1 6 2025

Happy New year to all the listeners.Thank you for listening in 2024 and hope to see you here weekly in 2025.Hi, This Week in Medicine, we will be discussingNew England Journal of MedicineFinal, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma Asundexian versus Apixaban in Patients with Atrial Fibrillation Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma Journal of  American Medical Association Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth Annals of Internal MedicineImplementation of Billing for Patient Portal Messages as E-Visits in a Large Integrated Health System British Medical JournalComparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease  LancetGuselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis  journal of HepatologyMetabolic phenotyping of patients with advanced chronic liver disease for better characterization of cirrhosis regression Gastroenterology Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets Clinical Infectious DiseasesClinical characterisation and outcomes of human clade IIb mpox virus disease  CirculationMultiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification Journals of the American College of CardiologyUsing Electrocardiogram to Assess Diastolic Function and Prognosis in Mitral Regurgitation AMA CardiologyArtificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension Journal of Clinical Endocrinology & MetabolismRegional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women  NeurologyPatient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study ChestExacerbation History and Risk of Myocardial Infarction and Pulmonary Embolism in COPD Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations The American Journal of Respiratory and Critical Care MedicinePyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial  Clinical Journal of American Society of NephrologyBenefits and Harms of Coronary Revascularization in Non–Dialysis-Dependent Chronic Kidney Disease and Ischemic Heart Disease: A Systematic Review and Meta-Analysis  Kidney International reportsProjecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories