1 6 2025

Happy New year to all the listeners.

Thank you for listening in 2024 and hope to see you here weekly in 2025.

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma

Asundexian versus Apixaban in Patients with Atrial Fibrillation

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy

Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma

 Journal of  American Medical Association

Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth

 Annals of Internal Medicine

Implementation of Billing for Patient Portal Messages as E-Visits in a Large Integrated Health System

 British Medical Journal

Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease

  Lancet

Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis

  journal of Hepatology

Metabolic phenotyping of patients with advanced chronic liver disease for better characterization of cirrhosis regression

 Gastroenterology

Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

 Clinical Infectious Diseases

Clinical characterisation and outcomes of human clade IIb mpox virus disease 

 Circulation

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification

 Journals of the American College of Cardiology

Using Electrocardiogram to Assess Diastolic Function and Prognosis in Mitral Regurgitation

 AMA Cardiology

Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension

 Journal of Clinical Endocrinology & Metabolism

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

  Neurology

Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study

 Chest

Exacerbation History and Risk of Myocardial Infarction and Pulmonary Embolism in COPD

Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations

 The American Journal of Respiratory and Critical Care Medicine

Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial

  Clinical Journal of American Society of Nephrology

Benefits and Harms of Coronary Revascularization in Non–Dialysis-Dependent Chronic Kidney Disease and Ischemic Heart Disease: A Systematic Review and Meta-Analysis

  Kidney International reports

Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories