#95 — The Next Rapamycin?: Ora Biomedical’s Million Molecule Moonshot w/CEO Mitchell Lee, PhD

Today we are talking with Mitchell Lee, PhD about the biology of aging and how pharmaceutical and natural product interventions can help older athletes prolong our healthy, active lives while fighting disease by addressing the root causes of aging. This conversation is aimed at the lay-person to allow us non-scientists to benefit from Dr Lee's deep knowledge of this topic. What biological aging really is...what is actually happening in the bodyRecent progress made in aging science Longevity and healthspan interventions available today and where is the research going Want to support the show? If you are enjoying WiseAthletes, a great way to support the show is by leaving a review on the Apple Podcasts. It only takes a minute and helps more people find the episodes. Thanks. Dr Mitchell Lee Bio Dr Lee received his PhD in Experimental Pathology from the University of Washington School of Medicine, where he trained with Matt Kaeberlein . He is the Co-founder and CEO of Ora Biomedical, a new pharmaceutical company seeking to realize the full potential of healthy aging therapeutics by developing "a new generation of broad use small molecule healthy aging interventions for humans, companion pets, and all other organisms for which prolonged healthy survival is desired." Links to checkout: Dr Lee on Twitter @michellblee33Ora Biomedical websiteNIA ITP programrapamycin.news Lifespan extending chemicals confirmed by NIA ITP: Rapamycin Acarbose (males>females)17a-estradiol (males only)Canagliflozin (SLGT2 inhibitor; males only)Smaller but significant benefits from three other agents: NDGA, Protandim, glycineMany more currently being tested (see website for details) The National Institute on Aging Interventions Testing Program was designed to be the most exhaustive testing framework and system to evaluate whether longevity molecules extend longevity in mice and understand the underlying mechanisms leading to those benefits. Outline of Discussion: Intro 00:08Discussion begins 2:15Dr Lee’s background 3:00Aging is more than entropy 3:48Modeling aging 4:44What can we learn from studying worms? 5:18What is aging, really? 7:25Lifespan vs healthspan / chronological vs biological age 8:24Hallmarks of aging 12:45More on aging process 15:39Dr Lee’s advice 23:13National Institute of Aging / Dog Aging project / Interventions Testing Program 26:49Rapamycin deep dive 32:38How to accelerate the search for better interventions? 36:18What can older athletes do now to take advantage of longevity interventions 46:30Watch out for over exuberance 48:29How much of a benefit is possible? 49:47How to learn more about ora 51:47 Aging hallmarks Genomic instability – DNA damage that mutates cells and can potentially cause cancer a