PODCAST · science
Dr RR Baliga's "Got Knowledge Doc" Podkast
by Dr RR Baliga, MD, MBA
"Got Knowledge Doc" Podkast with Dr. RR BaligaThe "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond.Each episode delves into topics such as cardiology, precision medicine, artificial intelligence in healthcare, epigenetics, and medical ethics—making complex advancements accessible and relevant to clinical practice. Importantly, this podcast is purely educational and does not provide medical advice or clinical opinions.Join Dr. Baliga and his esteemed guests as they navigate the evolving landscape of medical knowledge, empowering healthcare professionals with evidence-based insights that shape the fu
Episodes
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🤖🩺 The Doctor's AI Assistant: Smarter Visits, Better Conversations?
🤖🩺 AI, Answers & Appointments: Is Your Doctor's New Assistant a Chatbot? Could your next doctor's visit begin with a conversation with AI? 🔬 A fascinating 2026 Lancet study tested conversational AI in primary care. 📊 Among 98 patients completing the study: ✅ Zero predefined safety stops ✅...
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🩸 Great Doctors Series: Ambroise Paré — From Battlefield Bloodshed to Better Surgery
⚔️ What happens when a battlefield surgeon dares to question centuries of tradition? Meet Ambroise Paré (c.1510–1590)—barber-surgeon, innovator and one of the fathers of surgery. 🩺 From abandoning agonizing boiling-oil wound treatment to championing arterial ligatures, Paré showed that careful...
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📚 Myths, Metaphors & Magic: Anne Carson Wins the 2026 Nobel Prize!
🏆📚 Myths, Metaphors & Magic: Meet Anne Carson, the 2026 Nobel Literature Laureate! What happens when ancient Greek myths meet modern love, grief, and imagination? ✨ Canadian poet Anne Carson has reinvented literature by blending poetry, storytelling, and classical scholarship. 📖 Three...
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🏆👻 Ghost Particles, Frozen Ice & Cosmic Secrets: The 2026 Nobel Prize in Physics!
🏆👻 Ghost Particles, Frozen Ice & Cosmic Secrets! What if a cubic kilometer of Antarctic ice could unlock the universe's deepest mysteries? 🌌❄️ The 2026 Nobel Prize in Physics honors Francis Halzen for pioneering IceCube, a giant observatory that detects elusive neutrinos—tiny particles that...
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🏆 People, Prices & Policy: The 2026 Economics Nobel Explained
🏆 What can physicians learn from the 2026 Economics Nobel? Robert E. Hall and Michael Woodford transformed macroeconomics by looking beneath the headline numbers—to the decisions and expectations of households and businesses. 🧠 The lesson feels remarkably clinical: diagnose before you treat. A...
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💪 Protein, Portions & Perspective: How Much Is Enough for South Asians?
🥗 Protein in India: Myths, Meals & Muscle Are claims of widespread protein deficiency overlooking calories and food quality? Anura Kurpad and Harshpal Singh Sachdev's newspaper article examines this debate. 💪 Its calorie-based estimates translate to ~45 g/day for active adults and up to 60…
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⚖️ GZMK vs GZMB: The T-Cell Balance That May Define Healthy Aging
🧬 Can your T cells reveal how well you're aging? A remarkable Immunity study integrated 2,609 people and >12 million cells across 8 cohorts. Researchers identified divergent CD8+ effector-memory T-cell trajectories: a higher GZMK+/GZMB+ ratio tracked healthier aging, while GZMB+ cells were…
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62.5% 5-year all-cause mortality in symptomatic Peripheral Arterial Disease
🦵 PAD is not simply a disease of the legs—it is systemic atherosclerosis with profound cardiovascular and human consequences. 📊 Symptomatic PAD: 62.5% 5-year all-cause mortality. 🌍 >316 million adults affected globally. 🚶 Yet mobility, pain, independence and mental health are too often...
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🔍 Great Doctors Series: Vesalius—The Doctor Who Dared to Look
🫀 What happens when a young doctor stops trusting the textbook—and looks for himself? Meet Andreas Vesalius (1514–1564), whose human dissections exposed errors inherited from Galen's animal anatomy. 🔍 At just 28, he published the magnificent De Humani Corporis Fabrica (1543), helping transform...
