55: Paternal Exercise Epigenetics: Sperm microRNAs Transmit Endurance to Offspring

from Listen, Learn, Adapt · host Anthony Novello

This episode details experimental evidence demonstrating that paternal exercise in mice, either via treadmill training or muscle-specific genetic overexpression of PGC-1α, transmits enhanced endurance capacity and metabolic health to offspring.Yin X, Anwar A, Yan L, Yu R, Luo Y, Shi L, et al. Paternal exercise confers endurance capacity to offspring through sperm microRNAs. Cell Metab. 2025;37:1-18. doi:10.1016/j.cmet.2025.09.003.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠

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This episode was published on November 1, 2025.

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