finding the right sleep solution is highly individual, requires patience and experimentation, and is an ongoing conversation as treatment plans evolve. If you're struggling with insomnia during cancer treatment, this episode offers both validation and practical guidance.Resources mentioned: Melatonin: https://www.mayoclinic.org/drugs-supplements-melatonin/art-20363071Medical Cannabis: https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/medical-marijuana/art-20137855Cannabis Nurse Association: https://cannabisnurses.org/Hemp: https://pmc.ncbi.nlm.nih.gov/articles/PMC7891210/Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this powerful episode, Victoria Goldberg sits down with Lesley Stephen MBE, a patient advocate from Edinburgh, Scotland, who has defied all odds living 12 years with stage 4 HER2+ metastatic breast cancer—far beyond her initial prognosis of "a year or two."Lesley shares her remarkable story: from being a busy communication consultant and mother of four who thought she had a simple chest infection, to receiving the devastating news of extensive metastatic disease in her lungs, liver, and bones. When standard treatments failed and she was told to "get her affairs in order," a last-chance clinical trial became her lifeline—keeping her stable for seven years.This episode explores the stark realities of the UK's "postcode lottery" healthcare system, where treatment access varies dramatically between England and Scotland. Lesley candidly discusses navigating brain metastases, losing her short-term memory to whole brain radiotherapy, self-funding expensive treatments, and ultimately finding hope through clinical trials and newer therapies like Tucatinib.Lesley has transformed her experience into extraordinary advocacy work as a trustee of Make 2nds Count, the UK's only charity focused exclusively on metastatic breast cancer. She discusses pioneering initiatives including the annual Patient Summit (the only one of its kind in Europe), the groundbreaking trial matching service, and her contributions to the Lancet Breast Cancer Commission examining global cancer disparities.The conversation also celebrates Lesley's recent recognition: receiving an MBE (Member of the British Empire) from Princess Anne at Windsor Castle for her tireless work supporting the metastatic breast cancer community.Throughout this 50-minute conversation, Lesley's determination, humor, and commitment to making "second count" for every metastatic patient shines through—proving that even in the face of incurable disease, one person can create extraordinary change.Topics covered: Stage 4 breast cancer survival, clinical trials, UK healthcare system, patient advocacy, Make Second Count charity, brain metastases, HER2+ treatments, MBE honorsThanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this episode of our Symptoms Spotlight series, hosts Melanie Sisk and Abigail Johnston tackle a topic many cancer patients experience but few feel comfortable discussing—constipation. From understanding what constipation really looks like (hint: it's not always what you think) to practical remedies you can try at home, this episode breaks down the stigma around bowel health.Melanie, a nurse and cancer patient on CDK4/6 inhibitors, shares her go-to over-the-counter solutions like MiraLax and Colace, plus an often-overlooked remedy: movement. Abigail introduces the "prune juice slider"—a surprisingly effective trick shared by her chemo nurse—and opens up about the challenge of swinging between constipation and diarrhea.Whether you're dealing with medication side effects, reduced mobility, or just trying to understand your symptoms better, this episode offers honest, practical advice. Learn when to troubleshoot on your own, when to reach out to your care team, and why talking to a GI specialist might be the missing piece of your symptom management puzzle.Key Topics:Recognizing the signs of constipation beyond strainingOver-the-counter remedies and natural solutionsThe role of movement in digestive healthAvoiding the pendulum swing between constipation and diarrheaWhen to seek help from your medical teamThanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

Join hosts Victoria Goldberg and Dr. Jill Tirabassi for a special episode where they take a break from their usual metastatic breast cancer discussions to dive deep into their latest obsession: the HBO Max series "Heated Rivalry."In this fun and heartfelt conversation, Victoria and Jill explore why this hockey romance has captured their hearts and become the perfect escape during difficult times. They discuss their favorite episodes (especially that emotional tunnel scene in episode 5), the powerful representation of LGBTQ+ athletes in professional sports, and the cultural complexities of the story.Victoria brings a unique perspective as a native Russian speaker, sharing personal reflections on language, cultural differences, and what it means to hear certain words for the first time. The hosts also draw parallels between the tight-knit bonds of sports teams and the MBC community, finding unexpected connections between elite athletes and their own experiences with metastatic breast cancer.Whether you're already obsessed with the show or curious about what all the buzz is about, this episode offers a refreshing reminder that we all need joy, distraction, and a little romance in our lives—especially during the hardest times.Content Note: This episode contains spoilers for the HBO Max series "Heated Rivalry."Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this candid episode of Symptoms Spotlight, hosts Melanie Sisk and Abigail Johnston tackle one of the most disruptive yet often under-discussed side effects of cancer treatment: diarrhea caused by cancer medications.Melanie and Abigail share their personal experiences managing different grades of diarrhea, from mild disruptions to severe grade three episodes that can mean seven to 10 extra bathroom trips per day. They discuss the real impact on quality of life, including the embarrassment and isolation that can come with this challenging symptom.In this episode, you'll learn:Understanding diarrhea grades and what they mean for your daily lifePractical management strategies including diet modifications, over-the-counter medications, and prescription optionsThe importance of staying hydrated and managing skin breakdownWhen to seek help from specialists like gastroenterologists and pharmacistsHow to advocate for yourself with your medical teamThe role of probiotics and prophylactic treatment approachesResources available through symptom management clinicsWhether you're dealing with CDK 4/6 inhibitors, Herceptin, Enhertu, or other cancer medications, this episode offers honest, practical advice from two women who understand the challenges firsthand. Melanie brings her nursing perspective while Abigail shares insights from working with specialists at Mayo Clinic and beyond.Remember: you don't have to suffer in silence. Your quality of life matters, and there are solutions available when you know where to look and how to ask for help.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this episode of our Podcasters Roundtable series, we sit down with Melissa Berry, the voice behind "Dear Cancer, I'm Beautiful" and founder of Cancer Fashionista.Before her Stage 1 triple negative breast cancer diagnosis at 42, Melissa was a fashion and beauty publicist working with Vogue editors and celebrities like Sarah Jessica Parker. When she couldn't find beauty and fashion resources for cancer patients all in one place, she created them herself—starting with a simple list that has grown into a thriving blog, social media presence, and podcast.In this conversation, we explore:Why Melissa chose the name Cancer Fashionista and how her podcast got a different nameThe transition from blogging to podcasting and why evergreen content mattersHer most memorable episodes, including the emotional interview with her fatherHow she selects topics and manages a publishing schedule of 2-4 episodes per monthThe importance of inclusive language when addressing both early-stage and metastatic breast cancer communitiesFinancial toxicity and the challenges of maintaining identity during ongoing treatmentWhat keeps her connected to advocacy years after her own diagnosisWorking with sponsors and promoting podcasts through social mediaWe also discuss step therapy (fail first policies), the emotional toll of losing your sense of self during treatment, and why resources around intimacy and sexual health are so critically needed in the cancer community.Special segment: Learn about Ana Ono Intimates, the chest-inclusive lingerie brand founded by breast cancer survivor Dana Donofree, now available at Victoria's Secret after a decade in business. Fun fact: they have a bra named after Melissa!Whether you're a podcaster, advocate, patient, or supporter, this conversation offers valuable insights into building community, creating lasting resources, and helping people feel like themselves again.Connect with Melissa Berry:Podcast: "Dear Cancer, I'm Beautiful" (available on all platforms)Follow Cancer Fashionista on Instagram and social mediaHosted and produced by Victoria Goldberg and Abigail JohnstonNote: We do not accept payment for product placements. Resources are shared because they matter to our community.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

Join hosts Melanie Sisk and Abigail Johnston as they shine a light on the real experiences of managing cancer symptoms. In each episode of the Symptoms Spotlight series of short episodes, we explore different symptoms caused by cancer or its treatment, sharing practical insights and hard-won wisdom directly from patients who've been there.This isn't just medical information—it's peer-to-peer support at its finest. Melanie and Abigail believe that patients learn best from each other, and that we're stronger together. Each episode features candid conversations about symptom management strategies, what works, what doesn't, and the collective knowledge of the cancer community.In this episode, Melanie and Abigail Johnston tackle one of cancer's most challenging side effects: fatigue. With 5-8+ years of experience managing treatment-related exhaustion, they share practical strategies that have helped them maintain quality of life. Topics include structured exercise programs (LiveStrong at YMCA, 2Unstoppable, Cancer Wellness for Life), Medicare fitness benefits like Silver Sneakers, medication interventions including Ritalin for severe fatigue, and the value of palliative care specialists. They also emphasize basics like proper nutrition, hydration, and monitoring blood work for underlying issues like low hemoglobin or vitamin deficiencies.Whether you're navigating treatment side effects, managing ongoing symptoms, or supporting someone who is, Symptom Spotlight offers the kind of practical, patient-centered guidance you won't find in a textbook. Have a symptom you'd like us to cover? Let us know—this series is driven by what matters most to you.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