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🧠 Menopause, Molecules & Memory: Is the Brain Sending a Warning?
🧠 Menopause, Molecules & Memory Could menopause be a "stress test" for the brain? 🔬 Researchers identified 16 brain-related blood proteins elevated after menopause. The signature tracked with higher FSH and lower estradiol, while inflammatory cytokines were especially elevated in women…
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🐾 Why Big Dogs Age Faster: An Epigenetic Answer
🐕 Bigger Dogs, Faster Clocks, Shorter Lives? A fascinating Science study analyzed 1,640 DNA methylomes from 894 dogs. 🧬 Epigenetic age predicted mortality, with each additional year of residual biological age associated with a 15% higher mortality hazard. Most strikingly, larger dogs showed 31%...
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2026 Nobel Chemistry Prize: ⚗️ Tiny Tilt, Giant Shift: How Chemistry Chooses a Side
🏆🧬 Tiny Tilt, Giant Shift: How Chemistry Chooses a Side Why does life favor one molecular "hand"? The 2026 Chemistry Nobel honors Henri Kagan and Kenso Soai for showing how tiny chiral imbalances can become dramatically amplified. ⚗️ In Soai's landmark experiment, just 2% enantiomeric excess...
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🛡️ Beyond Cholesterol: GIMAP6, Vascular Defense & Atherosclerosis
🧬 Can atherosclerosis become lethal even without high cholesterol? A fascinating Cell study identifies GIMAP6 as an immune–vascular safeguard. Loss of GIMAP6 disrupts endothelial integrity and activates a mitoROS → PPARγ → CD36 pathway, driving macrophage lipid uptake, foam cells, inflammation,...
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Beyond Breast Cancer 🩻❤️: When a Mammogram Warns the Heart
🩻 Could a mammogram also offer a window into cardiovascular risk? ❤️ Breast arterial calcification (BAC), once largely dismissed as incidental, is increasingly recognized as a cardiovascular risk signal. Greater BAC burden has been associated with adverse outcomes, including stroke and heart...
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🌿➡️🧠 From Algae to the Brain: Optogenetics Wins the 2026 Nobel
🏆💡 From algae to the brain—a Nobel journey! The 2026 Nobel Prize in Physiology or Medicine honors Karl Deisseroth, Peter Hegemann & Georg Nagel for discoveries involving light-gated ion channels and optogenetics. 🌿 Channelrhodopsin in algae ➡️ 💡 Blue light opens the channel ➡️ ⚡ Ions flow ➡️…
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💊 Great Doctors Series: Paracelsus—When Poison Becomes Medicine & the Birth of Toxicology
☠️ Only the dose makes the poison. Meet Paracelsus (1493–1541)—physician, alchemist, provocateur, and a father of toxicology. ⚗️ He challenged Galen and Avicenna, championed observation over unquestioned authority, brought chemistry and minerals into therapeutics, studied miners' diseases, and...
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Missed by Stockholm, Remembered by Science magazine
🏅 Six breakthroughs. Zero Nobels. Medicine transformed. Why do some discoveries that fundamentally reshape biology never receive science's most famous prize? 🧬🧠 From Avery showing that DNA carries hereditary information, to Milner redefining memory, Till & McCulloch establishing stem cells,...
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🔥 The 25% Effect: Retatrutide Redefines Weight Loss
In TRIUMPH-1, once-weekly retatrutide produced mean weight loss of up to 25% at 80 weeks—but the story extends beyond the scale. ⚖️ 🦵 Less knee osteoarthritis pain 😴 Fewer obstructive sleep apnea events ❤️ Improved cardiometabolic measures 🩸 89–93% with prediabetes reverted to normoglycemia A...
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Eat More, Eat Less, Live Better 🍎❤️: The 2026 ACC Guide to Cardiovascular Nutrition
🥗 Can we eat our way to a healthier heart? ❤️ The 2026 ACC Scientific Statement shifts the conversation from isolated nutrients to foods, dietary patterns, and degree of processing. 🌱 The message is remarkably practical: eat more vegetables, fruits, legumes, whole grains, nuts, seeds and…
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🧬 One Mutation, Massive Risk: EGFR T790M and Inherited Lung Cancer
🧬 Rare Variant, Real Risk: EGFR T790M and Lung Cancer Can lung cancer risk be inherited—even in never-smokers? 🫁🚭 In >3.3 million individuals, germline EGFR T790M was rare (~1 in 15,850) but strongly associated with lung cancer (OR 25.18). The association was particularly striking among...
