🧬 Aging Hearts, Arrested Cells: The Cellular Villain in CardioVascular Aging 🫀

🧬 Cellular senescence is more than just a marker of aging — it's a key driver of ❤️ cardiovascular disease. From the p53/p21 and p16/Rb axes to mTOR, SIRT1/6, NF-κB, and ROS/DDR, these molecular pathways halt cell division, fuel inflammation 🔥, and impair cardiac repair. Emerging data spotlight the roles of 💣 SASP, 🧓 senescent MSCs, and 🎯 microRNAs in accelerating vascular aging. Time to rethink how we tackle heart disease — at the cellular level. 🫀   📄 Based on: The role of cellular senescence in cardiovascular disease (doi:10.1038/s41569-023-00899-1) #Cardiology #Senescence #CVD #Inflammaging #PrecisionMedicine #MolecularCardiology #HeartHealth