Welcome to the first episode of 2026! Join host Victoria Goldberg in conversation with Dr. Francisco Esteva, a prominent board-certified medical oncologist specializing in the research and treatment of breast cancer, Chief of the Division of Hematology and Medical Oncology at Lenox Hill Hospital in New York, and Professor of Medicine at the Zucker School of Medicine at Hofstra/Northwell, as they dive deep into the groundbreaking research presented at the San Antonio Breast Cancer Symposium.In this comprehensive discussion, Dr. Esteva shares his expert insights on the latest advances transforming metastatic breast cancer treatment across all subtypes:HER2-Positive Disease:DESTINY-BREAST09 approval: trastuzumab deruxtecan plus pertuzumab as the new first-line standard with unprecedented 40-month progression-free survivalHER2CLIMB-05: Tukatinib's promise for preventing brain metastasesPATINA trial: Adding CDK4/6 inhibitors to maintenance therapyThe evolution from CLEOPATRA to combination approachesHormone Receptor-Positive Disease:Oral SERDs revolutionizing treatment: imlunestrant, elacestrant, and camizestrantSERENA-6 trial: Using liquid biopsies to detect ESR1 mutations and switch therapy before radiographic progressionPersonalized treatment strategies based on molecular profilingTriple-Negative Breast Cancer:Sacituzumab govitecan establishing itself as the preferred first-line optionCombining antibody drug conjugates with immunotherapyExpanding HER2-targeted therapy to HER2-low and HER2-ultralow patientsDr. Esteva also discusses the role of artificial intelligence in pathology, the importance of real-world evidence, and how treatment personalization is becoming the cornerstone of modern oncology. From his early work on trastuzumab and the PI3K pathway to today's cutting-edge ADCs, Dr. Esteva provides both historical context and forward-looking perspectives on where the field is headed.Whether you're a patient, caregiver, or healthcare professional, this episode offers valuable insights into how 2025 is shaping up to be a year of continued innovation and hope in metastatic breast cancer treatment.Disclaimer: This podcast is for educational purposes only and does not constitute medical advice. Always consult with your healthcare team about your specific treatment options.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this episode, co-hosts Victoria Goldberg and Martha Carlso are joined by Josh Newby, Founder and Executive Director of Theresa’s Research Foundation (TRF), for an in-depth conversation about the evolving landscape of metastatic breast cancer research and advocacy. Josh shares the origins and mission of his foundation, the challenges faced in funding and organizing medical conferences, and the shift toward curative approaches for metastatic breast cancer. The discussion covers the impact of recent funding cuts, the importance of collaboration among institutions and industry partners, and the critical role of patient advocates. The group also explores the realities of grant funding, the effects of political and economic changes on research, and the need for credible information and community support for patients. Throughout, the conversation highlights the resilience and determination required to push forward in the face of uncertainty, emphasizing the message: we can’t turn back now.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

What happens when one person’s story becomes a beacon of hope for thousands? In this powerful episode, host Victoria Goldberg sits down with Tami Bowling, creator of LightUp MBC Live, to explore her path from a shocking metastatic breast cancer diagnosis to becoming a passionate advocate and fundraiser.Tami opens up about her early days navigating uncertainty, the emotional impact on her family, and how she transformed adversity into action. Discover the inspiring origins of LightUp MBC—a campaign that now lights up hundreds of landmarks worldwide, raises millions for research, and unites communities in support and education.You’ll hear about the campaign’s global reach, the importance of advocacy, and the many ways people can get involved—from lighting up their own towns to supporting vital research grants. Plus, Tami shares stories of resilience, the power of community, and her vision for the future of metastatic breast cancer awareness.Tune in for an episode filled with hope, actionable inspiration, and a reminder that one person truly can make a difference.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this episode we get urgent and personal: with deep cuts to NIH and NCI funding threatening labs, jobs, and future treatments, what happens to science — and to patients — when the pipeline is squeezed?To make that real, we’re talking with Na Zhao, a research assistant professor at Baylor College of Medicine. We  follow Na’s experience as she navigates a pivotal moment in her research career. Facing institutional financial challenges and limited startup support, Na remains undeterred, leveraging multiple foundation grants and the potential activation of her NIH career grant to continue her groundbreaking work.  