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🌱 A Probiotic for Longevity? Microbes, Metabolites & Healthier Aging
🦠 Could a gut microbe help counter inflammaging? A fascinating Nature Aging study identifies Bifidobacterium pseudocatenulatum as a candidate geroprotective species that declines with age. Its metabolite 5-AVAB also falls with aging. In naturally aged mice, probiotic treatment improved…
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🌾 60–100 Grams a Day: The Whole-Grain Cardiometabolic Advantage
🌾 Whole Grains, Real Gains! 🫀 How much whole grain does it take to move cardiometabolic risk factors? A meta-analysis of 87 randomized trials suggests a sweet spot around 60–100 g/day dry weight. Benefits were most clinically relevant for lipids and systolic blood pressure, while effects on...
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🫀 The Heart's Forgotten Drain: Aging, Lymphatics & Inflammation
🫀 Could the aging heart have a drainage problem? A fascinating study in Nature Cardiovascular Research shows that aging reduces cardiac lymphatic vessels, with tighter junctions, impaired clearance, inflammation, edema, fibrinogen and amyloid accumulation. 🔥 🧬 Mechanistically: aging → ↓VEGFC →...
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🩸 Reengineering Coagulation: Bridging Factors, Bypassing Factor VIII, Transforming Hemophilia
🩸 Can you replace factor VIII without actually replacing factor VIII? Emicizumab does something more ingenious: this bispecific antibody bridges factor IXa and factor X, functionally recreating a critical role of factor VIIIa. 🔬 After screening ~40,000 candidates, researchers engineered a…
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Great Doctors Series: 🦠 Fracastoro, Fomites & the Seeds of Contagion
🦠 Before Germ Theory: Fracastoro, Fomites & the Seeds of Contagion In 1546—centuries before microbes could be seen—Girolamo Fracastoro proposed that epidemic diseases spread through transferable "seeds" or "spores": by direct contact, contaminated objects, or even at a distance. 🔬 He introduced...
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🧠 Orexin Awakens: Sleep, Science & Serendipity
🧠 From Discovery to Lasker to Drug Therapy! In 1998, Emmanuel Mignot and Masashi Yanagisawa helped launch discoveries that transformed our understanding of orexin and narcolepsy—work now recognized with the 2026 Albert Lasker Award for Basic Medical Research. 🏆 The translational arc is...
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🎭 Afib Ablation vs Sham: When Rhythm and Relief Part Ways
🫀 Less AF—but not more relief? PVI-SHAM-AF delivers a provocative lesson. In symptomatic atrial fibrillation, catheter ablation substantially reduced AF detected on Holter, yet did not demonstrate superiority over sham for AF-related quality of life at 6 months. 🎭 💡 The clinical pearl: rhythm...
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🍞 Starch, Signals & Systemic Immunity: Not All Carbs Behave Alike
🍞 Same calories—but very different immune signals. A randomized controlled feeding trial examined 44 adults after ~15% weight loss on a very-low-carbohydrate diet. Reintroducing refined starch activated immune and metabolic pathways, increased adipsin/complement signaling, and produced…
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🫀 The Infarct Ends. The Risk Doesn't.
🫀 The infarct ends. The risk doesn't. After myocardial infarction, atherosclerosis, thrombosis, inflammation, depression, deconditioning—and declining adherence—can sustain risk for decades. Our editorial proposes Persistent Prevention: 🔄 reassess evolving risk, 🎯 treat residual risk, 💊…
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🫀 The Spleen–Heart Axis: Could the spleen hold a missing clue to coronary artery disease?
🫀 Could the spleen hold a missing clue to coronary artery disease? Kamineni et al. used deep learning to extract 107 splenic MRI features in >42,000 UK Biobank participants. 🔬 Ten were associated with CAD, while genomics identified 219 loci—including the enigmatic 9p21 CAD locus. 🧬 The...
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🚨❤️ Pregnancy as a Cardiovascular Stress Test: A Window Into Lifelong Cardiovascular Health
🤰❤️ Pregnancy may be one of our earliest cardiovascular stress tests. A Lancet editorial reminds us that cardiovascular disease complicates up to 15% of pregnancies and accounts for up to one-third of maternal deaths. Gestational hypertension predicts a 6× higher risk of later chronic...
