61: Functional Genomics, Epigenetics + Oxidative Stress for Holistic Health | Jaclyn Downs episode artwork

EPISODE · Sep 9, 2025 · 1H 7M

61: Functional Genomics, Epigenetics + Oxidative Stress for Holistic Health | Jaclyn Downs

from Holistic Savage Podcast · host Metabolic Solutions

Hey Functional Friends!This week I'm speaking with one of my favorite people, the brilliant Jaclyn Downs, a leading expert in functional genomics. We explore Jaclyn's journey into functional medicine, the impact of oxidative stress and inflammation, and the importance of comprehensive genetic testing. We delve into the interplay of genetics and environmental factors, particularly in relation to fertility challenges and the future of genomic medicine, and address the impact of trauma on health, the significance of methylation, and the nuances of interpreting genetic data. This was a super awesome conversation and I think you're going to love it. Jaclyn Downs, MS, is a functional nutrigenomics practitioner with advanced training in holistic nutrition, health coaching, and epigenetics. With a lifelong passion for “outside the box” approaches to health, she specializes in uncovering genetic root causes, nutrient imbalances, and environmental stressors that impact fertility and overall wellness. Through personalized protocols that integrate genetic testing, functional lab work, and lifestyle insights, Jaclyn empowers clients to restore vitality and optimize their health at the deepest level.Check out Jaclyn's new book, "Enhancing Fertility through Functional Medicine"00:00 Introduction to Functional Genomics00:59 Jaclyn's Journey into Functional Medicine04:07 Understanding Oxidative Stress and Inflammation07:52 The Importance of Comprehensive Genetic Testing11:53 Navigating Genetic Variants and Their Implications17:07 The Role of Epigenetics in Health21:06 Integrating Genomics into Functional Medicine25:00 Key Genetic Variants to Consider29:09 The Future of Genomic Medicine39:07 Understanding Glutathione Recycling and Genetic Variants41:58 The Role of Organic Acids in Functional Genomics43:15 Exploring Autism Through Functional Genomics45:10 The Impact of Environmental Toxins on Health48:17 Fertility Challenges and Genetic Influences52:15 Optimizing Health for Future Generations56:13 Navigating Genetic Testing and Supplementation01:01:19 Folinic Acid vs. Methylfolate: A Nutritional Debate01:06:33 Resources for Understanding Functional GenomicsCheck Out Brendan:Brendan’s Instagram: ⁠⁠⁠⁠@the_holistic_savage⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Brendan Online⁠⁠⁠⁠- - - Send in a voice message:⁠⁠⁠⁠http://podcasters.spotify.com/pod/show/holisticsavagepodcast/message

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61: Functional Genomics, Epigenetics + Oxidative Stress for Holistic Health | Jaclyn Downs

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