NIEHS Superfund Research Program - Research Brief Podcasts

Using an innovative method to simulate the gastrointestinal (GI) system, an NIEHS Superfund Research Program (SRP)-funded study revealed the interplay between arsenic exposure and the gut microbiome. The scientists assessed how arsenic alters the microbiome and how much arsenic can be dissolved into the bloodstream after being broken down by the gut, also known as bioaccessibility.

People with higher lead exposure before birth may have lower cognitive function in late adulthood, according to researchers from the Harvard School of Public Health Superfund Research Program (SRP) Center. This finding was most significant for women exposed to lead during the second trimester.

Researchers funded by the NIEHS Superfund Research Program developed a new biocatalyst technology to clean up chlorinated hydrocarbons, or CHCs, a large class of persistent groundwater pollutants.

SRP Researchers developed an advanced cell culture model that better represents the human lung.

SRP Researchers uncovered how underground conditions influence the success of chemical oxidation-based groundwater cleanup.

Uranium exposure leaves a fingerprint in the body that could help identify kidney damage before it becomes irreversible, according to an NIEHS SRP-funded study in mice.

Scientists funded by the NIEHS Superfund Research Program developed a novel material that enhances the ability of plants to remove PFAS from soil and water.

Dioxin-like compounds can alter how white blood cells develop and do so in ways that current risk assessment methods fail to predict, according to a study from the Michigan State University Superfund Research Program Center.

Researchers partially funded by the NIEHS Superfund Research Program (SRP) designed a scaled-up electrochemical system that combines electricity with the mineral pyrite, a mineral commonly found in the environment, to continuously remove organic and heavy metal contaminants from groundwater for a year. The study was led by Akram Alshawabkeh, Ph.D., from the Northeastern University SRP Center, and Kitae Baek, Ph.D., from Jeonbuk National University in Korea.

Exposure to inorganic arsenic before conception can trigger changes in gene activity that are passed down to offspring and increase their risk of developing diabetes, according to a study in mice funded by an NIEHS individual research grant and by the NIEHS Superfund Research Program. These changes, known as epigenetic changes, alter how genes work without changing the genes themselves. In this study, the researchers looked at a type of change called CpG methylation.

Machine learning algorithms can fill gaps in sparse or incomplete groundwater datasets, according to researchers partially funded by the NIEHS Superfund Research Program. The study tested the ability of two algorithms to help scientists analyze co-occurring pollutants in groundwater by filling in missing field data points and was led by researchers from Arizona State University, Harvard University, and North Carolina State University.

Researchers funded by the NIEHS Superfund Research Program, or SRP, developed the linear mixed-effects model – abbreviated as LMM – a framework for statistical analysis, to quickly and effectively estimate the effects of individual metals and metal mixtures on zebrafish larvae behaviors.

Scientists at the NIEHS-funded North Carolina State University Superfund Research Program Center created machine learning models that can help predict how well granular activated carbon can clean up contaminated water. With his student Yoko Koyama, Detlef Knappe, Ph.D., developed models that consider properties of the micropollutants — such as PFAS and volatile organic compounds — specific characteristics of the water being treated, and features of different GAC types.

Researchers funded by the NIEHS SRP developed a model that predicts how PFAS move and build up within food webs. The model lays the groundwork for screening the thousands of PFAS compounds that could potentially pose a risk for ecological or human health. PFAS are synthetic chemicals used in consumer products that are ubiquitous on the planet and in some cases harmful to humans and wildlife.

Researchers funded by the NIEHS Superfund Research Program designed a new material that effectively degrades harmful compounds, like PFAS, and bacteria. By combining the power of sunlight and a component of plants, called lignin, this approach harnesses sustainable and renewable resources to reduce exposures and protect health.

A new technology, developed by researchers at the NIEHS-funded Massachusetts Institute of Technology Superfund Research Program Center, can detect the contaminant N-nitrosodimethylamine (NDMA) in water. This breakthrough tool offers a quick way to monitor NDMA by triggering a visible color change when light interacts with the contaminated solution.

Common low-cost samplers may be an effective technology for tracking PFAS levels in aquatic environments, according to a study funded by the NIEHS Superfund Research Program (SRP). The research team found that frequently used passive sampling devices, which collect samples over time, can monitor how PFAS mitigation strategies affect PFAS levels along a stretch of the Cape Fear River in North Carolina. Erin Baker, Ph.D., a project leader at the Texas A&M SRP Center and part of the analytical core at the North Carolina State University SRP Center, led the team.

Exposure to certain chemicals during early pregnancy may influence how a baby’s immune system develops, according to a study partly funded by the NIEHS Superfund Research Program (SRP). The scientists discovered that some per- and polyfluoroalkyl substances (PFAS) and metals may alter how an infant’s immune system responds to environmental triggers.

Adding a common mineral, pyrite, to an electrochemical system can simultaneously remove organic and heavy metal contaminants from groundwater, according to a study funded in part by the NIEHS Superfund Research Program (SRP). Led by Akram Alshawabkeh, Ph.D., researchers at the Northeastern University SRP Center found that combining two types of remediation techniques – one that relies on applying an electrical current to destroy contaminants and one that uses minerals to adsorb contaminants – removed pollutants more effectively than either strategy alone.