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Great Doctors Series: Pietro d'Abano⚕️ The Great Reconciler
🔥 Medicine, Heresy & the Stars: Pietro d'Abano Meet Pietro d'Abano (c.1257–1315/16)—physician, philosopher, astrologer, and one of medieval medicine's great intellectual boundary-crossers. 🩺📚 Drawing on Aristotle, Avicenna and Averroes, his Conciliator tried to reconcile medicine with natural...
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🔥 Drop Aspirin? Not So Fast in High-Ischemic-Risk Patients
🩸 Drop aspirin after 12 months? A-CLOSE says: not so fast. In 3,203 high-ischemic-risk patients after drug-eluting stenting, clopidogrel alone was noninferior to extended DAPT for net clinical events (5.0% vs 5.1%). But beneath that reassuring composite was a striking trade-off: ischemic events...
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💉 Lysis Before Collapse: PRAGUE-26 Changes the PE Conversation
🫁 Stable—but not safe. Should we intervene before patients crash? PRAGUE-26 randomized 558 patients with intermediate-high–risk acute pulmonary embolism to catheter-directed low-dose alteplase + anticoagulation or anticoagulation alone. The 7-day composite of death, recurrent PE, or...
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💊 Food as Medicine—from Beneath the Waves
🦪 Small Creatures, Mighty Nutrition, Global Impact Could aquatic invertebrates help close the global micronutrient gap? 🌊 A fascinating Nature study finds that current production supplies the equivalent annual requirements of vitamin B12 and selenium for >5 billion people—and copper, omega-3...
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🔌 Unplugging Pulmonary Hypertension: Can Denervation Change Heart Failure?
🫀 Cut the Signal, Cut the Risk? Could pulmonary-artery denervation change the trajectory of heart failure–related pulmonary hypertension? In PADN-HF-PH, 264 symptomatic patients were randomized to denervation + guideline-directed medical therapy or medical therapy alone. Clinical worsening at 2...
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🧬 Semaglutide, Senescence & Survival: Can GLP-1 Slow Ageing?
🧬 Could semaglutide do more than treat obesity and diabetes? A fascinating study in aged female mice suggests that late-life semaglutide may act partly as a calorie-restriction mimetic—improving cognition, physical function and glucose control while attenuating multiple hallmarks of ageing. 🐭⏳...
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30% Fewer Cardiovascular Events: Statins Still Matter After age 70
🫀 Should we start a statin after age 70? STAREE delivers an important answer. In 9,971 adults ≥70 without cardiovascular disease, diabetes, or dementia, atorvastatin 40 mg reduced major cardiovascular events by 30% over 5.9 years (HR 0.70; NNT 37). 💊 Yet it did not prolong disability-free...
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✍️ The Great Translator: How Constantine of Africa Carried Medicine Across Cultures
🌍 The Monk, the Manuscripts, the Medical Bridge How did Arabic medical knowledge reach medieval Europe? 📚🩺 Meet Constantine the African (c. 1010–1087)—North African physician, multilingual translator, and Benedictine monk at Monte Cassino. His Latin translations of major Arabic medical works...
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🫀 Plaque in Your 20s? The REACT Wake-Up Call
🫀 Atherosclerosis doesn't wait for middle age. In the REACT study of 16,808 adults without known ASCVD, silent plaque was found in 57.1% overall—and even in 8.7% of men and 6.7% of women aged 18–29. Plaque burden rose dramatically with age and increasingly involved multiple arterial territories....
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🛡️ One Risk Factor in Atrial Fibrillation: Is It Time for a DOAC?
🫀 AF + just one stroke-risk factor: anticoagulate or not? The SINGLE-AF randomized trial tackled this common clinical gray zone. At 24 months, the composite of stroke, systemic embolism, major bleeding, or cardiovascular death occurred in 0.5% with a DOAC vs 1.5% without anticoagulation (HR…
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🫀 Primary, Secondary, Procedural: Myocardial Infarction's New Big Three
🫀 MI has been redefined—and the numbers are gone. The Fifth Universal Definition of Myocardial Infarction (2026) replaces the familiar numerical MI types with a clinically intuitive trio: 🔴 Primary MI — acute coronary pathology 🟢 Secondary MI — supply–demand imbalance from another acute…
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Dapagliflozin Before the Cardiac Surgery: Kidney Protection in Four Doses
🫀💊 Can 4 doses help protect the kidney after cardiac surgery? MERCURI-2 randomized 784 patients to perioperative dapagliflozin or placebo. AKI within 7 days fell from 52% to 28%—RR 0.54, an absolute reduction of ~24% and NNT ≈4. 📉 Intriguingly, the signal was driven largely by...
