A stool sample for early detection of Alzheimer's Disease? |Espresso Knowledge Shots.

New study finds gut microbe patterns may serve as an early indicator of Alzheimer's risk, before symptoms arise. Explained by Dr. E.F.Rain. Alzheimer's disease afflicts millions, but we still lack ways to catch it early before irreversible brain damage occurs. What if a routine stool sample could signal Alzheimer's risk years before memory and thinking problems surface? This exciting new research suggests our gut microbes may provide clues about brain changes linked to Alzheimer's, opening up new possibilities for early screening and prevention. This paper investigates whether there are differences in gut microbiome composition between healthy individuals and those with preclinical Alzheimer's disease (AD). Preclinical AD refers to the stage where biomarker evidence of AD pathology is present but symptoms have not yet appeared. The authors hypothesized that gut microbiome dysbiosis may be detectable at this early disease stage and could serve as an accessible indicator of AD risk. ///~Social media~///: These episodes of 'Espresso Knowledge Shots' or quick paper reviews are also available on the 'Decoding Healthcare Research' Podcast. You can find it as 'Decoding Healthcare Research' on Spotify, Apple Podcasts, and Amazon Music. Enjoy! -Follow us on Instagram and TikTok @agora_health and on Facebook at Agora Health. -Find Dr. E.F.Rain as @dr.ef.rain on Instagram. Visit our website at agora-community.com, where you can access all our content and join our exclusive online community of healthcare professionals. It's the perfect place for networking, case discussions, conversations about our professional practice as healthcare professionals, and more! -Reference: Ferreiro AL, Choi J, Ryou J, Newcomer EP, Thompson R, Bollinger RM, Hall-Moore C, Ndao IM, Sax L, Benzinger TLS, Stark SL, Holtzman DM, Fagan AM, Schindler SE, Cruchaga C, Butt OH, Morris JC, Tarr PI, Ances BM, Dantas G. Gut microbiome composition may be an indicator of preclinical Alzheimer's disease. Sci Transl Med. 2023 Jun 14;15(700):eabo2984