Researchers funded by the NIEHS Superfund Research Program (SRP) revealed how characteristics of water treatment systems may alter the ability of novel nanomaterials to remove PFAS. Scientists should be aware of factors like water pH ' a measure of acidic or basic conditions ' or salt level to ensure that these nanomaterials effectively remove PFAS in aqueous environments, according to the team based at the State University of New York at Buffalo.

A study funded by the NIEHS Superfund Research Program (SRP) found that consuming some types of commercial seafood in high quantities may increase the risk of PFAS exposure. Led by Celia Chen, Ph.D., Kate Crawford, Ph.D., and Megan Romano, Ph.D., at Dartmouth College, the research team believes their findings can support the development of consumption guidelines to protect communities from further PFAS exposure.

Oregon State University scientists and engineers developed an approach to cleaning polluted groundwater that uses tiny beads containing chemical-eating bacteria. In this study, funded by the NIEHS Superfund Research Program (SRP), the team identified a formula to maximize bead durability and bioremediation, or the removal of contaminants using bacteria.

NIEHS Superfund Research Program (SRP)-funded researchers, led by Heileen Hsu-Kim, Ph.D., of the Duke University SRP Center, provided insight into how and at what timescale mercury changes within a wetland ecosystem. They found mercury from different sources is converted into other mercury forms that eventually have similar properties. This finding can inform environmental management or pollution control strategies.

NIEHS Superfund Research Program (SRP)-funded researchers developed a new strategy that uses limestone and a naturally occurring mineral to clean up water contaminated with arsenic and uranium — two of the most frequently detected drinking water pollutants in Tribal communities.

Scientists funded partly by the NIEHS Superfund Research Program (SRP) developed a computer model to determine the health effects of exposure to dioxins. Researchers use the model to combine data on exposures and on known health outcomes to assess the overall risk chemicals could pose to health.For this study, researchers at the Michigan State University SRP Center and Emory University created a computational model to show how the highly toxic chemical 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) affects biological processes that increase cholesterol levels in the liver.

Researchers partially funded by the NIEHS Superfund Research Program (SRP) mapped interactions between microbes that may support the growth of certain bacteria that degrade polychlorinated biphenyls (PCBs), a harmful contaminant. By harnessing those microbial relationships, researchers could improve the bioremediation, or bacterial breakdown, of PCBs from the environment, according to a team led by Timothy Mattes, Ph.D., University of Iowa SRP Center.

Toxic air pollutants called environmentally persistent free radicals (EPFRs) may react with certain polycyclic aromatic hydrocarbons (PAHs) on the surface of airborne particles to form more toxic chemicals, according to researchers funded by the NIEHS Superfund Research Program (SRP). The study, led by Slawomir Lomnicki, Ph.D., of the Louisiana State University SRP Center, demonstrated that interactions between components of fine particulate matter mixtures may enhance their overall toxicity.

Adding biochar produced at a high temperature may be an effective way to immobilize arsenic in sediment, according to researchers partially funded by the NIEHS Superfund Research Program (SRP). The study, led by Owen Duckworth, Ph.D., of the University of North Carolina at Chapel Hill SRP Center, in partnership with researchers from the Luiz de Queiroz College of Agriculture, University of São Paulo, Brazil, also provided further insight into the conditions that influenced the effectiveness of biochar for soil remediation.

A particular class of extracellular vesicles protects against neurotoxicity caused by cadmium exposure, according to an NIEHS Superfund Research Program (SRP)-funded study. Extracellular vesicles are small packages of fats, nucleic acids, or proteins that allow cells to communicate with each other and support numerous cellular functions.

Iron particles coated in a nontoxic material may enhance PFAS degradation by a certain bacterium, according to researchers funded by the NIEHS Superfund Research Program. The study could inform bioremediation efforts that harness the microbe, known as Acidimicrobium Strain A6, for cleaning up contaminated soil, sediments, and aquifers.

Prenatal exposure to the air pollutant benzene may lead to a higher risk of metabolic diseases later in life, according to a study in mice partially funded by the NIEHS Superfund Research Program (SRP). Benzene affects neurodevelopment, predisposing offspring to harmful metabolic effects, according to a research team led by Marianna Sadagurski, Ph.D., of the Wayne State University SRP Center.

Researchers funded in part by the NIEHS Superfund Research Program (SRP) uncovered a key mechanism explaining how inflammation caused by cadmium exposure makes lung infections more severe and deadly.

Exposure to synthetic chemicals called polychlorinated biphenyls (PCBs) through a mother's milk could cause short-term glucose intolerance in offspring, according to a study by researchers from the University of Kentucky (UK) and funded by the NIEHS Superfund Research Program (SRP). Intolerance to glucose, signified by high blood levels of the sugar, is a hallmark of diabetes. The study, conducted with mice, builds on earlier SRP-funded work by the same group that found connections between maternal PCB exposure and diabetes risk factors in progeny.

