136. What Does 5-MeO-DMT Do to Trust?
from SetSet with April Pride Hosted by Of Like Minds
Psychedelics & Trust is a 12-week Substack series created and written by host April Pride, who is microdosing psilocybin while writing. In this episode, she reads her Week Two dispatch, which happened to be the week of her first 5-MeO-DMT experience, which she approached with the intention of exploring where her self-trust broke down, the brain science behind why distrust can feel like knowing, and why distrust is a prediction that can be revised. Topics include how 5-MeO-DMT differs from N,N-DMT, synthetic versus toad-derived 5-MeO-DMT, what the StepWise protocol is, and how fear conditioning, extinction learning, and estrogen may shape the way we trust. Additional Resources Who was Amanda Fielding? From the Mac to the Mystical Bill - from The Pattern Project Read the full Trust Series and show notes on Substack: https://aprilpride.substack.com Psychedelic Salon at Town Hall Seattle - 2026-27 Schedule Follow April on Substack Visit aprilpride.com Hosted by April Pride IG: @aprilpridecreates YouTube: youtube.com/@aprilpridecreates
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