A Blood Test Before Symptoms: PPP2R5C and the Molecular Clock of Alzheimer's

🧠 Alzheimer's doesn't begin when memory fails — it begins years earlier.   A new Cell Reports Medicine study identifies PPP2R5C, a brain-derived protein detectable in blood, that declines before significant Tau hyperphosphorylation.   📉 ↓ 61% in amnestic mild cognitive impairment 📊 AUC 0.85 for Alzheimer's diagnosis 🔬 Mechanism: activates Protein Phosphatase 2A and ULK1-driven autophagy to regulate Tau   A blood signal before symptoms. Early detection means earlier intervention.