PODCAST · health
Listen, Learn, Adapt
by Anthony Novello
Evidence over everything. Health and wellness is full of noise. We provide the signal. We break down the latest in physical medicine, rehab, and pain science—one research article at a time. No opinions. No "hacks." Just clear, actionable evidence for athletes, clinicians, and the health-conscious human.Understand the science. Master your movement.Dr. Anthony Novello, PT, [email protected]
Episodes
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172: Psychosocial Risk Factors and Outcomes in Rotator Cuff Disorders
This episode does a deep dive in a systematic review that investigates the association between psychosocial risk factors and clinical outcomes in adults with rotator cuff (RC) disorders. By analyzing thirty-eight observational studies following PRISMA guidelines, the literature review evaluates…
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171: Oat-Induced Cholesterol Lowering via Microbial Phenolic Metabolites
This episode dissects a recent clinical trial that investigated the cholesterol-lowering effects of oats in individuals suffering from metabolic syndrome. Klümpen L, Mantri A, Philipps M, et al. Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic...
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170: Does Meal Proximity Influence Sleep in Young Adults?
This episode does a deep dive into cross-sectional study that investigates the connection between evening meal timing and sleep quality among 793 university students aged 18 to 29. Chung N, Bin YS, Cistulli PA, Chow CM. Does the proximity of meals to bedtime influence the sleep of young adults? A...
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169: The Ergogenic Effect of Swearing on Physical Performance
This episode dissects a research article that indicates that profanity functions as a potent ergogenic aid, significantly improving physical performance and muscular strength during brief, high-intensity exercises. Washmuth NB, Stephens R, Ballmann CG. Effect of swearing on physical performance…
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168: Neuromuscular Training Sustains Knee Biomechanical Improvements in Female Soccer Players
This episode dissects a research study that evaluated how well adolescent female soccer players retained improvements in knee abduction moment (KAM)—a key risk factor for anterior cruciate ligament (ACL) injuries—following a six-week neuromuscular training (NMT) program. One hundred fifty...
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167: Female-Specific Clinical Risk Factors for Hip Osteoarthritis: Systematic Review
This episode dissects a systematic review that investigates the specific clinical risk factors that contribute to the development of hip osteoarthritis in females. Wright AA, Christopher S, Burgemeister M, et al. Female-specific clinical risk factors associated with hip osteoarthritis: a…
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166: Heat Therapy and Muscular Adaptations After Resistance Training
This episode dissects a systematic review and meta-analysis that evaluates how applying heat therapy immediately after resistance training affects long-term muscle growth and strength. Hopper A, Coleman M, Piñero A, et al. Feeling the heat: a systematic review with meta-analysis on the effects of...
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165: Heat Therapy versus Aerobic Exercise for Improving Vascular Function
This episode does a deep dive into a research article that investigates whether passive heat therapy through hot water immersion can provide similar cardiovascular benefits to aerobic exercise for overweight or obese older adults. Over a 12-week period, researchers compared the effects of…
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164: Pelvic Floor Symptoms in Performing Artists and Artistic Athletes
This episode dissects a systematic review that examines the prevalence and impact of pelvic floor symptoms among performing artists and artistic athletes, such as dancers, gymnasts, and cheerleaders. Frydenberg JC, et al. Prevalence and impact of pelvic floor symptoms in performing artists and...
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163: Sleep Disorders in Patients with Knee, Hip and Hand Osteoarthritis
This episode dives into a systematic review and meta-analysis that investigates the frequency of sleep disorders among individuals suffering from osteoarthritis of the knee, hip, and hand. Krag-Andersen KK, van Zaane JH, Gaban GL, et al. Prevalence of sleep disorders in patients with knee, hip…
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162: Multivitamin Supplementation and Metabolomic Profiles in the COSMOS Trial
This episode dissects a research article that examines the impact of daily multivitamin supplementation on the metabolic health and biological aging of older adults over a two-year period. Utilizing data from the COSMOS randomized clinical trial, scientists analyzed blood samples from nearly 400...
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161: SONAFE-Brazil Clinical Practice Guideline for Hamstring Strain Injury Rehabilitation
This episode dives into the SONAFE-Brazil Clinical Practice Guideline that provides an evidence-based framework for the rehabilitation of athletes with hamstring strain injuries. Based on a systematic review of randomized clinical trials, the article offers specific recommendations regarding...
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160: Metabolic Effects of Diet Composition on Weight Loss Outcomes
This episode dissects a research report that investigates how different nutritional compositions influence health outcomes during a ten percent reduction in body weight. The clinical trial compared three popular eating patterns—ketogenic, Mediterranean, and low-fat plant-based—specifically in...
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159: Exercise Efficacy for Chronic Low Back Pain: A FITT Review
This episode dissects a systematic review and meta-analysis that investigates the impact of various exercise prescription parameters on functional disability in adults suffering from nonspecific chronic low back pain. By utilizing the FITT principle, the authors analyzed seventy randomized...
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158: Personalized Report-Back Interventions to Improve Environmental Health Literacy
This episode does a deep dive into a research article that investigates the effectiveness of personalized report-back interventions in reducing exposure to endocrine-disrupting chemicals (EDCs) like phthalates and parabens. Researchers analyzed a Northern Nevada population to determine if…
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157: HEPA Filtration and Cognitive Function in Near-Highway Residents
This episode dissects a scientific report that investigates how HEPA air purifiers affect the cognitive performance of adults living near high-traffic areas. By utilizing a randomized crossover trial, researchers compared mental test results after participants used either functional or inactive...
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156: The Plasticity of Well-Being: A Training-Based Framework for Flourishing
This episode dissects a research paper that proposes a unifying framework for human flourishing based on the scientific premise that well-being is a trainable skill. The authors identify four core pillars—awareness, connection, insight, and purpose—that can be strengthened through intentional...
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155: Exercise Reverses Age-Related Hippocampal Atrophy and Enhances Memory
This episode does a deep dive into a research study that demonstrates that aerobic exercise can effectively reverse the natural shrinkage of the hippocampus in older adults. Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl…
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154: Fear Factors and Disability in Rotator Cuff Resistance Exercise
This episode dissects a research report that investigates how psychological barriers like fear of movement and pain-related anxiety influence recovery during a two-month resistance exercise program for shoulder issues. Mears CK, Heindel MD, Abeles RE, Vila-Dieguez O, Beneciuk JM, Michener LA....
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153: Zinc Supplementation Effects on Metabolic and Inflammatory Markers in Diabetes
This episode does a deep dive into systematic review and meta-analysis that evaluates how zinc supplementation affects patients with type 1, type 2, and gestational diabetes. Loaiza-Giraldo JP, Amigo-Fierro F, Cancino-Castro Cl, et al. Effects of zinc supplementation on glycemic control, insulin...
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152: Comparative Effectiveness of Global Well-being Interventions: A Network Meta- Analysis
This episode does a deep dive into a systematic review and network meta-analysis that evaluates the comparative effectiveness of various well-being interventions for adults in the general population. Wilkie L, Fisher Z, Geidel A, Goodall I, Kamil S, Davies E, Kemp AH. A systematic review and...
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151: Resistance Training and Cardiovascular Health in Postmenopausal Women
This episode dissects a comprehensive systematic review and meta-analysis that investigates how chronic resistance training impacts the cardiovascular and autonomic health of postmenopausal women. Rivera-Mejía SL, Rúa-Alonso M, Rial- Vázquez J, et al. Resistance training improves cardiovascular...
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150: Acute Immune Responses to Finnish Sauna Heat Exposure
This episode dissects a research paper that investigates how acute Finnish sauna bathing impacts the human immune system by analyzing blood samples from middle-aged adults. Heinonen IHA, Koivula T, Hollmén M, et al. Acute Finnish sauna heat exposure induces stronger immune cell than cytokine...
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149: Creatine Supplementation in Women Across the Lifespan
This episode does a deep dive into a research article that suggests that creatine supplementation offers significant health and performance benefits for females across their entire lifespan. Smith-Ryan AE, Cabre HE, Eckerson JM, Candow DG. Creatine supplementation in women’s health: a lifespan...
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148: Aromatherapy Versus Oral Ondansetron for Emergency Department Nausea Relief
This episode dissects a randomized controlled trial that investigates whether inhaled isopropyl alcohol is more effective than oral ondansetron for treating nausea in emergency department patients. April MD, Oliver JJ, Davis WT, et al. Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy...
