127: Coffee Intake and the Microbiota–Gut–Brain Axis

This episode dissects a research study that investigates the microbiota-gut-brain axis by comparing coffee drinkers to non-drinkers and observing the effects of caffeine withdrawal and reintroduction. Boscaini S, Bastiaanssen TFS, Moloney GM, Bergamo F, Zeraik L, O’Leary C, et al. Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition. Nat Commun. Published online April 21, 2026. doi:10.1038/s41467-026-71264-8Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