Listen, Learn, Adapt

This episode does a deep dive into a study by Northwestern University researchers who examineed how extended overnight fasting (EOF), specifically ending meals at least three hours before sleep, impacts the health of middle-aged and older adults. Grimaldi D, Reid KJ, Abbott SM, Knutson KL, Zee PC. Sleep-aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function. Arterioscler Thromb Vasc Biol. 2026;46(4):e323355. doi:10.1161/ATVBAHA.125.323355 [1, 2].Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects the findings from the DO-HEALTH trial, a large-scale clinical study examining how vitamin D, omega-3, and exercise influence the biological aging of older adults.Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nature Aging. Published online February 3, 2025. doi:10.1038/s43587-024-00793-yFollow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and meta-analysis that evaluates the impact of exercise training on five key blood lipid markers to assist in the management of dyslipidemia.Smart NA, Downes D, van der Touw T, et al. The effect of exercise training on blood lipids: a systematic review and meta-analysis. Sports Med. 2025;55:67-78. doi:10.1007/s40279-024-02115-zFollow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a 2026 study that investigates whether meat consumption influences cognitive decline and dementia risk based on a person's APOE genetic profile.Norgren J, Carballo-Casla A, Grande G, Börjesson-Hanson A, Xu H, Eriksdotter M, et al. Meat consumption and cognitive health by APOE genotype. JAMA Netw Open. 2026;9(3):e266489. doi:10.1001/jamanetworkopen.2026.6489Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and meta-analysis that investigates how physical activity affects inhibitory control in adults diagnosed with ADHD.Yang Y, Wu CH, Sun L, Zhang TR, Luo J. The impact of physical activity on inhibitory control of adult ADHD: a systematic review and meta-analysis. J Glob Health. 2025;15:04025.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a study that examines how psychological factors, specifically pain-related fear and catastrophizing, influence recovery in patients with rotator cuff tendinopathy during an 8-week exercise program. Researchers tracked 64 participants to observe if their beliefs about movement and pain changed alongside improvements in shoulder disability.Mears C, Heindel MD, Abeles R, Vila Dieguez O, Beneciuk JM, Michener LA. Changes in pain-related fear predict shoulder disability in rotator cuff tendinopathy with resistance exercise. *J Orthop Sports Phys Ther*. Published online 2026. doi:10.2519/jospt.2026.13563Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a network meta-analysis that evaluates the effectiveness of various non-surgical interventions for children diagnosed with pediatric flexible flatfoot. Researchers categorized treatments into active exercise-based physical therapy, such as neuromuscular electrical stimulation (NMES) and corrective exercises, and passive orthotic interventions, including talus control insoles and corrective shoes.Lin LY, Lin AC, Lai PC, Fang CJ, Tu YK, Huang MT, et al. Effects of non-surgical interventions on standing posture and pain in children with flexible flatfoot: a network meta-analysis of randomized controlled trials. Phys Ther. 2026;106(5):pzag033. doi:10.1093/ptj/pzag033Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a systematic review that examines the safety of creatine monohydrate supplementation among adolescents and physically active youth. By analyzing five studies published between 2015 and 2025, researchers evaluated the supplement's impact on renal function, liver health, and cardiometabolic markers.Rubinchuk A, Dulkoski Z, Persaud NA, Wallen M. Evaluating the Safety of Creatine Monohydrate in Adolescents: A Systematic Review of Renal, Hepatic, and Cardiometabolic Outcomes. Cureus. 2026;18(4):e106808. doi:10.7759/cureus.106808Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a research study that investigates the microbiota-gut-brain axis by comparing coffee drinkers to non-drinkers and observing the effects of caffeine withdrawal and reintroduction. Boscaini S, Bastiaanssen TFS, Moloney GM, Bergamo F, Zeraik L, O’Leary C, et al. Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition. Nat Commun. Published online April 21, 2026. doi:10.1038/s41467-026-71264-8Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into an academic perspective that introduces Peakspan, a novel metric defined as the period when an individual maintains at least 90% of their maximum functional capacity in specific physiological or cognitive areas. The authors argue that while humans are living longer, most biological systems—including cardiorespiratory, renal, and immune functions—peak in early adulthood, creating a significant "functional gap" where people are clinically healthy but significantly declined. This misalignment poses a major threat to economic productivity and the sustainability of retirement systems as the "Biological Retirement Age" approaches earlier than the chronological one.Zhavoronkov A, Ying K, Wilczok D. Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan. Aging Dis. Published online February 25, 2026. doi:10.14336/AD.2026.0080.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a 2026 study by the MULTI Consortium that identifies a systemic, U-shaped relationship between sleep duration and biological ageing across the human body. By analyzing data from the UK Biobank, researchers utilized 23 biological ageing clocks derived from MRI imaging, plasma proteomics, and metabolomics to show that both insufficient and excessive sleep accelerate ageing in nine organ systems.O’Toole CK, Song Z, Anagnostakis F, Yang Z, Tian YE, Duggan MR, et al; MULTI Consortium. Sleep chart of biological ageing clocks in middle and late life. Nature. Published online May 13, 2026. doi:10.1038/s41586-026-10524-5Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a comprehensive systematic review and meta-analysis regarding the recovery of the median nerve after carpal tunnel release surgery. Spanning 199 studies and over 15,000 patients, the research investigates structural and functional healing through metrics like nerve conduction, sensory testing, and grip strength.Sobeeh MG, Elsisy M, Abozaid EM, et al. Neural recovery after carpal tunnel release: a systematic review with meta-analysis. J Orthop Sports Phys Ther. Published online 2026. doi:10.2519/jospt.2026.13846Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode examines the potential of creatine monohydrate as a therapeutic tool for managing osteosarcopenia, an age-related decline in both bone density and muscle mass.Candow DG, Kirk B, Chilibeck PD, Duque G. The potential of creatine monohydrate supplementation in the management of osteosarcopenia. Curr Opin Clin Nutr Metab Care. 2025;28(3):235-239. doi:10.1097/MCO.0000000000001118Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into an academic review that examines the diagnosis and management of cervical facet joint pain resulting from aging or whiplash injuries.Hellinga MD, van Eerd M, Stojanovic MP, et al. 7. Cervical facet pain: degenerative alterations and whiplash-associated disorder. Pain Pract. 2025;25(2):e70005. doi:10.1111/papr.70005Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a meta-analysis and systematic review that examines the clinical impact of early exercise versus brace immobilization for patients recovering from arthroscopic rotator cuff repair.Hao BR, Li HQ, Liang A. Effects of early exercise and immobilization after arthroscopic rotator cuff repair surgery: a systematic review and meta-analysis of randomized controlled trials. BMC Musculoskelet Disord. 2025;26:254. doi:10.1186/s12891-025-08500-7,.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a study that investigates whether vitamin D levels in early midlife are linked to early brain indicators of dementia. Researchers analyzed data from the Framingham Heart Study, tracking participants for over 16 years to compare their initial blood samples with later PET scans.Mulligan MD, Scott MR, Yang Q, Wang R, Ghosh S, Johnson KA, et al. Association of circulating vitamin D in midlife with increased tau-PET burden in dementia-free adults. Neurol Open Access. 2026;2:e000057. doi:10.1212/WN9.0000000000000057.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a systematic review and meta-analysis evaluating the impact of multidisciplinary interventions that incorporate exercise to treat non-specific chronic low back pain. By analyzing 31 studies published between 1998 and 2021, the authors sought to determine if combined therapies effectively improve health outcomes across various global regions.Vega-Retuerta N, Sánchez-Parente S, Segura-Jiménez V. Effectiveness of multidisciplinary approaches including exercise to treat non-specific chronic low back pain: A systematic review and meta-analysis across multiple regions. Prev Med. 2025;199:108381. doi:10.1016/j.ypmed.2025.108381Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and meta-analysis that evaluates how CrossFit training impacts adults who are overweight or obese.Blanco-Martínez N, González-Devesa D, Sanchez-Lastra MA, Diz-Gómez JC, Ayán-Pérez C. The effects of CrossFit® training in adults with obese or overweight: a systematic review of randomized controlled trials. Med Fam SEMERGEN. 2025;51:102512. doi:10.1016/j.semery.2025.102512Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into the 2025 EULAR updated recommendations for integrating physical activity and reducing sedentary behavior in the care of patients with inflammatory arthritis and osteoarthritis.Rausch Osthoff AK, Vliet Vlieland TPM, Ferreira RJO, Amarnani R, Battista S, Orlinov D, et al. EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis: 2025 update. Ann Rheum Dis. 2026;1-13. doi:10.1016/j.ard.2026.03.006Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a research article that investigates how long-term aerobic exercise influences various biological markers associated with cardiovascular disease (CVD) risk and psychological stress. Researchers conducted a year-long clinical trial with middle-aged adults, comparing a 150-minute weekly exercise regimen against a control group receiving only health information. The study measured diverse outcomes, including