Ageotypes 4 New Personal Aging Makers Dr. Michael Snyder Stanford University Part V

Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department  of Genetics and Director, Center for Genomics and Personalized Medicine  at Stanford University. He is a leader in the field of functional  genomics and proteomics. Seminal findings from the Snyder laboratory  include the discovery that much more of the human genome is transcribed  and contains regulatory information than was previously appreciated, and  a high diversity of transcription factor binding occurs both between  and within species. He has also pioneered the use of different  state-of-the-art “omics” technologies as well as wearable devices for  managing human health.    In this episode, Dr. Snyder will talk about Ageotypes, defined as the part  of the body where the aging process was most active based on a research  study led by him, which could explain why we age at different rates. The study tracked 106 healthy individuals, aged between 29 and 75,  taking blood and biological samples to investigate each person at a deep  molecular level. They carried out tests at least five times over two  years in order to record any changes, with Dr. Snyder even taking part  as a subject of his own research.    Researchers discovered four “ageotypes,” – defined as the part of the  body where the aging process was most active. Those involved in the  trial tended to age most within the immune system, kidney, liver, or at a  metabolic level.  Ageotypes may provide a molecular assessment of personal aging,  reflective of personal lifestyle and medical history, that may  ultimately be useful in monitoring and intervening in the aging process. Personal aging markers and ageotypes revealed by deep longitudinal  profiling