083 - Botox / Boosters / Magic Mushrooms

What does the body of evidence say on the topic of Botox injections? Plus: we address the confusion over bivalent COVID-19 booster shots, and we look at a trial of magic mushrooms for alcohol use disorder!   Block 1: (3:00) Botox: what it is and what botulism does to you   Block 2: (9:00) Botox: how Botox works on wrinkles, a comparison between formulations, what can go wrong, why repeated injections are needed, and the non-cosmetic uses of the botulinum toxin   Block 3: (23:08) Bivalent booster vaccines and the reactive, libertarian public health response   Block 4: (36:01) Magic mushrooms for alcohol use disorder     * Jingle by Jillian Correia of Roctavio Canada * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl. * Assistant researcher: Nicholas Koziris   To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.   To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Patrons get a bonus show on Patreon called “Digressions”! Check it out!     References:   1) Our episode on sunscreen: https://bodyofevidence.ca/019-sunscreen-and-the-mmr-vaccine   2) The cosmetic benefit of botulinum toxin: https://doi.org/10.1067/mjd.2002.121356   3) Differences between formulations: https://doi.org/10.1046/j.1524-4725.2003.29017.x   4) The FDA’s black box warning for Botox: https://jamanetwork.com/journals/jama/article-abstract/184061   5) Antibody formation after Botox: https://doi.org/10.1002/mds.23254   6) Cochrane review of Botox for migraine: https://doi.org/10.1136/bmjopen-2018-027953   7) Cochrane review of Botox for cervical dystonia: https://doi.org/10.1002/14651858.CD003633.pub4   8) Botox for urgency urinary incontinence: https://www.nejm.org/doi/full/10.1056/nejmoa1208872#:~:text=In%20summary%2C%20we%20found%20that,improvements%20in%20quality%20of%20life   9) New clinical trial of psilocybin-assisted psychotherapy for alcohol use disorder: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2795625     Music Credits:   The following music was used for this media project: Music: Main Theme (The Grand Score) by Alexander Nakarada Free download: https://filmmusic.io/song/4960-main-theme-the-grand-score License (CC BY 4.0): https://filmmusic.io/standard-license Artist website: https://www.serpentsoundstudios.com/