61: Functional Genomics, Epigenetics + Oxidative Stress for Holistic Health | Jaclyn Downs episode artwork

EPISODE · Sep 9, 2025 · 1H 7M

61: Functional Genomics, Epigenetics + Oxidative Stress for Holistic Health | Jaclyn Downs

from Holistic Savage Podcast · host Metabolic Solutions

Hey Functional Friends!This week I'm speaking with one of my favorite people, the brilliant Jaclyn Downs, a leading expert in functional genomics. We explore Jaclyn's journey into functional medicine, the impact of oxidative stress and inflammation, and the importance of comprehensive genetic testing. We delve into the interplay of genetics and environmental factors, particularly in relation to fertility challenges and the future of genomic medicine, and address the impact of trauma on health, the significance of methylation, and the nuances of interpreting genetic data. This was a super awesome conversation and I think you're going to love it. Jaclyn Downs, MS, is a functional nutrigenomics practitioner with advanced training in holistic nutrition, health coaching, and epigenetics. With a lifelong passion for “outside the box” approaches to health, she specializes in uncovering genetic root causes, nutrient imbalances, and environmental stressors that impact fertility and overall wellness. Through personalized protocols that integrate genetic testing, functional lab work, and lifestyle insights, Jaclyn empowers clients to restore vitality and optimize their health at the deepest level.Check out Jaclyn's new book, "Enhancing Fertility through Functional Medicine"00:00 Introduction to Functional Genomics00:59 Jaclyn's Journey into Functional Medicine04:07 Understanding Oxidative Stress and Inflammation07:52 The Importance of Comprehensive Genetic Testing11:53 Navigating Genetic Variants and Their Implications17:07 The Role of Epigenetics in Health21:06 Integrating Genomics into Functional Medicine25:00 Key Genetic Variants to Consider29:09 The Future of Genomic Medicine39:07 Understanding Glutathione Recycling and Genetic Variants41:58 The Role of Organic Acids in Functional Genomics43:15 Exploring Autism Through Functional Genomics45:10 The Impact of Environmental Toxins on Health48:17 Fertility Challenges and Genetic Influences52:15 Optimizing Health for Future Generations56:13 Navigating Genetic Testing and Supplementation01:01:19 Folinic Acid vs. Methylfolate: A Nutritional Debate01:06:33 Resources for Understanding Functional GenomicsCheck Out Brendan:Brendan’s Instagram: ⁠⁠⁠⁠@the_holistic_savage⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Brendan Online⁠⁠⁠⁠- - - Send in a voice message:⁠⁠⁠⁠http://podcasters.spotify.com/pod/show/holisticsavagepodcast/message

Hey Functional Friends!This week I'm speaking with one of my favorite people, the brilliant Jaclyn Downs, a leading expert in functional genomics. We explore Jaclyn's journey into functional medicine, the impact of oxidative stress and inflammation, and the importance of comprehensive genetic testing. We delve into the interplay of genetics and environmental factors, particularly in relation to fertility challenges and the future of genomic medicine, and address the impact of trauma on health, the significance of methylation, and the nuances of interpreting genetic data. This was a super awesome conversation and I think you're going to love it. Jaclyn Downs, MS, is a functional nutrigenomics practitioner with advanced training in holistic nutrition, health coaching, and epigenetics. With a lifelong passion for “outside the box” approaches to health, she specializes in uncovering genetic root causes, nutrient imbalances, and environmental stressors that impact fertility and overall wellness. Through personalized protocols that integrate genetic testing, functional lab work, and lifestyle insights, Jaclyn empowers clients to restore vitality and optimize their health at the deepest level.Check out Jaclyn's new book, "Enhancing Fertility through Functional Medicine"00:00 Introduction to Functional Genomics00:59 Jaclyn's Journey into Functional Medicine04:07 Understanding Oxidative Stress and Inflammation07:52 The Importance of Comprehensive Genetic Testing11:53 Navigating Genetic Variants and Their Implications17:07 The Role of Epigenetics in Health21:06 Integrating Genomics into Functional Medicine25:00 Key Genetic Variants to Consider29:09 The Future of Genomic Medicine39:07 Understanding Glutathione Recycling and Genetic Variants41:58 The Role of Organic Acids in Functional Genomics43:15 Exploring Autism Through Functional Genomics45:10 The Impact of Environmental Toxins on Health48:17 Fertility Challenges and Genetic Influences52:15 Optimizing Health for Future Generations56:13 Navigating Genetic Testing and Supplementation01:01:19 Folinic Acid vs. Methylfolate: A Nutritional Debate01:06:33 Resources for Understanding Functional GenomicsCheck Out Brendan:Brendan’s Instagram: ⁠⁠⁠⁠@the_holistic_savage⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Brendan Online⁠⁠⁠⁠- - - Send in a voice message:⁠⁠⁠⁠http://podcasters.spotify.com/pod/show/holisticsavagepodcast/message

NOW PLAYING

61: Functional Genomics, Epigenetics + Oxidative Stress for Holistic Health | Jaclyn Downs

0:00 1:07:47

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

That Hoarder: Overcome Compulsive Hoarding That Hoarder Hoarding disorder is stigmatised and people who hoard feel vast amounts of shame. This podcast began life as an audio diary, an anonymous outlet for somebody with this weird condition. That Hoarder speaks about her experiences living with compulsive hoarding, she interviews therapists, academics, researchers, children of hoarders, professional organisers and influencers, and she shares insight and tips for others with the problem. Listened to by people who hoard as well as those who love them and those who work with them, Overcome Compulsive Hoarding with That Hoarder aims to shatter the stigma, share the truth and speak openly and honestly to improve lives. The Small Business Startup School – Business Notes | Financial Literacy | Retail Psychology – For Professionals & Entrepreneurs The Small Business Startup School Inc. Starting or buying a small business? While personal circumstances may vary, business patterns remain timeless. On The Small Business Startup School, we explore strategies, insights, and practical solutions to help entrepreneurs confidently navigate their journey.Hosted by Ola Williams—a retail entrepreneur, fintech founder, and financial coach with over two decades of experience—this podcast marries financial awareness and retail psychology with optimism to deliver actionable takeaways.Join us to learn, grow, and connect as we uncover the keys to business success.Let’s continue to learn together and be encouraged to keep on connecting! DIOSA. Carolina Sanper This podcast is a sacred space created by Carolina Sanper where you connect with your inner wisdom and embody your magnetic feminine power.It is the realization that the mystical realm is where you plant the seeds of your desired reality.It is a portal to your true essence: awareness, presence, and receiving with ease. Welcome home, DIOSA. 🖤 XXX Tech by SOVRYN Dr. Brian Sovryn The crossroads between technology, sensuality, and metaphysics - and the longest running anarchist podcast in the world! Brought to you by Dr. Brian Sovryn.

Frequently Asked Questions

How long is this episode of Holistic Savage Podcast?

This episode is 1 hour and 7 minutes long.

When was this Holistic Savage Podcast episode published?

This episode was published on September 9, 2025.

What is this episode about?

Hey Functional Friends!This week I'm speaking with one of my favorite people, the brilliant Jaclyn Downs, a leading expert in functional genomics. We explore Jaclyn's journey into functional medicine, the impact of oxidative stress and inflammation,...

Can I download this Holistic Savage Podcast episode?

Yes, you can download this episode by clicking the download button on the episode player, or subscribe to the podcast in your preferred podcast app for automatic downloads.
URL copied to clipboard!