inflammation biomarkers, heart rate variability, and brain activity during stress-related tasks.Gianaros PJ, Wan L, DeCataldo MK, et al. Effects of a year-long aerobic exercise intervention on neuroendocrine, autonomic, and neural correlates of stress, emotion, and cardiovascular disease risk in midlife adults. J Sport Health Sci. 2026;101135. doi:10.1016/j.jshs.2026.101135Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and meta-analysis evaluating various preventative treatments for vestibular migraine (VM), a condition characterized by episodic vertigo and headaches. By analyzing 13 clinical studies, the authors examined the efficacy of pharmacologic agents—such as beta-blockers, calcium channel blockers, and antidepressants—alongside vestibular rehabilitation and dietary changes.Byun YJ, Levy DA, Nguyen SA, Brennan E, Rizk HG. Treatment of Vestibular Migraine: A Systematic Review and Meta-analysis. Laryngoscope. 2021;131(1):186-194. doi:10.1002/lary.28546Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a systematic review that synthesizes qualitative research to explore the lived experiences of individuals suffering from lower limb tendinopathy. The researchers identified ten core themes.Hopes M, Stubbs P, Grimaldi A, Nasser A. Lived experiences of people with lower limb tendinopathy – a systematic review with qualitative evidence synthesis. J Orthop Sports Phys Ther. Published online 2026. doi:10.2519/jospt.2026.13666Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a clinical research article that investigates the impact of per- and polyfluoroalkyl substances (PFAS) on the bone mineral density of children as they enter adolescence. By tracking 218 participants from birth to age 12, researchers evaluated how exposure to these "forever chemicals" at different developmental stages correlates with skeletal health. Buckley JP, Marquess KM, Braun JM, et al. Per- and polyfluoroalkyl substances and adolescent bone mineral density: assessing periods of susceptibility. J Endocr Soc. 2026;10(4):bvag039. doi:10.1210/jendso/bvag039.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a clinical study that evaluates the efficacy of low-load blood flow restriction training (LL-BFRT) compared to traditional heavy-load resistance training (HLRT) during the initial recovery phase following ACL reconstruction. Researchers conducted a randomized controlled trial on patients with patellar tendon grafts to determine if lighter weights paired with blood flow occlusion could effectively restore muscle strength without aggravating the joint.Koc BB, Schotanus MGM, Ehlen T, Truyens A, de Bie R, Jansen EJP. Low-load blood flow restriction training as an alternative to heavy-load resistance training in early-stage rehabilitation following bone–patellar tendon–bone anterior cruciate ligament reconstruction: a randomized controlled trial. JOSPT Open. 2026;4(2):166-173. doi:10.2519/josptopen.2026.0185Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into an article that investigates the genetic factors that influence how different individuals respond to GLP1 receptor agonists like semaglutide and tirzepatide. Su QJ, Ashenhurst JR, Xu W, et al. Genetic predictors of GLP1 receptor agonist weight loss and side effects. Nature. Published online April 8, 2026. doi:10.1038/s41586-026-10330-zFollow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a systematic review and meta-analysis that investigates how physical activity and exercise training influence the structural health of intervertebral discs (IVDs) in the human spine. By evaluating data from 39 studies, researchers compared MRI-based measurements of disc integrity between active individuals and less active controls. Samanna CL, Owen PJ, Mitchell UH, et al. The impact of exercise on intervertebral disc health: a systematic review and meta-analysis. Sports Med. Published online March 16, 2026. doi:10.1007/s40279-025-02336-w.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and meta-analysis published in The Journal of Spinal Cord Medicine that investigates whether robotic-assisted gait training (RAGT) can alleviate neuropathic pain in patients with spinal cord injuries. Researchers analyzed 32 studies involving 567 participants to determine if using robotic exoskeletons or end-effector devices improved pain intensity, pain interference, and health-related quality of life. White C, Klus S, Ho WH, Barrett L, Doherty O, Lennon O. Robotic-assisted gait training for spinal cord injury neuropathic pain: A systematic review. J Spinal Cord Med. Published online June 6, 2025. doi:10.1080/10790268.2025.2503049Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a research article that explores how daily caffeine consumption interacts with chronic sleep restriction to influence grey matter plasticity in the human brain.Lin YS, Lange D, Baur DM, et al. Repeated caffeine intake suppresses cerebral grey matter responses to chronic sleep restriction in an A1 adenosine receptor-dependent manner: a double-blind randomized controlled study with PET-MRI. Sci Rep. 2024;14:11042. doi:10.1038/s41598-024-61421-8Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and meta-analysis that evaluates the effectiveness of digital activity trackers and smartphone applications in boosting physical activity among community-dwelling adults aged 60 years and older.Hamdani N, Oliveira J, Santana P, et al. Are you counting? Effectiveness of interventions using activity trackers and smartphone applications for increasing physical activity in older people living in the community: a systematic review with meta-analysis. J Orthop Sports Phys Ther. 2026;56(4):235-247. doi:10.2519/jospt.2026.13825Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode explores the long-term relationship between visceral adipose tissue (VAT) and neurological health in adults during late midlife. Pachter D, Klein H, Kamer O, et al. Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife. Nat Commun. 2026. doi:10.1038/s41467-026-71141-4Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into how healthcare professionals can effectively encourage long-term lifestyle changes by teaching patients to form healthy habits. Rather than relying on fleeting willpower or complex instructions, the authors suggest a small changes approach where simple actions are repeated consistently in the same contextual environment. Gardner B, Lally P, Wardle J. Making health habitual: the psychology of ‘habit-formation’ and general practice. Br J Gen Pract. 2012;62(605):664-666. doi:10.3399/bjgp12X659466Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a research article investigateing how momentary fluctuations in motivation influence human decision-making during daily life. Using a microlongitudinal study with smartphone-based assessments, researchers tracked participants over two weeks to observe how their willingness to exert effort changed alongside their internal states. Hewitt SRC, Norbury A, Huys QJM, Hauser TU. Day-to-day fluctuations in motivation drive effort-based decision-making. Proc Natl Acad Sci U S A. Published March 17, 2025. doi:10.1073/pnas.2417964122Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into an article from the journal GeroScience that details a randomized controlled trial investigating how resistance training impacts the biological aging of the brain in older adults. Researchers utilized resting-state fMRI and machine learning to develop brain clock models, which estimate an individual's "brain age" based on neural connectivity patterns. Gonzalez-Gomez R, Demnitz N, Coronel C, et al. Randomized controlled trial of resistance exercise and brain aging clocks. GeroScience. Published online February 10, 2026. doi:10.1007/s11357-026-02141-xFollow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episodes dissects a paper that analyzes how daily nutritional choices immediately impact objective sleep architecture and nocturnal heart rate using data from thousands of participants. The study identifies two primary "levers" of sleep regulation: dietary composition and meal timing. Shkolnik M, Sapir G, Shilo S, Talmor-Barkan Y, Segal E, Rossman H. Day-to-day dietary variation shapes overnight sleep physiology: a target-trial emulation in 4.8 thousand person-nights. Preprint. 2025Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a systematic review that examines the effectiveness of psychosocial interventions in minimizing long-term pain for patients undergoing total knee arthroplasty (TKA). By analyzing fifteen clinical studies, the researchers evaluated various methods such as cognitive-behavioral therapy (CBT), mindfulness, and relaxation techniques to address the psychological drivers of chronic discomfort. Rojas Marcos C, Schiller N, Braun S, et al. Psychosocial interventions to reduce post operative pain in total knee arthroplasty: a systematic review. HSS J. 2026;22(1):71-79. doi:10.1177/15563316241260717Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a narrative review that examines 38 publications to evaluate the effectiveness of spinal manipulative therapy (SMT) for managing fibromyalgia.Roecker CB, Hewawasam SR. Spinal manipulation for fibromyalgia: a narrative review. J Can Chiropr Assoc. 2025;69(1):33-48.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a systematic review that evaluates the safety and effectiveness of exercise as a treatment for individuals suffering from long COVID. McDowell CP, Tyner B, Shrestha S, et al. Effectiveness and tolerance of exercise interventions for long COVID: a systematic review of randomised controlled trials. BMJ Open. 2025;15:e082441. doi:10.1136/bmjopen-2023-082441Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and meta-analysis that evaluates the effectiveness of acupuncture as a treatment for whiplash-associated disorders (WAD) resulting from vehicular accidents. Researchers synthesized data from eight randomized controlled trials involving over 500 patients to determine if the practice alleviates symptoms better than standard medical care. Lee SH, Park SY, Heo I, Hwang EH, Shin BC, Hwang MS. Efficacy of acupuncture for whiplash injury: a systematic review and meta-analysis. BMJ Open. 2024;14:e077700. doi:10.1136/bmjopen-2023-077700Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a research review that evaluates how physical activity and exercise impact the health of occupational drivers, a group prone to chronic illness due to high sedentary behavior and obesity. Zeb A, Verbrugghe J, Neven A, et al. Effects of Physical Activity and Exercise Interventions on Health Outcomes in Occupational Drivers: A Systematic Review. Workplace Health Saf. 2024. doi:10.1177/21650799241291903Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a study examining how natural daylight compared to artificial office lighting affects the metabolic health of individuals with type 2 diabetes.Harmsen JF, Habets I, Biancolin AD, et al. Natural daylight during office hours improves glucose control and whole-body substrate metabolism. Cell Metab. 