Researchers funded by the NIEHS Superfund Research Program (SRP) created a novel class of materials that can attract and remove per- and polyfluoroalkyl substances (PFAS) from water. According to the authors, the new technology — called Fluor Mop — can be regenerated, reused, and is potentially less expensive than current remediation strategies.

NIEHS Superfund Research Program (SRP)-funded scientists developed a method to extract metals from water using synthetic molecules inspired by those produced by bacteria. The biodegradable molecules, called rhamnolipids, could one day be used to remove toxic metals or extract rare and valuable elements from aqueous mining and industrial waste.

Researchers partially funded by the NIEHS Superfund Research Program (SRP) developed a model to estimate individual exposure to four per- and polyfluoroalkyl substances (PFAS) commonly found in drinking water. The model integrates published data from multiple studies on PFAS levels in human blood along with measured PFAS concentrations in drinking water. Tools for estimating PFAS exposure from contaminated drinking water can inform public health risk assessments and advisories.

NIEHS Superfund Research Program (SRP)-funded researchers demonstrated a significant step toward identifying individual chemical components in complex mixtures. Their approach uses advanced analytical techniques and sophisticated machine learning approaches while overcoming the time-consuming separation steps that preceded traditional chemical analysis.

An NIEHS Superfund Research Program (SRP)-funded study in mice reported that exposure to a type of dioxin can alter cells in the liver, their metabolic characteristics, and how they are organized within the liver. According to the researchers, these changes in cell behavior and organization play a role in the development of dioxin-induced liver diseases, such as fibrosis and fatty liver disease.

A NIEHS Superfund Research Program (SRP)-funded study showed how unique microsensors that harness powerful molecular interactions can selectively detect trace amounts of aromatic volatile organic compounds (VOCs) in the environment.

NIEHS Superfund Research Program (SRP)-funded researchers found that elevated levels of per-and polyfluoroalkyl substances (PFAS) in the blood of participants of the GenX Exposure Study were associated with higher cholesterol. Led by Jane Hoppin, ScD., of the North Carolina State University SRP Center, the study started in 2017 in response to the concerns of residents of Wilmington, North Carolina, about PFAS in their drinking water.

By combining data across three different populations, NIEHS Superfund Research Program (SRP) researchers were able to better characterize sources of arsenic exposure that should be included in risk assessments. The study was a collaboration among the University of California (UC), Berkeley, University of New Mexico (UNM), and Columbia University SRP centers.

NIEHS Superfund Research Program (SRP) grantees demonstrated a method to break down per- and polyfluoroalkyl substances (PFAS) into smaller, non-toxic molecules. Led by Yujie Men, Ph.D., of the University of California, Riverside, the team also showed that some types of PFAS can be more easily degraded than others.

New types of per-and polyfluoroalkyl substances (PFAS) can induce significant increases in gene expression and lipid accumulation in human liver cells at lower concentrations compared to PFAS no longer in use, according to researchers funded by the NIEHS Superfund Research Program (SRP).

NIEHS Superfund Research program (SRP) grantees discovered toxic breakdown products of polychlorinated biphenyls (PCBs) in contaminated sediments at proportionally higher levels than found in commercial PCB mixtures.

A protein called fibrinogen can be an indicator of cadmium exposure in people with chronic obstructive pulmonary disease (COPD), according to a study led by Veena Antony, M.D., director of the NIEHS Superfund Research Program (SRP) Center at the University of Alabama, Birmingham.

NIEHS Superfund Research Program (SRP)-funded researchers, led by Heileen Hsu-Kim, Ph.D., of the Duke University SRP Center, showed that a small plastic sampling device can efficiently predict the potential for methylmercury — an environmental contaminant — to form in freshwater wetlands and to accumulate in organisms living there.

NIEHS Superfund Research Program (SRP) grantees developed a new computational approach to predict how hazardous substances may affect health based on key changes in cells. Led by April Z. Gu, Ph.D., of the Northeastern University Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) SRP Center, researchers used machine learning and advanced algorithms to link biological changes from high throughput cell studies with health outcomes observed in animal studies.

A technology developed by NIEHS-funded Superfund Research Program (SRP) researchers may remove uranium and other heavy metals from groundwater near abandoned mines. Small business GlycoSurf, LLC worked with partners at the University of Arizona SRP Center to determine the best environmental conditions for effectively removing uranium from contaminated water.

A sophisticated biosensor may provide information about contaminant distribution in the aftermath of natural disasters, according to an NIEHS Superfund Research Program (SRP)-funded study. Led by former Texas A&M University SRP Center trainee Krisa Camargo and Michael Unger, Ph.D., from the Virginia Institute of Marine Sciences, the team demonstrated this type of tool is useful for quickly characterizing and prioritizing environmental samples for further analysis, particularly in the context of disaster research response.

Researchers from the NIEHS Superfund Research Program (SRP)-funded centers at the University of Rhode Island (URI) and Brown University developed a new type of passive sampling device for per- and polyfluoroalkyl substances (PFAS). Their new tool overcomes many limitations to traditional approaches, such as detecting short-chain PFAS and low concentrations of the chemicals in water.