Through resilience and determination, Na exemplifies the spirit of scientific progress in the face of adversity, offering hope for the future of cancer research and patient care.This episode drops on the first day of the San Antonio Breast Cancer Symposium, where thousands including Dr. Zhao gather to share breakthroughs even as funding uncertainty looms. In this episode, we dive deep into the real-world impact of research funding cuts on scientists, patients, and the future of cancer care.Wee’ll explore the struggles junior scientists face, the importance of advocacy, and why supporting research is crucial for everyone touched by cancer.Whether you’re a patient, advocate, or simply passionate about science, this conversation will open your eyes to the human stories behind the headlines—and remind us all why the fight for research funding matters.Let’s get started.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

Join us for a powerful conversation with Dr. Rebecca Shatsky, Director of Breast Medical Oncology at UC San Diego, as she shares her experiences fighting for patients with breast cancer. In this episode, Dr. Shatsky discusses the growing challenges clinicians face—from insurance denials and funding cuts to the emotional toll of burnout and the spread of cancer misinformation.Hear real stories about advocating for life-saving treatments, navigating the complexities of clinical trials, and the importance of patient empowerment. Dr. Shatsky also offers hope, highlighting the latest breakthroughs in metastatic breast cancer research and the progress being made in treatment options.Whether you’re a patient, caregiver, or healthcare professional, this episode delivers candid insights, practical advice, and a message of resilience and hope in the face of adversity.Tune in to “Live from Stage 4” for an honest look at the realities of modern cancer care—and the people who refuse to give up the fight.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this episode, hosts Victoria Goldberg and Abigail Johnston sit down with Samira Daswani, host of "The Patient From Hell" podcast, for a candid and insightful conversation about patient advocacy, storytelling, and the evolving landscape of cancer care. Samira shares her path from reluctant podcast guest to passionate host, highlighting the importance of amplifying patient voices and democratizing information for those navigating cancer diagnoses—especially in communities where open discussion is rare.The discussion delves into the challenges of reaching diverse audiences, the power of authentic, minimally edited conversations, and the need for both scientific and personal perspectives in patient-centered content. The trio reflects on the shifting attitudes in cancer communities, the critical role of support networks, and the ongoing mission to educate and empower patients worldwide. The episode wraps up with ideas for future collaborations and a shared commitment to making a meaningful impact through storytelling and advocacy.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In today's episode, the first in our ongoing “Live Chat” series — informal conversations with members of the medical community, advocates, and patients about what matters most to them and to us, hosts Victoria Goldberg and Dr. Ellen Landsberger are joined by Dr. Sherry Shen, a breast cancer medical oncologist at Memorial Sloan Kettering Cancer Center, for a clear, patient-centered conversation on the evolving role of SERDs (Selective Estrogen Receptor Degraders) in hormone receptor–positive metastatic breast cancer.Dr. Shen explains the science behind SERDs, the importance of ESR1 mutations, and why oral SERDs are generating excitement. We review recent and ongoing trials—including evERA (giredestrant), SERENA-6 (camizestrant), and updates on FDA‑approved agents such as elacestrant and imlunestrant—while discussing regulatory and insurance hurdles, quality-of-life considerations, side-effect management, and how these drugs are shaping real-world treatment strategies and combination approaches.Bonus clip: a preview from an upcoming episode with Rebecca Shatsky, MD, where she discusses the evERA trial and shares her enthusiasm for emerging combination strategies, including capivasertib paired with oral SERDs.Whether you’re a patient, caregiver, or clinician, tune in for practical insights, expert perspectives, and a hopeful look at the future of breast cancer therapy.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

This is the first episode of the recurring MBC Insiders series created by and starring the podcast team. In the first episode, published on October 13th, the National Metastatic Breast Cancer Awareness Day, we meet seven panelists with 80+ years  living with Metastatic Breast Cancer between them and they are here to share the hard-won wisdom of true MBC insiders.  We'll explore the issues that matter most to people living with MBC, including how the language clinicians and media use can harm or help, and candid conversations about progression and the idea of "cure."Joining Victoria Goldberg:Martha Carlson -- diagnosed de novo in December of 2014, a writer and advocate who mentors, contributes to research and publications, and works to improve understanding of the MBC patient experience. Melanie Sisk -- diagnosed with early breast cancer at 43 and later, metastatic at 47, which ended her nursing career, she channels urgency into advocacy. Lynda Weatherby -- living with MBC since 2013 after 2001 DCIS, a Seattle-based patient advocate and advocate founder of “The Project to End Postpartum Breast Cancer."Ellen Landsberger, MD --  a retired  OB/GYN from New York has lived with metastatic breast cancer for years, but it was the loss of a close friend to the disease that sparked her interest in using her voice to help educate others. Jill Tirabassi, MD --  researcher and advocate, and another physician on our team, diagnosed with breast cancer during her second pregnancy at the age of 36, she now works part-time while raising her two young sons with her husband outside of Buffalo, New York.Alexis Desai -- born and raised New Yorker, and former educator, diagnosed with MBC at the age of 37, actively involved with Metavivor and is a recent graduate of NBCC Project Lead. Last but not least, Judy Perkins -- cancer Immunotherapy pioneer, who is the first person to be very likely cured of metastatic breast cancer through a form of immunotherapy known as tumor infiltrating lymphocytes or TILs.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this episode of "Live from Stage 4: MBC News for Us, by Us," host Victoria Goldberg sits down with Dr. Gloria Echeverria, a leading researcher at Baylor College of Medicine, to discuss the urgent challenges facing cancer research in the United States. Dr. Echeverria shares her career path  from PhD student to running her own lab, focusing on triple negative breast cancer (TNBC)—one of the most aggressive and difficult-to-treat forms of the disease.The conversation delves into the real-world impact of federal funding cuts on scientific research, the importance of diversifying funding sources, and the ripple effects on young scientists and future breakthroughs. Dr. Echeverria explains the critical role of mitochondria in TNBC, the day-to-day realities of running a research lab, and the vital connection between researchers, clinicians, and patient advocates.Despite the uncertainty and challenges, Dr. Chavarria offers hope, highlighting recent scientific advances and the resilience of the research community. Whether you’re a patient, advocate, or simply curious about the future of cancer research, this episode provides an inside look at the passion, perseverance, and innovation driving the fight against breast cancer.Tune in for an inspiring and eye-opening discussion about the future at risk—and the people working tirelessly to protect it.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

What if the decades of progress against cancer — the breakthroughs, the rising survival rates, the new vaccines and cutting‑edge therapies — were suddenly put in jeopardy? Five decades after the “war on cancer” began, the U.S. has built a world‑class research engine that has pushed survival from roughly 49% in the 1970s to about 68% today. But that hard‑won momentum now faces existential threats: canceled grants and clinical trials, proposals to slash the National Cancer Institute budget, and an unprecedented politicization of biomedical research funding.In this episode we ask the urgent question: can we protect cancer research — and the patients who depend on it?Host Victoria Goldberg is joined by Pam Traxel, Senior Vice President at the American Cancer Society Cancer Action Network and a lifelong patient advocate. Pam’s journey from politics to advocacy gives her a rare view of how policy and personal stories intersect. She breaks down how federal funding fuels basic science, clinical trials, and drug development; explains why patient voices matter in shaping laws; and shares real examples of how advocacy has changed public health — from smoke‑free laws to lives saved. She also offers candid, compassionate advice for people living with metastatic disease about using their voices to protect research that could change everything.In addition, Abigail Johnston describes  what funding cuts mean in practical, heartbreaking terms: halted clinical trials, lost opportunities for patients, and the emotional and financial toll on families. Her account underscores why the stakes are so high and why action can’t wait.Listen for a conversation that’s part policy primer, part patient testimony, and all call to action: protecting cancer research is protecting lives.If you’d like to get involved or learn more, visit fightcancer.org or livefromstage4.orgThanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.

In this powerful panel episode, hosts Victoria Goldberg and Abigail Johnston  are joined by Dr. Jill Tirabassi and Alexis Desai—each bringing their unique perspective as patients, advocates, and experts living with metastatic breast cancer (MBC). Together, they share personal stories about navigating diagnosis, the critical role of research in extending lives, and the real-world challenges of accessing clinical trials.The conversation dives deep into why research funding matters, how advocacy can drive change, and the urgent need for patient-centered care. Whether you’re a patient, caregiver, or ally, this episode offers insight, hope, and a call to action for everyone invested in the future of cancer research.Tune in to hear firsthand experiences, learn about the latest advocacy efforts, and discover how you can help move the needle for those living with MBC.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.