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147: Acute Cognitive Effects of Sitting Interruptions: A Meta-Analysis
This episode does a deep dive into a 2026 systematic review and meta-analysis that examines how brief standing or physical activity breaks affect acute cognitive performance compared to uninterrupted sitting. Zhuang M, Yin M, Liu Z, et al. Acute cognitive effects of interruptions to prolonged...
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146: Resistance Training and Long-Term Mortality Risk Reduction Strategies
This episode dissects a study that analyzes data from over 147,000 participants across three decades to determine how long-term resistance training influences life expectancy. Zhang Y, Lee DH, Rezende LFM, Ma Y, Giovannucci E. Long-term resistance training with all-cause and cause-specific...
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145: Optimizing Exercise Interventions for Low Back Pain: A Meta- Analysis
This episode dissects a systematic review and meta-analysis that evaluates the efficacy of six specific exercise therapies—core stability, Tai Ji, aquatic therapy, yoga, sling exercise, and combined training—for treating low back pain. Cheng M, Tian Y, Ye Q, Li J, Xie L, Ding F. Evaluating the...
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144: Effectiveness of Chiropractic Spinal Manipulation for Headache Treatment
This episode does a deep dive into a systematic review that evaluates whether chiropractic spinal manipulation effectively treats various headache types, including migraines, tension-type, and cervicogenic headaches. Ceballos-Laita L, Ernst E, Carrasco-Uribarren A, García-García D,...
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143: Preventing Upper Limb Repetitive Strain Injuries in Computer Users
This episode dissects a scoping review that investigates therapeutic interventions designed to prevent upper limb repetitive strain injuries (RSIs) among workers using computers in the 21st century. de Waal A, Killian A, Gagela A, Baartzes J, de Klerk S. Therapeutic approaches for the prevention…
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142: Long-Term Risk of Knee Replacement After ACL Reconstruction
This episode dissects an article that analyzes data from over 135,000 patients to determine the long-term probability of requiring a knee replacement following ACL reconstruction. Hennessy C, Murray J, Price AJ, Abram SGF. Long-term risk of knee replacement after ACL reconstruction using the...
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141: Intervention Strategies for Preventing Knee Osteoarthritis: A Systematic Review
This episode dissects a systematic review that evaluates the effectiveness of various medical and behavioral strategies used to prevent knee osteoarthritis. By analyzing data from multiple randomized controlled trials, the researchers assessed interventions such as weight management, physical...
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140: Early-Stage Symptomatic Hip Osteoarthritis: A New Window of Opportunity
This episode does a deep dive into an article that addresses the critical need for a standardized approach to early-stage symptomatic hip osteoarthritis, a phase where pain and functional decline occur before major damage appears on traditional X-rays. Heerey J, van Klij P, Diamond LE…
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139: Dietary Guidelines and the Gap in Cardio-Protective Flavanol Intake
This episode does a deep dive into a research paper that investigates whether following standard dietary guidelines provides enough flavanols to achieve the cardiovascular benefits observed in the COSMOS clinical trial. Ottaviani JI, Erdman JW Jr, Steinberg FM, et al. Adhering to dietary…
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138: Creatine Supplementation: A Multi- System Approach to Healthy Aging
This episode does a deep dive into a review paper that explores the diverse health advantages of creatine supplementation specifically for the aging population. Evans C, Pereira F, Candow D, Antonio J. Creatine supplementation as an adjunct to improving healthy aging. Longevity.…
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137: Creatine Supplementation: Science Behind Common Questions and Misconceptions
This episode does a deep dive into a scientific review by an international panel of experts that systematically addresses and clarifies common misconceptions regarding creatine supplementation. The authors provide evidence-based refutations of myths suggesting that the supplement causes kidney...
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136: Ketamine Treatment for PTSD: A Meta-Analysis and Systematic Review
This episode dissects a systematic review and meta-analysis that evaluates the potential of ketamine as a novel treatment for Post-Traumatic Stress Disorder (PTSD). Researchers analyzed ten clinical studies involving 363 participants to determine if the drug effectively reduces core symptoms like...
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135: Sleep-aligned Extended Overnight Fasting for Cardiometabolic Health
This episode does a deep dive into a study by Northwestern University researchers who examineed how extended overnight fasting (EOF), specifically ending meals at least three hours before sleep, impacts the health of middle-aged and older adults. Grimaldi D, Reid KJ, Abbott SM, Knutson KL, Zee…
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134: Nutritional and Exercise Impacts on Epigenetic Aging Clocks
This episode dissects the findings from the DO-HEALTH trial, a large-scale clinical study examining how vitamin D, omega-3, and exercise influence the biological aging of older adults. Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and...
