68: Metformin Blunts Vascular Insulin Sensitivity After E...

What this episode covers

This episode does a deep dive into a study that investigated the combined effects of the drug metformin and various exercise training intensities on vascular health. The research utilized a double-blind, placebo-controlled trial involving adults at risk for Metabolic Syndrome, dividing participants into groups receiving either low-intensity exercise (LoEx) or high-intensity exercise (HiEx), each with either metformin (Met) or a placebo (PL). Malin SK, Heiston EM, Battillo DJ, Ragland TJ, Gow AJ, Shapses SA, Shah AM, Patrie JT, Barrett EJ. Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome. J Clin Endocrinol Metab. 2025. doi:10.1210/clinem/dgaf551.Follow Dr. Anthony Novello, PT, DPT⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@anthonynovello.dpt⁠⁠

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How long is this episode of Listen, Learn, Adapt?

This episode is 39 minutes long.

When was this Listen, Learn, Adapt episode published?

This episode was published on December 10, 2025.

What is this episode about?

This episode does a deep dive into a study that investigated the combined effects of the drug metformin and various exercise training intensities on vascular health. The research utilized a double-blind, placebo-controlled trial involving adults at...

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