EPISODE · May 19, 2026 · 57 MIN
A Conversation with Entrepreneur Reid Hoffman
from Live with Tim O’Reilly · host O'Reilly
There may be a few people who are still unfamiliar with at least some aspect of Reid Hoffman’s long career—among other things, he’s a cofounder of LinkedIn, a partner at Greylock, the author of Blitzscaling and Superagency, and the cohost of the podcasts Masters of Scale and Possible. As Tim O’Reilly put it in his introductory remarks in this episode, “Reid has really been a force for good in the world.” Reid joined Tim for a conversation that touched on topics from across his career but was focused squarely on how AI is transforming business.Drawing on Reid’s investment work (he led OpenAI’s first commercial round), they first looked toward important areas for further research and funding—Reid argues that one promising area will be reinventing current industrial processes, like that for drug discovery, to be AI native. Then, in their wide-ranging discussion, Reid and Tim considered the implications on business as AI becomes enmeshed in business and society, grappling with weighty questions that will guide whatever the future may hold:Will the future of AI look more like Windows, with OpenAI in place of Microsoft, or the open web, with a proliferation of standard protocols like MCP?How will job roles and skills evolve in fields as varied as programming, medicine, marketing, and customer services? And more importantly, what choices should businesses make as AI disrupts the workforce to continue valuing the skills that are uniquely human?And why should people just entering the workforce optimize their career for AI—and have fun doing it?Stick around until the end to watch Reid chat with his AI-generated 1985 self about his fears and hopes for the future.
What this episode covers
There may be a few people who are still unfamiliar with at least some aspect of Reid Hoffman’s long career—among other things, he’s a cofounder of LinkedIn, a partner at Greylock, the author of Blitzscaling and Superagency, and the cohost of the podcasts Masters of Scale and Possible. As Tim O’Reilly put it in his introductory remarks in this episode, “Reid has really been a force for good in the world.” Reid joined Tim for a conversation that touched on topics from across his career but was focused squarely on how AI is transforming business.Drawing on Reid’s investment work (he led OpenAI’s first commercial round), they first looked toward important areas for further research and funding—Reid argues that one promising area will be reinventing current industrial processes, like that for drug discovery, to be AI native. Then, in their wide-ranging discussion, Reid and Tim considered the implications on business as AI becomes enmeshed in business and society, grappling with weighty questions that will guide whatever the future may hold:Will the future of AI look more like Windows, with OpenAI in place of Microsoft, or the open web, with a proliferation of standard protocols like MCP?How will job roles and skills evolve in fields as varied as programming, medicine, marketing, and customer services? And more importantly, what choices should businesses make as AI disrupts the workforce to continue valuing the skills that are uniquely human?And why should people just entering the workforce optimize their career for AI—and have fun doing it?Stick around until the end to watch Reid chat with his AI-generated 1985 self about his fears and hopes for the future.
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A Conversation with Entrepreneur Reid Hoffman
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