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133: Exercise Training and Blood Lipids: A Meta-Analysis
This episode dissects a systematic review and meta-analysis that evaluates the impact of exercise training on five key blood lipid markers to assist in the management of dyslipidemia. Smart NA, Downes D, van der Touw T, et al. The effect of exercise training on blood lipids: a systematic review…
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132: Meat Consumption and Cognitive Health by APOE Genotype
This episode does a deep dive into a 2026 study that investigates whether meat consumption influences cognitive decline and dementia risk based on a person's APOE genetic profile. Norgren J, Carballo-Casla A, Grande G, Börjesson-Hanson A, Xu H, Eriksdotter M, et al. Meat consumption and cognitive...
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131: Physical Activity and Inhibitory Control in Adult ADHD
This episode dissects a systematic review and meta-analysis that investigates how physical activity affects inhibitory control in adults diagnosed with ADHD. Yang Y, Wu CH, Sun L, Zhang TR, Luo J. The impact of physical activity on inhibitory control of adult ADHD: a systematic review and...
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130: Fear and Catastrophizing Trajectories in Rotator Cuff Exercise Outcomes
This episode dissects a study that examines how psychological factors, specifically pain-related fear and catastrophizing, influence recovery in patients with rotator cuff tendinopathy during an 8-week exercise program. Researchers tracked 64 participants to observe if their beliefs about…
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129: Non-Surgical Interventions for Pediatric Flexible Flatfoot Network Meta-Analysis
This episode dissects a network meta-analysis that evaluates the effectiveness of various non-surgical interventions for children diagnosed with pediatric flexible flatfoot. Researchers categorized treatments into active exercise-based physical therapy, such as neuromuscular electrical…
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128: Creatine Safety in Adolescents: A Systematic Review of Clinical Outcomes
This episode does a deep dive into a systematic review that examines the safety of creatine monohydrate supplementation among adolescents and physically active youth. By analyzing five studies published between 2015 and 2025, researchers evaluated the supplement's impact on renal function, liver...
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127: Coffee Intake and the Microbiota–Gut–Brain Axis
This episode dissects a research study that investigates the microbiota-gut-brain axis by comparing coffee drinkers to non-drinkers and observing the effects of caffeine withdrawal and reintroduction. Boscaini S, Bastiaanssen TFS, Moloney GM, Bergamo F, Zeraik L, O’Leary C, et al. Habitual coffee...
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126: Peakspan: Defining and Extending the Boundaries of Human Performance
This episode does a deep dive into an academic perspective that introduces Peakspan, a novel metric defined as the period when an individual maintains at least 90% of their maximum functional capacity in specific physiological or cognitive areas. The authors argue that while humans are living...
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125: Sleep Chart of Biological Ageing Clocks Across Systems
This episode does a deep dive into a 2026 study by the MULTI Consortium that identifies a systemic, U-shaped relationship between sleep duration and biological ageing across the human body. By analyzing data from the UK Biobank, researchers utilized 23 biological ageing clocks derived from MRI...
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124: Neural Recovery After Carpal Tunnel Release: A Systematic Meta-Analysis
This episode dissects a comprehensive systematic review and meta-analysis regarding the recovery of the median nerve after carpal tunnel release surgery. Spanning 199 studies and over 15,000 patients, the research investigates structural and functional healing through metrics like nerve…
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123: Creatine Supplementation in the Management of Osteosarcopenia
This episode examines the potential of creatine monohydrate as a therapeutic tool for managing osteosarcopenia, an age-related decline in both bone density and muscle mass. Candow DG, Kirk B, Chilibeck PD, Duque G. The potential of creatine monohydrate supplementation in the management of...
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ABOUT THIS SHOW
Evidence over everything. Health and wellness is full of noise. We provide the signal. We break down the latest in physical medicine, rehab, and pain science—one research article at a time. No opinions. No "hacks." Just clear, actionable evidence for athletes, clinicians, and the health-conscious human.Understand the science. Master your movement.Dr. Anthony Novello, PT, [email protected]
HOSTED BY
Anthony Novello
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