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Shingles Shot, Heart Shield? 🛡️❤️
💉 Shingles Shot, Heart Shield? 🛡️❤️ Could recombinant shingles vaccination protect more than the skin? In a natural experiment involving >72,000 matched adults ≥60 years, the recombinant vaccine was associated with 9% lower cardiovascular disease burden over 7 years, including lower burdens of...
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⚖️ Pooling Without Fooling: When Meta-Analysis Deserves Your Trust
🔎 Can you believe that meta-analysis? Meta-analyses sit near the summit of evidence-based medicine—but pooling more studies does not automatically produce more truth. 📊 Lee and colleagues offer a powerful clinical lesson: credibility requires alignment of evidence, methods, and inference. Ask...
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🧠 Physician, Philosopher, Polymath: The Genius of Avicenna
🩺 Avicenna: Medicine, Mind & a Millennium of Influence Nearly 1,000 years ago, Ibn Sina—Avicenna—was already asking questions that still animate medicine: How should we observe disease? How do reason and experience guide diagnosis? How are mind and body connected? 🧠 His monumental Canon of...
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🫀 Smart Drugs, Vulnerable Hearts: Antibody Drug Conjugates Cardiotoxicity in Breast Cancer
🎯 Target the Tumor, Guard the Heart! ❤️ Antibody-drug conjugates are transforming breast cancer therapy—but precision oncology does not eliminate cardiovascular risk. 🧬🫀 This excellent JACC: CardioOncology Primer explores how the antibody, linker & payload may contribute to cardiotoxicity....
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Cardiovascular-Kidney-Metabolic syndrome Starts Young: The Arteries Already Know 🚨
🫀 Can vascular injury begin in your early 20s? Apparently, yes. In 1,283 young adults (mean age 22.9 years), ~79% had Stage 1–3 Cardiovascular-Kidney-Metabolic (CKM) syndrome. Higher CKM stage tracked with poorer Life's Essential 8 scores and greater carotid arterial injury. 🚨 Strikingly, even...
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The Trial of Epigenetic Aging Clocks ⏰: ⏳ Promise, Proof & Pitfalls
⏳ Can we measure aging before disease arrives? A fascinating Nature Medicine analysis puts epigenetic aging clocks to the test. Across 51 intervention studies and 3,128 blood samples, reliable next-generation clocks—particularly DunedinPACE and PCGrimAge—were the most responsive. 🧬 Pharmacologic...
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ABOUT THIS SHOW
"Got Knowledge Doc" Podkast with Dr. RR BaligaThe "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond.Each episode delves into topics such as cardiology, precision medicine, artificial intelligence in healthcare, epigenetics, and medical ethics—making complex advancements accessible and relevant to clinical practice. Importantly, this podcast is purely educational and does not provide medical advice or clinical opinions.Join Dr. Baliga and his esteemed guests as they navigate the evolving landscape of medical knowledge, empowering healthcare professionals with evidence-based insights that shape the fu
HOSTED BY
Dr RR Baliga, MD, MBA
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How many episodes does Dr RR Baliga's "Got Knowledge Doc" Podkast have?
Dr RR Baliga's "Got Knowledge Doc" Podkast currently has 1000 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Dr RR Baliga's "Got Knowledge Doc" Podkast about?
"Got Knowledge Doc" Podkast with Dr. RR BaligaThe "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in...
How often does Dr RR Baliga's "Got Knowledge Doc" Podkast release new episodes?
Dr RR Baliga's "Got Knowledge Doc" Podkast releases new episodes frequently with a large back catalog of 1000 episodes. Check the episode list for recent publication dates.
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Dr RR Baliga's "Got Knowledge Doc" Podkast is created and hosted by Dr RR Baliga, MD, MBA.
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