2026;38:65-81. doi:10.1016/j.cmet.2025.11.006Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode explores the critical link between cardiovascular wellness and maintaining proper hydration levels. It examines how a lack of sufficient fluids can negatively impact the heart's ability to function efficiently. Medically Reviewed Editorial - Authored by Julie Stewart and clinically vetted by Dr. Ecler Ercole Jaqua MD.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a systematic review and evidence map examining the prognostic factors that influence the long-term recovery of individuals with patellofemoral pain. Neal BS, Bolgla LA, Lack SD, et al. Prognosis of patellofemoral pain: a systematic review with evidence- and gap-map. J Orthop Sports Phys Ther. 2025;55(10):661-670. doi:10.2519/jospt.2025.13491Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects an article that investigated whether a patient’s pre-treatment expectations influence the success of manual therapy for reducing knee osteoarthritis pain. By pooling data from two randomized trials involving 375 participants, researchers compared the outcomes of combined exercise and manual therapy against exercise alone.Caya R, Gayed M, Wilson R, et al. Do treatment expectations moderate the effect of manual therapy in people with knee osteoarthritis? A secondary analysis of randomised clinical trials. JOSPT Open. Advance publication. doi:10.2519/josptopen.2026.0180Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a comprehensive 2026 position stand from The International Society of Sports Nutrition regarding the impact of antioxidants on physical performance and recovery. Gonzalez DE, Dickerson BL, Roberts BM, et al. International Society of Sports Nutrition position stand: effects of dietary antioxidants on exercise and sports performance. J Int Soc Sports Nutr. 2026;23(1):2629828. doi:10.1080/15502783.2026.2629828Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into an article on Nicotinamide adenine dinucleotide (NAD+), which is an essential coenzyme that facilitates vital biological processes such as energy production, DNA repair, and metabolic balance. Because NAD+ levels naturally decline with age, researchers are investigating various precursors like NR and NMN, alongside enzyme inhibitors, to restore cellular health.Yusri K, Jose S, Vermeulen KS, Tan TCM, Sorrentino V. The role of NAD+ metabolism and its modulation of mitochondria in aging and disease. npj Metab Health Dis. 2025;3:26. doi:10.1038/s44324-025-00067-0Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a research paper that examines whether Valentine’s Day influences the occurrence of myocardial infarctions, or heart attacks, among adults in Quebec. Auger N, Bilodeau-Bertrand M, Ayoub A, Potter BJ. Matters of the heart: case-crossover analysis of myocardial infarction on Valentine’s Day. CJC Open. 2021;3:1075-1078. doi:10.1016/j.cjco.2021.03.013Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a paper that examines exercise as a treatment for depression.Clegg AJ, Hill JE, Mullin DS, et al. Exercise for depression. Cochrane Database Syst Rev. 2026;1:CD004366. doi:10.1002/14651858.CD004366.pub7Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a review paper that evaluates physical therapy for ALS, finding that multimodal and pulmonary interventions offer modest benefits for functional and respiratory health.Macpherson CE, Wani DK, Li H, et al. Physical Therapist Interventions for People With Amyotrophic Lateral Sclerosis Across Disease Stages: A Systematic Review of Efficacy. Phys Ther. 2026;106(1):pzaf142. doi:10.1093/ptj/pzaf142.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode does a deep dive into a study showing how creatine monohydrate improves vascular function in older adults.Clarke HE, Akhavan NS, Behl TA, Ormsbee MJ, Hickner RC. Effect of creatine monohydrate supplementation on macro- and microvascular endothelial function in older adults: a pilot study. Nutrients. 2024;17(1):58. doi:10.3390/nu17010058Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

This episode dissects a Mendelian randomization study that identifies a high body mass index (BMI) as a causal risk factor for vascular-related dementia.Nordestgaard LT, Luo J, Emanuelsson F, et al. High body mass index as a causal risk factor for vascular-related dementia: a Mendelian randomization study. J Clin Endocrinol Metab. Published online January 22, 2026. doi:10.1210/clinem/dgaf662Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