165: E. coli: NDM and PBP variants

As a new microbiologist sometimes terms like beta-lactams, beta-lactamases, or penicillin-binding proteins (PBPs) can be confusing. Are you familiar with the New-Delhi metallo-beta-lactamase (NDM) and its variants? How many are there? How does this enzyme affect beta-lactam drugs?How about NDM-5? In this episode Luis is joined by Dr. Raneem Pallotta, an infectious diseases pharmacist. In the episode we go over these terms. Dr. Pallotta also talks about an NDM-producing E. coli that harbors PBP3 variants. How do these variants affect beta-lactam antibiotics? Tune in for a great episode. Link to Dr. Pallotta's article: https://www.contagionlive.com/view/ndm-producing-e-coli-harboring-pbp-insert-variants-emerges-as-new-threat Link to other articles: https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-017-1012-8 https://pmc.ncbi.nlm.nih.gov/articles/PMC5527577/ https://pubmed.ncbi.nlm.nih.gov/34800710/ https://pubmed.ncbi.nlm.nih.gov/32040179/ https://pubmed.ncbi.nlm.nih.gov/25634992/ https://www.idsociety.org/practice-guideline/amr-guidance/ Questions? Feedback? Send those to [email protected] Want to support the podcast? Here's how: Venmo: https://venmo.com/u/letstalkmicro Buy me a Ko-fi: https://ko-fi.com/letstalkmicro