19. Clinical Insights into PMDD, Severe PMS & the Role of Methylation

In this episode of The Histamine Well, Joanne dives deep into Premenstrual Dysphoric Disorder (PMDD) and severe PMS — the kind that can leave you feeling anxious, depressed, exhausted, and unlike yourself for half the month.Joanne shares insights from her clinical practice to explore what’s really going on beneath the surface, including:Hormone imbalances like estrogen dominance and low progesteroneInflammation, oxidative stress, and their impact on ovulationNutrient deficiencies that affect mood and hormone functionThe surprising role of methylation imbalances — particularly overmethylation — and how this biochemical pathway can disrupt neurotransmitters and moodShe also introduces the concept of testing methylation in real time, and shares a powerful patient story that shows how personalized treatment can dramatically improve mood and cycle symptoms.Whether you’ve been diagnosed with PMDD or you just know your PMS isn’t normal, this episode offers a fresh perspective and hope for more stable cycles and moods.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!